GLP-1s and Muscle Loss: What Ozempic Users Need to Know
Notes de l’épisode
One in eight American adults have now tried a GLP-1 (Ozempic, Wegovy, Mounjaro, Zepbound). The drugs work—people lose 15-22% of their body weight in clinical trials. But new research published this month confirms what many suspected: 25-40% of that weight loss is muscle, not fat. That is catastrophic for long-term metabolic health, strength, and healthspan.
This episode breaks down the latest meta-analysis, explains why muscle loss matters (it's not just vanity—muscle is your metabolic engine, structural support, and predictor of longevity), and offers five practical steps to preserve muscle if you're on or considering GLP-1s.
If you're considering GLP-1s, on them currently, or have an aging parent using them—this is the conversation you need to hear.
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- GLP-1 muscle loss — the biggest health and fitness story of the week
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