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Latent Space: The AI Engineer Podcast
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Latent Space: The AI Engineer Podcast

NeuDesigning for Agents — Zeno Rocha, Resend10.11.2026 · 1 Std. 26 Min.
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297
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10. Nov. 2026

Über den Podcast

The main Latent Space podcast: AI engineering, Forward Deployed Engineering, AI for science, and ⚡ Lightning episodes. Other feeds: Engineering and FDE: https://podcast.latent.space/eng.xml; Science: https://podcast.latent.space/science.xml; Misc (Lightning and other shows): https://podcast.latent.space/misc.xml; Firehose (all available shows): https://podcast.latent.space/firehose.xml. Feed directory: https://latent.space/pods

Folgen 297

  1. Designing for Agents — Zeno Rocha, Resend

    1 Std. 26 Min.

    swyx had already connected Cloudflare email. Then a coding agent opened a pull request that quietly chose Resend for him. Zeno Rocha, Resend’s founder and CEO, explains what answer engine optimization (AEO) …

  2. What Frontier Labs Buy: A Data Deep Dive with Handshake AI — Garrett Lord & Team

    2 Std. 44 Min.

    Our first deep dive with an AI data company. In roughly a year, Handshake built an AI training business doing nearly $1 billion in gross annualized revenue. What are frontier labs buying? Garrett Lord joins us …

  3. [One Million AI Engineer Special] How Stanford Teaches AI-Native Engineering — Mihail Eric, Monaco

    2 Std. 1 Min.

    What do you assign when a coding agent can finish last year’s homework in one prompt? In the second run of Stanford’s CS146S, Mihail Eric brought open-source maintainers into the course. Students have to learn …

  4. Deep Dive: Anthropic S-1 Myths and Mythos — Jamin Ball, Altimeter

    1 Std. 42 Min.

    Watch the full show on YouTube: https://www.youtube.com/watch?v=P735f1xlpL0Full show notes and links

  5. Controlling Biology - Fabian Theis, Helmholtz Munich

    51 Min.

    Fabian Theis has been one of the key players in the various iterations of the Virtual Cell concept and initiatives. It is not hyperbole at all to say that his lab has been pushing the frontier of algorithms to …

  6. ⚡ Behind Latent Space: A Rare Look Inside the Pod | AIEi Shanghai

    1 Std. 12 Min.

    Watch the full show on YouTube: https://www.youtube.com/watch?v=QmDLDy3ZSNEFull show notes and links

  7. ⚡️ The 2026 Software Factory Standard — Zach Lloyd, Warp.dev

    35 Min.

    Watch the full show on YouTube: https://www.youtube.com/watch?v=LL0YmIyBKSUFull show notes and links

  8. Building Legal Agents When You Can't See the Data - Jacob Lauritzen, CTO of Legora

    1 Std. 7 Min.

    Legora can’t read a single trace of what its agent does for a lawyer. The data belongs to the law firm’s clients. How do you build and test an agent when you can’t see its work? Jacob Lauritzen is the CTO of …

  9. Building Legal Agents When You Can't See the Data - Jacob Lauritzen, CTO of Legora

    1 Std. 7 Min.

    Legora can’t read a single trace of what its agent does for a lawyer. The data belongs to the law firm’s clients. How do you build and test an agent when you can’t see its work? Jacob Lauritzen is the CTO of …

  10. Using Agents for Long-Horizon Financial Work — Aman Singh, Arca

    26 Min.

    Arca head of AI Aman Singh joins Latent Space head of editorial Richard MacManus at AI Engineer New York, to discuss how Arca is building an AI-native wealth management firm. Singh explains Arca's architecture …

  11. ⚡ Building ChatGPT for Finance — Joseph Kim, OpenAI's Head of Financial Services

    28 Min.

    Watch the full show on YouTube: https://www.youtube.com/watch?v=v-d1WTqIULsFull show notes and links

  12. Why Agents Love Supabase

    1 Std. 17 Min.

    AI agents are creating more software—and that changes what a backend needs to do. Supabase co-founders Paul Copplestone and Ant Wilson join swyx to discuss running long-lived workloads alongside the database …

  13. How Anthropic ships the #1 LLM in the World safely: Separating the Brain from the Hands

    1 Std. 47 Min.

    Katelyn Lesse and Angela Jiang join Latent Space to explain the engineering behind the Claude Platform: launching Opus 5.5, separating the model’s “brain” from the agent’s “hands,” scaling APIs, and building …

  14. ⚡ An Eval for AI Scientists That Knows the Answer Key - Ian Quigley, Leash Bio

    17 Min.

    Watch the full show on YouTube: https://www.youtube.com/watch?v=vhPCo-8K78UFull show notes and links

  15. Why AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO

    1 Std. 26 Min.

    Warm welcome to Basil Chatha, our newest cohost from the Forward Deployed side of the AI Engineering world! We’ll be ramping up a new show with him and couldn’t pass up an interview with Modal’s CEO Eric on the …

  16. The Recommendation Engine for Commodity Traders — Anekha Sokhal, Moshi

    27 Min.

    Anekha Sokhal, CEO of Moshi, joins swyx to discuss building a recommendation engine for commodity traders, turning market data into useful signals, and designing AI that fits users’ workflows. Watch: YouTube · …

  17. AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess

    44 Min.

    Alex Lieberman and CJ Hess join swyx at AI Engineer New York to discuss Tenex’s approach to AI-native engineering, paying for outcomes, MetaHarness, enterprise AI adoption and rebuilding SaaS. Show notes …

  18. The Programmable Data Center — Evan Conrad, SF Compute

    37 Min.

    This was recorded on the sidelines of the new Compute Trading track at AIE NYC. Catch us next at AIE CODE, our last flagship for the top agentic engineers in the world. In the early days of cloud, former guest …

  19. 🔬 Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio

    1 Std. 50 Min.

    A few years ago I stumbled upon Leash Bio’s Substack, and was hooked. Be it their Kaggle competition that showed that no, we really haven’t solved protein-ligand binding, or their crazy discovery that knowing a …

  20. Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics

    1 Std. 12 Min.

    Watch along AIE NYC and join us at AIE CODE in SF next month! This episode includes a live demo of the Taku robot that is best enjoyed on YouTube. Last month, Dyna made waves by announcing Dyna-2, a …

  21. 🔬 Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

    32 Min.

    From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding, Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes to build AI that truly understands …

  22. 🔬 Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

    1 Std. 24 Min.

    It’s hard to believe that Periodic was only launched last September: One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent density and astonishing progress in the …

  23. ⚡️ Which GPU Clouds Are Actually Good? | ClusterMAX 3.0

    58 Min.

    Watch the full show on YouTube: https://www.youtube.com/watch?v=MWX36ZYnsm0Full show notes and links

  24. Academia is for Ambition — Alex Zhang, MIT

    1 Std. 41 Min.

    Last call for regular tickets for AI Engineer NYC! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for new tickets only, no refunds! See you in 2 weeks! …

  25. Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week

    39 Min.

    Three months ago Dwarkesh, who has been posting incredible blogs and episodes about RL, posted a framing question for his video essay on RLVR which upset a lot of Computer Use folks: We are no strangers to …

  26. Claude Code’s Next Era — Thariq Shihipar, Anthropic

    1 Std. 32 Min.

    We are excited to have Anthropic share their latest AI x Finance work at AI Engineer New York ( https://ai.engineer/nyc/2026 ), coming up in 2 weeks! In case you’ve been under a rock, here’s a non-exhaustive …

  27. OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha

    1 Std. 21 Min.

    From the earliest days of open-weight models to becoming the neutral routing layer for more than 10 million developers, OpenRouter is one of the clearest bets that the future of AI will be multi-model. In this …

  28. Runway’s WorldPrompt and the Engineering of Real-Time Worlds

    1 Std. 36 Min.

    Earlier this month, world model company Runway introduced GWM Worlds 2, a research preview that “turns high-fidelity video and audio generation into real-time interactive simulation.” Runway calls this an …

  29. 🔬 Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

    1 Std. 32 Min.

    The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. The natural question is: what about bio-security …

  30. 🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

    2 Std. 1 Min.

    How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar, two textbook algorithms, two named asteroids, and an …

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