Gene Therapy's Dark Ages

Gene therapy is based on a simple-sounding, yet deceptively complicated premise: adding or replacing faulty genes to fix medical problems. A compelling idea that came out of breakthroughs in DNA research, the field grew lightning fast. But the death of teenager Jesse Gelsinger after a gene therapy clinical trial left the public and scientists questioning the field's promise.

Why did researchers push ahead with clinical trials despite gene therapy still being in its infancy? What does the Jesse Gelsinger story tell us about the personal risk behind medical breakthroughs?

Credits

Host: Alexis Pedrick Executive Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Samia Bouzid Music by Blue Dot Sessions

Resource List

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"Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy." Georgetown University Library.

Rinde, Meir. "The Death of Jesse Gelsinger, 20 Years Later." Science History Institute, June 4, 2019.

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