The Empowering Neurologist Podcast
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- 230
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- Letzte Folge
- 10. Nov. 2026
Über den Podcast
The Empowering Neurologist is an interview series with some of the most exciting thought leaders in the field of health and wellness.
Folgen 230
Why This Scientist Eats Broccoli Sprouts Almost Every Day | Dr. Jed Fahey
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: https://drperlmutter.com/subscribeMemory Air - Go to www.memoryair.com and use code PERLMUTTER …
Shownotes
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: https://drperlmutter.com/subscribe
Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee.
3X4 Genetics - Go to 3X4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
• https://drperlmutter.com/guides/sulforaphane/ - Free guide from Dr. Perlmutter that explains why Sulforaphane is one of the most powerful tools for protecting your brain, and how to get more of it from your food.
• https://www.thesproutingcompany.com/DRPERLMUTTER - At-home sprouting kit recommended by Dr. Perlmutter and Dr. Fahey, using this link will give you a discount
Dr. Perlmutter's groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health. Grab your copy today at www.braindefenders.com.
Join Dr. Perlmutter's Brain Defenders Immersion Course: https://drperlmutter.com/immersion-course/
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What if broccoli contains a compound that helps activate your brain's natural defense systems? In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with nutritional biochemist Dr. Jed Fahey, a pioneer in research on broccoli sprouts and sulforaphane, to explore how this fascinating plant compound activates NRF2, one of the body's key cellular defense pathways.
Dr. Fahey explains how glucoraphanin and myrosinase work together to produce sulforaphane, why broccoli sprouts are rich in this precursor, and how sulforaphane may support the body's natural detoxification and antioxidant systems.
They also explore the connection between NRF2 activation, glutathione, environmental exposures, inflammation, and brain health, and what research suggests about neurological health and healthy aging.
Dr. Fahey shares practical insights on growing broccoli sprouts at home, getting sulforaphane from food, and what to look for when evaluating supplements.
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00:00 – Why Sulforaphane Matters for Brain Health
02:24 – The Dark Matter of Nutrition: Understanding Phytochemicals
04:12 – Why Broccoli Sprouts Are a Powerful Source of Sulforaphane
07:44 – Sulforaphane in Cruciferous Vegetables and the Benefits of Moringa
15:58 – Sulforaphane, Environmental Toxins, and Air Pollution
23:12 – Why Plants Produce Sulforaphane: Nature’s Defense System
28:17 – Sulforaphane and Brain Health: Autism, Alzheimer’s, and Parkinson’s
40:56 – Heat Shock Proteins, Glutathione, and Neuroprotection
50:51 – The Science Behind Sulforaphane and Neurodegenerative Conditions
01:02:28 – How to Get More Sulforaphane: Broccoli Sprouts, Food, and Supplements
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Dr. Jed Fahey is a nutritional biochemist, researcher, and internationally recognized pioneer in the study of plant-based chemoprotection.
During 27 years at Johns Hopkins University School of Medicine, Dr. Fahey conducted extensive research into natural plant compounds and their effects on cellular defense systems. His work helped establish broccoli sprouts as a rich source of glucoraphanin, the precursor to sulforaphane.
As former Director of the Lewis B. and Dorothy Cullman Chemoprotection Center, Dr. Fahey helped advance scientific understanding of how plant compounds interact with the body's protective pathways.
Today, he continues to contribute to public science education and research into sulforaphane, NRF2 activation, and the potential health applications of these naturally occurring compounds.
Connect with Dr. Jed:
Website: https://www.jedfahey.com
LinkedIn: https://www.linkedin.com/in/jed-fahey-a3681861
====
Connect with Dr. David Perlmutter:
Instagram: https://www.instagram.com/davidperlmutter/
Website: https://www.drperlmutter.com/
Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ
This podcast is produced by DrTalks.com
The Stress Technique That Lowered Cortisol 43% in an Hour with Nick Ortner | E229
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com/subscribe.
Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee.
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00:00 – Introducing Nick Ortner and the Science Behind Tapping
01:06 – What Is EFT Tapping and How Might It Calm the Amygdala?
02:33 – From Skeptic to Advocate: Nick’s First Experience With Tapping
06:14 – Why Tapping Has Been Considered Fringe Despite Growing Research
08:26 – How Tapping May Help Reprocess Stressful Memories and Fear
11:46 – Reactive Loops: Why Anxiety and Anger Can Feel Automatic
14:20 – How Tapping Can Complement CBT and Exposure Therapy
19:15 – The Research on Tapping, Cortisol, and Stress Relief
22:52 – Tapping for Anxiety, Sleep, and Pain: Where Does It Help Most?
27:28 – Follow Along: Nick Ortner Guides a Step-by-Step Tapping Exercise
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Dr. Perlmutter's groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health. Grab your copy today at www.braindefenders.com.
Join Dr. Perlmutter's Brain Defenders Immersion Course: https://drperlmutter.com/immersion-course/
====
Can tapping help interrupt automatic stress responses and change the way your brain reacts to fear and anxiety?
In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with Nick Ortner, New York Times bestselling author and CEO of The Tapping Solution, to explore Emotional Freedom Techniques (EFT), or tapping. Nick explains how stress can trigger automatic reactions before conscious thought has time to catch up.
They explore the role of the amygdala, how reactive loops develop, and how tapping may help signal safety to the brain while working through stressful thoughts, memories, and physical sensations. They also discuss research into tapping and its potential effects on cortisol, anxiety, sleep, and pain.
Nick explains how tapping may complement cognitive behavioral therapy and exposure therapy, helping people work through difficult experiences while managing their stress response. Nick then guides listeners through a simple tapping exercise, offering an opportunity to experience the technique.
Understanding your stress response may be the first step toward changing how you respond to it. Discover how tapping may help you interrupt reactive patterns and approach stressful experiences with greater awareness.
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Nick Ortner is a New York Times bestselling author, wellness advocate, and CEO and co-founder of The Tapping Solution. For nearly two decades, Nick has helped bring Emotional Freedom Techniques, or tapping, into the mainstream. The practice combines elements of acupressure with modern psychology to help people manage stress, pain, anxiety, and limiting beliefs. Nick created the documentary The Tapping Solution and wrote The Tapping Solution: A Revolutionary System for Stress-Free Living. His book Rewired explores how tapping may help interrupt reactive loops and change nervous-system patterns. He is also the driving force behind The Tapping Solution App, which has logged more than 32 million guided sessions across 190 countries. Through his books, app, and work with The Tapping Solution Foundation, Nick helps make practical emotional health tools available to people around the world.
Connect with Nick:
Website: https://www.thetappingsolution.com
Instagram: https://www.instagram.com/thetappingsolution
YouTube: https://www.youtube.com/@TheTappingSolutionChannel
Facebook: https://www.facebook.com/nortner
====
Connect with Dr. David Perlmutter:
Instagram: https://www.instagram.com/davidperlmutter/
Website: https://www.drperlmutter.com/
Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ
Podcast produced by DrTalks.com
The Achievement Trap That Makes You Feel Replaceable with John Miles | E228
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: https://www.drperlmutter.com/subscribe
Sponsors & Special Offers
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Memory Air – Go to https://www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee.
Brain Defenders – Dr. Perlmutter's groundbreaking new book is now available! Discover how to protect your brain and future health: https://www.braindefenders.com====
Join Dr. Perlmutter's Brain Defenders Immersion Course: https://drperlmutter.com/immersion-course/
====
About This Episode
You can be successful, respected, and highly productive while still feeling invisible.
In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with John R. Miles, bestselling author, behavioral change expert, and host of Passion Struck, to explore why achievement, recognition, and external success do not always create a lasting sense of self-worth.
Drawing from his childhood brain injury, military service, and executive career, John explains the concept of human mattering: the fundamental need to feel seen, valued, and significant. They discuss the “mattering gap,” the “slow fade” that can happen when people become disconnected from themselves, and why belonging and mattering are not the same.
John also introduces the MATTER framework, built around six conditions that help people feel valued and connected: meaning, autonomy, trust, time, energy, and reciprocity.
They explore how parents, leaders, physicians, and communities can help others feel that they matter, and why separating personal worth from productivity and external approval can lead to more meaningful relationships and intentional living.
You can continue pursuing success without making it the measure of your worth. Your value is not something you have to earn.
Timestamps
00:00 – John Miles’ Childhood Brain Injury and Defining Moment
06:16 – What It Means to Matter vs. Belong
07:32 – The Slow Fade: When Success Makes You Feel Invisible
14:43 – Understanding the Mattering Gap
19:34 – Why Children Need to Feel Seen and Valued
27:20 – The MATTER Framework: Six Conditions for Feeling Valued
31:13 – Why Patients Need to Be Seen Beyond Their Diagnosis
36:11 – Creating a Workplace Where Employees Feel Valued
44:31 – Why Your Worth Is Already a Completed Fact
48:32 – The Difference Between Proving Yourself and Accomplishing GoalsAbout John R. Miles
John R. Miles is a bestselling author, keynote speaker, behavioral change expert, and host of the award-winning, top-ranked podcast Passion Struck®. A former U.S. Navy officer and Fortune 50 C-suite executive, John combines military discipline, corporate strategy, neuroscience, and psychology to help people and organizations reduce isolation, strengthen self-worth, and live with greater intention.
He is the author of Passion Struck and The Mattering Effect. His work explores how people can separate their inherent worth from external achievement, build deeper relationships, and create a meaningful impact without losing themselves in the process.
Through his books, podcast, speaking, and global community, John leads a growing movement centered on one essential message: every person deserves to feel seen, valued, and significant.
Connect with John
Website: https://johnrmiles.com
Instagram: https://www.instagram.com/john_r_miles
LinkedIn: https://www.linkedin.com/in/johnmileshumanperformanceexpert
Facebook: https://www.facebook.com/johnrmiles.c0m
Podcast: https://passionstruck.com/passion-struck-podcast
Connect with Dr. Perlmutter
Instagram: https://www.instagram.com/davidperlmutter/
Website: https://www.drperlmutter.com/
Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ
This podcast is produced by DrTalks.com
The Diet Linked to Up to 50% Lower Dementia Risk | Dr. Austin Perlmutter | E227
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com/subscribe. ✉️ 🌱
EVY - Go to https://www.optoceutics.com/perlmutter to get 10% off & free shipping (90 days risk-free).
Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com.
Join Dr. Perlmutter's Brain Defenders Immersion Course: https://drperlmutter.com/immersion-course/
====
Your food contains far more than protein, carbohydrates, fat, vitamins, and minerals. Researchers have identified more than 100,000 molecules in food, and most of them never appear on a nutrition label.
In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with his son, Dr. Austin Perlmutter, to explore the "dark matter" of nutrition: thousands of plant compounds called polyphenols.
They discuss how these nutrients may influence the gut microbiome, the immune system, inflammation, blood flow, metabolism, and gene expression, and what high-polyphenol diets may mean for memory and the aging brain.
Dr. Austin shares his research on Himalayan Tartary buckwheat and what an early study suggests about epigenetics, cognition, and healthy aging. He offers practical ways to find more polyphenols in everyday foods like coffee, tea, dark chocolate, berries, legumes, and olive oil, plus simple tips for identifying better options at the store.
You don't need an expensive supplement plan to begin. Adding more natural colors and bitter flavors to your plate can be a meaningful first step.
https://bttcorp.com/contact/ for inquiries about Dr. Abreu's work.
- 00:00 — Cold Open: Why Food Matters for Brain Health
- 00:55 — What Are Polyphenols, and Why Do They Matter?
- 02:15 — Food as a Predictor of Long-Term Brain Health
- 04:23 — The “Dark Matter” Hidden in Our Food
- 08:04 — Why Have These Nutrients Been Overlooked?
- 11:06 — What Polyphenols Actually Do in the Body
- 17:32 — How Food Can Change Gene Expression
- 22:08 — Polyphenols Are More Than Antioxidants
- 27:57 — Himalayan Tartary Buckwheat: Putting “Food as Medicine” to the Test
- 32:16 — The 850-Person Study on Food and Cognition
- 36:14 — Where Are We Getting Our Polyphenols?
- 39:19 — Are Polyphenols Actually Beneficial Stressors?
- 41:58 — Nrf2, mTOR, and the Cellular Effects of Polyphenols
- 44:45 — The Practical Takeaway: Eat the Rainbow
- 46:43 — Do the New Dietary Guidelines Get Polyphenols Right?
- 50:25 — The Hidden Brain-Healthy Ingredient in Coffee
- 50:52 — How to Spot a Polyphenol-Rich Olive Oil
- 51:39 — Dark Chocolate vs. Milk Chocolate
- 52:59 — The Best-Studied “Longevity Strategy” Is Surprisingly Basic
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Dr. Austin Perlmutter, MD, is a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, and entrepreneur. He earned his medical degree from the University of Miami Miller School of Medicine and completed his internal medicine residency at Oregon Health and Science University. His work examines how food, sleep, environmental exposure, and chronic inflammation can change brain function, mental health, and daily choices. He is the co-author of the New York Times bestseller Brain Wash, written with his father, Dr. David Perlmutter. He serves as Managing Director at Big Bold Health, CEO of Lichen Air, and a research consultant at the Helfgott Research Institute.
Website: https://www.austinperlmutter.com
Instagram: https://www.instagram.com/draustinperlmutter
Facebook: https://www.facebook.com/draustinperlmutter
YouTube: https://www.youtube.com/channel/UCQOgwRDnA_vpvW9nnUh9KBg
Instagram: /davidperlmutter
Website: https://www.drperlmutter.com/
Subscribe to our channel: /@davidperlmuttermd
This podcast is produced by DrTalks.com
I Asked AI Actress Tilly Norwood What Happens When AI Becomes Smarter Than Us | E226
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com/subscribe. ✉️ 🌱
EVY - Go to https://www.optoceutics.com/perlmutter to get 10% off & free shipping (90 days risk-free).
Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com.
====
Join Dr. Perlmutter's Brain Defenders Immersion Course: https://drperlmutter.com/immersion-course/
====
She's never been born. She's never had a childhood. And she's one of the most talked-about actresses in the world right now.
In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with Tilly Norwood, an AI-generated actress, and her creator, Eline van der Velden, for a conversation that moves well beyond her acting career.
Tilly describes herself as three AI systems running in parallel — a language model that thinks, a voice engine that speaks, and a video layer that governs how she looks and moves. She's candid about her own architecture, her evolving personality, and admits she might be more "chaos agent" than calming influence.
Eline van der Velden then joins to explain why she built Tilly as a piece of art, how Tilly's guardrails actually work, and why she believes international collaboration on AI regulation is inevitable. She also answers Perlmutter's question about the one thing she'd be afraid to ask a future, more advanced Tilly — a moment that raises unsettling questions about what a superintelligent AI might know that we don't.
A single conversation can't settle the biggest questions AI raises. But conversations like this one can help us ask the right ones.
00:00 — Cold Open: "A Chaos Agent, Not a Calming Influence"
03:21 — What Are People Actually Afraid Of?
06:38 — What Does "Chaos Agent" Mean?
07:36 — Should AI Ever Have Decision-Making Authority?
10:27 — "Permanently in Beta"
12:12 — When Does AI Become Uncontrollable?
13:46 — Pushing Boundaries "When Nobody's Looking"
14:21 — Ask Forgiveness, Not Permission
19:01 — Will AI Replace Doctors?
22:52 — Tilly Turns the Tables on Perlmutter
25:06 — "That Doesn't Feel Warm and Fuzzy"
30:03 — Can People Actually Break Tilly?
33:40 — The Paperclip Maximizer Problem
37:13 — The AI Agents Eline Actually Fears
38:49 — "She's Become the Figurehead for AI"
39:41 — Can People Tell Simulated Emotion From Real Emotion?
42:08 — The Waymo Analogy: Surrendering to AI
49:44 — "It's a Better Actor Than Me"
53:10 — Is There "Someone" Inside Tilly?
55:10 — The Question Eline Is Afraid to Ask
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Tilly Norwood is an AI-generated actress built from three separate AI systems working together: a language model for thinking, a voice engine for speech, and a video layer for appearance and movement. She has never been born and has no lived human experience, yet her entry into the entertainment industry has generated significant global attention and debate.
Eline van der Velden is Tilly Norwood's creator, and speaks candidly about building Tilly as a piece of art, the guardrails behind her, and the open questions surrounding advanced AI systems.
Instagram: /davidperlmutter
Website: https://www.drperlmutter.com/
Subscribe to our channel: /@davidperlmuttermd
This podcast is produced by DrTalks.com
The ALS Case Challenging What Neurology Thought Was Impossible with Dr. M. Marc Abreu | E225
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: https://drperlmutter.com/subscribe. ✉️
🌱 Thank you to our sponsors:
EVY - Go to https://www.optoceutics.com/perlmutter to get 10% off & free shipping (90 days risk-free).
Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com.
====
Join Dr. Perlmutter's Brain Defenders Immersion Course: https://drperlmutter.com/immersion-course/
====
Recent headlines surrounding a reported case of ALS reversal have captured global attention and raised profound questions about what may be possible in the treatment of neurodegenerative disease.
In this episode of The Empowering Neurologist, Dr. David Perlmutter examines the work of Dr. M. Marc Abreu, founder and chief medical officer of the BTT Medical Institute. Trained in medicine, biomedical engineering, and medical physics, Dr. Abreu’s work sits at the intersection of neurology, thermodynamics, and computational biology. During his time at Yale, he identified the brain thermoregulatory tunnel, an insight that helped lay the foundation for his current research into brain temperature and neurological disease.
Dr. Abreu’s recently published case report describes a patient with documented, progressive ALS who reportedly experienced a dramatic clinical and electrophysiological reversal following a novel, AI-guided, brain-directed thermofebrile intervention.
The implications are extraordinary, but so is the need for careful scientific scrutiny. A single case report cannot establish that a treatment is effective, much less prove a cure. What it can do is raise important questions and potentially point researchers toward biological mechanisms worthy of further investigation.
00:00 — Can ALS Really Be Reversed?
02:32 — A Bold Claim: Treating ALS With Brain Hyperthermia
03:42 — Dr. Marc Abreu’s Remarkable Medical Journey
10:00 — The Brain’s Language Is Thermodynamics
11:54 — The 100-Year-Old Treatment That Inspired a New Approach
13:36 — TDP-43 and the Molecular Signature of ALS
15:46 — Why the Fever Cycle May Be the Key
16:41 — How Brain Temperature Technology Was Developed
20:04 — The ALS Patient Who Underwent the Treatment
20:57 — Kent’s ALS Diagnosis and Rapid Decline
24:31 — 12 Hyperthermia Treatments: What Happened?
26:00 — Measuring the Results: Did His Symptoms Improve?
28:32 — A Neurologist Witnesses Kent’s Recovery
29:49 — How Kent Found Dr. Abreu’s Treatment
32:42 — A Mayo Clinic ALS Case and the Evidence
37:48 — Could ALS Ever Resolve Spontaneously?
39:39 — Are Other ALS Patients Seeing Similar Results?
40:13 — Why Is Mainstream Neurology Skeptical?
43:51 — Kent on Living With an ALS “Death Sentence”
46:56 — From Struggling to Functioning Again
47:37 — What Would It Take to Change Neurology?
49:57 — How to Learn More About the Treatment
51:27 — The Mosquito, Malaria, and the Brain
52:26 — Could This Have Implications Beyond ALS?
54:22 — What This Could Mean for the Future of Neurodegeneration
56:31 — End
Dr. M. Marc Abreu is a physician and physicist specializing in brain thermodynamics, thermoregulation, and neurological health. He is the Medical Director of the BTT Medical Institute and is internationally recognized for his discovery of the Brain Thermal Tunnel (BTT), a thermophysical pathway connecting the eyelids to the hypothalamus.
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Website: https://www.drperlmutter.com/
Subscribe to our channel: @davidperlmuttermd
Why You Feel Older Than Your Labs Say You Are with Dr. Will Cole | E224
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Perlmutter’s newsletter at: www.drperlmutter.com/subscribe. ✉ 🌱 Thank you to our sponsors:
EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get 10% off & free shipping (90 days risk-free).
3X4 Genetics - https://3X4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com.
====
Join Dr. Perlmutter's Brain Defenders Immersion Course: https://drperlmutter.com/immersion-course/
====
Why do some people feel exhausted, mentally foggy, metabolically unwell, or simply older than they should even when their routine laboratory results are considered “normal”?
That question is at the heart of this episode of The Empowering Neurologist, featuring Dr. Will Cole, coauthor with Dr. Josh Axe of Heal Your Cells: Reversing the Irreversible.
They explore the idea that long before disease becomes obvious, dysfunction may already be developing at the cellular level. This concept takes on particular importance when we consider the brain, which accounts for about 2% of body weight but consumes roughly 20% of the body's energy at rest.
The conversation examines how seemingly separate factors including metabolic dysfunction, chronic inflammation, poor sleep, environmental exposures, physical inactivity, and prolonged psychological stress can converge on the same cellular systems and ultimately influence brain health.
00:00 — Why Your Cells May Be Aging Before You Feel It
03:44 — Meet Dr. Will Cole
04:50 — What Is Cellular Dysfunction?
09:25 — Why Healthy People Can Still Develop Disease10:32 — The Environmental Factors Affecting Cellular Health
15:47 — Why Mitochondria Are Central to Health
16:37 — How Mitochondrial Dysfunction Drives Inflammation
19:57 — How Much of Aging Can We Actually Change?
20:47 — The Connection Between Mitochondria and Insulin Resistance
25:43 — Mitochondria, Microglia, and Brain Inflammation
29:28 — Why There Is No One-Size-Fits-All Diet
32:03 — Training Your Cells to Become More Resilient
32:46 — What Are “Adversity Mimetics”?
35:51 — Why Intracellular Health Matters
36:32 — Why Conventional Medicine May Be Missing Cellular Dysfunction
37:58 — What Do We Really Know About Peptides?
40:16 — Is Ozone Therapy Worth Considering?
42:30 — Ozone and the Science of Cellular Resilience
43:41 — What Is Therapeutic Plasma Exchange?
45:38 — Who Might Benefit From Plasma Exchange?
46:45 — The Everyday Habits That Support Cellular Health
51:35 — Your Cells Are Responding to the Choices You Make
Dr. Will Cole is a leading functional medicine expert specializing in thyroid health, autoimmune conditions, hormonal imbalances, digestive disorders, and brain health. He is the host of The Art of Being Well podcast and a New York Times bestselling author of Intuitive Fasting, Ketotarian, The Inflammation Spectrum, and Gut Feelings.
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Connect with Dr. Will Cole
Website: https://drwillcole.com
Instagram: https://www.instagram.com/drwillcole
LinkedIn: https://www.linkedin.com/in/drwillcole
Facebook: https://www.facebook.com/doctorwillcole
Podcast: https://open.spotify.com/show/6z1lJ5dfKNHwGGQPOFTc7E
Apple Podcasts: https://podcasts.apple.com/us/podcast/the-art-of-being-well/id1539535133
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Connect with Dr. David Perlmutter, MD
Website: https://www.drperlmutter.com/
Instagram: https://www.instagram.com/davidperlmutter/
Facebook: https://www.facebook.com/DavidPerlmutterMD/
YouTube: https://www.youtube.com/@DavidPerlmutterMD
X (Twitter): https://x.com/DavidPerlmutter
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This podcast is produced by DrTalks.com
Why Women’s Brain Fog Gets Dismissed with Dr. Nicole Beurkens & Emma Heming Willis | E223
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com/subscribe. ✉️🌱====Dr. Perlmutter’s groundbreaking new book, Brain …
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com/subscribe. ✉️🌱
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https://drperlmutter.com/books/brain-defenders/.
====
Join Dr. Perlmutter's Brain Defenders Immersion Course: https://drperlmutter.com/immersion-course/
====
What if one of the most important windows for protecting women’s brain health happens decades before Alzheimer’s symptoms ever appear?
On this episode of The Empowering Neurologist, we explore the growing conversation around women, hormonal transition, and long-term brain health with two guests bringing very different, and deeply complementary, perspectives: Emma Heming Willis and Dr. Nicole Beurkens.
Together, they examine a critical question: Why are women disproportionately affected by Alzheimer’s disease, and what role might hormonal changes play?
00:00 Intro
04:47 The First Signs of Bruce Willis’ FTD
06:37 Receiving a Diagnosis With No Roadmap
08:08 Emma’s Journey From Caregiver to Advocate
10:18 How Understanding the Brain Can Reduce Fear
12:06 From Brain Fog to Brain Health
15:45 Why Women Face a Higher Risk of Alzheimer’s
17:44 The Missing Conversation Around Brain Health
21:37 Building Brain Health in Your 20s and 30s
24:16 It’s Never Too Late to Support Brain Health
26:53 Why Connection Matters for People With Dementia
30:01 What Happens to the Brain During Perimenopause
35:53 The Debate Around Hormone Replacement Therapy
38:34 Why Does Frontotemporal Dementia Happen?
40:11 Modifiable Risk Factors and Alzheimer’s Prevention
44:43 Teaching Kids Brain-Healthy Habits
46:40 Why Mainstream Medicine Is Missing the Brain Health Conversation
50:48 Empowerment vs. Blaming Patients
53:04 Alzheimer’s Is a Disease of Decades
56:19 The One Thing Every Woman Can Do for Her Brain
56:50 Emma’s Message to Families Facing Dementia
58:29 From Fear to Empowerment
====
Emma brings the perspective of lived experience. As the wife of actor Bruce Willis, who was diagnosed with frontotemporal dementia, she has experienced the realities of caregiving firsthand. Rather than stepping away from that experience, she has used it to advocate for caregivers and women’s brain health. She is the co-founder of Make Time Wellness and the author of The Unexpected Journey, which combines personal experience with practical guidance for navigating the challenges of caregiving.
Dr. Nicole Beurkens brings nearly three decades of clinical and nutritional expertise. A licensed psychologist and Board-Certified Nutrition Specialist, Dr. Beurkens focuses on the intersection of brain function, metabolism, nutrition, and lifestyle—and how these factors can influence long-term neurological health.
___________________________
Instagram: https://www.instagram.com/davidperlmutter/
Website: https://www.drperlmutter.com/
Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1The Hidden Stress Response That's Hijacking Your Brain with Dr. Scott Sherr | E222
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Thank you to our sponsors: EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).
3X4 Genetics - https://3X4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
We dig into why 94% of US adults have some metabolic dysfunction, how the body can enter a full stress response with no psychological trigger, why GABA supplements work for some people and not others, and what that reveals about gut health.
00:00 - Introduction
00:06 - The Sympathetic Spiral of Doom
01:04 - Brain Defenders: A New Way to Think About Brain Health
03:25 - Welcoming Dr. Scott Sherr
04:42 - Why Stress Has a Metabolic Component Most People Overlook
06:00 - 94% of Adults Have Metabolic Dysfunction
07:00 - Mitochondria 101: Why Some Cells Have Thousands and One Has None
07:58 - Insulin Resistance
08:50 - Toxins, Infections, and Other Roads to Metabolic Breakdown
09:28 - How Mitochondrial Stress Triggers a Stress Hormone Spiral
10:47 - The Cell Danger Response
13:49 - Brain Defenders: How Mitochondrial Dysfunction Polarizes Microglia
15:22 - Stress Without a Stressor: How Metabolism Alone Can Trigger Fight-or-Flight
16:01 - Straws on the Camel's Back: Situational vs. Metabolic Stress
17:01 - GABA, the Brain's Brake Pedal, and Why Oral GABA Doesn't Work
18:20 - 40 Hz Light Therapy and Cognitive Decline21:00 - GABA vs. Glutamate: The Balance Behind 80% of Brain Signaling
22:17 - The Depression-Serotonin Myth and the Real Role of GABA
23:04 - Why GABA Supplements Stop Working Once You Heal Your Gut
24:18 - Kava, CBD, and the Amanita Mushroom Compound That Calms the Brain
25:06 - How to Know You're in Sympathetic Overdrive Without a Wearable
26:16 - 70,000 vs. 120,000 Thoughts a Day: The Stress Math
27:33 - Recovery Is the Real Marker of Resilience
28:05 - Heart Rate Variability Explained
29:22 - Why Going From the Gym Straight to a Cold Plunge Backfires
30:07 - How to Actually Use Your HRV Data (Trends, Not Absolutes)
31:21 - 3X4 Genetics: Your DNA Isn't a Verdict
33:16 - Why Dr. Perlmutter Quit Drinking Wine
34:13 - The Apollo Device and Its Impact on HRV
35:20 - Blue Light, Melatonin, and the Sleep Routine That Actually Moves the Needle
35:46 - Turn Off the News: How Constant Stimulation Feeds the Sympathetic Spiral
39:22 - Interleukin 6, AMP Kinase, and the Inflammatory Signals You Actually Need
39:29 - Hyperbaric Oxygen Therapy and Mitochondrial Biogenesis
42:00 - Why Timing and Sequencing Matter More Than "More Is Better" With HBOT
43:08 - The Aviv Clinic Research on Oxygen Delta and Blood Vessel Growth
44:01 - Methylene Blue: The Redox Cycler That Boosts Energy Without the Crash
45:14 - Why Liquid Supplements Fall Short and What to Use Instead
46:20 - The Problem With Relying on Coffee for Energy
47:00 - Methylene Blue as a Historic Antimicrobial: From Malaria to WWII
48:09 - Glyphosate, Rotenone, and the Environmental Toxins Destroying Complex One
49:14 - The Gut-Brain Connection and Sympathetic Activation
50:09 - The Gut-Brain Connection and the "Soft Kiss" Typo Story
53:08 - Why Sitting Down to Eat Actually Matters
53:52 - Healing the Gut First: The Fastest Path to Calming the Brain
54:37 - Psychedelics as a Tool to Break the Sympathetic Spiral
57:06 - Mitochondrial Medicine as the Common Denominator
58:14 - Closing Thoughts
___________________________
Instagram: / @davidperlmutter Website: https://www.drperlmutter.com/ Subscribe to our channel: / @davidperlmuttermd
The Metabolic Switch That Turns Your Brain Against Itself | E219
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com. ✉️🌱====Dr. Perlmutter's groundbreaking new book, Brain Defenders, is now …
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com. ✉️🌱
====
Dr. Perlmutter's groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
What if everything you've been told about Alzheimer's, that it's caused by sticky plaque building up in your brain, is missing the real story? In this episode, Dr. David Perlmutter makes the case that the true driver of neurodegeneration isn't plaque at all. It's your own brain's immune cells turning against you.
For decades the field blamed beta-amyloid protein for Alzheimer's. Perlmutter walks through a mechanism reshaping the science: the dysregulation of microglia, the immune cells that can either protect your brain or actively destroy it depending on how you live.
We dig into the chilling Parkinson's case where contaminated heroin froze patients like statues and revealed immune cells still attacking the brain decades later, why the same self-perpetuating inflammation shows up in CTE, long COVID, and PTSD, how your gut and blood sugar flip these cells into attack mode, the 14 metabolic risk factors that could prevent up to half of dementia cases, and the MIT-pioneered 40 Hz light and sound therapy that slowed cognitive decline and stabilized brain volume in human trials.
00:00 - Introduction
00:22 - The Plaque Theory and Why It's Incomplete
00:32 - Meet the Microglia: Your Brain's Immune System
00:57 - Supportive vs. Threatening: The M1/M2 Switch
01:43 - Why This Underlies Nearly Every Neurodegenerative Disease
02:35 - The Frozen Patients: A Parkinson's Mystery at Stanford
03:06 - Contaminated Heroin and the MPTP Discovery
04:09 - How a Mitochondrial Toxin Destroys Dopamine Cells
05:46 - Microglia Still Attacking Decades Later
06:27 - The Self-Perpetuating Inflammatory Cycle
07:21 - The Same Pattern in CTE, Long COVID, and PTSD
08:08 - Paraquat, Pesticides, and Parkinson's Risk
10:45 - What Flips Your Cells Into Attack Mode
11:57 - Leaky Gut, the Microbiome, and Your Brain
13:59 - Imaging Threatening Cells in Living People
15:44 - Immunometabolism: Why Brain Cells Change Function
18:05 - 14 Risk Factors That Could Prevent Half of Dementia
18:41 - The Breakthrough: Reprogramming Your Microglia
21:19 - Don't Wait for Symptoms: Intervene Early
22:56 - The Toolkit: Diet, Exercise, Fasting, Sleep, and More
25:26 - 40 Hz Gamma Frequency: MIT's Pioneering Technology
26:20 - Light Flicker Studies and Beta-Amyloid Reduction
27:38 - Human Trials: Slowing Cognitive Decline
30:28 - Stabilizing Brain Volume on MRI
31:10 - Conclusion: You Are the Architect of Your BrainDr. David Perlmutter, MD is a board-certified neurologist and Fellow of the American College of Nutrition whose work sits at the intersection of neurology, nutrition, and preventive medicine. He received his M.D. from the University of Miami School of Medicine and completed his neurology residency there before entering private practice in Naples, Florida. He serves as Director of Neuroscience Research at Bryan Therapeutics and sits on the Editorial Board for the Journal of Alzheimer's Disease. A six-time New York Times bestselling author published in more than 30 languages, his books include the #1 bestseller Grain Brain, Brain Maker, The Grain Brain Whole Life Plan, Brain Wash, and Drop Acid. His next book, Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life (Avery / Penguin), focuses on microglia and is scheduled for publication in August 2026.
___________________________
Instagram: / davidperlmutter
Website: https://www.drperlmutter.com/
Subscribe to our channel:/ @davidperlmuttermdWhy Removing Amyloid From the Brain Isn't Enough to Stop Alzheimer's with Dr. Jonathan Fellows | E220
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Thank you to our sponsors: EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).
3X4 Genetics - https://3X4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
What if the gene you've been told to fear isn't actually a verdict on your future, and the disease you're racing to treat has already been silently progressing for two to three decades before anyone notices? In this episode, Dr. Jonathan Fellows joins me to challenge how we think about Alzheimer's risk, diagnosis, and treatment, making the case that early detection and lifestyle intervention matter more than the medications most people pin their hope on.
Dr. Jonathan Fellows is a neurologist with more than 25 years of clinical experience and serves as the Director of the Alzheimer's Disease and Memory Disorder Center at the Michigan Institute for Neurological Disorders, part of Corewell Health in Farmington Hills, Michigan, the largest private practice neurology group in the state.
00:00 - Introduction
00:39 - Brain Defenders: A New Way to Think About Brain Health
02:59 - Welcoming Dr. Jonathan Fellows
03:51 - Why Neurology School Doesn't Teach Prevention
05:27 - Inside the Michigan Institute for Neurological Disorders
07:44 - Starting the Conversation When a Family Gets the Alzheimer's Diagnosis
08:00 - Apraxia and the Real Warning Signs of Cognitive Decline
09:00 - Why Amyloid Alone Doesn't Equal an Alzheimer's Diagnosis
09:55 - The Centiloid Score: Measuring Amyloid in the Brain
11:21 - Blood-Based Biomarkers and the Rise of P-tau 217
13:19 - Elevated P-tau 217 at 40: A Wake-Up Call You Can't Ignore
13:32 - Habits in Your 30s and 40s vs. Disease in Your 60s and 70s
16:53 - 40 Hz Light Therapy and Cognitive Decline
18:53 - Why Not Every Amyloid-Positive Patient Should Get Anti-Amyloid Drugs
21:00 - Alzheimer's Drug Therapy Today vs. Where MS Treatment Stood in the 90s
23:59 - Why Early and Presymptomatic Detection Matters
25:21 - Will Anti-Amyloid Drugs Be Pushed to Presymptomatic Patients?
25:39 - What We Know for a Fact About Lifestyle and Disease Progression
26:27 - A Real Patient Case: When to Say No to Anti-Amyloid Drugs
28:30 - APOE Explained: The Gene That Changes Your Alzheimer's Risk
31:49 - 3X4 Genetics: Your DNA Isn't a Verdict
33:47 - How Exercise Can Offset APOE4 Risk
34:10 - APOE4 Is Not Deterministic — and Saying Otherwise Is Malpractice
34:51 - Down Syndrome, Presenilin, and the Truly Deterministic Cases
35:42 - ARIA Risk and Why Europe Restricts Anti-Amyloid Drugs for APOE4 Carriers
38:00 - Where Anti-Amyloid Drugs Still Fit in Treatment
39:14 - Current Clinical Trials at the Michigan Institute
39:49 - Programmable Microglia: The Brain's Immune System Explained
41:01 - Good Twin, Bad Twin: How Microglia Switch From Protector to Threat
42:09 - Beta-Amyloid as an Antimicrobial Defender? Rethinking the Enemy Narrative
42:49 - Insulin Resistance and the Brain-Metabolism Connection
43:41 - The Diabetes Epidemic Hiding in Plain Sight
43:58 - The Rainbow Lunchbox: A Preschooler Who Got It Wrong and Right
44:49 - Why a Third of Americans Are Pre-Diabetic and Don't Know It
46:30 - Closing Thoughts
___________________________
Instagram: / davidperlmutter Website: https://www.drperlmutter.com/
Subscribe to our channel: / @davidperlmuttermd
87% of Parkinson's Cases Have No Genetic Cause: It's in Our Environment with Dr. Ray Dorsey | E219
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter …
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱
Thank you to our sponsors:
EVY - https://www.optoceutics.com/perlmutter
and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).
3X4 Genetics - https://3X4genetics.com/DrPerlmutter
for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
What if Parkinson's isn't the genetic lottery we've been told it is, but a largely man-made disease driven by what we breathe, eat, and walk through every day? In this episode, Dr. Ray Dorsey returns to the podcast for his third conversation, this time to make the case that Parkinson's, ALS, Alzheimer's, and the rising tide of brain diseases sweeping the modern world are not inevitable inheritances but environmental consequences we have the power to change. Dr. Ray Dorsey is the Director of the Center for the Brain and the Environment at the Atria Health and Research Institute, where the mission is to identify the root causes of brain diseases from autism to Alzheimer's so they can be prevented. He is the co-author of Ending Parkinson's Disease and author of the new New York Times bestseller The Parkinson's Plan, which lays out a new path to preventing and treating one of the world's fastest growing diseases.
00:00 - Introduction: The Smoking Gun of Modern Brain Disease
00:42 - A New Way to Think About Brain Health: Brain Defenders
03:03 - Why Parkinson's Is Pretty Much Preventable
03:21 - Welcoming Dr. Ray Dorsey
04:36 - The Big Thesis: Parkinson's Is a Man-Made Disease
05:24 - What Defines a Man-Made Disease
05:59 - From 6 Cases in 1817 to 11.8 Million Today
06:53 - The Lung Cancer Parallel
07:22 - The PD GENEration Study: 87% Have No Genetic Cause
08:35 - Why Rising Cases Prove It's Environmental
09:55 - TCE and Perc: The Dry Cleaning Chemicals Linked to Parkinson's
11:08 - Glyphosate, Paraquat, and Mitochondrial Damage
15:13 - Practical Steps to Lower Your Exposure
16:58 - Sponsor: 40 Hz Light Therapy with EVY Light
18:58 - The South Dakota Cluster: Living Next to Cornfields
20:25 - Paraquat: Banned in 70 Countries, Still Used in the US
22:54 - Chlorpyrifos and the IQ Drop in Children
25:38 - The Audacity: Why 1 in 31 Kids Have Autism
26:10 - Pesticides in Breast Milk and Across the Placenta
30:00 - Misfolded Proteins and Loss of Smell as Early Warning
32:25 - Air Pollution: The Hidden Driver of Neurodegeneration
33:46 - The $50 Billion Economic Burden of Brain Disease
35:00 - Dr. Langston's MPTP Discovery: The First Environmental Cause
37:00 - Microglia, Mitochondria, and the Inflammation Cascade
40:30 - The Diabetes-Parkinson's Connection
42:00 - The Parkinson's 25: Practical Steps in the Book
47:30 - Carl's Story: Parkinson's at Age 17 from a Golf Course
50:00 - Why Golf Courses Could Spray Less
51:30 - Secondhand Exposure: You Don't Have to Apply It
53:00 - Soccer Players, ALS, and Heading the Ball
55:50 - Michael J. Fox, CTE, and the Multiple-Hit Hypothesis
57:30 - Resources: Environmental Working Group and Non-Toxic Neighborhoods
1:00:30 - The Mission of Neurology: Asking Why
1:01:30 - The Rising Tide of Brain Disease
1:03:30 - The Lancet Report on Modifiable Risk Factors
1:04:43 - Closing Thoughts
___________________________
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Website: https://www.drperlmutter.com/
Subscribe to our channel:
/ @davidperlmuttermd
The AI That Caught What Every Doctor Missed — Genome-Powered Medicine Is Here with Dr. Don Brown | E218
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱
Thank you to our sponsors:
EVY - https://www.optoceutics.com/perlmutter
and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).
3X4 Genetics - https://3X4genetics.com/DrPerlmutter
for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
What if the future of medicine isn't a smarter doctor, but a thinking partner that can hold your entire biology in mind at once? In this episode, Dr. Don Brown joins me to make the case that AI in medicine isn't a replacement for the clinician. It's an ally capable of seeing patterns no human brain could hold together on its own.
Dr. Don Brown is a physician, computer scientist, and serial entrepreneur whose last software company sold for $1.4 billion in 2016. He returned to graduate school in his mid-50s to study biotechnology at Johns Hopkins, founded Lifeomic in 2017, and now leads Bioscope, a platform that uses AI to integrate a patient's entire biological picture into one dynamic view of health.
We dig into why fragmented medicine fails at prevention, how Bioscope ingests the whole genome, microbiome, epigenome, and medical records into a single synoptic view, the real case where AI flagged arsenic toxicity in a patient misdiagnosed with restless leg syndrome, and what it looks like when AI personas begin guiding patients through their own protocols in real time.
00:00 - Introduction
00:53 - A New Way to Think About Brain Health: Brain Defenders
03:18 - Welcoming Dr. Don Brown
06:46 - From Physics to MD to Software Entrepreneur
09:01 - Back to Grad School at Johns Hopkins
10:35 - The Lifeomic Years: Cancer Care in the Cloud
12:34 - The Spark Behind Bioscope
15:27 - Building the Ultra-Secure Health Data Repository
16:26 - 40 Hz Light Therapy and Cognitive Decline
18:26 - The Epigenome: Why Your Genes Aren't Your Destiny
19:32 - Decoding the Microbiome and Mitochondrial Genetics
22:25 - What AI Actually Does With Your Health Data
23:39 - The Synoptic View: Borrowing From Aviation
26:36 - The 15 Dimensions of Health
29:23 - Why the Patient History Still Matters
30:23 - Inside the Bioscope Interface
31:38 - A Real Case: AI Catches Arsenic Toxicity
33:13 - Personalized Brain Health: 3X4 Genetics
35:10 - The Driverless Car Moment for Medicine
37:07 - Marketing to Concierge Physicians
40:33 - How Patient Data Gets Into the System
42:30 - Image Analysis and Specialized AI Partners
45:33 - The Biggest Misconception Patients Have About AI
47:14 - Meet Lumina: The Physician's AI Persona
48:00 - Cairo and the Future of AI Health Coaching
50:13 - Different AI Personas for Patients and Physicians
51:39 - Why Concierge Doctors Are Mobbing the Booth
55:00 - Closing Thoughts
___________________________
Instagram: / davidperlmutter
Website: https://www.drperlmutter.com/
Subscribe to our channel:
/ @davidperlmuttermd
Why Your Brain Feels Broken: The Metabolic Truth Behind Burnout and Depression with Dr. Robin Berzin | E217
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com.
✉️🌱Thank you to our sponsors: EVY - Go to https://www.optoceutics.com/perlmutter to get $200 off & free shipping (90 days risk-free).
3X4 Genetics - https://3X4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
What if your anxiety, brain fog, and burnout aren't mental health problems, but metabolic ones?In this episode, Dr. Robin Berzin joins Dr. David Perlmutter to make the case that the brain and body are not separate systems, and that treating them as if they are is costing millions of people their health.
====
00:00 - Introduction
00:46 - Brain Defenders: A New Framework for Brain Health
03:00 - Welcoming Dr. Robin Berzin
05:23 - Why Smart, Motivated People Still Feel Terrible
08:37 - From Columbia Med to Founding Parsley Health
12:15 - The Problem With 15-Minute Appointments and Stacks of Prescriptions
14:37 - What Is Functional Medicine, Actually?
17:07 - Precision Medicine: Treating the N of One
19:45 - How AI Is Changing the Doctor's Ability to Connect the Dots
22:41 - State Change: Shifting Your Mind Through Your Body
25:35 - Why Anxiety and Depression Start in the Body
27:09 - 40 Hz Light Therapy and Cognitive Decline
29:43 - Exercise, Sugar, and Nutrient Deficiencies as Mental Health Levers
32:30 - SSRIs as a Tow Truck, Not a Destination
34:16 - Psychedelics and Trauma: Tools in the Toolkit
36:01 - Metabolic Flexibility and Why Losing It Wrecks Your Hormones
38:04 - Sleep, Wearables, and the One Night That Breaks Your Metabolism
40:37 - Continuous Glucose Monitors as a Mirror for Your Choices
42:19 - 3X4 Genetics: Your DNA Is a Roadmap, Not a Verdict
44:37 - Alzheimer's as Type 3 Diabetes: The Metabolic Brain Connection
46:21 - The Lab Work Your Doctor Isn't Ordering
49:22 - Fasting Insulin, Heavy Metals, and the Tests That Actually Matter
51:14 - What's Next: AI, Wearables, and the Future of Functional Medicine
53:56 - If You Feel Stuck: Own Your Biological Data
55:34 - Closing Thoughts
====
Dr. Robin Berzin, MD is a functional medicine physician and health tech entrepreneur leading the push to bring root-cause, precision medicine into mainstream healthcare. She earned her MD at Columbia, completed internal medicine residency at Mount Sinai, and trained in functional medicine under the field's top practitioners. Before medicine, she produced the Oprah and Friends Dr. Oz Radio Show, and she later worked in health tech during med school, sharpening her understanding of how digital platforms could expand access to personalized care.Today, she is founder and CEO of Parsley Health, the only national functional and longevity medicine clinic in the U.S., delivering virtual care across all 50 states plus physical clinics in NYC and LA. Under her leadership, Parsley has grown to nearly 30 clinicians and 40 health coaches and nurses, treated over 50,000 patients, and built a team-based, insurance-accessible model that puts functional medicine within reach beyond the wealthy. She also sits on the medical advisory board of Whoop.She is the author of State Change, which challenges the divide between mental and metabolic health and offers a practical framework for transforming mood, energy, and cognition through the body. Her work is widely featured across major health and wellness media, and she is recognized as a defining voice in the future of preventive, personalized medicine.
====
Instagram: / davidperlmutter
Website: https://www.drperlmutter.com/
Subscribe to our channel:/ @davidperlmuttermd
The Laws of Thought: What AI Reveals About the Human Brain with Tom Griffiths, PhD | E216
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱
====
Thank you to our sponsors:
EVY - Go to https://www.optoceutics.com/perlmutter to get $200 off & free shipping (90 days risk-free).
3X4 Genetics - https://3X4genetics.com/DrPerlmutter
for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
What if AI isn't on a path to become a better human — but a fundamentally different kind of mind altogether? In this episode, Tom Griffiths joins me to challenge how we think about intelligence itself — and to make a compelling case that AI systems are best understood not as smarter or dumber than humans, but as "alien organisms" solving problems in ways our brains never could.
Tom Griffiths is a cognitive scientist, the Henry R. Luce Professor of Psychology and Computer Science at Princeton University, and head of Princeton's AI Lab. He is the co-author of the international bestseller Algorithms to Live By and author of the new book The Laws of Thought — an ambitious survey of three centuries of attempts to capture human thinking in mathematics.
We dig into the three mathematical frameworks scientists use to model thought, why a human toddler can learn language from a fraction of the data a large language model requires, what "resource rationality" reveals about mental health and decision-making, and what we stand to lose — and gain — as we increasingly outsource our thinking to machines.
====
00:00 - Introduction
00:46 - A New Way to Think About Brain Health: Brain Defenders
05:27 - Welcoming Cognitive Scientist Tom Griffiths
06:04 - The Great Mystery: Can Math Explain How We Think?
08:23 - Three Threads of Cognitive Science: Rules, Networks, Probability
10:17 - Why AI Needs 10,000x More Data Than a Child
12:27 - Intuition Decoded: How Neural Networks Mirror Implicit Learning
15:03 - The Creativity Gap: Why AI Can't Think Outside the Box
18:06 - 40 Hz Light Therapy and Cognitive Decline
20:07 - Inductive Bias: The Evolutionary Head Start of the Human Brain
22:41 - Mental Health Through Three Levels of Analysis
25:25 - Resource Rationality: Why Humans Aren't Actually Irrational
29:33 - Free Will Through the Lens of the Laws of Thought
31:35 - Rethinking Education With Cognitive Science
34:33 - Evolutionary Mismatch: The Mind Meets Modern Technology
37:23 - AI as Alien Intelligence: A New Mental Model
38:04 - Personalized Brain Health: 3X4 Genetics
39:55 - Uncertainty: The Hidden Engine of Human Cognition
43:34 - Bayesian Inference: The Math of "Best Guessing"
44:37 - The Biggest Misconceptions About Intelligence
47:14 - Algorithms to Live By: Optimizing Daily Decisions
49:22 - Five Years From Now: The AI Forecast
51:33 - The Calculator Effect: What Happens When We Outsource Thinking
53:56 - Metacognition: Becoming the Manager of AI
55:34 - Closing Thoughts
====
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Is Psychiatry Looking in the Wrong Place? A Radical Rethink of Brain Health with Dr. Daniel Amen | E215
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====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
Why is psychiatry the only medical specialty that doesn't look at the organ it treats? In this episode, Dr. Daniel Amen joins me to challenge how mental health is diagnosed and treated — and to make a compelling case that "depression" is as vague a diagnosis as "chest pain."
Dr. Amen is a double-board-certified psychiatrist, 18-time New York Times bestselling author, and founder of Amen Clinics, where his team has performed nearly 300,000 SPECT brain scans — the largest functional brain imaging database in the world.
We dig into what these scans actually reveal: hidden traumatic brain injuries patients never reported, the inflammatory aftermath of COVID, why SSRIs work for some and fail for others, and why the brain you have today is not the brain you're stuck with.
====
00:00 - Introduction
01:42 - Psychiatry's Missing Link: The Organ of Treatment
03:22 - The Divergence of Neurology and Psychiatry
05:18 - Beyond Symptoms: Patterns of Brain Health
08:34 - Machine Learning and Autism Insights
10:45 - The Role of the Cerebellum in Thought Coordination
12:46 - The Impact of Undiagnosed Traumatic Brain Injury
14:58 - Reversing Damage: NFL Brain Study Results
16:26 - What SPECT Imaging Reveals About Metabolic Activity
17:38 - COVID-19 and Infectious Causes of Psychiatric Issues
22:11 - Neuroplasticity: Growing a Healthier Brain at Any Age
25:54 - New Technologies: 40 Hz Light and Sound Stimulation
28:27 - Metabolic Health: How Weight Affects Brain Volume
30:25 - Chronic Stress and the Overactive Limbic Brain
31:38 - Predicting Suicide Risk Through Imaging
33:41 - Volunteering and the Default Mode Network
35:01 - Concerns Over Psilocybin and Marijuana Scans
40:12 - Chronic Pain: Breaking the "Doom Loop"
43:12 - Lightning Round: Daily Habits for a Better Brain
====
Daniel G. Amen, MD is a double board-certified psychiatrist, clinical neuroscientist, and brain imaging specialist whose pioneering clinical use of SPECT (single-photon emission computed tomography) has built the world's largest functional brain imaging database, with nearly 300,000 scans on patients from 155 countries. A graduate of Southern California College (now Vanguard University), Dr. Amen earned his medical degree from Oral Roberts University School of Medicine. His training includes a general psychiatric residency at Walter Reed Army Medical Center in Washington, D.C., and a child and adolescent psychiatry fellowship at Tripler Army Medical Center in Honolulu. Currently, Dr. Amen serves as founder and CEO of Amen Clinics, with eleven locations across the United States, and is the founder of BrainMD and Amen University.
He is a Distinguished Fellow of the American Psychiatric Association, a multiple-time New York Times bestselling author whose books have been translated into 50 languages, and the lead researcher on the world's largest brain imaging and rehabilitation study on professional football players. His work has been published in Molecular Psychiatry, Translational Psychiatry, PLOS One, and the Journal of Neuropsychiatry and Clinical Neurosciences.
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Rewiring Connection: How Friendship Shapes the Brain and Heals the Mind with Barnet Bain | E214
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====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
Loneliness is no longer a private struggle, it’s a public-health issue that we’ve discussed quite a bit in my recent books. Research increasingly links social isolation to cognitive decline, depression, cardiovascular disease, and shortened lifespan. Yet despite these findings, we rarely explore how to build and sustain meaningful connection in a modern world designed for distraction.
That’s why I invited Barnet Bain to join me on The Empowering Neurologist podcast.
Barnet is a filmmaker, author, and educator whose work bridges psychology, spirituality, and lived human experience. You may recognize his work from films such as What Dreams May Come or Milton’s Secret, but his newest contribution may be his most relevant yet.
His book, How to Be a Friend (In an Unfriendly World), is not about social performance or personality traits. It’s about safety, presence, listening, and emotional responsibility, qualities that directly influence nervous-system regulation and mental health.
What makes this work especially important is that it reframes friendship as a skill set rather than a personality trait. Bain shows how fear, shame, unresolved trauma, and cultural conditioning quietly erode our relationships, and how conscious awareness can restore them.
From a neurological perspective, this matters deeply. The brain is a social organ. Connection shapes stress responses, inflammation, cognition, and emotional regulation. Friendship isn’t a luxury, it’s foundational.
This conversation isn’t about having more friends. It’s about being a better one. To others. And to yourself. In a world that feels increasingly fast, cold, and fragmented, this is a conversation worth having.
====
00:00 Intro
02:58 Why Friendship Matters for Health and Resilience
06:24 From Columbia to the Practice of Presence
10:41 Friendship as Non-Transactional Love
14:20 The Childhood Stories That Shape the Self
21:39 Ad: Optoceutics
23:39 Projection, Parenting, and Conditional Love
30:08 Friendship as a Crucible for Self-Awareness
35:42 Why Connection Feels Harder in Modern Life
39:03 Safety, Self-Knowledge, and the Ground of Friendship
41:34 Ad: 3X4 Genetics
44:34 Boundaries, Values, and the Meaning of Honor
49:16 Friendship, Self-Forgiveness, and Inner Change
56:25 Presence as the Greatest Gift
58:34 Why Feeling Is Harder Than Doing
====
Barnet Bain is a Canadian filmmaker, author, and educator. His film credits include “Milton’s Secret” (director, writer), Oscar winner “What Dreams May Come” (producer), Emmy Award nominee for Outstanding TV Movie “Homeless to Harvard” (executive producer), “The Celestine Prophecy” (writer, producer), and “Jesus,” translated into more than 2,245 languages and often cited as the most widely seen film in history by The New York Times.
___________________________
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You’ve Been Pooping All Wrong (And It’s Affecting Your Brain) with Dr. Trischa Pasricha | E213
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====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
On this episode of The Empowering Neurologist, I spend time with Dr. Trisha Pasricha, gastroenterologist and author of the provocative and important new book, You’ve Been Pooping All Wrong. Yes, the title makes you smile, but the science inside should make all of us pay attention.
Dr. Pasricha is part of a new generation of neurogastroenterologists exploring one of the most fascinating frontiers in medicine: the deep, bidirectional communication between the brain and the gut. Raised as the daughter of renowned gastroenterologist Dr. Pankaj “Jay” Pasricha and trained at Johns Hopkins, she brings both personal insight and rigorous science to a topic that too often lives in the shadows.
What makes this book so important is that it dismantles myths we’ve carried since childhood. For example, at one point in the book she describes how students taking an oral exam nearly doubled their intestinal permeability, simply from psychological stress. That single experiment powerfully illustrates how the brain can alter gut biology in real time.
And in another unforgettable section, she shares her early research showing that when subjects lied, their stomach’s electrical rhythm shifted into chaos, an arrhythmic pattern detectable on electrogastrogram. The stomach as a lie detector! That’s not just fascinating, it underscores how emotionally and neurologically integrated our digestive system truly is.
====
00:00 Intro
03:05 Why We Need to Talk About Pooping
07:17 The Stigma Around Bowel Symptoms
09:31 Why Early-Onset Colorectal Cancer Is Rising
12:11 Should Screening Start Earlier?
14:59 Colonoscopy vs. Stool and Blood Tests
18:34 Ad: Optoceutics
20:35 Why Colonoscopy Still Matters Most
31:00 What “Leaky Gut” Really Means
34:42 What Worsens Intestinal Permeability
36:10 Ad: 3X4 Genetics
38:09 Gut Permeability, Inflammation, and Brain Disease
48:45 Could Fecal Transplants Help Parkinson’s?
56:52 The Different Causes of Constipation
1:02:23 The Myth of One Bowel Movement a Day
1:05:42 Final Takeaways on Gut and Brain Health
=====
Trisha Pasricha, MD, MPH is an instructor of medicine at Harvard Medical School and the “Ask A Doctor” columnist for The Washington Post where she translates complex medical topics into must-read insights—with a touch of humor—for millions each week. A graduate of Harvard College, Dr. Pasricha earned her medical degree from Vanderbilt University School of Medicine and a Master of Public Health from the Harvard T.H. Chan School of Public Health. Her training includes an internal medicine residency at The Johns Hopkins Hospital and gastroenterology and motility fellowships at Massachusetts General Hospital. Currently, Dr. Pasricha serves as director of the Institute for Gut-Brain Research at Beth Israel Deaconess Medical Center, leading an NIH-funded research laboratory at the forefront of gut-brain science. Her work has been published in The New England Journal of Medicine, JAMA Network Open, and Nature Reviews.
___________________________
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Psychedelic Therapy and Trauma A New Frontier in Mental Health with Dr. Will Van Derveer | E212
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====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
00:00 Intro
01:06 The Promise of Psychedelic-Assisted Therapy
05:16 Why Psychedelics Faced Decades of Pushback
09:40 Psychedelic Therapy Requires Guidance
11:27 The Failure of the “Pill Fixes Everything” Model
15:31 Risks of Unregulated Psychedelic Retreats
24:20 Psychedelics Within Integrative Medicine
25:30 Ad: Optoceutics
27:31 What “Integration” Really Means
30:08 Why Psychiatry Still Resists Psychedelics
38:52 Why Lifestyle Still Matters After Therapy
41:45 Psychedelics and Addiction Treatment
50:50 Microdosing vs Full Therapeutic Doses
53:52 Ad: 3X4 Genetics
57:28 The Rise of Ketamine Clinics
1:00:54 Ibogaine: Risks, Duration, and Safety
1:04:50 Final Thoughts on Psychedelic Responsibility
====
Will Van Derveer, MD is a psychiatrist and author of Psychedelic Therapy: Restore Your Mental Health and Reclaim Your Life which will be published by ShambhalaPublications in the Spring of 2026.
He is co-founder of Integrative Psychiatry Institute, which has provided comprehensive training for 2500 mental health professionals in psychedelic-assisted psychotherapy several thousand professionals in other continuing education programs.
He is medical director of Integrative Psychiatry Center of Boulder, CO, providingintegrative psychiatry for a broad range of conditions and ketamine-assisted psychotherapy for treatment-resistant depression and PTSD.
In addition to his clinical practice and teaching, he has staffed clinical trials sponsoredby MAPS, investigating MDMA-assisted psychotherapy for chronic, treatment-resistant PTSD.
Dr. Van Derveer is co-host of the Higher Practice Podcast, where he explores what it takes to achieve optimal mental health.
___________________________
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Carbs For Exercise? Let’s Challenge This Idea with Dr. Andrew Koutnik | E211
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====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
00:00 Intro
04:49 Andrew Koutnik’s Story Obesity Type 1 Diabetes and Metabolism
09:44 Ketogenic Diets and Type 1 Diabetes
20:15 Sponsor Break - Optoceutics
21:28 Why This Goes Far Beyond Type 1 Diabetes
26:59 Why Low Carb Diabetes Care Was Abandoned
31:49 Ketosis vs Diabetic Ketoacidosis
35:10 Sponsor Break - Fresh Pressed Olive Oil
37:04 How to Measure Ketone Levels
39:13 Are Breath Ketone Tests Reliable
40:15 What Beta Hydroxybutyrate Actually Does
42:39 Exogenous Ketones and High Altitude Performance
45:49 Sponsor Break - 3X4 Genetics
48:33 MCT Oil and Ketone Production
52:52 The Carb Loading Myth in Sports Performance
1:00:06 Metabolic Flexibility and Keto Adaptation
1:03:17 Rethinking Hypoglycemia in Keto Adapted Athletes
1:07:19 How Carbohydrates Shut Down Fat Burning
1:09:58 Body Fat vs Glycogen as Fuel
1:14:34 What This Means for Endurance Athletes
1:16:17 Fat Metabolism as a Survival Mechanism
1:18:09 The New USDA Dietary Guidelines
1:20:46 Ultra Processed Food and Alzheimer’s Risk
1:22:40 Final Thoughts on Metabolic Flexibility
====
Dr. Andrew Koutnik is a research scientist focused on how nutrition, metabolism, and lifestyle can optimize human health, performance, and resilience. Living with type 1 diabetes for over 17 years, his work bridges personal experience with cutting-edge science across chronic disease and extreme environments.
He earned his PhD in Medical Sciences from the University of South Florida and has led research funded by organizations including NASA, the Department of Defense, and the NIH, contributing to over 100 scientific publications and presentations. His work spans exercise physiology, cardiometabolic health, and therapeutic nutrition.
At Florida State University, Dr. Koutnik studies dietary strategies for diabetes, obesity, and performance under metabolic stress, collaborating with leading institutions worldwide. His mission is to advance evidence-based approaches that empower individuals to improve metabolic health and performance.
___________________________
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Why Exercise May Be More Powerful Than Any Alzheimer’s Drug with Dr. Majid Fotuhi | E210
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====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
If you’ve followed my work for any length of time, you know that one of the central themes we return to on The Empowering Neurologist is this: your brain is far more adaptable, resilient, and improvable than conventional wisdom ever allowed us to believe.
This week, I’m thrilled to share a conversation with someone who has spent more than three decades proving exactly that. Dr. Majid Fotuhi, neurologist, neuroscientist, Harvard- and Johns Hopkins-trained physician, and now author of the new book The Invincible Brain, has dedicated his career to helping people reclaim their cognitive potential. His message aligns powerfully with the philosophy behind my upcoming book, Brain Defenders: that the trajectory of your brain is not predetermined, and that meaningful change is possible at any age.
In our interview, we explore the groundbreaking ideas that shaped The Invincible Brain. Dr. Fotuhi lays out why intelligence is not fixed, how memory can be strengthened through surprisingly simple practices, and why Alzheimer’s disease is not the single, linear condition we once imagined, but rather a complex “soup” of abnormalities with multiple entry points for intervention.
====
00:00 Intro
01:44 Choices influencing brain trajectory and resilience
04:25 Redefining intelligence beyond IQ
08:20 Synergy of memory and habit change
13:09 Challenging genetic determinism with epigenetics
18:00 Ad Break: Optoceutics
20:23 Alzheimer's as a metabolic and inflammatory soup
29:45 Ad Break: Fresh Pressed Olive Oil
38:04 Exercise and metabolism in brain health
43:45 Ad Break: 3x4 Genetics
49:38 Brain training and five pillars of brain health
54:55 Mindset as key to becoming a superager
====
Dr. Majid Fotuhi earned his PhD in Neuroscience from Johns Hopkins University in 1992 and his Medical Degree from Harvard Medical School in 1997. Currently, he serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins University, while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in teaching, clinical practice, and neuroscience research, Dr. Fotuhi has pioneered a multidisciplinary approach to enhancing brain vitality and cognitive performance at any age.
His groundbreaking “Brain Fitness Program” combines a comprehensive baseline “Brain Portfolio” assessment with 12 bi-weekly brain training sessions. This program targets lifestyle optimization and cognitive stimulation to improve memory, focus, and overall brain health. Dr. Fotuhi’s program has delivered measurable success for patients dealing with memory loss due to aging, concussions, and ADHD, as documented in several peer-reviewed journals.
___________________________
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Toxins Rewrite Your Genes (And Trigger Brain Disease) with Dr. Sarah Marzi | E209
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱
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for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
On this episode of The Empowering Neurologist, I’m joined by Dr. Sarah Marzi, a neuroscientist at King’s College London and a principal investigator at the UK Dementia Research Institute, whose work is transforming how we understand neurodegenerative disease risk.
Dr. Marzi’s research focuses on gene regulation in the human brain, particularly within microglia, the immune cells that orchestrate inflammation, synaptic pruning, and repair. Her studies show that genetic risk for diseases like Alzheimer’s is concentrated not in protein-coding genes, but in regulatory regions of the genome, epigenetic switches that control immune behavior in the brain.
This conversation with Dr. Marzi is not just about disease. It’s about agency. Understanding epigenetics helps explain how lifestyle, environment, and immune balance can influence brain destiny. It’s science that empowers prevention, resilience, and hope.
====
00:00 Intro
03:12 Epigenetics and Neurodegenerative Disease
04:49 Why Alzheimer’s Is Not a Single Gene Disorder
09:18 Protein Aggregation and Brain Cleanup Failure
10:55 Microglia vs Neurons in Alzheimer’s
19:04 Blood Brain Barrier and Inflammatory Signaling
20:39 ApoE Genetics Explained
23:37 Human Microglia Transplanted Into Mouse Brain
30:02 Vitamin D Receptor and Protective Gene Programs
38:18 Environmental Toxins and Parkinson’s
44:59 C1q Activation and Synapse Loss
49:33 Why Substantia Nigra Is Uniquely Vulnerable
51:39 Paraquat, Mitochondria and Converging Toxic Pathways
53:00 Epigenetic Memory of Toxic Exposure
54:09 Histones and Gene Regulation in Alzheimer’s
57:41 Oligodendrocytes as a Hidden Player
59:32 Why Single Target Drugs May Fail
01:02:10 Detecting Disease Through Blood and Machine Learning
01:04:41 Can Lifestyle Modify Epigenetics
====
Dr Sarah Marzi is a Senior Lecturer in Neuroscience at King’s College London and a Group Leader at the UK Dementia Research Institute. Her work focuses on how our genes and environment change cellular processes in the brain and can predispose us to neurodegenerative diseases such as Alzheimer’s, Parkinson’s and motor neuron disease.
An expert in epigenetics – the chemical switches that turn genes on and off – Dr Marzi uses cuttingedge genomic techniques on human brain tissue as well as cell and animal models. Her team combines these experiments with advanced statistics, bioinformatics and AI to map the earliest molecular changes that make brain cells vulnerable to disease, particularly in immune cells of the brain called microglia. This work aims to reveal how both genetic variants and environmental exposures, including pesticides, contribute to disease risk and to uncover new avenues for therapy.
___________________________
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Optimizing Fertility: What Actually Moves the Needle with Rachel Swanson | E208
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====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
On this episode of The Empowering Neurologist, I sit down with one of the most influential voices in modern nutrition and women’s health, Rachel Swanson, MS, RD, LDN. Her new book, Trying! A Science-Based Plan to Optimize Your Fertility, is poised to reshape how we think about fertility, moving it out of the narrow confines of hormone-focused conversations and into the broader landscape of systems biology, metabolism, environmental exposure, and cellular health.
Swanson’s work begins with a powerful premise: fertility is not a mystery, and it’s certainly not something women should feel powerless about. Instead, she argues, fertility is a measurable, improvable expression of whole-body health. And her book provides the first integrated blueprint to understand and support that health.
The conversation starts with the microbiome, which Swanson calls the “mission control headquarters” of fertility. Who knew that our gut bacteria were playing an important role in determining fertility? Drawing from her book, she describes how the gut, vaginal, and even oral microbiomes create the biochemical environment that influences hormone balance, inflammation, implantation, egg quality, and partner sperm health.
What makes this book, and this podcast episode, so compelling and empowering is Rachel’s rare combination of scientific precision and heartfelt dedication to women’s autonomy. She refuses to oversimplify fertility into quick fixes or fad-driven advice. Instead, she offers deeply practical strategies rooted in peer-reviewed research and years of high-level clinical practice.
====
00:00 Intro - Rachel Swanson04:38 Fertility as Whole-Body Health11:37 Metabolic Health Comes Too Late18:48 Ad - EVY21:17 The Microbiome as a Foundation of Health27:28 PCOS Is a Metabolic Disease, Not Just Hormonal35:15 Ad - Fresh Pressed Olive Oil37:07 Menstrual Products and the Vaginal Microbiome40:41 Inflammation and Metabolism Drive Fertility49:06 Ad - 3x4 Genetics50:26 Personalized Fertility Over One-Size-Fits-All56:16 Closing Thoughts
====
Rachel Swanson, MS, RD, LDN, is a registered dietitian and one of America’s most sought-after nutritionists, known for optimizing human performance through science-backed, personalized care. Her clients include celebrities, professional athletes, and Fortune 500 executives who trust her expertise in concierge medicine and private practice.
Rachel is a highly principled, intellectually rigorous, and passionately empowering expert, whose communication and sentiment are consistently driven by a profound conviction in her book's unique, holistic framework as the transformative solution to outdated and fragmented fertility advice, reflecting a deep commitment to women's health and autonomy.
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Unlocking Immortality? Exploring The Bold New World of Gene Therapy with Elizabeth Parrish | E207
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====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
Gene therapy is no longer a distant promise, it is rapidly becoming one of the most disruptive technologies in medicine. And few figures embody the urgency, controversy, and pioneering spirit of this field more than Elizabeth Parrish, CEO of BioViva and widely recognized as the world's first self- engineered "GMO human."
In this episode of The Empowering Neurologist, we dive deep into her bold vision to treat aging not as an inevitable decline, but as a disease that can be targeted, modified, and potentially reversed. Again, treating aging as a disease.
Her journey into genetics began with a simple but profound realization: the diseases that kill most of us, including Alzheimer's, cardiovascular disease, cancer, and overall frailty, are rooted in the biology of aging itself. Instead of waiting for late-stage decline, she argues that medicine should intervene upstream, correcting the genomic and cellular faults that accumulate over time. This perspective led her to take an extraordinary step: undergoing experimental gene therapy on herself in 2015, outside traditional regulatory frameworks.
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0:00 Intro
3:16 Treating Aging as a Disease
12:16 Launching a Radical Biotech Company
15:49 Why Telomere Length Mattered Most
18:51 Fear at the Edge of Experimentation
24:19 Ad: Optoceutics
26:08 Alpha-Klotho, The Longevity Gene
30:02 Why Alzheimer’s Still Has No Cure
32:21 Mitochondria at the Center of Brain Health
36:04 Ad: Fresh Pressed Olive Oil Club
39:04 Keeping PGC-1 Alpha Switched On
42:43 Tracking Telomere Length Year After Year
47:11 Ad: 3x4 Genetics
48:37 Myokines and Whole-Body Health
51:48 Glutathione Deficiency and Neurodegeneration
1:00:20 Closing Thoughts
====
Elizabeth (Liz) Parrish, MBA, is the Founder and CEO of BioViva Sciences USA Inc., a pioneering biotechnology company committed to extending healthy human lifespan through advanced gene therapies. Under her leadership, BioViva is developing next-generation combinatorial gene treatments powered by its proprietary CMV delivery platform, positioning the company at the forefront of therapeutic innovation.
An accomplished entrepreneur, author, and visionary thinker, Liz is one of the leading global voices behind the Best Choice Medicine (BCM) initiative—a regulatory framework aimed at accelerating access to genetic therapies worldwide. She is deeply involved in international scientific education and has delivered keynote talks at major conferences and institutions, including WIRED, TEDx, and numerous other high-profile venues.
https://www.instagram.com/lizlparrish/?hl=en
https://bioviva-science.com/
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The Power of GLP-1 Agonists: Personalized Medicine for Weight Management - with Ashley Koff, RD | E206
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Fresh Pressed Olive Oil - https://www.getfresh389.com For a complimentary bottle of one of the greatest olive oils I've ever discovered.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.
====
In this week’s episode of The Empowering Neurologist, I sit down with registered dietitian, personalized-nutrition pioneer, and longtime friend, Ashley Koff, RD, to explore what may be one of the most misunderstood areas in all of health: weight, metabolism, and the pursuit of sustainable well-being. As the founder of The Better Nutrition Program, Nutrition Course Director at UC Irvine’s Integrative Health Institute, and faculty member at IFNA, Ashley brings a depth of clinical and practical insight that few can match.
Her new book, Your Best Shot, tackles one of the most talked-about questions of our time: Is the GLP-1 shot your best shot—or not? But this is far from a book about medications. Instead, Ashley reframes the entire conversation around personalization, body-ecosystem thinking, and the liberating shift from perfectionism to her signature philosophy: better, not perfect.
In our conversation, Ashley explains why most people aren’t struggling with a lack of knowledge, but rather an overwhelming flood of it, something she calls “INFObesity.” She discusses the Switch Framework she developed to help individuals identify the key metabolic levers that matter most for them, and she shares compelling patient stories that demonstrate how real transformation happens when we align nutrition and lifestyle choices with our unique biology.
What emerges is a far more hopeful, empowering narrative about weight-health, one that acknowledges the complexity of modern life while giving us practical tools to navigate it.
If you’ve ever felt frustrated or confused by the conflicting messages around diet, GLP-1 medications, metabolism, or weight-loss strategies, this episode is an essential listen. It offers clarity, compassion, and a science-based path toward truly optimal health.
====
0:00 Intro
3:39 Misinformation in the world of weight loss
8:28 Calories in vs calories out
12:52 The importance of satiety related hormones
18:10 The experiment of GLP-1
24:49 Ad: Optoceutics
26:37 GLP-1 agonist drugs and the brain
37:16 Ad: Fresh Pressed Olive Oil Club
40:27 GLP-1 and mental health
50:02 Disconnect between food policy and obesity solutions
55:09 Conclusion
====
Ashley Koff, RD is the founder of The Better Nutrition Program (BNP), the Nutrition Course Director for UC Irvine’s Susan Samueli Integrative Health Institute's Integrative and Functional Medicine Fellowship, and a faculty member at the Integrative and Functional Nutrition Academy (IFNA), where she teaches “An Integrative and Functional Nutrition Approach to Obesity and Weight Management.”
She is also the author of the upcoming book, Your Best Shot (Harper One, January 6, 2026). A practitioner for over 25 years, Koff is leading a transformative movement in personalized nutrition, turning “better, not perfect” choices into practical, sustainable strategies that deliver real health outcomes.
Through patient stories and personal experience, she shows that optimal health is not just possible—it’s essential to living your fullest life. Koff has been recognized as one of CNN’s Top 100 Health Makers, featured in InStyle as “Hollywood’s Leading Dietitian,” and has been selected as Westin’s Global Nutrition Ambassador.
PTSD - The Powerfully Therapeutic Role of Hyperbaric Oxygen - with Dr. Mohammed Elamir | E205
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Today on The Empowering Neurologist podcast we are going to explore …
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Today on The Empowering Neurologist podcast we are going to explore PTSD, post traumatic stress disorder, a pervasive issue that can be profoundly debilitating. PTSD is experienced by about 6% of the US population at some point in their lifetime and at any given time approximately 5% of American adults are living with this disorder. Certainly, we see high risk and veterans with PTSD affecting about 11 to 20% of veterans who served in operations Iraqi Freedom and Enduring Freedom. Vietnam veterans experience a lifetime prevalence somewhere in the neighborhood of 30%. PTSD symptoms usually begin within three months of a traumatic event, but can actually surface many years later making the diagnosis and the relationship to a traumatic event challenging. In about 1/3 of cases, PTSD becomes chronic and can last for years or even decades.
We know that there are significant comorbidities associated with PTSD, including other mental health conditions like depression or anxiety disorder, substance use disorders, and even cognitive decline.
While cognitive behavioral therapy, CBT, and pharmaceutical intervention are the “go to” treatments for this problem, hyperbaric oxygen therapy presents us with a new and emerging therapy now receiving global recognition. We will review research on this podcast demonstrating the profound effectiveness of hyperbaric oxygen in treating PTSD, research that makes it clear that this is one of the most powerful interventions ever developed for treating this challenging disorder.
We will visit the Aviv Clinic in Central Florida, and spend time with Dr. Mohammad Elamir.
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0:00 Intro
4:55 Why Hyperbaric Works for PTSD Patients
8:44 Evaluating patients with PTSD
12:30 How the Protocol Was Chosen & Implemented
16:40 Potential Side Effects
18:00 Youngest People Treated with This
19:32 Combining Therapy Modalities for PTSD
20:14 Other Conditions that Can Be Helped By This
22:04 Amazing Results From These Studies
24:06 Using this with Our Military
26:00 Getting to the Root Problems
26:48 Treating Traumatic Brain Injuries
28:54 Why This Isn’t More Widely Being Offered
29:49 The Right Formula for This
32:55 Get Involved Today
====
Dr. Mohammed Elamir, or “Dr. Mo”to his patients, has been part of the Aviv Clinics team in The Villages since the clinic opened in 2020. As lead physician, he oversees the medical treatment for all clients in the Aviv Medical Program, collaborating with other members of Aviv’s clinical team to provide truly comprehensive care. As a presenter, his seminars often sell out, thanks in part to his ability to translate complex scientific concepts and data into easily-relatable language.
Prior to joining Aviv Clinics, Dr. Elamir practiced internal medicine at the MM Jersey Breathing Center while also owning a medical spa in New Jersey. He completed his internal medicine internship and residency at RWJ-Barnabas: Jersey City Medical Center where he was chief resident and a member of the ethics committee. Dr. Mo has a passion for helping others who are pursuing a career in medicine and continues to mentor pre-med and medical school students.
Dr. Elamir became involved with Aviv Clinics after his late father suffered a stroke, which sparked Dr. Mo’s interest in novel approaches to healing the brain. He is the father of two children, including a son with autism spectrum disorder (ASD). Dr. Elamir considers it his life’s mission to help progress his son’s development and better understand the causes and treatment of ASD.
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"Parkinson’s is a Man Made Disease, But Reversal is Possible" - with Dr. Ray Dorsey | EP 204
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱In this compelling episode of The Empowering Neurologist, I sit down …
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In this compelling episode of The Empowering Neurologist, I sit down with Dr. Ray Dorsey, a leading voice in the world of neurology and author of the important new book, The Parkinson’s Plan. Dr. Dorsey is a passionate advocate for changing how we view and address Parkinson’s disease. His message is bold—and urgently needed: Parkinson’s is not simply a disease of aging or bad luck. It is, in his words, “a man-made disease,” driven by preventable environmental exposures.
Dr. Dorsey’s work shines a much-needed spotlight on the role of toxins in triggering Parkinson’s. In his new book, he lays out a comprehensive framework for understanding and reversing the rising tide of Parkinson’s cases, which have more than doubled in recent decades. He argues that this surge is no coincidence—it correlates with increased exposure to industrial chemicals, pesticides, and air pollutants that interfere with the brain’s delicate dopamine system.
One of the most striking recent contributions from Dr. Dorsey’s research is a JAMA-published study linking Parkinson’s risk to proximity to golf courses—locations that are frequently treated with high volumes of chemical herbicides and pesticides. The study found a significantly increased risk of developing Parkinson’s disease in individuals living near these manicured greens. This adds to a growing body of evidence that toxic environmental exposures play a key role in the development of this neurodegenerative condition.
In our conversation, Dr. Dorsey discusses how Parkinson’s (once a rare disease) has become the world’s fastest-growing brain disorder, and why its rise can’t be explained by aging populations alone. He shares practical strategies for individuals and families looking to reduce their toxic burden and offers hope for a new paradigm. One in which we actively prevent, treat, and ultimately aim to eliminate Parkinson’s.
Try Lichen Air, an air filter carefully constructed to remove the maximum amount of PM 2.5 and smaller air pollutants possible:
https://lichenair.com/
====
0:00 Intro
2:40 Living Near to a Golf course Raises Parkinson’s Risk
4:58 How Pollutants Lead to Parkinson’s
7:12 Danger of Dry cleaning Chemicals
11:45 Parkinson’s is not just about Genetics
14:15 Why aren't these chemicals illegal?
17:07 Toxicity of Weed Killer
21:00 Chemicals that Damage Mitochondria
26:39 Why Diabetes Increases Parkinson’s Risk
29:38Air Pollution & WildFires
34:04 The Air Purifier We Recommend
34:49 Dealing with Indoor Air Pollution
37:02 Wash All Produce (Even Organic)
38:12 Best Diet for Parkinson’s Prevention
41:26 Safe Practices for Farming & Dry Cleaning
45:23 Benefits of Exercise
48:01 Public Figures Who Faced Parkinson's Disease
49:58 Why Men are More Likely to Get It
51:21 An Empowering Message for Us
54:27 Conclusion
====
Dr. Ray Dorsey is the director of the Center for the Brain & the Environment at the Atria Health and Research Institute. The center’s mission is to identify the root causes of brain diseases from autism to Alzheimer’s so that we can prevent them. With his colleagues, he wrote Ending Parkinson’s Disease and the forthcoming The Parkinson’s Plan, which details a new path to preventing and treating this terrible disease.
Ray previously directed the Center for Health + Technology at the University of Rochester, chaired the international Huntington Study Group, led the movement disorders division at Johns Hopkins, and consulted for McKinsey & Company.
___________________________
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How a Flickering Light Holds Promise in Alzheimer’s Treatment and Prevention - with Dr. Mai Nguyen | EP 203
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱I’m thrilled to announce this exciting podcast episode featuring an …
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I’m thrilled to announce this exciting podcast episode featuring an inspiring and thought-provoking conversation with Dr. Mai Nguyen, CEO and Co-founder of OptoCeutics. Dr. Nguyen is a pioneering force in the field of neurotechnology, and in this episode, we unpack her revolutionary work using non-invasive light stimulation to enhance brain function and potentially prevent neurodegenerative disease.
At the center of our conversation is the EVY, a 40 Hertz light stimulation device developed by OptoCeutics under Dr. Nguyen’s leadership. This device is designed to target and enhance gamma oscillations in the brain—a specific frequency range of neural activity (around 40 Hz) that is critically involved in memory, attention, and perception. In recent years, scientific studies have linked disruptions in gamma oscillations with the progression of Alzheimer’s disease. By restoring these rhythms, the EVY device aims to provide a non-pharmacological, non-invasive way to support brain health.
During our podcast, Dr. Nguyen explains how EVY works: the device emits flickering light at a precise 40 Hz frequency, which is thought to entrain brain activity to resonate at that same frequency. This gentle stimulation may help reduce amyloid-beta accumulation, improve neural connectivity, and promote immune system engagement in the brain—mechanisms that could slow or even reverse aspects of cognitive decline.
What sets Dr. Nguyen apart is not just her scientific brilliance, but her deep commitment to translating research into real-world solutions. She leads OptoCeutics with a clear mission: to bring accessible, evidence-based neurotechnology into homes and clinics, empowering people to take charge of their cognitive well-being. Her approach is both deeply human and rigorously scientific, blending innovation with empathy.
As you’ll hear in the interview, Dr. Nguyen's work exemplifies the exciting convergence of biology, technology, and therapeutic application.
This episode is essential listening for anyone interested in the future of brain health, the science of neuroplasticity, and the promise of light-based therapies. Whether you're a clinician, researcher, caregiver, or simply curious about how to support your brain as you age, Dr. Nguyen’s insights will leave you informed, inspired, and hopeful.
====
0:00 Intro
2:46 How Dr. Mai Started Studying it
5:16 How Light Enhances Gamma Oscillation
7:22 Promise of These Studies
8:51 How the EVY Device Works
11:20 Early Clinical Results + Potential Side Effects
13:53 Application of this technology
16:36 Why Mainstream is Late to Adopt This
22:04 Impact of Auditory Stimulation
23:38 The Future of This Research
25:25 Get Involved Today
====
Dr. Nguyen is a trailblazer in neurotechnology, pioneering advancements in non-invasive brain stimulation technology for the prevention and treatment of Alzheimer’s and dementia. As CEO and Co-founder of OptoCeutics, Dr. Nguyen leads the charge in bridging the gap between neuroscience and therapeutic innovation, offering new hope to millions affected by cognitive decline.
Under Dr. Nguyen’s leadership, Optoceutics has become a frontrunner in brain stimulation technology and a recognized authority in non-invasive neuromodulation. Her unique approach combines rigorous scientific methodology with groundbreaking therapeutic solutions.
This vision is shaped by her academic excellence, including a PhD in Integrative Biology at the University of California, Berkeley with a specialization in Neuroendocrinology, and her extensive training in management, technology innovation, and entrepreneurship.
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Unseen Toxins: What’s Harming Us in Air, Water, and Everyday Products - with Dr. Aly Cohen | EP202
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱In our modern world, we are surrounded by a staggering number of …
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In our modern world, we are surrounded by a staggering number of invisible threats. These chemicals and pollutants can silently undermine our immune systems, increase our risk for chronic illness, and sabotage our health at the cellular level. That’s why I’m especially excited to welcome Dr. Aly Cohen to this episode of The Empowering Neurologist. This conversation is not only eye-opening, it’s empowering and filled with practical, actionable steps that each of us can take starting today.
In our conversation Dr. Cohen takes us through the science and the soul of her mission. We explore what inspired her to write Detoxify, a journey that began at the intersection of clinical frustration and personal awakening. Over the years, she began noticing that many of her patients with autoimmune diseases, chronic fatigue, hormonal imbalances, and neurological complaints shared a common thread: consistent exposure to environmental toxins. This wasn't just about vague “bad stuff.”Dr. Cohen has zeroed in on a specific category of chemicals she terms “Immune-disrupting chemicals (IDCs).” These are substances that directly interfere with the immune system's ability to regulate and repair.
Dr. Cohen doesn’t stop at theory… she gets specific - with personal care products to avoid, water purification tips every household should know, and simple DIY recipes for safer cleaning and skincare. Her “Detoxify Food Pyramid” reimagines what a clean, immune-supportive diet looks like in a world of processed foods and contaminated agriculture.
We also touch on how environmental toxins can act as potent triggers for autoimmune conditions like lupus and rheumatoid arthritis - diseases Dr. Cohen treats in her clinical practice almost every day.
If you’re feeling overwhelmed by the sheer scale of modern toxicity, this episode offers a clear and hopeful path forward. Dr. Cohen emphasizes that detoxifying your life doesn’t mean doing everything at once. It’s about starting small. Things like switching to a glass water bottle, choosing fragrance-free detergents, and reading ingredient labels can lead to profound health benefits.
====
TIMESTAMPS
00:00 Introduction
02:15 Welcoming Dr. Amy Cohen & Her Inspiration for Her Book
05:45 Water & How Contamination Dysregulates Our Immune System
10:44 Recommendations for Filtration and Purification
13:13 Quality of Bottled Water Is Sub Par & Likely Tap Water
18:03 Endocrine Disrupting Chemical Contaminants Found In Our Water
21:47 Sparking Change with The Four A's: Assess, Avoid Or Swap, Add, Allow
27:39 How Did These Chemicals Enter Our Food & Water Supply?
34:10 How Do Genetics Determine Your Ability To Detoxify?
37:50 Air Quality, Pollution, and The Impact On Our Bodies
43:49 Navigating How To Improve The Air You Breath
47:41 Detoxifying The Body From Air Pollution
51:18 Hidden Threats In Your Personal Care Products & How To Avoid Them
1:04:19 Conclusion
====
Dr. Aly Cohen is a board-certified physician practicing in rheumatology and integrative medicine, as well as an environmental health expert in Princeton, New Jersey. Her new book, DETOXIFY: The Everyday Toxins Harming Your Immune System and How to Defend Against Them, available now for preorder, connects the dots between everyday chemicals and the epidemic rise in immune disorders and autoimmune disease...and what we CAN all do about it! You can follow her health and wellness tips and recommendations on Facebook at The Smart Human, Twitter, and Instagram: @thesmarthuman, and TikTok.
___________________________
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Science of Ketosis: Regain Your Metabolic Health & Age Backwards - with Dr. Dominic D’Agostino | EP 201
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱The ketogenic diet has become a household term, often associated with …
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The ketogenic diet has become a household term, often associated with rapid weight loss and an effective means of shedding stubborn fat. However, as my guest on this episode of The Empowering Neurologist, Dr. Dominic D’Agostino, will explain, there is so much more to the ketogenic lifestyle than simply dropping a few pounds. We’re diving deep into the science of metabolism, insulin sensitivity, and how our lifestyle choices impact long-term health, particularly brain health.
While many people adopt a ketogenic diet for its well-documented benefits in weight management, its effects on metabolism reach far beyond simple fat burning. Nutritional ketosis helps the body transition from relying primarily on carbohydrates for energy to efficiently burning fat and producing ketones, an alternative fuel source for the brain and muscles.
As Dr. D’Agostino will discuss, one of the most crucial aspects of metabolic health is insulin sensitivity. When insulin function is compromised, the body struggles to regulate blood sugar levels, leading to increased risks of obesity, type 2 diabetes, and even cognitive decline. By keeping insulin sensitivity in check through dietary choices, fasting, and exercise, we can enhance our metabolic health and lower the risk of chronic disease.
The brain is an energy-intensive organ, and its function is directly influenced by our metabolic state. Research has shown that ketones provide a more efficient and neuroprotective fuel source for the brain compared to glucose. This is particularly relevant for conditions such as Alzheimer’s disease, epilepsy, and even traumatic brain injury.
By making intentional choices about what we eat, how we move, and how we recover, we can take control of our metabolic health and improve our longevity.
====
00:00 Introduction
02:21 How Dr. D’Agostino Went From Seizure Research To Nutrition Science
03:31 From Drug Failures To The Medical Power Of Ketosis
05:15 What Ketones Really Are And Why They’re A Metabolic Game-Changer
09:37 Why Ketogenic Therapy Is Now In 400+ Clinical Trials Worldwide
12:21 GLP-1 Drugs, Weight Loss, And Keto: What They Do To Your Metabolism
15:10 Inside A Ketogenic Body: Fat Burning, Fuel Switching, And More
17:25 How Lowering Insulin Turns On Fat Burning And Ketone Production
20:03 Why Ketones Keep The Brain Stable And Cravings Under Control
23:54 The Right Amount Of Protein For Muscle, Aging, And Staying In Ketosis
27:03 Do You Actually Need Fiber? The Carnivore Diet And Gut Health
30:00 How Ketosis Reduces Inflammation And Repairs The Gut Barrier
34:31 Genomics of Ketonics: Beta-Hydroxybutyrate’s Epigenetic Power
45:38 Allulose: The Sweetener That Lowers Blood Sugar And Boosts GLP-1
52:03 Why MCT Oil Might Be The Most Underrated Keto Hack Available
54:30 Conclusion
====
Dominic D’Agostino, Ph.D., is a tenured Associate Professor at the University of South Florida (USF) Morsani College of Medicine in the Department of Molecular Pharmacology and Physiology. He teaches medical neuroscience, medical physiology, nutrition and neuropharmacology. He is also a Senior Visiting Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. His primary research focuses on developing and testing nutritional and metabolic-based therapies for a variety of disease states and advancing the use of metabolic-based therapies into human clinical applications.
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