NPP BrainPod
- Épisodes
- 77
- Parution
- irrégulière
- Dernier épisode
- 10 Nov 2026
À propos du podcast
BrainPod is the podcast from the journal Neuropsychopharmacology, produced in association with Nature Publishing Group. Join us as we delve into the latest basic and clinical research that advance our understanding of the brain and behavior, featuring highlighted content from a top journal in fields of neuroscience, psychiatry, and pharmacology. For complete access to the original papers and reviews featured in this podcast, subscribe to Neuropsychopharmacology.
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Épisodes 77
Altered thalamo-prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition
Joshua Gordon is a professor and chair of the Department of Psychiatry at Columbia University, and one of the authors of a new study in the journal Neuropsychopharmacology. There can be a strong genetic risk …
Notes de l’épisode
Joshua Gordon is a professor and chair of the Department of Psychiatry at Columbia University, and one of the authors of a new study in the journal Neuropsychopharmacology. There can be a strong genetic risk factor for schizophrenia, and loss of function mutations in the gene SETDIA raise the risk of schizophrenia by about 60-80 fold, a dramatic increase in risk. Sofiya Hupalo is the clinical and regulatory science lead at the Usona Institute and is another one of the study’s authors.Hosted on Acast. See acast.com/privacy for more information.
Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders
Problematic alcohol use frequently occurs in conjunction with anxiety disorders. Between 20 to 40 percent of individuals with anxiety disorders are also diagnosed with alcohol use disorder. Anxiety can lead …
Notes de l’épisode
Problematic alcohol use frequently occurs in conjunction with anxiety disorders. Between 20 to 40 percent of individuals with anxiety disorders are also diagnosed with alcohol use disorder. Anxiety can lead people to use alcohol to self-medicate, and disordered alcohol use can cause increased anxiety for people when they go through withdrawal.
Joshua Gray is an associate professor in the department of psychology at Uniformed Services University, and one of the authors of a new study in the journal Neuropsychopharmacology. For the study, he and his colleagues drew on data from biobanks that originally included more than a million individuals. The samples were then modified to minimize overlap between the datasets, and the team ended up with about 860,000 individuals in the problematic alcohol use analysis and about 620,000 in the anxiety analysis.
Read the full study here: https://www.nature.com/articles/s41386-026-02494-z
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Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia
Insomnia and depression are two serious and debilitating conditions. Insomnia on its own is linked to an increase in suicide risk, and insomnia can also exacerbate the severity of depression.Andrea …
Notes de l’épisode
Insomnia and depression are two serious and debilitating conditions. Insomnia on its own is linked to an increase in suicide risk, and insomnia can also exacerbate the severity of depression.
Andrea Goldstein-Piekarski, assistant professor in the department of psychiatry and behavioral sciences at Stanford, and Adam Krause, post-doctoral research fellow in Stanford’s psychiatry department, are two of the authors of a recent study in the journal Neuropsychopharmacology. Cognitive behavioral therapy for insomnia, or CBTI, is the gold standard for treating insomnia, and it’s been shown to relieve depressive symptoms as well.
Read the full study here: https://www.nature.com/articles/s41386-026-02431-0
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Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats
There are a number of theories that have been studied to try to explain addiction and drug use escalation, and thus to also create animal models of that behavior that can then serve to help develop treatments …
Notes de l’épisode
There are a number of theories that have been studied to try to explain addiction and drug use escalation, and thus to also create animal models of that behavior that can then serve to help develop treatments. One theory for escalation is that people feel worse and worse over time and so they take the drug to feel better. Another is that they just don’t get as much of a reaction to the drug and so need more and more of it to get the euphoria. And then there’s something called incentive salience, which is a craving for the drug.
Read the full study here: Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats | Neuropsychopharmacology
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Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles
Oxytocin has become known for having anti-anxiety and affiliative behavioral effects. That’s why clinicians and researchers are excited about using oxytocin as a potential therapeutic. Brian Trainor is a …
Notes de l’épisode
Oxytocin has become known for having anti-anxiety and affiliative behavioral effects. That’s why clinicians and researchers are excited about using oxytocin as a potential therapeutic.
Brian Trainor is a professor at UC Davis, and his lab has been studying this complexity for the past decade. For an animal model, they work with a territorial, aggressive, monogamous rodent species called California mice. If the male is removed and the female is forced to defend their nest, she will experience what’s known as social defeat, and she will exhibit what’s called inhibited affiliative behavior, the type that can be affected by oxytocin — and this effect can be studied in a mouse’s brain.
Read the full study here: https://www.nature.com/articles/s41386-026-02352-y
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The genetics of cannabis lifetime use
Cannabis, which is increasingly legally available, both for therapeutic and recreational use, is now one of the most commonly used drugs worldwide. Of people who have ever used cannabis, studies vary, but they …
Notes de l’épisode
Cannabis, which is increasingly legally available, both for therapeutic and recreational use, is now one of the most commonly used drugs worldwide. Of people who have ever used cannabis, studies vary, but they estimate that about 10-25 percent of people who use cannabis go on to develop cannabis use disorder.
Uri Bright is a postdoctoral associate at the Yale School of Medicine and is one of the authors of a recent study in the journal Neuropsychopharmacology on the genetics of cannabis lifetime use — which is anyone who has ever used cannabis even once. That’s a distinct population from people who have cannabis use disorder, as his colleagues had looked into in the previous study.
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Older and wiser? The neural correlates of worry induction and reappraisal in older adults
Worry seems like something most people do from time to time, but for some people, severe worry can become an overwhelming sensation, and for older adults later in life, severe worry has been associated with an …
Notes de l’épisode
Worry seems like something most people do from time to time, but for some people, severe worry can become an overwhelming sensation, and for older adults later in life, severe worry has been associated with an increased risk of stroke and coronary heart disease. Carmen Andreescu is a professor of psychiatry and bioengineering at the University of Pittsburgh School of Medicine. She says mild worry is useful evolutionarily, to help us make plans or adapt behavior.
Read the full study here: https://www.nature.com/articles/s41386-025-02193-1
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Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls
There’s been a fair amount of animal data suggesting that nicotine can affect the developing brain, but there hadn’t been the equivalent human studies done on people whose brains are still developing. And today …
Notes de l’épisode
There’s been a fair amount of animal data suggesting that nicotine can affect the developing brain, but there hadn’t been the equivalent human studies done on people whose brains are still developing. And today there are two predominant forms of nicotine delivery - tobacco cigarettes, and e-cigarettes, or vaping.
Laurie Zawertailo is a senior scientist at the Center for Addiction and Mental Health in Toronto and an associate professor in the department of pharmacology and toxicology at the University of Toronto. Kanwar Boparai recently completed her PhD, working with Dr. Zawertailo, and is now a postdoc. For their new study, they and some colleagues recruited young adults age 18-25, and these people fell into three groups: one that had only smoked cigarettes, one that had only ever vaped, and a third that functioned as a control, that had never used either. They ended up with 26 smokers, 27 vapers, and 25 controls. This is the first human study to separate cigarette smokers and vapers into distinct groups.
Read the full study here: https://www.nature.com/articles/s41386-025-02086-3
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Validation of L-type calcium channel blocker amlodipine as a novel ADHD treatment through cross-species analysis, drug-target Mendelian randomization, and clinical evidence from medical records
Attention deficit hyperactivity disorder, or ADHD, is a common condition that, for a lot of people, is difficult to treat. The drugs that exist have a number of adverse side effects, and about 25 percent of …
Notes de l’épisode
Attention deficit hyperactivity disorder, or ADHD, is a common condition that, for a lot of people, is difficult to treat. The drugs that exist have a number of adverse side effects, and about 25 percent of patients don’t respond to existing drugs. And so a team of researchers in Iceland, led by Karl Karlsson, professor of biomolecular engineering at Reykjavik University, undertook a number of different steps to narrow in on and then test what the team has determined to be a novel treatment for ADHD, using an existing drug, amlodipine.
Read the full study here: https://www.nature.com/articles/s41386-025-02062-x
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Rapid and sustained antidepressant effects of vaporized N,N-Dimethyltryptamine: A Phase 2a clinical trial in Treatment-Resistant Depression.
Draulio Araujo, professor at the Brain Institute in the University of Rio Grande Norte in Natal, Brazil, has been studying ayahuasca for more than 20 years. It’s a psychedelic plant used in rituals in South …
Notes de l’épisode
Draulio Araujo, professor at the Brain Institute in the University of Rio Grande Norte in Natal, Brazil, has been studying ayahuasca for more than 20 years. It’s a psychedelic plant used in rituals in South America that has also been researched for its potential to treat depression. The effects of ayahuasca can last for hours and also lead to side effects including vomiting and diarrhea. The active psychedelic drug in ayahuasca is DMT, and so Dr. Araujo and his colleagues decided to conduct the first test of DMT itself, which is also an endogenous chemical and has been demonstrated to be safe.
Read the full article here: https://www.nature.com/articles/s41386-025-02091-6
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Endocannabinoid contributions to the perception of socially relevant, affective touch in humans
New drugs that target the endocannabinoid system are being proposed for disorders that are usually characterized by the dysregulation of social processing, like social anxiety disorder and autism spectrum …
Notes de l’épisode
New drugs that target the endocannabinoid system are being proposed for disorders that are usually characterized by the dysregulation of social processing, like social anxiety disorder and autism spectrum disorder. Researchers have been trying to understand the mechanisms for how these drugs work.
Leah Mayo is assistant professor at the University of Calgary, and she’s one of the authors of a new study in the journal Neuropsychopharmacology in which they examined two aspects of the system. One is the endocannabinoid system itself. And then there’s another aspect of social processing called the C tactile system.
Read the full study here: Endocannabinoid contributions to the perception of socially relevant, affective touch in humans | Neuropsychopharmacology
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Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats
The scientific literature has shown that females demonstrate more aversion to risk-taking than males. Studies have also demonstrated that the basal lateral amygdala, or BLA, is a critical hub for processing …
Notes de l’épisode
The scientific literature has shown that females demonstrate more aversion to risk-taking than males. Studies have also demonstrated that the basal lateral amygdala, or BLA, is a critical hub for processing risk and reward information. And yet further research has shown that activity in the amygdala differs between males and females, and that the expression of particular dopamine receptors called D2 receptors are greater in females than in males. The authors hypothesized that one mediating mechanism that leads to greater risk aversion in females is differential activity of dopamine in the basal lateral amygdala.
Caitlin Orsini is an assistant professor in the departments of psychology and neurology at UT Austin.
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Biomarker development for menstrual Cycle affective change: the need for greater temporal, mechanistic, and phenotypic specificity.
The menstrual cycle is known to affect things like mood and changes in pain. But there can also be symptoms that have a serious impact on a person’s function, ability to work, ability to maintain friendships …
Notes de l’épisode
The menstrual cycle is known to affect things like mood and changes in pain. But there can also be symptoms that have a serious impact on a person’s function, ability to work, ability to maintain friendships and romantic relationships. This is a rare condition known as premenstrual dysphoric disorder. But it’s not the only psychiatric condition that can worsen with changes in the menstrual cycle. For instance, nearly 60 percent of menstruating patients with depression can experience cyclical worsening similar to PMDD. Conditions such as these are generally referred to as menstrual cycle affective change. Menstrual cycle affective change is more common in those with chronic psychiatric disorders.
The authors are interested in reframing the conversation around menstrual cycle affective change to be something that is a more fundamental process that we can study across disorders, across categories, and identify biomarkers that might help us predict who's going to have those symptoms in more complex ways than we might be able to do with categories. This paper represents how can we take this dimensional way of thinking about menstrual cycle affective change and talk about the specific ways that we can be precise in looking at the time the time characteristics of that, the specific mechanisms, et cetera.
Tory Eisenlohr-Moul is an associate professor of psychiatry at the University of Illinois at Chicago in the department of psychiatry, and she’s one of the authors. Jordan Barone is an MD/PhD candidate at the University of Illinois at Chicago, and she’s another author.
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Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations
Researchers are interested in understanding the biology of why some people are more likely to overconsume substances. Some substances are difficult to study—people might not admit to illegal substance abuse or …
Notes de l’épisode
Researchers are interested in understanding the biology of why some people are more likely to overconsume substances. Some substances are difficult to study—people might not admit to illegal substance abuse or to how much alcohol they drink. But Americans are more likely to accurately recall and share how much coffee they drink—which is related to how much caffeine they consume. And so a team of researchers paired up with the company 23 and Me to try to understand genetic differences among a large set of people, to try to tease out any genetic similarities that could be correlated with coffee consumption. Sandra Sanchez-Roige is an associate professor in the department of psychiatry at the University of California San Diego, and she’s one of the study’s authors. Abraham Palmer is a professor and vice chair of basic research in the department of psychiatry at UC San Diego, and he’s another of the study’s authors.
Read their full study here: https://www.nature.com/articles/s41386-024-01870-x
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C-reactive protein moderates associations between racial discrimination and ventromedial prefrontal cortex activation during attention to threat in Black American women
Scientists have been amassing an increasing amount of evidence about the impact of racial discrimination and racial trauma, including how it can have an impact on brain regions involved with threat vigilance …
Notes de l’épisode
Scientists have been amassing an increasing amount of evidence about the impact of racial discrimination and racial trauma, including how it can have an impact on brain regions involved with threat vigilance and emotional regulation. At the same time, there’s evidence that increased engagement in those areas has been linked to increased risk of mental health problems like depression, and they also suspect it could be a vulnerability for brain health issues such as dementia and Alzheimer’s disease.
Negar Fani is an associate professor in the department of psychiatry and behavioral sciences at Emory University School of Medicine, and she worked with Aziz Elbasheir, a PhD candidate at Emory University in the neuroscience program, on the study. They knew that C-reactive proteins, or CRPs, are a marker of immune activation in the blood.
Read their full study here: https://www.nature.com/articles/s41386-023-01737-7
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Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial
There’s a hormone called ghrelin that’s secreted in the stomach, and when someone is hungry it contributes to that feeling of hunger and the need to search for food. But neurological studies have suggested that …
Notes de l’épisode
There’s a hormone called ghrelin that’s secreted in the stomach, and when someone is hungry it contributes to that feeling of hunger and the need to search for food. But neurological studies have suggested that ghrelin might also play a role in compulsivity and impulsivity, and it might be related to substance use disorders.
Rebecca Boeme is an assistant professor at Linkoping University in Sweden. She and her colleagues decided to use human subjects to investigate how ghrelin affects reinforcement learning, basically how ghrelin influences decision making when subjects receive positive and negative feedback —and also how it might actually be affecting the brain.
Read the full study here: https://www.nature.com/articles/s41386-024-01821-6
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Spotlighting SHAPERS: Sex hormones associated with psychological and endocrine roles
Dr. Nicole Petersen is an assistant professor in the department of psychiatry and behavioral sciences at UCLA. Her commentary is a new paper in the journal Neuropsychopharmacology, called “Spotlighting SHAPERS …
Notes de l’épisode
Dr. Nicole Petersen is an assistant professor in the department of psychiatry and behavioral sciences at UCLA. Her commentary is a new paper in the journal Neuropsychopharmacology, called “Spotlighting SHAPERS: sex hormones associated with psychological and endocrine roles.” Dr. Petersen starts the paper describing an unnamed signaling molecule that can affect the physical structure of the brain and that seems to be related to a wide number of psychological and neurological conditions. Then she reveals that this is estradiol. The point she makes in the paper is that estrogen isn’t the only neuroactive substance that affects the brain in ways that we just don’t understand.
Read the full study here: https://www.nature.com/articles/s41386-024-01819-0
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Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making
Serotonin is a critical chemical when it comes to a number of psychiatric conditions, such as OCD, where it seems to play a particular role in cognitive flexibility. That is, serotonin levels are related to the …
Notes de l’épisode
Serotonin is a critical chemical when it comes to a number of psychiatric conditions, such as OCD, where it seems to play a particular role in cognitive flexibility. That is, serotonin levels are related to the fact that someone is perseverating on intrusive thoughts or compulsions and isn’t able to be as flexible as otherwise would be necessary.
Trevor Robbins, professor of cognitive neuroscience at the University of Cambridge, is one of the authors of a recent study titled Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making, and he says such cognitive flexibility also plays a role in depression and schizophrenia.
Read the full study here: https://www.nature.com/articles/s41386-023-01762-6
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Integrating public health and translational basic science to address challenges of xylazine adulteration of fentanyl
The drug naloxone, otherwise known as Narcan, is a critical tool in reversing fentanyl overdoses and reducing mortality. But now fentanyl is appearing on the streets adulterated with a drug called xylazine …
Notes de l’épisode
The drug naloxone, otherwise known as Narcan, is a critical tool in reversing fentanyl overdoses and reducing mortality. But now fentanyl is appearing on the streets adulterated with a drug called xylazine.
Justin Strickland, assistant professor at Johns Hopkins University School of Medicine, and Cassandra Gipson-Reichardt, associate professor in the department of pharmacology nutritional sciences at the University of Kentucky, are the coauthors of a new paper in the journal Neuropsychopharmacology about the importance of integrating public health and translational science to address the challenges of xylazine adulteration of fentanyl.
Read the full study here: https://www.nature.com/articles/s41386-023-01680-7
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The why, when, where, how, and so what of so-called rapidly acting antidepressants
Sanjay Mathew is a professor and vice chair for research at Baylor College of Medicine and director of the Mood and Anxiety Disorders Program. He’s one of the two authors of a recent review paper in the journal …
Notes de l’épisode
Sanjay Mathew is a professor and vice chair for research at Baylor College of Medicine and director of the Mood and Anxiety Disorders Program. He’s one of the two authors of a recent review paper in the journal Neuropsychopharmacology, “The why, when, where, how, and so what of so-called rapidly acting antidepressants.”
With his colleague Alan Schatzberg, professor of psychiatry and behavioral sciences and director of the Mood Disorders Center at Stanford University, they explore both the drugs that have been studied as rapidly-acting anti-depressants to date, and they also review the challenges and opportunities in how such research is conducted. They say that a version of ketamine has changed the field.
Read the full study here: https://www.nature.com/articles/s41386-023-01647-8
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AI-based analysis of social media language predicts addiction treatment dropout at 90 days
In-person treatment for substance use disorders is an incredibly important tool, but there’s a high failure rate — more than 50 percent of people who enter drop out within the first month. There hasn’t been a …
Notes de l’épisode
In-person treatment for substance use disorders is an incredibly important tool, but there’s a high failure rate — more than 50 percent of people who enter drop out within the first month. There hasn’t been a highly accurate method of identifying who might leave and who might succeed, and knowing this could help centers allocate resources to give the right type of assistance to the right people at the right time. One tool available is called the Addiction Severity Index, which is used to help identify the severity of the addiction and thus customize treatment, but it wasn’t developed to gauge whether a patient might drop out entirely. So a team of researchers decided to mine something known as a digital phenotype.
Dr. Brenda Curtis is a clinical researcher at the National Institute on Drug Abuse Intramural Research Program, and she’s one of the paper’s authors.
Read the full study here: https://www.nature.com/articles/s41386-023-01585-5
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Oxytocin effects on amygdala reactivity to angry faces in males and females with ASPD
Antisocial personality disorder, or ASPD, is a difficult disorder to study. There have been studies on psychopathic individuals, and on youth with psychopathic traits, but most studies on ASPD to date have been …
Notes de l’épisode
Antisocial personality disorder, or ASPD, is a difficult disorder to study. There have been studies on psychopathic individuals, and on youth with psychopathic traits, but most studies on ASPD to date have been on incarcerated adults. A team of researchers at Heidelberg University wanted to study individuals who are not incarcerated and see what these findings could elucidate about the brains, in particular the amygdalas, of individuals with ASPD.
Haang Jeung-Maarse is a medical doctor at Bielfeld University in Germany and is one of the authors of the paper in the journal Neuropsychopharmacology, on the effects of oxytocin on amygdala reactivity to angry faces in males and females with antisocial personality disorder.
Read the full study here: https://www.nature.com/articles/s41386-023-01549-9
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To dismantle structural racism in science, scientists need to learn how it works
It’s clear there are diversity issues in science, both in terms of who does or doesn’t receive research grants, as well as who is or isn’t represented at the highest levels of scientific research. When Caleb …
Notes de l’épisode
It’s clear there are diversity issues in science, both in terms of who does or doesn’t receive research grants, as well as who is or isn’t represented at the highest levels of scientific research. When Caleb Weinreb and Daphne Sun began their PhD program at Harvard University Medical School in systems biology, they took this on as an issue. They learned from others in their department, and they eventually created a course on the topic for incoming first year PhD students.
As they worked on improving their course over the years, they saw that in science there was a focus on narrowing racial gaps by correcting for implicit bias. For example, there had been a well-known study in which resumes with stereotypically African-American names weren’t considered as seriously as those with stereotypically white names. But the two PhD students realized that efforts to overcome such implicit bias weren’t moving the needle. They recently published a perspective paper in the journal Neuropsychopharmacology called “To dismantle structural racism in science, scientists need to learn how it works.” Caleb Weinreb is now a post-doc in the neuroscience department at Harvard Medical School.
Read the full paper here: https://www.nature.com/articles/s41386-023-01534-2
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Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
Psychedelic drugs have received attention recently for their potential use as treatments for psychiatric disorders. Single, high doses of LSD have shown promise for treating depressive disorders. But there’s …
Notes de l’épisode
Psychedelic drugs have received attention recently for their potential use as treatments for psychiatric disorders. Single, high doses of LSD have shown promise for treating depressive disorders. But there’s another way in which people have been using LSD, and it’s what’s known as micro-dosing, taking LSD at below noticeable levels, where it doesn’t seem to have a psychedelic impact—but users say it does in fact have an impact on their overall sense of well-being.
This is just what Harriet de Wit, University of Chicago professor in the department of psychiatry and behavioral neuroscience, wanted to study. Dr. de Wit partnered with James Glazer, a postdoc in psychiatry at Northwestern University.
Read their full study here: Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity | Neuropsychopharmacology (nature.com)
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Sex-dependent risk factors for PTSD: a prospective structural MRI study
After a traumatic event, women are more likely to be diagnosed with post-traumatic stress disorder, or PTSD. Research has been conducted on what might be causing this higher rate of diagnoses; for instance …
Notes de l’épisode
After a traumatic event, women are more likely to be diagnosed with post-traumatic stress disorder, or PTSD. Research has been conducted on what might be causing this higher rate of diagnoses; for instance, perhaps women had more cumulative trauma in their lives than the men in question. But scientists say that even taking prior childhood trauma into account, women are still diagnosed at a higher rate than men.
Alyssa Roeckner is a neuroscience PhD candidate at Emory University, she’s in the lab of Dr. Jennifer Stevens, assistant professor in the department of Psychiatry and Behavioral Sciences at Emory University. They are two of the authors of a recent study in NPP titled “Sex-dependent risk factors for PTSD: a prospective structural MRI study.”
Read the full study here: Sex-dependent risk factors for PTSD: a prospective structural MRI study | Neuropsychopharmacology (nature.com)
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Sex differences in appetitive and reactive aggression
Maladaptive aggression, while not a diagnosable neuropsychiatric disorder on its own, often presents as an important comorbid condition with other neuropsychiatric disorders. But while both men and women can …
Notes de l’épisode
Maladaptive aggression, while not a diagnosable neuropsychiatric disorder on its own, often presents as an important comorbid condition with other neuropsychiatric disorders. But while both men and women can and do display aggression, there’s been a bias to thinking of aggression, in both its adaptive and maladaptive forms, as a male behavior.
Sam Golden is an assistant professor at the University of Washington in the department of biological structure and also has an appointment in the Center for Excellence in the Neurobiology of Addiction, Pain, and Emotion. He’s one of the authors of a recent study on aggression in the journal Neuropsychopharmacology.
Read the full study here: Sex differences in appetitive and reactive aggression | Neuropsychopharmacology (nature.com)
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What’s wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research
Sometimes, when researchers are conducting an experiment, the results are confusing. Maybe the control group of animals doesn’t behave the way a control should in theory be behaving. Maybe a researcher repeats …
Notes de l’épisode
Sometimes, when researchers are conducting an experiment, the results are confusing. Maybe the control group of animals doesn’t behave the way a control should in theory be behaving. Maybe a researcher repeats a study and sees results that are unusually different from the first time around. The answers to these issues might lie in something called ‘hidden variables,’ according to a new study titled, “What’s wrong with my research? The impact of hidden variables on neuropsychopharmacology research.”
Brian Trainor is a professor of psychology at the University of California Davis, and he’s one of three authors of the study. His co-authors are Amanda Kentner, professor at the Massachusetts College of Pharmacy and Health Sciences, and Hannah Butler-Struben, a graduate student in the animal behavior group at UC Davis. They say that many of the articles in the review are from journals about animal behavior that wouldn’t typically come across the desk of those working in the field of neuroscience.
Read the full article here: What’s wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research
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A scientific approach to navigating the academic job market
Kirstie Cummings and Sofia Beas are both new assistant professors in the department of neurobiology at the University of Alabama, Birmingham. When they met, they discussed the job application process, their …
Notes de l’épisode
Kirstie Cummings and Sofia Beas are both new assistant professors in the department of neurobiology at the University of Alabama, Birmingham. When they met, they discussed the job application process, their support network, and their own personal processes, and they decided to write an article that could serve as a resource for candidates from different backgrounds, many of whom might not have the same resources that Dr. Cummings and Dr. Beas did. The result was their paper, “A Scientific Approach to Navigating the Academic Job Market,” published in the journal Neuropsychopharmacology.
Read the full article here: A scientific approach to navigating the academic job market | Neuropsychopharmacology (nature.com)
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Identification of THC impairment using functional brain imaging
Driving while under the influence of THC, known as drugged driving, is becoming more of an issue as more states legalize cannabis for both medical and recreational use around the country. THC is known to impair …
Notes de l’épisode
Driving while under the influence of THC, known as drugged driving, is becoming more of an issue as more states legalize cannabis for both medical and recreational use around the country. THC is known to impair cognitive and psychomotor performance and thus impair driving. Jodi Gilman is a neuroscientist and an associate professor of psychiatry at Mass General Hospital and Harvard Medical School, and she’s one of the authors of a new study in the journal Neuropsychopharmacology. She says that impairment and exposure are easier to correlate with alcohol. But tolerance to THC is so vastly different among different people, and the amounts that people use whether for pain or to get high are also so vastly different, that people can have detectible amounts of THC in their system, but it does not necessarily correlate with whether or not that person is too impaired to drive. Listen in to hear what she and her team did to try to detect brain impairment under the influence of THC.
Read the full article here: https://www.nature.com/articles/s41386-021-01259-0
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Evolution of prefrontal cortex
In the past, there had been a school of thought that looked at evolution linearly — that is, you could in theory draw a line among mammals as they evolved, and so, say, rodent brains would basically be less …
Notes de l’épisode
In the past, there had been a school of thought that looked at evolution linearly — that is, you could in theory draw a line among mammals as they evolved, and so, say, rodent brains would basically be less evolved primate brains. That turns out not to be true; evolution is much more like a branching tree, and each branch then goes on to develop independently, sometimes in parallel. Some groups of animals such as primates can evolve features of their brains that other groups simply don’t have. And now, with advanced DNA sequencing, scientists have been able to determine which groups of mammals are more closely related than others, and so they’ve figured out that, for instance, tree shrews and flying lemurs are more closely related to primates than rodents are. Here, we speak with Dr. Todd M. Preuss, professor of pathology at Emory University and an associate research professor at the Yerkes National Primate Research Center. Dr. Preuss is co-author with Steven Wise of a review article in Neuropsychopharmacology called “Evolution of prefrontal cortex.” Listen in!Hosted on Acast. See acast.com/privacy for more information.
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