Why Weight Loss Feels Impossible | Dr. Eric Trexler

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Guest Links

Dr. Eric Trexler's Links:

• Instagram: @trexlerfitness
• ResearchGate: Eric Trexler publications
• Research review: MASS Research Review

Timestamps

00:00 Weight-loss non-responders and the laws of thermodynamics

03:22 Rare medical conditions and extreme hunger

06:34 Hunger genetics, GLP-1s, and learning empathy

12:15 Lipedema and regionally resistant fat

21:48 PCOS, hypothyroidism, and what they do to metabolism

31:08 Three reasons weight loss can feel impossible

36:34 Tracking errors and the classic underreporting study

46:08 Food-label and restaurant-calorie errors

50:33 Controlled diet research and metabolic adaptation

58:39 Support, adherence, and why consistently showing up works

01:03:14 GLP-1s, side effects, and personalized dosing

01:10:45 Aging, activity, stress, and the myth of the 40-year-old metabolism