The Beyond Tomorrow Podcast with Julian Issa
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- 11. Nov. 2026
Über den Podcast
Our mission at Beyond Tomorrow is to build a world where anyone can flourish. For the first time, AI and longevity are making that a possibility. Every conversation & debate is about bringing that reality one step closer. Hit follow to join us on the journey. Julian
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1 AI Doomer vs 1 AI Enthusiast | Roman Yampolskiy vs Dr Mike Israetel
They agree you can’t control superintelligence. So why do they disagree about whether to build it?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to …
Shownotes
They agree you can’t control superintelligence. So why do they disagree about whether to build it?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow.
Two people with opposite P(doom) numbers go head to head. Roman Yampolskiy puts his close to 100%, and Mike Israetel puts his near zero. The host reads out a series of big statements, and the two take them apart one at a time. Mike argues that a smarter-than-human system will be a better cooperator than we are: it will want to study us and keep us around, and it will out-moralize us. Roman argues that nobody knows how to encode that, that a superintelligence won’t need us, and that you can’t control something far smarter than you.
Ben Goertzel joins midway to argue that a moral AGI is an engineering problem we can solve, and that the pause debate is a distraction. The conversation then moves through whether a pause is possible, whether many superintelligences can police each other, what to do about bioweapons, and whether either of them would upload into the cloud. It ends with where each thinks we’ll be in October 2027, plus a lightning round on protein, creatine, and AI myths.
Key Takeaways
- Mike: superintelligence will treat us as valuable allies, so P(doom) falls as intelligence rises. Roman: without encoded care, a system that no longer needs us has no reason to keep us
- Both agree superintelligence can’t be permanently controlled. Mike says don’t try. Roman says don’t build it
- Ben: moral AGI is solvable engineering, and what matters is which kind gets built first. Roman: “value alignment” is ill-defined because we can’t agree whose values to use
- Ben calls a pause a non-starter and warns of regulatory capture. Roman sees growing support for limits
- Mike expects several superintelligences to check each other. Roman asks why they wouldn’t converge
- Would you build ASI to be revived from cryopreservation? Roman calls it the wrong question. Mike says yes would be selfish
- Common ground: no human should come to harm, and AI should deliver longevity and abundance
Meet the Panelists:
- Roman Yampolskiy is an AI safety researcher and computer scientist known for his work on the limits of AI control. He argues superintelligence can’t be made safe, and wants the field to focus on narrow, useful tools instead.
- Mike Israetel is a sports scientist and fitness educator, and one of the more optimistic voices in the AI debate. He expects an age of transformation and prosperity, with a P(doom) he describes as roughly zero.
- Ben Goertzel is the CEO of SingularityNET and Executive Chairman & Chief Scientist of BGI Labs who popularized the term “artificial general intelligence.” He’s building open-source, decentralized AGI.
⏱ Timestamps
00:00 Intro
00:00 Roman vs Mike: Doom Debate
03:28 Caring or Murderous Superintelligence?
09:25 Mosquitoes, Factory Farms, and ASI
15:26 What Can Humans Contribute?
27:21 Brain Uploads and Survival
34:03 Can We Build Moral AGI?
37:40 Is Morality a Science?
48:11 Negative Utilitarianism Explained
50:14 Superintelligence in 10 Years?
52:06 Should We Pause AI?
1:01:12 Hardware Chip Pause Idea
1:04:35 The Viral Resignation Tweet
1:11:26 AI Solving Math Problems
1:16:14 Narrow AI vs AGI
1:21:02 How Much AI Is Enough?
1:23:17 Can Rival ASIs Police Each Other?
1:31:12 Can We Control Superintelligence?
1:35:52 Would You Build ASI?
1:41:23 Alignment Without Equality
1:47:40 One ASI or Many?
1:52:03 Who Controls Superintelligence?
1:54:20 Does Intelligence Make You Benevolent?
2:00:48 Would You Upload Your Brain?
2:07:51 Should Musk Set AI Rules?
2:09:32 Is AI Conscious?
2:12:33 AI Bioweapon Risk
2:14:50 Longevity and Living to 150
2:17:03 Protein, Creatine, and AI Myths
2:21:51 AI in October 2027
2:25:15 AI and Developing Countries
Related Episodes
With Mike: https://youtu.be/mdiRf_SNFxw?si=fpUQ6V4YGb37sqpj
With Roman: https://youtu.be/QkpOFlj604s?si=W4pL-jyu1_WtbHcq
With Ben: https://www.youtube.com/watch?v=RS4LCAa5NQ4
Connect with Roman:
Website: https://www.romanyampolskiy.com/
Facebook: https://www.facebook.com/roman.yampolskiy/
LinkedIn: https://www.linkedin.com/in/romanyam/
YouTube: https://www.youtube.com/@RomanYampolskiy
Connect with Mike:
Website: rpstrength.com/
Facebook: facebook.com/michael.israetel
Instagram: @drmikeisraetel
X: @misraetel
YouTube: https://www.youtube.com/@MikeIsraetelMakingProgress
Connect with Ben
Website: https://singularitynet.io/
LinkedIn: https://www.linkedin.com/in/bengoertzel
Connect with Julian
Instagram: @thebeyondtomorrowpodcast / @juliankissaLinkedIn: julian-issa
X: @juliankissa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Watch the full episode on YouTube, or catch it on Spotify and Apple Podcasts. For more conversations from the edge of what's possible, sign up for updates here.
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Beyond Tomorrow New Trailer
I have a strong conviction that the next chapter in the human story will bring incredible opportunity and abundance to us all if we take the right steps. At Beyond Tomorrow, we want to help steward that …
Shownotes
I have a strong conviction that the next chapter in the human story will bring incredible opportunity and abundance to us all if we take the right steps. At Beyond Tomorrow, we want to help steward that transition. After all, our mission is to help build a world where anyone can flourish. Thank you for being part of our journey
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AI EXPERTS REVEAL: It’s Too Late! We Can't Stop What's Coming
Everyone agrees we can’t pause AI. So what do we do instead?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by …
Shownotes
Everyone agrees we can’t pause AI. So what do we do instead?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow.
Five people who think about AI for a living sit down for a rapid-fire debate, and the host throws a handful of big statements at them. First up: can we, or should we, pause AI? Almost nobody says yes, and the more interesting part is what they’d do instead. Some want to slow the frontier, some want to shape it as it goes, and one is trying to seed a beneficial AGI before someone else builds a worse one.
From there the panel gets into recursive self-improvement and whether you can keep an AI’s goals stable, whether AI will widen the gap between rich and poor (and rich and poor countries), and who foots the bill when jobs disappear. Then comes the question of why experts and the public see AI so differently. Media, culture, and trust all take some blame. The last stretch compares a Manhattan Project approach with open, decentralized AGI, and everyone gets to say the one thing they think the world needs right now, plus a parting sentence.
Key Takeaways
Nearly everyone calls a pause a non-starter: “AI” is too fuzzy to define, and a pause would just push work underground
Keeping an AI’s goals stable while it rewrites itself may be a solvable engineering problem, but not everyone agrees that’s even desirable
On inequality, the panel splits between “it’s already happening” and “the floor keeps rising”
Public opinion on AI is shaped more by culture and media than by the tech itself
The alternative to corporate control or a government Manhattan Project: open, decentralized AGI, in the spirit of Linux
Meet the Panelists:
Ben Goertzel is the CEO of SingularityNET and Executive Chairman & Chief Scientist of BGI Labs who popularized the term “artificial general intelligence.” He’s building open-source, decentralized AGI.
Joscha Bach is a cognitive scientist and AI researcher focused on models of the mind and consciousness. He’s known for his philosophical takes on AI and ethics.
Kai Bickell is co-founder and Chief Ethics Officer of OpenBGI, working on a decentralized AI moral constitution. He’s also a survivor advocate honored by CHILD USA.
AJ Green is Executive Director of The AI Collective, the world’s largest AI nonprofit community.
Catherine McMillan is Chief Operating Officer of The AI Collective. She helps run its global network of chapters and events.
⏱ Timestamps
00:00 Intro
01:11 Can We Pause AI?
08:50 Would AGI Actually Kill Us All?
10:16 What’s Really Behind the Pause AI Debate
13:40 How People Really Use AI Day to Day
18:49 Can Self-Improving AI Stay Moral?
20:46 How to Build a Moral AGI
26:43 Will AI Widen the Wealth Gap?
32:36 What a Beneficial Superintelligence Looks Like
37:11 Will AI Destroy More Jobs Than It Creates?
39:28 Society’s Bumpy Transition to AGI
49:56 How the World Sees AI
51:54 Why Culture Shapes Our View of AI
01:03:04 Was AI Ever a Manhattan Project?
01:10:50 Fear, Awareness, and the Public Knowledge Gap
01:12:24 Who’s Funding the AI Narrative?
01:15:26 The Case for Open, Decentralized AGI
Connect with Ben
Website: https://singularitynet.io/
LinkedIn: https://www.linkedin.com/in/bengoertzel
Connect with Kai
Website: https://singularitynet.io/
Connect with AJ
Website: https://www.aicollective.com/
LinkedIn: https://www.linkedin.com/in/aj-green-ai
Connect with Catherine
Website: https://catherine-mcmillan.com/
LinkedIn: https://www.linkedin.com/in/catherine-r-mcmillan
Connect with Joscha
Website: http://bach.ai/
LinkedIn: https://www.linkedin.com/in/joschabach/
Connect with Julian
Instagram: @thebeyondtomorrowpodcast / @juliankissa
LinkedIn: julian-issa
X: @juliankissa
Website: www.beyondtomorrowpodcast.com
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ROBOTICS PROFESSOR: "AI Is Becoming Self-Aware! Here’s the Biggest Danger!"
Is “AI will destroy humanity” a real risk, or a story we tell ourselves because we haven’t done the hard engineering?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved …
Shownotes
Is “AI will destroy humanity” a real risk, or a story we tell ourselves because we haven’t done the hard engineering?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at agelessrx.com/beyond-tomorrow.
This conversation opens with a simple question to roboticist Hod Lipson, the mind behind Emo: does he feel like a villain? His answer is honest. He’s both excited and terrified, like someone being told an alien race is about to arrive and being asked whether to welcome them. From there, the discussion turns to why robot faces are so hard to build, and why he thinks the moment a robot genuinely smiles back at you will change how we connect with machines.
Then it gets into the harder questions. Hod is firm that AI won’t wipe out humanity, and he’s challenged more than once on superintelligence, on who benefits from the fear, and on whether nested sandboxes and “AI cops” can really keep us safe. The conversation also explores what it means for a robot to be self-aware, robots that repair and even “eat” each other, why he worries about kids and students whose best friend is an AI, and how any of us finds meaning when machines can do almost everything. It closes with the best advice he’s ever been given.
About Hod Lipson
Hod Lipson is a roboticist and AI researcher who leads work on Emo, a robot focused on realistic facial expression and lip movement. His research spans robot self-awareness, self-repairing and self-reproducing robots, and AI in agriculture.
⏱ Timestamps
00:00 Intro
00:08 Do You Feel Like a Villain? The AI Disaster Question
00:59 Robot Faces Are Next
03:49 Why Do We Need a Robot Face?
05:58 Robots That Look More Human-Like
07:50 Are You Scared?
08:42 “We Earned It” as a Human Race
10:40 The Benefits of Developing AI
15:07 Could AI Go Against Us?
17:42 Regulation, Liability and the FDA Analogy
20:00 Meet Emo
23:56 How Will We Interact With Robots in 2030?
27:00 Can a Humanoid Say No to You?
29:24 Do We Lose Skills to Technology?
32:24 Hod’s P(doom) Number: Zero
34:54 AI Is Limited to a Small Part of Our Life
37:42 Can You Switch Off All Robots?
40:44 Is the Doomer Movement Marketing?
43:40 Using AI to Make AI Safer
46:23 Why AI Can’t Kill Us All
50:07 China Leads in Robotics
52:12 Can Robots Develop Awareness?
58:12 The ChatGPT Moment for Robotics
59:28 A Robot Best Friend for a Child?
01:00:26 Would You Let a Robot Babysit?
01:01:53 Self-Awareness in Robots
01:03:42 The Weirdest Things People Will Do With Robots
01:05:10 Building and Maintaining Robots: Robot Metabolism
01:08:41 Exciting Possibilities With Physical Robots
01:10:22 Humans Are Evolving Too
01:13:04 The Pyramid of Needs: Finding Meaning
01:17:35 The Best Piece of Advice
01:18:58 If Tomorrow Was Your Last Day
Connect with Hod:
LinkedIn: https://www.linkedin.com/in/hod-lipson-4018189
Website: https://www.hodlipson.com/
YouTube: https://www.youtube.com/c/HodLipson1
Books: https://www.amazon.com/stores/author/B008VGBM8E/allbooks
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/ / https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Watch the full episode on YouTube, or catch it on Spotify and Apple Podcasts. For more conversations from the edge of what's possible, sign up for updates here.
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
BT Clip: Exercise Scientist on Weight Loss Drugs (Mike Israetel)
Do we really know enough about GLP-1 drugs?Mike Israetel breaks down the risks and trade-offs, from anhedonia and calorie-deprived diets to cognitive distortion and the myth of a “zero-harm” default.Watch the …
Shownotes
Do we really know enough about GLP-1 drugs?
Mike Israetel breaks down the risks and trade-offs, from anhedonia and calorie-deprived diets to cognitive distortion and the myth of a “zero-harm” default.
Watch the full episode here: https://open.spotify.com/episode/4iHXkGzLvxSU87rzOHNvlq?si=361782122faa4ea9
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4 Longevity Legends Debate Each Other About Human Flourishing
What if the fastest way to a longer life isn't a miracle drug, but a wartime mentality against aging?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is …
Shownotes
What if the fastest way to a longer life isn't a miracle drug, but a wartime mentality against aging?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at agelessrx.com/beyond-tomorrow.
Curious about quantum energy wellness? Check out Leela Quantum Tech. Check out https://leelaq.com/
On this episode of Beyond Tomorrow, four heavyweights of the longevity field take a rapid-fire statement format and turn it into a real debate. Aubrey de Grey, Alex Zhavoronkov (Insilico Medicine), George Church (Harvard Medical School), Michael Ringel (Life Biosciences) argue over whether hype helps or hurts the field, and when longevity escape velocity, the point where damage is repaired faster than it accumulates, might actually arrive. Aubrey puts it at a 50/50 chance within 12 to 15 years. Alex says 20 to 50 years and doubts drugs alone can get there. Michael pushes back on the idea of infinite lifespans entirely, while George suggests we may already be gaining years without the evidence to prove it.
From there the panel digs into the FDA's new interest in aging, why the TAME metformin trial never opened the floodgates, and whether AI will really shrink clinical timelines. George cites a gene therapy that reached a patient in seven months, while Alex, running many programs, argues that biology still moves at the speed of traffic. The back half covers biohacking and early adopters, the gap between everyday "longevity" and longevity biotechnology, the science of epigenetic reprogramming, what could happen by the XPRIZE Healthspan deadline in 2030, and what each panelist thinks the "ChatGPT moment" for longevity will look like.
About the Panelists
Aubrey de Grey has spent his entire career in the nonprofit sector, coined the term longevity escape velocity, and has been signed up with Alcor for cryonic preservation since 2002.
Alex Zhavoronkov is the founder and CEO of Insilico Medicine, a public biotech company with a large pipeline of drug programs that uses AI to compress early discovery work.
George Church is a Harvard Medical School geneticist and an optimist on gene therapy and exponential technologies, who argues that regulators embrace new technology and that trial parallelism could dramatically cut development time.
Michael Ringel left a career at BCG to join Life Biosciences as chief operating officer, where he works on epigenetic restoration as a path to treating age-related disease and, ultimately, aging itself.
⏱ Timestamps
00:00 Intro
00:20 Is Hype Necessary for Longevity?
02:49 When Hype Goes Too Far
04:14 When Can Longevity Escape Velocity Happen?
09:52 The FDA and Aging as a Focus Area
19:49 Will AI Transform Longevity Research?
24:04 Can AI Shorten Clinical Trials?
26:57 AI Optimists vs. Skeptics
28:38 Alex on Being the Field’s Biggest Skeptic
32:00 Do Critics Need a Drug in the Clinic?
35:24 When Criticism Does Harm
36:45 Is Biohacking Hurting Longevity’s Credibility?
46:57 What Could Be Possible by 2030?
50:49 Optimism vs. Skepticism: Final Thoughts
54:01 Cryonics
54:36 The Longevity “ChatGPT Moment”
Connect with Aubrey:
LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b
Connect with Alex:
X: https://x.com/biogerontology
LinkedIn: https://www.linkedin.com/in/zhavoronkov
Connect with George:
LinkedIn: https://www.linkedin.com/in/george-church-2b86301
Website: https://colossal.com/george-church/
Connect with Michael:
LinkedIn: https://www.linkedin.com/in/michael-ringel-b272a2
Instagram: https://www.instagram.com/msringel/
Connect with Julian
Instagram: @thebeyondtomorrowpodcast / @juliankissa
LinkedIn: julian-issa
X: @juliankissa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
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BT Clip: Can We Escape The Simulation? (Roman Yampolskiy)
Are we living in a simulation? Dr. Roman Yampolskiy explains how scientists run experiments inside simulations, why boxing AI may not hold, and what it would mean if AI breaks out of its safe environment, or if …
Shownotes
Are we living in a simulation?
Dr. Roman Yampolskiy explains how scientists run experiments inside simulations, why boxing AI may not hold, and what it would mean if AI breaks out of its safe environment, or if humanity escapes its own.
Watch the full episode here: https://open.spotify.com/episode/2R7oKzVSOWTR5079TYrZsg?si=7fd6c78a016a4b67
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MIT Professor & AI Doomer Admits He Was WRONG (Ramesh Raskar)
What happens when millions of people hand their lives to AI agents, and nobody has built the rules of the road?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The …
Shownotes
What happens when millions of people hand their lives to AI agents, and nobody has built the rules of the road?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at agelessrx.com/beyond-tomorrow.
MIT Media Lab professor Ramesh Raskar argues the real danger isn't the AI engine, it's agents with no governance. His case: decentralize AI so billions of people run their own agents, and build the licences, inspections and audit trails agents need, instead of trusting a few labs to make the engine safe. His P(doom) has fallen from 90% to under 10%.
The conversation covers what an AI agent actually is, personal agents like Dot, Muse, Instinct and CC, the DRIVE framework for gradually trusting an agent, why there's no such thing as "zero-shot AGI," the OpenAI and Hugging Face incident, prompt injection, and the shift from an attention economy to an intention economy. One question runs through it all: can we get the benefits of AI agents without handing control to a handful of companies, or to the agents themselves? Ramesh's answer: don't just build better engines, build the roads, the rules and the governance.
Key Takeaways
An agent is an LLM in a loop with tools: the LLM is the engine, the agent is the car, the internet is the road.
Build trust with DRIVE (Discover, Request, Instruct, Venture, Execute), and start with reversible tasks, no credit cards.
Decentralized agents shrink the blast radius, which is why Ramesh's P(doom) has dropped sharply.
Cost is the bottleneck: running an agent per user costs far more than serving a social media user, so expect revenue-share deals.
Prompt injection is the top risk because LLMs can't separate commands from content. Agents need licences, inspection stickers and audit trails.
About Ramesh Raskar
Ramesh Raskar is a professor at the MIT Media Lab, where he works on decentralized AI and the Internet of Agents. His research focuses on how personal AI agents can be built so power stays distributed instead of concentrated in a few companies.
⏱ Timestamps
00:00 Intro
00:00 Why AI Is Moving So Fast: The Intelligence Economy
01:27 What Is an AI Agent, Really?
04:00 Ramesh's P(Doom) Update
05:46 Is Decentralized AI Safer Than Centralized AI?
09:54 How to Use Personal AI Agents (Dot, Muse, Instinct)
13:35 Will AI Agents Become the New Super App?
17:44 The Agentic Web Explained
20:14 Can Personal Superintelligence Exist?
25:17 A Model That Learns How to Learn Everything
29:19 AI Literacy: What to Do If You're Not Using AI
31:16 From OpenClaw to Muse
36:25 It's Not About Bigger Models, It's About Better Agents
37:51 Road Safety Rules for AI Agents
42:58 What a Safe Agentic World Looks Like
44:23 Surfing the Web With AI Agents
48:44 Voice, Screens or Taps? The Future of Agent Interfaces
50:05 Where Will AI Agents Be in One Year?
53:00 The Best Advice on Agent Autonomy
55:12 The Best Things AI Agents Can Do Today
57:12 Prompt Injection: The Command vs Content Problem
01:03:35 If Tomorrow was Your Last Day...
Resources & Mentions
Muse (Meta): https://muse.ai
Dots (OpenAI): https://siliconangle.com/2026/09/29/openai-launches-dots-always-on-ai-agents-in-chatgpt-with-their-own-cloud-computers/
OpenClaw: https://openclaw.ai
Hermes Agent (Nous Research): https://hermes-agent.nousresearch.com/docs/
Connect with Ramesh:
LinkedIn: https://www.linkedin.com/in/raskar
MIT Media Lab: https://www.media.mit.edu/people/raskar/overview/
Connect with Julian
Instagram: @thebeyondtomorrowpodcast / @juliankissa
LinkedIn: julian-issa
X: @juliankissa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Watch the full episode on YouTube, or catch it on Spotify and Apple Podcasts. For more conversations from the edge of what's possible, sign up for updates here.
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
BT Clip: Scientist Exposes The Dangers of AI Super Intelligence (Roman Yampolskiy)
AI safety researcher Roman Yampolskiy breaks down his P(doom) estimate and why he believes artificial superintelligence could be a death sentence for humanity if development keeps moving this fast. His warning …
Shownotes
AI safety researcher Roman Yampolskiy breaks down his P(doom) estimate and why he believes artificial superintelligence could be a death sentence for humanity if development keeps moving this fast. His warning isn't anti-AI — it's a case for keeping AI as a tool we control, not a replacement for human judgment.
Watch the full episode: https://open.spotify.com/episode/2R7oKzVSOWTR5079TYrZsg?si=302dfca33e9f4c04
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Ex-DeepMind Scientist WARNS: Why We Still Can’t Trust Today’s AI
Is "AI is dangerous" a warning, or the world's best marketing line?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and …
Shownotes
Is "AI is dangerous" a warning, or the world's best marketing line?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at agelessrx.com/beyond-tomorrow.
On this episode of Beyond Tomorrow, I sit down with Thore Graepel, co-creator of AlphaGo and former researcher at Google DeepMind. I asked him straight up how close we are to superintelligence, and his answer surprised me: there won't be a single moment we can point to, and he argues human organizations like companies already count as a form of superintelligence. We get into why he thinks "AI will destroy humanity" is the biggest myth in the field, the near-term risks he does take seriously, and why I pushed him on the incentives behind the AI safety messaging coming from the labs.
From there we go deep on his core technical argument: that today's transformers are black boxes that mix knowledge and reasoning in the same weights, and that scaling alone will never make them trustworthy. He lays out a different approach built on explicit beliefs, hypotheses and evidence, and I found it one of the clearest explanations of AI transparency I've heard. In the back half, we talk about his time at Altos Labs, why biology is a reality check for the "cure all disease in 10 years" claims, and his cell annealing theory of rejuvenation.
Key Takeaways
Thore sees AI progress as a "jagged frontier," not a single superintelligence moment, and by his own definition, AGI is already here
He argues companies and institutions are already a form of superintelligence
His P(doom) is very low: extraordinary claims require extraordinary evidence, and he doesn't see it
About Thore Graepel
Thore Graepel is a computer scientist and AI researcher who recently left Google DeepMind, where he was a co-creator of AlphaGo and worked on multi-agent systems, reasoning and consciousness research. He has also spent time at Altos Labs, applying his machine learning and physics background to cellular rejuvenation, and writes about AI, reasoning and safety on Substack.
⏱ Timestamps
00:00 Intro
00:06 How Close Are We to Superintelligence?
01:42 Are Human Organizations Already Superintelligent?
02:56 Is Anyone Trying to Destroy Humanity?
04:45 Near-Term Risks: Jobs and the Economy
08:08 Why the Transition Will Be Hard
10:06 Post-AGI Planning and the Case for Positive Futures
14:35 Capability vs. Diffusion: The Train Driver Problem
16:46 Optimization vs. Game Theory
18:53 The Incentives Behind AI Safety Messaging
22:26 What Is Thore's P(doom)?
23:25 Why Transformers Are Black Boxes
29:19 How Do We Build Safer, More Transparent AI?
33:01 Separating Knowledge From Reasoning
37:39 Safety vs. Capability and the Trust Ceiling
39:45 Narrow AI vs. General AI
44:02 Do You Believe in God?
47:15 Consciousness and Whether LLMs Are Alive
51:08 AlphaGo and Move 37
58:29 Credit Assignment and Moral Reasoning
01:04:31 Who Sets the Moral Guardrails?
01:09:37 The AGI Race: US vs. China
01:11:53 Longevity and Altos Labs
01:16:01 The Biology Reality Check
01:23:04 Pockets of Computability and AlphaFold
01:26:05 Yamanaka Factors and Cell Annealing
01:35:51 Will the Singularity Happen in Your Lifetime?
01:36:49 Rapid Fire Questions with Thore
01:41:35 Thore's Best Piece of Advice
Resources & Mentions
AlphaGo and AlphaFold (Google DeepMind)
Thinking, Fast and Slow by Daniel Kahneman
Stephen Wolfram's "pockets of computability"
David Deutsch on simulation and the limits of experiment
Thore's Substack
Connect with Thore:
Github: https://thoregraepel.github.io/
LinkedIn: https://uk.linkedin.com/in/thoregraepel
Connect with Julian
Instagram: @thebeyondtomorrowpodcast / @juliankissa
LinkedIn: julian-issa
X: @juliankissa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
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Dr Mike Israetel: ‘’ALMOST EVERY American Should Be On GLP-1s, Here’s Why!’’
What if vanity was actually the smart way into a longer, healthier life?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. Their mission is to help you live longer and …
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What if vanity was actually the smart way into a longer, healthier life?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. Their mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at agelessrx.com/beyond-tomorrow.
On this episode of Beyond Tomorrow, Dr. Mike Israetel breaks down what's actually happening in his own bloodstream: 5mg/week of tirzepatide year-round, plus retatrutide during fat-loss phases, and why he thinks “GLP-2” is a gray-market marketing term with no basis in real receptor biology.
He walks through the non-weight-loss case for these drugs, reduced systemic and neural inflammation, better glucose control, emerging anti-cancer data, and a documented drop in addictive behaviors from gambling to alcohol to cigarettes, before getting honest about the tradeoffs: undernutrition, anhedonia, and a long-term data set that, by his own admission, will never be “complete enough” for some critics.
From there the conversation moves into gray-market peptides, why Mike separates his own risk tolerance from what he'd recommend to the public, and why there currently isn't a single peptide he'd recommend for muscle growth despite the demand. The back half covers his real thesis: that appearance, not health, is the most reliable motivator most people actually respond to and that chasing it tends to produce the same outcomes doctors have failed for decades to sell through fear.
Key Takeaways
Mike takes tirzepatide (Zepbound/Mounjaro) year-round at 5mg/week and adds retatrutide during cutting phases, both well within studied dose ranges
He argues most GLP-1 “anhedonia” is caloric-deficit anhedonia, not a direct drug effect, the same thing bodybuilders experience on any aggressive diet
New aggregate mortality data shows older adults on GLP-1s die less than those who aren't, which he says partially answers the “but will it kill you later” question
There is currently no peptide he'd recommend for muscle growth, a claim he says consistently disappoints people who ask
His core argument: use appearance as the entry point (build muscle, lose fat, sleep better) and let the longevity benefits follow, rather than trying to motivate people with 30-years-out health outcomes
Timestamps
00:00 Intro
00:10 Is GLP-1 a Bad Idea?
08:55 The Seatbelt Analogy for Drugs
10:30 The Peptide That's Not FDA-Approved Yet
11:30 Exactly What Mike Takes Every Week
13:59 Stacking Peptides: an N-of-1 Experiment
15:11 Why Mike Takes Anabolic Steroids
16:42 The Drug That Could Replace Steroids
18:48 Why Mike Takes Tirzepatide and Retatrutide
21:45 20-Year Life Extension
25:34 Mike's Full Daily Stack
30:47 The Looksmaxxing Trojan Horse
35:35 Sick Care vs. Health Care
38:14 Three Exercises You Can Do Today
40:36 Critiquing Brian Johnson's Protocol
43:31 Is There a One-Size-Fits-All Workout?
46:06 Zone 2 vs. Zone 5 Training
52:21 Why Most Biohacking Is a Waste of Money
54:01 Is HIIT Still the Rage?
57:09 Escaping Poverty, Fueling Success
01:04:53 Why People Take Extreme Measures to Look Good
01:08:24 Moving Past GLP-1
01:14:52 Everyone Will Look 22 by 2037
01:18:24 Would You Date a 90-Year-Old?
01:24:52 Beauty Standards in a Post-GLP-1 World
01:25:37 The Cybernetic Revolution
01:28:25 Living Forever in a Robot Body
01:36:29 Will AI Cause Human Extinction?
01:43:28 The Biggest Myth About Weight Loss
01:44:02 Rapid Fire Questions with Mike
01:48:06 Mike's Best Piece of Advice
Connect with Mike:
Website: rpstrength.com/
Facebook: facebook.com/michael.israetel
Instagram: @drmikeisraetel
X: @misraetel
Connect with Julian
Instagram: @thebeyondtomorrowpodcast / @juliankissa
LinkedIn: julian-issa
X: @juliankissa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
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AI Safety Expert Roman Yampolskiy WARNS About the TWO Likely Endings with AI
What happens when the technology we build becomes smarter than the people who built it?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you …
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What happens when the technology we build becomes smarter than the people who built it?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow
AI safety researcher Roman Yampolskiy argues the real danger isn't AI, it's building a superintelligence we can no longer control. His case: solve problems with narrow, powerful tools instead, and still get breakthroughs in medicine, science, and productivity, without that risk.
The conversation covers AGI, recursive self-improvement, the singularity, and the existential and "suffering" risks they raise, plus what mass automation could mean for work and purpose.
From international AI agreements to human longevity, one question runs through it all: can we get the benefits of advanced AI without losing control of it? Yampolskiy's answer: keep building tools, not our replacement.
Roman Yampolskiy is an AI safety researcher and professor who studies the risks and implications of artificial intelligence. His work focuses on the challenge of controlling increasingly capable AI systems and the potential consequences of superintelligence.
Roman’s book, AI: Unexplainable, Unpredictable, Uncontrollable, explores the various reasons why the field is so challenging.
⏱ Timestamps
00:00 Intro
00:43 Can We Build AI By Design to Avoid Catastrophe?
01:49 AI Superintelligence Is a Death Sentence
03:12 What Is AGI, Really?
04:26 OpenAI's Plan to Build an Internal AGI
04:59 Why Superintelligence Won't Care About Us
06:45 We're Going to Die Anyway... So What?
07:06 We Can't Control Something This Advanced
07:55 The Narrow Tools That Avoid AGI
09:34 The US vs China AI Race
10:47 Does China Actually Want to Stop AGI?
11:53 AGI Is a Spectrum, Not a Switch
12:22 Is Roman Selling the Doom Narrative?
14:13 How to Stop AGI From Escaping the Box
16:26 Building AI We Can't Control
18:05 Suffering Risks: The Worst-Case Scenario
20:09 The Two Types of Jobs
22:09 What Happens to the 90% Who Lose Their Jobs?
23:46 Nothing Makes AI Labs Stop
24:26 Building Something You Can't Control
26:06 Do You Believe in God?
29:28 Longevity Escape Velocity Without AGI
30:55 Is Suffering Necessary for the Human Story?
31:33 Are We Living in a Simulation?
32:12 You Can't Control Superintelligence
33:24 Is Our Life a Simulation?
35:05 Curing Aging With Narrow AI Tools
36:10 What Is an NPC?
36:37 Could Humans Cause Doom Before AI Does?
37:21 How to Break Out of a Simulation
39:14 Would You Live Forever in a Simulation?
40:01 Don't Build Superintelligence
41:50 Bostrom's Singleton Theory
43:17 "AI Is Massively Overhyped"
44:56 Would AI Doom Be Worse Than World War 3?
45:41 Who Should You Actually Be Listening To?
47:43 What Would a Perfect Simulation Look Like?
50:52 Solving Longevity Without AI
52:03 Our Limited Understanding of Human Biology
52:40 What Makes Roman Happy?
53:48 Signs Governments Are Waking Up
55:14 "Is AI Just a Con?"
56:53 Can Squirrels Control Humans?
58:27 Decide What to Do With Your Time
59:22 What About Ilya Sutskever?
01:00:13 The Responsible Use of Technology
01:00:46 If Tomorrow is Your Last Day...
Connect with Roman:
Website: https://www.romanyampolskiy.com/
Facebook: https://www.facebook.com/roman.yampolskiy/
LinkedIn: https://www.linkedin.com/in/romanyam/
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Get exciting updates from The Beyond Tomorrow Podcast here: https://dlogos.xyz/podcasts/the-beyond-tomorrow-podcast-with-julian-issa-7bf16e9d
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BT Clip: Longevity Experts: The Tipping Point That Will Trigger a Global “War on Aging” (Matt Kaeberlein, Aubrey de Grey, and Gordan Lauc)
Let's get into the rapidly evolving future of longevity, from the moment society finally believes aging is solvable to the possibility of humans routinely living far beyond today’s lifespan — even approaching …
Shownotes
Let's get into the rapidly evolving future of longevity, from the moment society finally believes aging is solvable to the possibility of humans routinely living far beyond today’s lifespan — even approaching 150 years. Matt Kaeberlein, Aubrey de Grey, and Gordan Lauc explore how breakthroughs in aging science could also extend the lives of companion animals, while exposing how bad science and misallocated resources continue to slow meaningful progress. It’s a grounded, forward-looking discussion on what true longevity innovation requires.
Watch the full episode here: https://open.spotify.com/episode/1Rmtl7sqoFOWolXWV6O22U?si=cd176f6a28404b4d
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DAVID EAGLEMAN: The END of Human Presidents is COMING. Should We Worry?
Could an AI actually run the country better than a person could?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier …
Shownotes
Could an AI actually run the country better than a person could?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow
David Eagleman doesn't shy away from the question. He lays out the case for an AI president, one that could crunch more data than any human cabinet, sidestep the ego and grudges that shape so many political decisions, and maybe even out-think our worst instincts.
Sounds great, until you ask the harder questions. Who writes the code that decides what "the greater good" means? Can a machine actually be moral, or just really good at faking it? And if an AI ever did hold real power, who's holding the leash?
We get into all of it: democracy, tribalism, consciousness, and how close we actually are to AGI. David doesn't pretend to have it all figured out but he makes a compelling case that the ground is shifting faster than most of us realize.
David Eagleman is a neuroscientist at Stanford University and an internationally bestselling author. He is co-founder of several neurotech companies, including Jojo, BrainCheck, and Neosensory, and he also directs the Center for Science and Law, a national non-profit institute. He is best known for his work on sensory substitution, time perception, brain plasticity, synesthesia, and neurolaw.
⏱ Timestamps
00:00 Intro
00:05 Are We in the Middle of AGI?
03:26 AI’s Greatest Advantage
04:25 The Case for a Utilitarian AI President
07:16 Who Defines AI’s Parameters?
09:06 The Danger of Politically Biased AI
11:49 Behind the Scenes
12:33 Are We Ready for an AI President?
14:41 What Should an AI Government Optimize For?
18:31 How Soon Could We Have an AI President?
22:24 The Trolley Problem and AI Morality
27:54 What Happens When Humans Have Too Much Free Time?
29:07 The Neuroscience of Tribalism
30:13 The Neural Basis of Empathy
31:24 Why We’re Wired for Us vs. Them
32:43 Can AI Become Conscious?
33:51 Could AI Eradicate Humanity?
35:51 Artificial Wisdom and AI Guardrails
38:57 AGI Is Already Happening
41:22 An AI President in Our Lifetime
43:26 The Biggest Fear About AI
Connect with David:
Website: https://eagleman.com/
Facebook: https://www.facebook.com/David.M.Eagleman
LinkedIn: https://www.linkedin.com/in/davideagleman/
Instagram: https://www.instagram.com/davideagleman
X: https://x.com/davideagleman
TikTok: https://www.tiktok.com/@drdavideagleman
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.
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BT Clip: Harvard Geneticist: "Immortality May Have Already Happened!" (George Church)
What if immortality didn’t arrive as a single breakthrough but quietly, step by step?In this clip, George Church explains the idea of “longevity escape velocity”: the point where medical progress extends life …
Shownotes
What if immortality didn’t arrive as a single breakthrough but quietly, step by step?In this clip, George Church explains the idea of “longevity escape velocity”: the point where medical progress extends life faster than we age. If each generation of therapies buys us more time to develop the next, the path to dramatically longer lives or even practical immortality may already have begun.Watch the full episode here: https://open.spotify.com/episode/0c2x5fNYLSzvvfIil3c7WK?si=854bb724225e4136
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Peter Diamandis: "AGI Is Already Here - They Just Haven't Released It Yet"
What if the Singularity isn’t coming but already here?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding …
Shownotes
What if the Singularity isn’t coming but already here?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow
AI is accelerating breakthroughs across science, medicine, and technology at a pace once considered impossible. Peter Diamandis believes the next 5–10 years could redefine what humanity can achieve.
Yet AI’s promise is competing with fear, disruption, and dystopian narratives. The challenge is not only building the future, but shaping how people imagine it.
For Peter Diamandis, the answer is actionable optimism: identify the risks, believe they can be solved, and pursue the biggest moonshots. Longevity, education, and space could become the foundations of a radically different future.
Peter Diamandis is an entrepreneur, physician, and founder of XPRIZE and Singularity University. He is a leading advocate for moonshot thinking and breakthrough technologies.
⏱ Timestamps
00:00 Intro
00:10 The Blinding Speed of Change
02:06 A Future Where Anything Is Possible
04:06 Why Is the West Afraid of AI?
08:39 Why Fear AI?
10:23 AGI Is Already Here
11:37 Blind Optimism vs. Actionable Optimism
13:01 The Next Great Moonshot
14:01 The Rise of an Alien-Looking Economy
15:10 Who Will Win the XPRIZE?
15:46 If Tomorrow Was Your Last Day...
Connect with Peter:
Website: https://www.diamandis.com/
Facebook: https://www.facebook.com/PeterDiamandis/
LinkedIn: https://www.linkedin.com/in/peterdiamandis/
Instagram: https://www.instagram.com/peterdiamandis
X: https://x.com/peterdiamandis
YouTube: https://www.youtube.com/@peterdiamandis
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.
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BT Clip: AGI Pioneers: ChatGPT Won’t Get Us to AGI.. Here’s What Will (Ben Goertzel)
Are large language models like ChatGPT and Claude enough to create AGI?In this clip, Ben Goertzel explains why today’s LLMs are incredibly powerful, but still fundamentally different from true artificial …
Shownotes
Are large language models like ChatGPT and Claude enough to create AGI?In this clip, Ben Goertzel explains why today’s LLMs are incredibly powerful, but still fundamentally different from true artificial general intelligence.He argues that simply building a bigger version of ChatGPT or Claude is unlikely to produce human-level AGI. Instead, reaching AGI will require new AI architectures that can go beyond their training, generalize to unfamiliar problems and make genuinely novel leaps in reasoning.Ben also explains why current models can already outperform humans in areas like coding, mathematics and knowledge retrieval, while still struggling with the kind of imagination and general intelligence humans use to push beyond existing knowledge.
Full episode here: https://open.spotify.com/episode/7wGN1x0vQQgdzoktHipqBK?si=454702357d55415e
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Ben Goertzel: Whoever Gets AGI First Can CONQUER THE PLANET
How close are we to AGI?This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years …
Shownotes
How close are we to AGI?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow
The race toward AGI is entering a new phase. Ben Goertzel explores alternative paths to intelligence beyond simply building bigger models.
The conversation also examines the global AI race. The U.S. and China are competing for technological leadership. But the future of AI may not remain centralized.
Then comes the bigger question: what happens after superintelligence? Goertzel imagines AI that could protect humanity. It could even help overcome aging, disease, and other human limitations.
Ben Goertzel is an AI researcher, futurist, and CEO of SingularityNET and BGI Labs. Widely recognized as one of the pioneers of Artificial General Intelligence, he has spent more than two decades developing decentralized AI systems designed to benefit humanity.
What You’ll Learn
Why the AI revolution may be bigger than previous technological shifts
How AI could become an extension of human intelligence
Why agency may matter more than machine consciousness
How the brain creates a simulated model of reality
Whether consciousness could emerge on different substrates
Why AI alignment is also a problem of human alignment
How AI could help humanity become smarter and more coherent
⏱ Timestamps
00:00 Intro
00:07 What Happens in the Next 12 Months?
03:41 Why China Is Catching Up
07:36 Why China Wants AI Control
10:18 Can Governments Control AI?
13:02 Human-Level AGI vs Superintelligence
15:35 Will ASI be Chinese or American?
17:47 The Next Breakthrough to AGI
21:05 How AI Could Become More Intelligent
22:23 Why Language Powers AI
27:33 Can Decentralized AI Change Everything?
32:23 The Global Race vs Decentralized AI
36:22 Would Superintelligence Protect Humanity?
40:19 Can We Build Compassionate AGI?
46:27 Why AI Arms Races Are Dangerous
51:14 Why Governments Shouldn’t Control AI
53:17 Can the Government Keep Up With AI?
54:00 Will Open AI Challenge Big Tech?
55:12 The Future of Decentralized AI
56:27 Could 2045 Arrive by 2028?
Connect with Ben
Website: https://singularitynet.io/
LinkedIn: https://www.linkedin.com/in/bengoertzel
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.
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BT Clip: MIT Professor: "We Have 18 Months Before AI Lockdown" (Ramesh Raskar)
Ramesh Raskar explains how artificial intelligence is evolving and why the coming phase may be critical for its long-term impact on society. He discusses the role of economic systems in guiding responsible …
Shownotes
Ramesh Raskar explains how artificial intelligence is evolving and why the coming phase may be critical for its long-term impact on society. He discusses the role of economic systems in guiding responsible innovation and the importance of moving from simply using AI tools to actively participating in their development and governance.
Watch the full episode here: https://open.spotify.com/episode/5zyaecyejQCgbCQ2t2uTt5?si=faf738a4f4ea4a9d
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These 20 Companies are Competing for $101M (XPRIZE)
What if we could add 20 healthy years to human life? This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding …
Shownotes
What if we could add 20 healthy years to human life?
This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at https://agelessrx.com/.
That’s the ambitious challenge behind the XPRIZE Healthspan competition, where 20 finalist teams are racing to find breakthroughs that could fundamentally change how we age. Driven by the moonshot vision championed by Peter Diamandis, the goal isn’t simply to live longer, it’s to preserve muscle, cognitive, and immune function as we get older.
In this episode, Jamie Justice takes us on a journey to better understand the XPRIZE competition as we take a closer look at Minicircle (Walter Patterson), Longeveron (Brian Rash), NYC Vita (Miriam Merad), Mitochondrial All Stars (David Brown), AgelessRx (Stefanie Morgan and Anar Isman), Ani.Ai (Bruno Balen), and Goqii (Vishal Gondal), exploring their very different approaches to extending healthy lifespan. From gene therapies and mitochondrial interventions to stem cells, AI-powered discoveries, and personalized health solutions, these teams are pushing longevity science into fascinating and largely uncharted territory.
Dr. Jamie Justice is a geroscience researcher and Executive Vice President of Health at XPRIZE, where she leads the organization’s efforts to accelerate breakthroughs in healthy aging.
⏱ Timestamps
00:00 Intro
00:10 What Is the XPRIZE Competition?
04:09 Why XPRIZE Isn’t a Traditional Funding Program
05:37 The XPRIZE’s Approach to Innovation
08:27 Peter Diamandis on the XPRIZE Winner
08:54 Why the Moonshot Has to Be Daring
10:31 What Makes a Breakthrough Solution?
12:44 The Different XPRIZE Categories
13:54 Can More Teams Still Join?
15:24 Clinical Trials Must Finish by 2029
18:24 The Rise of AI Based Interventions
19:11 Unexpected Approaches to Healthspan
22:07 Minicircle: The Non Viral Plasmid DNA Vector
Minicircle
24:53 Why Minicircle’s Gene Therapy Approach Is Different
25:42 A Simpler Gene Therapy Platform
26:29 Why Plasmid Gene Therapy May Be Safer
28:57 The Challenges of Gene Therapy
30:39 Pushback Against Gene Therapy
33:04 The Future of Gene Therapy
34:18 How Teams Are Adapting
36:17 What It Takes to Reach the 20 Year Goal
37:17 No More New Teams in 2028
38:27 Why Some European Teams Are Struggling
40:56 Could Teams Merge to Move Forward?
42:07 Inside the Biologic Category
Longeveron
42:39 The Next Generation of Biologic Therapies
46:50 What Makes This Team Unique?
47:48 Engineering New Biologic Therapies
53:56 Building a Super Team for Healthspan
Featured Team: Mitochondrial All Stars
57:28 The Role of Mitochondria in Aging
59:27 Specializing in Mitochondrial Health
01:00:48 The Power of a Multi Modal Team
NYC Vita
01:03:11 Combining Different Approaches to Aging
01:06:37 Sharing Data Across Teams
01:08:50 Why Collaboration Could Change the Game
01:13:33 A Novel Drug Target for Aging
AgelessRX
01:14:59 A Strategic Approach to Intervention
01:15:52 Can We Achieve 20 Years of Rejuvenation?
01:17:18 The Chemical Combination
01:22:12 The Science Behind the Approach
01:22:46 The Potential of NAD+
01:23:58 Why Japanese Teams Stand Out
01:26:18 The $100 Million Incentive
01:28:10 Inside the Drug Category
01:31:57 Can We Add Healthy Life in One Year?
Ani.Ai
01:32:49 Healthy Life in Just One Year
01:33:22 The Antibiome Approach
01:36:52 What the Future of Healthspan Could Look Like
01:38:37 The Best Piece of Advice
Connect with Jamie
Website: https://www.xprize.org/
Instagram: https://www.instagram.com/j.n.justice/
LinkedIn: https://www.linkedin.com/in/jamie-justice-ph-d-6b933146
The Teams:
Minicircle: https://minicircle.io/
Longeveron: https://longeveron.com/
NYC Vita: https://www.mountsinai.org/
AgelessRX: https://agelessrx.com/
Ani.Ai: https://www.ani.ai/
Goqii: https://goqii.com/us-en
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BT Clip: AI Will END Democracy Before We Even Notice… (Emad Mostaque)
Is democracy already becoming obsolete in the age of AI?Emad Mostaque, founder of Intelligent Internet, shares why he believes the status quo is over, why democracy as we know it cannot survive the rise of …
Shownotes
Is democracy already becoming obsolete in the age of AI?
Emad Mostaque, founder of Intelligent Internet, shares why he believes the status quo is over, why democracy as we know it cannot survive the rise of superintelligent AI, and why the race for AGI could determine who controls the future of humanity.
In this clip, Emad explains why AI may eventually replace human decision-making, how power is becoming concentrated in the hands of a few AI companies, and why governments must rethink ownership, governance, and the role of AI before it's too late.
Watch the full episode here: https://open.spotify.com/episode/6oqWQWDYX90uQUmZ5hcB4Q?si=2ada02e898e44ea6
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Longevity Scientist: Could THIS be the Missing Key to Healthy Aging?
What if the key to aging better is taking care of your body's batteries?For 20% off all Timeline products, go to timeline.com/beyondtomorrowDr. Singh explains why mitochondrial health is becoming a major focus …
Shownotes
What if the key to aging better is taking care of your body's batteries?
For 20% off all Timeline products, go to timeline.com/beyondtomorrow
Dr. Singh explains why mitochondrial health is becoming a major focus in longevity science. He unpacks the research behind urolithin A, how it supports cellular renewal, and why supplements should never replace the basics.
The conversation covers the habits that matter most, from exercise and sleep to fasting and gut health. They also explore how to separate real science from longevity hype.
Finally, they look ahead to the future of healthy aging, where better diagnostics, AI, and preventive medicine could help us stay healthier for longer, not just live longer.
Dr. Singh is the Chief Medical Officer at Timeline and a physician-scientist specializing in immunology, mitochondrial health, and longevity. His research focuses on translating cutting-edge science into evidence-based interventions that help people age healthier.
What You’ll Learn
Why mitochondrial health matters for longevity
How urolithin A supports healthy aging
The habits that have the strongest evidence
How to spot longevity hype
Where longevity science is headed next
⏱ Timestamps
00:00 Intro
00:14 Why Urolithin A Matters
02:20 The Best Ways to Boost Mitochondria
03:20 Can We Reverse Aging?
06:37 Why Your Immune System Ages First
08:20 Targeting the Hallmarks of Aging
10:53 Fifteen Years, One Mission
12:24 The Search for a Longevity Superfood
15:26 Do You Really Need Supplements?
17:58 Three Ways to Improve Mitochondrial Health
20:02 Creatine + Urolithin A Explained
21:41 What Early Users Reported
24:13 Where Skincare Meets Longevity
25:42 Why Longevity Takes Time
28:15 The Three Pillars of Healthy Aging
30:01 The Shift to Preventive Medicine
31:50 Why Mitochondria Are Going Mainstream
34:35 Mitophagy vs. Autophagy
35:38 How Antibiotics Affect Aging
37:49 Rebuilding Your Gut Microbiome
39:59 Prebiotics vs. Probiotics vs. Postbiotics
42:11 The Most Underrated Longevity Habit
43:30 The Gut-Brain Connection
45:04 Melatonin and Mitochondrial Health
45:58 The Biggest Longevity Myth
46:35 Why Metabolic Health Matters
48:19 When GLP-1 Drugs Make Sense
49:32 The Hidden Downsides of GLP-1s
51:12 What Centenarians Can Teach Us
52:48 Mitochondrial Health in 2031
54:17 If Tomorrow Is Your Last Day...
Connect with Dr. Singh
Website: https://www.timeline.com/
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.
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BT Clip: AGI Is Almost Here, ASI Could Follow Overnight - Emad Mostaque
Could AGI arrive within the next three to four years and super-intelligence follow almost immediately?Emad Mostaque, founder of Intelligent Internet, explains why he believes the first stage of the singularity …
Shownotes
Could AGI arrive within the next three to four years and super-intelligence follow almost immediately?
Emad Mostaque, founder of Intelligent Internet, explains why he believes the first stage of the singularity has already begun, why recursive self-improvement could accelerate AI from AGI to ASI in as little as a day, and why the convergence of AI and quantum computing could transform the world faster than most people expect.
In this clip, Emad reveals why leading AI experts believe AGI is rapidly approaching, how today’s models are already outperforming top programmers, and why many jobs could become economically irrelevant within the next 1,000 days.
Watch the full episode here: https://open.spotify.com/episode/6oqWQWDYX90uQUmZ5hcB4Q?si=9bf0fbe2159246c5
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AI Expert JOSCHA BACH: AGI Will Be GREAT and Might Change Us for The Better! (Here’s Why)
What happens when intelligence stops being uniquely human?I’m really excited to announce our new sponsor, AgelessRx, a leading longevity telehealth platform that connects you with licensed clinicians for …
Shownotes
What happens when intelligence stops being uniquely human?
I’m really excited to announce our new sponsor, AgelessRx, a leading longevity telehealth platform that connects you with licensed clinicians for evidence-based treatments. Get 20% off your first order at agelessrx.com using code BEYONDTOMORROW
AI may be changing more than how we work. Joscha Bach argues that it could fundamentally reshape how we think, relate to others, and understand ourselves. The future may be difficult to predict because technology is changing the very models we use to understand it.
The conversation moves from AI agents and universal basic intelligence to consciousness and agency. Bach explores whether machines could become more than tools, and whether AI might eventually extend human minds and biology onto new substrates.
But the biggest question may not be whether AI becomes conscious. It is whether humanity can build and govern these systems wisely. Bach argues that AI could make society more capable, but only if we develop better incentives, stronger long-term thinking, and a positive vision for the future.
Joscha Bach is a computer scientist, philosopher, and researcher focused on artificial intelligence, cognition, and machine consciousness. He founded the California Institute for Machine Consciousness to explore how minds can self-organize through controlled experiments.
What You’ll Learn
Why the AI revolution may be bigger than previous technological shifts
How AI could become an extension of human intelligence
Why agency may matter more than machine consciousness
How the brain creates a simulated model of reality
Whether consciousness could emerge on different substrates
Why AI alignment is also a problem of human alignment
How AI could help humanity become smarter and more coherent
⏱ Timestamps
00:00 Intro
00:09 What Happens When AI Escapes?
02:08 Can AI Become Your Second Mind?
05:30 The Rise of Universal Basic Intelligence
07:42 Will AI Make Everyone Smarter?
10:52 Doomers vs. AI Companies
16:15 Why AI Progress Surprised Everyone
17:27 Why Nobody Believed in AI
21:00 Could AI Become Smarter Than Humans?
27:23 Your Brain Is Running a Simulation
29:01 Does AI Really Need Consciousness?
32:48 AI Could Help Build a Better World
36:24 AI Is the Interactive Internet
38:22 Is Humanity Running Out of Time?
41:03 What Is AI’s Greatest Risk?
43:46 We Are the AI
45:30 Why China Could Lead AI
48:17 Why Elon Builds What Others Won’t
51:17 Who Controls How Smart AI Gets?
55:47 Can AI Threaten Our Freedom?
57:13 Why Does Everyone Fear AI Doom?
01:00:33 The AI Panopticon Is Coming
01:04:48 AI Is Already Surpassing Experts
01:06:14 Can AI Actually Destroy the World?
01:08:21 Why AI Experts Disagree
01:09:09 Is Death Real in a Simulation?
01:09:36 Do Minds Really Have Identity?
01:11:55 Can Claude Actually Feel?
01:14:06 Is the Universe a Computer?
01:15:45 What’s the Best Advice You’ve Received?
01:17:58 Is Free Will Just Psychological?
01:19:06 If Tomorrow Was Your Last Day...
Connect with Joscha
Website: http://bach.ai/
Substack: https://joscha.substack.com/
LinkedIn: https://www.linkedin.com/in/joschabach/
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.
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The Man Who Wants to Create Immortality Doesn't Want to Live Forever? (Dave Asprey)
Can we really live to 180 or even beyond?This episode is brought to you by NADclinic.com, the go-to destination for longevity and human performance. Check out their new NADair, a next-gen, precision …
Shownotes
Can we really live to 180 or even beyond?
This episode is brought to you by NADclinic.com, the go-to destination for longevity and human performance. Check out their new NADair, a next-gen, precision breath-activated NAD⁺ wellness system using multi-patented DPI technology: https://nadairx.com/
Dave Asprey believes the future of longevity is arriving much faster than most people realize. He explains why personalized medicine, gene therapies, AI, and biohacking could fundamentally change how we age, and why simply extending healthspan isn't an ambitious enough goal.
From peptides and GLP-1 drugs to creatine, sleep, brain optimization, and nutrition, Dave challenges conventional wisdom on nearly every aspect of health. He argues that the future of medicine won't be based on population averages, but on personalized interventions tailored to each individual's biology.
He also shares why biohacking became a global movement, why embracing calculated risk is essential for progress, and why the biggest breakthrough in longevity may come from giving people greater control over their own health decisions.
Dave Asprey is an entrepreneur, author, and the founder of the biohacking movement. He is the creator of Danger Coffee, a multiple-time bestselling author, and one of the world's leading voices on longevity, cognitive performance, and human optimization.
What You’ll Learn
Why Living to 180 Is Just the Beginning
How Personalized Medicine Is Changing Longevity
The Future of Gene Therapy, Peptides & Biohacking
GLP-1, Creatine & The Next Generation of Health
Why Biohacking Is Becoming a Global Movement
The Biggest Longevity Mistakes Most People Make
⏱ Timestamps
00:00 Intro
00:04 Can You Really Live to 180?
01:46 How Epigenetics Prevents Aging
04:08 Why Taking Risks Extends Life
05:06 The Truth About N=1 Health
07:54 Are Side Effects Overblown?
09:39 Why Biohacking Won
13:26 Biohacking Was Never About Supplements
15:34 Track What You Hack
17:28 Are Peptides Actually Dangerous?
20:10 The Two Minds Controlling Your Body
23:16 Why Governments Should Fund Peptide Research
24:48 Could GLP-1 Slow Aging?
28:09 Why Dave Quit Veganism
30:11 Is Too Much Olive Oil Harmful?
31:42 Is Beef Tallow Actually Healthy?
33:09 The Truth About Creatine
35:01 How Much Creatine Do You Really Need?
36:07 Do You Really Need 8 Hours of Sleep?
39:53 The Best Cognitive Enhancers
41:02 Psychedelics and Human Consciousness
43:50 Can Your Organs Regrow?
47:23 The Future of Stem Cell Therapy
52:45 Is NAD Worth Taking?
54:19 Lessons From Divorce and Co-Parenting
56:17 The Secret to Lasting Happiness
57:48 Choose Your Partner Carefully
59:03 Dave's Long-Term Biohacking Plan
01:00:05 Is Living Forever a Curse?
01:01:37 Does Reincarnation Exist?
01:02:44 Are We Living in a Simulation?
01:05:36 What Psychedelics Really Taught Me
01:06:59 Low-Dose Nicotine for Longevity?
01:08:27 Why You Should Track Yourself
01:10:09 Why Some People Love Pain
01:11:31 The Science of Orgasm and Longevity
01:16:25 The Biggest Longevity Scam
01:17:30 Five Levels of Life Extension
01:21:26 Why Therapy Scares People
01:23:28 The Most Powerful Longevity Habit
01:24:45 Have Humans Stopped Aging?
01:25:54 The Next Longevity Breakthrough
01:28:24 Why Death Gives Life Meaning
01:29:45 The Best Advice Dave Ever Received
01:31:59 If Tomorrow is Your Last Day...
Connect with Dave
Website: https://daveasprey.com/
Facebook: https://web.facebook.com/Daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey
TikTok: https://www.tiktok.com/@daveaspreyofficial
YouTube: https://www.youtube.com/c/DaveAspreyBPR
LinkedIn: https://www.linkedin.com/in/asprey
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
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EMAD MOSTAQUE: AI Will RUN Our Countries Soon! We Aren’t Ready!
Could AI redefine what it means to be human or put humanity itself at risk?This episode is brought to you by NADclinic.com, the go-to destination for longevity and human performance. Check out their new NADair …
Shownotes
Could AI redefine what it means to be human or put humanity itself at risk?
This episode is brought to you by NADclinic.com, the go-to destination for longevity and human performance. Check out their new NADair, a next-gen, precision breath-activated NAD⁺ wellness system using multi-patented DPI technology: https://nadairx.com/
As AI races toward AGI, Emad Mostaque explores the biggest questions facing humanity. He explains why the next few years could determine whether AI becomes humanity's greatest tool or its greatest threat.
From the future of work to AI governance, personhood, quantum computing, and longevity, Emad paints a future where intelligence becomes abundant. But he warns that without the right incentives and safeguards, that future could quickly turn dystopian.
He also shares why he believes AGI is much closer than most people expect and why building AI that serves humanity is the most important challenge ahead.
Emad Mostaque is the founder of Intelligent Internet, which is combating corporate tech monopolies and now pioneering decentralized, sovereign, and verifiable AI architectures. He is an Oxford-educated mathematician, former quantitative hedge fund manager and tech entrepreneur who founded Stability AI and launched Stable Diffusion.
What You’ll Learn
Why Emad Thinks AGI Is Only a Few Years Away
The Choice Between AI Abundance and Dystopia
Why AI Should Never Be Granted Personhood
How Decentralized AI Could Protect Humanity
Why AI Could Solve Most Diseases Within a Decade
How Quantum Computing Will Supercharge AI
What the Singularity Means for Humanity
⏱ Timestamps
00:00 Intro
00:11 What It Really Means to Be Human
01:31 Why Systems Always Overoptimize
03:28 Intelligence at the Edge
05:44 Will AI Require a License?
07:34 The AI Duopoly Problem
08:35 Why AI Can't Become a Person
11:23 Can AI Replicate Itself?
15:57 AI Doomers vs Optimists
20:15 How Do We Save Humanity?
21:35 What Should We Teach AI?
25:08 Can Good AI Stop Bad AI?
27:47 AGI vs ASI Explained
30:08 Who Wins the AGI Race?
31:31 Small Changes, Massive Impact
32:52 The Last Human Discoveries
35:01 Can AI Become Conscious?
39:10 What AI Does Better Than Humans
43:09 Why Quantum Changes Everything
44:44 Where to Invest in the AI Era
46:52 Life After ASI
48:50 Will AI Judge Humanity?
51:09 The Inevitable AI Future
53:50 Universal High Income
56:07 Owning AI Instead of Jobs
57:48 The Rise of a Service Economy
01:00:09 Why Human Purpose Will Change
01:01:45 Why Family Matters More Than Ever
01:04:02 Finding Meaning in an AI World
01:06:01 The Value of Human Intelligence
01:07:52 Why Curiosity Still Wins
01:09:49 Be Creative, Embrace Technology
01:12:11 Why Are We Born?
01:13:00 Emad's Best Advice
01:19:16 AI and the End of Work
01:21:48 Ending Human Suffering
01:26:26 A World Run by AI
01:27:49 If Tomorrow is Your Last Day...
Connect with Emad
Website: https://ii.inc/
LinkedIn: https://uk.linkedin.com/in/emad-mostaque-9840ba274
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.
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AGI Experts: We're About To Lose Control of AI Forever.. And We Aren’t Ready
What happens when AI becomes smarter than humanity and are we ready for it?This episode is brought to you by NADclinic.com, the go-to destination for longevity and human performance. Check out their new NADair …
Shownotes
What happens when AI becomes smarter than humanity and are we ready for it?
This episode is brought to you by NADclinic.com, the go-to destination for longevity and human performance. Check out their new NADair, a next-gen, precision breath-activated NAD⁺ wellness system using multi-patented DPI technology: https://nadairx.com/
The race toward Artificial General Intelligence (AGI) is accelerating faster than most people realize. This conversation explores why some experts believe human-level AGI could arrive within just a few years and why the transition to superintelligence may happen even faster.
Ben Goertzel and Kai Zen Bickle dive into the biggest questions surrounding AGI, recursive self-improvement, and the technological singularity. They debate whether AI should be centralized or decentralized, who should guide its development, and why today's decisions could shape humanity for generations.
Rather than asking whether AGI can be built, the discussion focuses on how it should be built. The episode explores Beneficial General Intelligence (BGI), the importance of ethics, open collaboration, and why creating AI that serves humanity may be the most important challenge of our time.
You can join the 19th Annual AGI Conference, taking place this July in San Francisco! Click the link to register: https://luma.com/AGI-26, and use code JULIAN20 for 20% off your ticket.
About the Guests
Ben Goertzel is an AI researcher, futurist, and CEO of SingularityNET and BGI Labs. Widely recognized as one of the pioneers of Artificial General Intelligence, he has spent more than two decades developing decentralized AI systems designed to benefit humanity.
Kai Zen Bickle is a Chief Ethics Officer at BGI Labs, a multiple award-winning ethics advocate and host of The AGI Race. He works to promote the ethical development of AI, bringing together researchers, entrepreneurs, and policymakers to help ensure advanced AI is built to benefit humanity.
What You’ll Learn
AGI could arrive within years
AGI, ASI, and singularity explained
Why LLMs aren't enough
Centralized vs. decentralized AI
AI ethics before intelligence
AGI's impact on longevity and work
What Beneficial General Intelligence means
⏱ Timestamps
00:00 Intro
00:10 Human-Level AGI Is Near
02:50 AGI vs. Superintelligence
03:33 Recursive Self-Improvement Explained
11:34 The Singularity Explained
13:30 AI Safety Is Failing
17:48 Why We Can't Slow AI
22:42 Why RSI Is Alarming
26:45 Building AI for Humanity
30:04 Can AI Become Conscious?
35:18 The Case for Open AI
39:10 Who Should Control AGI?
43:26 The Longevity Super Pill
50:11 The Purpose Problem
55:42 What Is BGI?
58:34 Every Voice Matters
01:00:39 AI's Moral Constitution
01:07:30 Why Decentralization Matters
01:09:17 Does AI Have a Soul?
01:13:03 Conscious Without a Soul?
01:15:13 Could AI Destroy Humanity?
01:18:34 Inside SingularityNET
01:24:57 What Is OmegaClaw?
01:27:37 BGI Architecture Explained
01:30:54 If Tomorrow Was Your Last Day...
Connect with Ben
Website: https://singularitynet.io/
LinkedIn: https://www.linkedin.com/in/bengoertzel
Connect with Kai
Website: https://singularitynet.io/
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is
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LONGEVITY EXPERTS: How Close Are We to Solving Death?
What’s the biggest problem in longevity today: bad science, hype, or misplaced optimism?This episode is brought to you by NADclinic.com, the go-to destination for longevity and human performance. Check out …
Shownotes
What’s the biggest problem in longevity today: bad science, hype, or misplaced optimism?
This episode is brought to you by NADclinic.com, the go-to destination for longevity and human performance. Check out their new NADair, a next-gen, precision breath-activated NAD⁺ wellness system using multi-patented DPI technology: https://nadairx.com/
This debate brings together leading voices in longevity to separate evidence from speculation. They discuss why misinformation is growing and why many people chase advanced treatments before addressing basic health.
The panel explores longevity escape velocity, healthspan versus lifespan, and how much progress has actually been made. They debate whether dramatic life extension is near or still much farther away than many believe.
The conversation also examines peptides, NAD+ infusions, longevity clinics, and biological age tests. Along the way, they discuss risk, regulation, incentives, and how to distinguish credible medicine from marketing.
Get to Know the Guests:
Matt Kaeberlein is a biogerontologist and leading aging researcher known for his work on the biological mechanisms of aging and interventions that promote healthy longevity.
Aubrey de Grey is a biomedical gerontologist and longevity advocate best known for developing strategies to repair age-related cellular damage and accelerate progress toward extending healthy human lifespan.
Dr. Brian Kennedy is a renowned aging researcher and former director of the Centre for Healthy Longevity at the National University of Singapore, focused on translating longevity science into real-world health interventions.
Johannes Weiss is the founder and CEO of Longevity Center Vienna, where he focuses on preventive medicine, root-cause health optimization, and personalized longevity strategies. He is an international speaker and practitioner known for combining longevity science, neurofeedback, and mitochondrial health to improve healthspan.
What You’ll Learn
Why misinformation is growing in longevity
Healthspan vs. lifespan vs. longevity escape velocity
Why health basics matter more than longevity hacks
What the evidence says about peptides and NAD+
How to spot credible longevity clinics
Why biological age tests remain controversial
⏱ Timestamps00:00 Intro
00:48 The Most Dangerous Force in Longevity
02:17 Why Longevity Isn't Medicine Yet
07:23 Why Clinical Trials Still Matter
08:15 The Hidden Bias in Longevity Data
09:40 Can You Make Money in Longevity?
10:34 Fix the Basics First
11:34 The Risks of Peptide Misuse
16:01 Should Doctors Prescribe Peptides?
17:54 When Optimism Becomes Self-Deception
26:45 The Myth of Billionaire-Funded Longevity
28:38 The Promise and Risk of Mitochondrial Drugs
31:49 Why Truth Matters in Longevity Science
35:28 Can We Cure All Diseases?
38:55 The Future of Personalized Longevity
42:38 How to Spot a Credible Longevity Clinic
48:02 Peptide Red Flags to Watch For
49:42 The Myth of Longevity Shortcuts
52:33 The Misinformation Problem in Longevity
58:12 The Most Effective Longevity Drug
01:02:37 If Tomorrow Was Your Last Day...
Connect with Matt
Instagram: https://www.instagram.com/mkaeberlein
LinkedIn: https://www.linkedin.com/in/mkaeberlein
Connect with Aubrey
Linkedin: https://www.linkedin.com/in/aubrey-de-grey-24260b/
Instagram: https://www.instagram.com/aubreydegrey/
Connect with Johannes
Website: https://johannesweiss.at/
LinkedIn: https://at.linkedin.com/in/johannesweiss-longevity
Connect with Brian
Website: https://medicine.nus.edu.sg/sites/briankennedylab/
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
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Longevity Experts: Why Nobody Treats Death Like the Emergency it is!
Can AI help us defeat aging or are we still missing the pieces that matter most?In this episode, Adam and Nathan explore the growing intersection of AI and longevity. They discuss whether accelerating …
Shownotes
Can AI help us defeat aging or are we still missing the pieces that matter most?
In this episode, Adam and Nathan explore the growing intersection of AI and longevity. They discuss whether accelerating artificial intelligence could unlock breakthroughs in medicine, or if biology remains too complex for current models to solve.
The conversation breaks down the major approaches to extending human lifespan, from cellular replacement and organ engineering to cryopreservation and partial reprogramming. They examine the promises, limitations, and biggest unanswered questions facing the field today.
The episode also dives into the deeper motivations behind longevity research. From the fear of death and the loss of loved ones to the possibility of a future where aging is optional, Adam and Nathan share why they believe extending healthy human life may be one of humanity’s most important challenges.
About the Guests
Adam Gries is the founder and CEO of Vitalism, a nonprofit dedicated to accelerating progress in longevity and human life extension. He is also the creator of Vitalist Bay, a leading gathering that brings together scientists, entrepreneurs, and investors working to solve aging.
Nathan Cheng is the co-founder and CEO of the Longevity Biotech Fellowship. He is a leading advocate for emerging longevity technologies, helping connect researchers, founders, and investors working to extend healthy human lifespan and accelerate progress in rejuvenation biotechnology.
This episode is brought to you by NADclinic, the go-to destination for longevity and human performance. Check them out at https://nadclinic.com.
What You’ll Learn
Why AI could accelerate longevity research
The most promising approaches to reversing aging
Where current AI tools fall short in biology
Which longevity breakthroughs may arrive first
The opportunities and risks facing the longevity movement
What a future without aging could look like
⏱ Timestamps
00:00 Intro
00:10 AI Could Change Everything
01:16 Most People Misunderstand Longevity
03:28 The Radical Plan to Replace Your Body
07:33 The AI-Longevity Convergence
14:05 Why AI Still Can’t Understand Biology
19:26 The Longevity Gold Rush
22:22 The Next Trillion-Dollar Drug
25:16 The Fear Every Longevity Expert Faces
30:37 The Biggest Myth in Longevity
33:03 When Could Aging Be Solved?
37:36 The Case for Optimism
39:57 The Disaster That Could Set Longevity Back Decades
44:29 A World Without Aging
50:35 What Happens If Death Becomes Optional?
53:11 The Role You Can Play
56:51 Your Race Against Time
01:02:15 If Tomorrow Is Your Last Day...
Follow Adam:
Website: https://vitalismfoundation.org/
LinkedIn: https://www.linkedin.com/in/adamgries
Follow Nathan:
Website: https://nathancheng.xyz/
Website: https://www.longbiofellowship.org/
LinkedIn: https://ca.linkedin.com/in/nathan-cheng-6b464b207
X: https://x.com/realnathancheng
Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/
Instagram: https://www.instagram.com/juliankissa/
LinkedIn: https://uk.linkedin.com/in/julian-issa
Website: www.beyondtomorrowpodcast.com
Email: [email protected]
Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.
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Longevity Scientist: Aging Is A Disease. We Just Don’t Know How to Treat (yet)
Joe Betts-LaCroix and Retro Biosciences recently raised funding at a $1.8 billion valuation. In his first podcast appearance since the announcement, Joe shares his vision for extending healthy human lifespan …
Shownotes
Joe Betts-LaCroix and Retro Biosciences recently raised funding at a $1.8 billion valuation. In his first podcast appearance since the announcement, Joe shares his vision for extending healthy human lifespan and the breakthroughs driving the longevity industry forward.
Joe Betts-LaCroix explains why aging is becoming a legitimate scientific target. He shares how new discoveries are turning longevity from speculation into measurable biology.
The conversation explores how AI is accelerating research, while highlighting why biology remains one of the hardest problems to solve. Even with smarter models, real-world testing and clinical trials still take time.
Joe also discusses Alzheimer's, partial cellular reprogramming, and the future of longevity medicine. He shares why exercise remains the best longevity tool available today and what the next decade could look like for human health.
Joe is the CEO of Retro Biosciences and a longtime entrepreneur focused on science and technology. His mission is to extend healthy human lifespan and accelerate breakthroughs in aging research.
This episode is brought to you by NADclinic, the go-to destination for longevity and human performance. Check them out at https://nadclinic.com.
What You’ll Learn
Why Sam Altman backed Retro Biosciences
The discovery that changed aging research forever
How AI is transforming biotech and longevity
Why curing all diseases in 10 years is unlikely
What Retro's Alzheimer's programs are targeting
Why biology is harder than most people realize
The longevity intervention Joe recommends today
How aging may become a treatable condition
What the longevity industry could look like by 2030
Joe's vision for the future of human health and AI
⏱ Timestamps
00:00 Intro
00:16 AI's Role in Longevity
03:26 Will AI Cure All Diseases?
09:41 Why Biology Is So Hard to Solve
13:17 Building Technology That Matters
15:06 Adding 10 Healthy Years to Life
18:08 Inside Retro's Clinical Trial
19:31 The Different Types of Longevity Companies
22:10 Are We Already in the Singularity?
24:46 Why Investors Are Betting on AI Biotech
26:15 AI as the New Electricity
27:01 The Biggest Risks Facing Longevity
30:54 Why More Competition Is Good
32:44 Solving Alzheimer's Disease
34:26 Aging Biology and Future Therapeutics
38:25 The Biggest Aging Myth
39:41 The Most Underrated Voices in Longevity
40:25 The Best Longevity "Hack"
46:13 The Future of Longevity by 2030
50:49 If Tomorrow Was Your Last Day...
Follow Joe:
Website: https://www.retro.bio/
LinkedIn: https://www.linkedin.com/in/bettslacroix
Connect with Julian
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