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What Babies Today Are Missing in Their Gut (And Why It Matters) w/ Dr. Stephanie Culler

05.10.2026 · 54 Min.

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This conversation is one I truly believe can change lives. Dr. Stephanie Culler helped me see that a baby's gut bacteria are one of the most overlooked pieces of their health. The first 1,000 days of life shape so much more than I ever realized. What struck me most is that so few parents, and even pediatricians, are hearing about this research. I walked away wishing every pediatrician could hear it, and every mom too. Share this one with all your friends with littles!

Here are a few of my biggest takeaways from our conversation:

  1. The first 1,000 days matter more than we realize. A baby's gut microbiome is built during this early window. What happens there is connected to their digestion, immune system, and brain development, and its effects can reach into adulthood.
  2. Babies today have different gut bacteria than babies a generation ago. Stephanie led the My Baby Biome study, the largest U.S. study to profile the infant gut microbiome. It found that many babies today are missing key bacteria that used to be common.
  3. C-sections, antibiotics, and feeding choices all shape a baby's gut. Knowing how they affect gut bacteria simply helps parents make informed decisions.
  4. Gut bacteria are the missing piece alongside nutrition. Gut bacteria play an important role in how a baby digests and uses that nourishment. We talk about how to make sure a baby's gut microbiome is in a good place!
  5. Gut health matters at every age. We also talked about adult gut health, why fiber is so important for feeding good bacteria, and why researchers are paying close attention to the rise in colorectal cancer among younger adults.

Tune in now and share this one with a parent friend who needs to hear it!

About Dr. Stephanie Culler

Stephanie Culler, Ph.D., is the co-founder and CEO of Persephone Biosciences, where she is pioneering microbiome-based medicines to transform human health. She is the lead author of the My Baby Biome study, the largest U.S. study to profile the infant gut microbiome, and her work spans applications from infant health to oncology. Stephanie earned her Ph.D. from the California Institute of Technology and has authored more than 20 scientific publications and patents.

Connect with Stephanie

Website: persephone.bio Instagram: @persephone.bio

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