This Week in Cardiology
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- 6. Nov. 2026
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This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.
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Nov 06, 2026 This Week in Cardiology
The moderate aortic stenosis TAVR trial, blinded withdrawal in the DECISION digoxin trial, CTO-PCI vs no CTO-PCI 10-year results, and the P4 trial are the topics John Mandrola, MD, discusses in this week’s …
Shownotes
The moderate aortic stenosis TAVR trial, blinded withdrawal in the DECISION digoxin trial, CTO-PCI vs no CTO-PCI 10-year results, and the P4 trial are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I PROGRESS Trial
- PROGRESS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607326
- PROGRESS Trial Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2613400
- Genereux Classification https://academic.oup.com/eurheartj/article/38/45/3351/4002776
II Withdrawing Digoxin in the DECISION trial
- DECISION Trial Substudy https://academic.oup.com/eurheartj/article/47/38/5545/8674856
- DECISION Trial - Main Trial https://www.nature.com/articles/s41591-026-04406-6
- Efficacy and Safety of Digitalis Glycosides in HF: Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2848972
- RADIANCE trial https://www.nejm.org/doi/full/10.1056/NEJM199307013290101
- PROVED trial https://www.jacc.org/doi/10.1016/0735-1097(93)90403-N
III DECISION CTO Trial at 10 Years
- DECISION-CTO Trial 10-Year Outcomes 10.1016/j.jacc.2026.10.068
- DECISION-CTO Main paper https://doi.org/10.1161/CIRCULATIONAHA.118.031313
- EURO-CTO trial https://eurointervention.pcronline.com/article/three-year-outcomes-of-eurocto-a-randomized-multicentre-trial-comparing-revascularization-and-optimal-medical-therapy-for-chronic-total-coronary-occlusions
- COMET-CTO trial https://pmc.ncbi.nlm.nih.gov/articles/PMC9868942/
- EXPLORE Trial https://www.ahajournals.org/doi/10.1161/JAHA.123.033556
- ORBITA-CTO trial https://www.jacc.org/doi/10.1016/j.jacc.2026.03.027
IV The P4 Trial
Coronary CT Angiography Cuts Procedural Time Relative to IVUS-Guided PCI https://www.medscape.com/viewarticle/coronary-ct-angiography-cuts-procedural-time-relative-ivus-2026a1001684
- P4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2610771
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
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Oct 30 2026 This Week in Cardiology
The ASPIRED syncope RCT, two studies in coronary artery calcium scoring, and the LEAP-Block trial of CSP vs RV pacing are the topics John Mandrola, MD, discusses in this week’s podcast.This podcast is intended …
Shownotes
The ASPIRED syncope RCT, two studies in coronary artery calcium scoring, and the LEAP-Block trial of CSP vs RV pacing are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Syncope
- ASPIRED Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605812
- REMOSYNCED Trial https://clinicaltrials.gov/study/NCT05066347
II TWO CAC Studies
- Atherosclerosis in Young Adults and Risk of Mortality Over 30 Years https://jamanetwork.com/journals/jamacardiology/fullarticle/2855732
- Predictive Utility of CAC Score Added to PREVENT Score https://jamanetwork.com/journals/jama/fullarticle/2853347
III Conduction System Pacing vs Standard RV Pacing for AV block
- LEAP-Block Trial https://jamanetwork.com/journals/jama/fullarticle/2855975
- Meta-analysis: CSP vs RV Pacing in Preserved or Mildly Reduced EF https://doi.org/10.1016/j.cjca.2026.04.009
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Oct 23, 2026 This Week in Cardiology Podcast
Listener feedback on the nonobstructive HCM trials, AI-enhanced visits, timing of non-culprit PCI in STEMI, new tricuspid valve intervention, and EP at a crossroads are the topics John Mandrola, MD, discusses …
Shownotes
Listener feedback on the nonobstructive HCM trials, AI-enhanced visits, timing of non-culprit PCI in STEMI, new tricuspid valve intervention, and EP at a crossroads are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Koelemen meta-analysis https://www.medrxiv.org/content/10.64898/2026.09.08.26362195v1.full.pdf
Improving SCD Risk Stratification in HCM https://pmc.ncbi.nlm.nih.gov/articles/PMC11026183/
II More on Nonobstructive HCM
Communication on Post-Hoc Analysis of ODYSSEY (mavacamten)
Mavacamten in Nonobstructive HCM 10.1016/j.jacc.2025.12.092
III Complete vs Staged PCI in STEMI With Multivessel Disease
Immediate vs Staged CR in Multivessel Disease and STEMI: Meta-Analysis https://doi.org/10.1016/j.jcin.2026.07.033
Timing of Nonculprit PCI for STEMI and Multivessel Disease: Editorial https://doi.org/10.1016/j.jcin.2026.08.009
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
FLOWER MI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2104650
FRAME AMI Trial https://doi.org/10.1093/eurheartj/ehac763
iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918
COCUA Trial https://doi.org/10.1016/j.ahj.2023.01.020
MULTISTARS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307823
OPTION STEMI Trial 10.1016/S0140-6736(25)01529-6 External Link
CULPRIT SHOCK Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1710261
BioVasc Trial Substudy https://eurointervention.pcronline.com/article/immediate-versus-staged-complete-revascularisation-in-patients-presenting-with-stemi-and-multivessel-disease
Main BioVasc Trial 10.1016/S0140-6736(23)00351-3 External Link
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
IV A Call to Action for Electrophysiologists
Twenty Years at the Crossroads 10.1016/j.jacep.2026.09.023
EP at a Crossroads - Josephson 2007 https://doi.org/10.1016/j.hrthm.2006.12.045
EP at a Crossroads: A Revisit - Josephson 2016 https://doi.org/10.1016/j.hrthm.2016.07.024
V FDA Approves Another Tricuspid Valve Repair System
Press release https://www.edwards.com/newsroom/news/2026-10-21-fda-approval-of-edwards-lifesciences--pascal-preci
TRIC I HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
CLASP II TR Trial https://pubmed.ncbi.nlm.nih.gov/42855029/
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
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Oct 16, 2026 This Week in Cardiology Podcast
Some promising studies in amyloidosis, aficamten in nonobstructive HCM, costs of the microaxial flow pump in cardiogenic shock, and more on the VESALIUS trial of evolocumab are the topics John Mandrola, MD …
Shownotes
Some promising studies in amyloidosis, aficamten in nonobstructive HCM, costs of the microaxial flow pump in cardiogenic shock, and more on the VESALIUS trial of evolocumab are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Light Chain Amyloidosis – A Potentially Helpful Drug
Anselamimab Does Not Reduce Light-Chain Amyloidosis Deaths
https://www.medscape.com/viewarticle/anselamimab-does-not-reduce-light-chain-amyloidosis-deaths-2026a1000z79
II Aficamten in Nonobstructive HCM: The ACACIA trial
III Microaxial Flow Pump Cost Analysis of Danger Shock
IV More on Evolocumab at ESC: Vesalius Trial Substudies
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
https://www.medscape.com/viewarticle/1003092
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Oct 09 2026 This Week in Cardiology
Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast.This podcast is intended for …
Shownotes
Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
POET II Response-Tailored or Standard-Duration ABX for Infectious Endocarditis
- POET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312
- POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887
II PVI-SHAM-AF trial Back in the News
- GAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337
- PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link
- Why Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External Link
- The Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External Link
III ICDs in HCM
- I CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597
- ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687
IV Agenda Laundering
- How Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
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Oct 02 2026 This Week in Cardiology
Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in …
Shownotes
Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
- DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7
- Identifying LV Posterior Wall Delay in RBBB Using Lead V8 https://doi.org/10.1016/j.jacep.2026.03.009
- Using Lead V8 as a Tool to Improve Patient Selection in CRT https://doi.org/10.1093/europace/euaf194
II POET II Response-Tailored or Standard-Duration Antibiotics for Endocarditis
- POET I https://www.nejm.org/doi/10.1056/NEJMoa1808312
- POET II https://www.nejm.org/doi/full/10.1056/NEJMoa2607887
III Obesity and AF – A Neat Study from the Team in Prague
- LA Remodeling and Functional Maladaptations in Obesity https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014509
IV Reducing CAC: The DANCODE Trial
- DANCODE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.082363
V Two Big RCTs of New GLP-1 Drugs
- TRIUMPH-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604169
- SYNCHRONIZE-2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607219
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
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Sep 25 2026 This Week in Cardiology
Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses …
Shownotes
Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback LBBP ICD Lead
- LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/
TRIC-I-HF trial
- TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
- Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030
II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial
- PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012
III Targeting CS leads in CRT devices – DANISH-CRT Trial
- DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7
IV Exercise for AF, Especially When There Is LA Disease
- Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999
V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX
- REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017
- ROTAS Trial https://heart.bmj.com/content/110/20/1223
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
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Sep 18 2026 This Week in Cardiology
Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is …
Shownotes
Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Correction on PROFID Trial
II Listener Feedback
III Fifth Universal Definition of MI
- Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101
- Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967
IV New ESC HF Guidelines
- ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100
- Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20
- Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/
V AIR STEMI Trial
- AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373
- CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051
- PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520
- COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
- FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
VI GLP-1 News – A SELECT Trial Secondary Analysis
- Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
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Sep 11 2026 This Week in Cardiology
A second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola, MD This podcast is intended for …
Shownotes
A second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola, MD
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Lp(a) Disappointment
- HORIZON https://clinicaltrials.gov/study/NCT04023552
- Press Release https://www.novartis.com/news/media-releases/novartis-announces-lpahorizon-phase-iii-topline-results-pelacarsen-patients-elevated-lpa-and-established-cardiovascular-disease-cvd
- Rationale paper https://doi.org/10.1016/j.ahj.2025.03.019
II FDA Clears AI-ECG for Acute MI Detection
- Accuracy of cath lab activation decisions for STEMI-equivalent and mimic ECGs: Physicians vs. AI (Queen of Hearts by PMcardio) 10.1016/j.ajem.2025.07.061
- AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry https://www.jacc.org/doi/10.1016/j.jcin.2025.10.018
- Queen of Hearts™ AI ECG App https://www.powerfulmedical.com/pmcardio-stemi/
III TARGET CTCA Trial
- Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain https://www.nejm.org/doi/10.1056/NEJMoa2608903
IV CorCal trial
- Press release https://www.escardio.org/news/press/press-releases/new-data-presented-on-the-use-of-coronary-artery-calcium-for-cardiovascular-risk-assessment/
- CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics https://doi.org/10.1016/j.ahj.2026.107473
V AMUNDSEN Trial
- LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial InfarctionThe AMUNDSEN Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2853274
VI TRIC-I-HF trial
- Tricuspid Repair Cuts Death, HF Hospitalization in Severe TR https://www.medscape.com/viewarticle/tricuspid-repair-cuts-death-hf-hospitalization-severe-tr-2026a1000wvk
- Tricuspid-Valve Intervention in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
You May Also Like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
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Sep 04 2026 This Week in Cardiology
ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this …
Shownotes
ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I SINGLE-AF Trial
To Anticoagulate or Not in Intermediate-Risk AF: The SINGLE-AF Trial https://www.medscape.com/viewarticle/anticoagulate-or-not-intermediate-risk-af-single-af-trial-2026a1000uko
- SINGLE-AF https://www.nejm.org/doi/10.1056/NEJMoa2607978
II Scar as an ICD risk stratifier
Is Scar on CMR an Indication for ICD? CMR Guide Leaves Doubts
https://www.medscape.com/viewarticle/scar-cmr-indication-icd-cmr-guide-leaves-doubts-2026a1000ukq
- CMTR GUIDE Trial https://jamanetwork.com/journals/jama/fullarticle/2853395
- MADIT II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa013474
III Single vs Dual Therapy in ATTR-CM
- HELIOS-B Trial Sub-analysis https://www.sciencedirect.com/science/article/pii/S0735109726072086
- HELIOS-B Sub-analysis Editorial https://www.sciencedirect.com/science/article/pii/S0735109726073766#bib8
- HELIOS-B main trial https://www.nejm.org/doi/10.1056/NEJMoa2409134
- CARDIO-TTRansform Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608510
IV A Stunning Result of another Sham-controlled AF ablation trial
Does AF Ablation Work? That's in Question After PVI-SHAM-AF https://www.medscape.com/viewarticle/does-af-ablation-work-s-question-after-sham-pvi-af-2026a1000uli
- PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link
- SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283
- PFA-Sham Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484
V Should Older Adults Take Statins: The STAREE trial.
STAREE Strengthens Case for Over-the-Counter Statins https://www.medscape.com/viewarticle/staree-strengthens-case-over-counter-statins-2026a1000vrw
- STAREE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607314
VII Declining ICD Benefit After MI
- Mortality Reduction with ICD for Prevention of SCD Post-MI https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag706/8768943
- CONTEMP-ICD Trial https://clinicaltrials.gov/study/NCT06543446
- PROFID-EHRA Trial https://profid-project.eu/profid-ehra-trial/
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
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Aug 28 2026 This Week in Cardiology
Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is …
Shownotes
Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback on Mechanical Compression Devices for OHCA
- Mechanical CPR Device Use and Cardiac Arrest Survival
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
- PARAMEDIC trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
- CIRC trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
- LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037
- Cochrane Review – Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
II PFA and Stroke
- Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092
- AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/
- EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008
III A New ICD Lead
- LEADR LBBAP Trial https://doi.org/10.1016/j.hrthm.2026.08.030
IV ESC Preview
- Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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August 21 2026 This Week in Cardiology
Mechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. This …
Shownotes
Mechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Mechanical Compression Devices for OHCA
· Mechanical CPR Device Use Cardiac Arrest Survival
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
· PARAMEDIC Trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
· CIRC Trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
· LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037
· Cochrane Review of Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
II ACC AF Performance Measures
· 2026 AHA/ACC Clinical Performance for Patients With AF https://www.jacc.org/doi/10.1016/j.jacc.2026.05.032#sec-3
III Two Critical Appraisals of the recent LAAC trials
· Reappraising CHAMPION-AF 10.1016/j.hrthm.2026.07.048 External Link
· CHAMPION and CLOSURE: Reconciling Contrast Results https://doi.org/10.1093/eurheartj/ehag608
ESC Early Preview
· CMR Guide trial https://pmc.ncbi.nlm.nih.gov/articles/PMC6931571/
· SINGLE AF Trial 10.1016/j.hroo.2025.12.008 External Link
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Aug 14 2026 This Week in Cardiology
Listener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is …
Shownotes
Listener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I ZEUS Fails
Rethinking Inflammation and ASCVD: Four Lessons From the ZEUS Trial
https://www.medscape.com/viewarticle/rethinking-inflammation-and-ascvd-four-lessons-zeus-trial-2026a1000rlm
- ZEUS Trial https://doi.org/10.1001/jamacardio.2025.4491
II Statins and the Elderly
- SAGA/SITE trial 10.1016/j.lanhl.2026.100884 External Link
III GLP-1 and CV Risk
- SURMOUNT-1 Trial https://www.nejm.org/doi/10.1056/NEJMoa2206038
- SURMOUNT-1 Post Hoc Analysis https://www.jacc.org/doi/10.1016/j.jacc.2026.04.044
- Reframing GLP-1s as Cardiometabolic Health Drugs: Editorial https://www.jacc.org/doi/10.1016/j.jacc.2026.06.039
IV Radiation Exposure to the Uterus in the EP Lab
- Occupational Radiation Safety in EP During Pregnancy https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.080556
- Survey: Working in Cath Lab During Pregnancy https://www.surveymonkey.com/share/d5c1edf7-6d99-49d4-a9fa-e9168f63ab55
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Jul 31 2026 This Week in Cardiology
Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD …
Shownotes
Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
- DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588
II Another Failure of Posterior Wall Isolation
- CORNERSTONE-AF Trial https://doi.org/10.1093/eurheartj/ehag486
- CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186
- PVIOTAL IDE Trial 10.1016/j.hrthm.2025.08.018 External Link
III First Line AF ablation – One new study and a discovery about a second one
- Catheter Ablation vs AAD for First-line Treatment of AF 10.1016/j.hrthm.2025.07.061 External Link
- EAST-AFNET 4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2019422
- Cardiology Trials Substack https://cardiologytrials.substack.com/p/summary-and-discussion-of-east-afnet
IV Left Atrial Appendage Closure Meta-analysis
- Long-Term Efficacy and Safety of LAAC vs OAC -- Meta-analysis https://academic.oup.com/europace/article/28/7/euag159/8739567
V Prevention of AKI after Cardiac Surgery: MERCURI-2
- MERCURI-2 Study https://jamanetwork.com/journals/jama/fullarticle/2852324
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July 24 2026 This Week in Cardiology
The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John …
Shownotes
The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Enlicitide Approved
First Oral PCSK9 Inhibitor Welcomed for Potential Primary Care Impact https://www.medscape.com/viewarticle/first-oral-pcsk9-inhibitor-welcomed-potential-primary-care-2026a1000own
- Dr Gregory Katz Substack https://gregorykatz.substack.com/p/are-we-sure-mercks-new-cholesterol
- CORALreef Lipids Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
- CORALreef HeFH Trial https://jamanetwork.com/journals/jama/fullarticle/2841258
- CORALreef Outcomes Trial https://clinicaltrials.gov/study/NCT06008756
II MRI Scans in Non-conditional CIEDs
Specialized Nurse Practitioners Safely Manage MRI in Patients With Cardiac Implantable Devices https://www.medscape.com/viewarticle/specialized-nurse-practitioners-safely-manage-mri-patients-2026a1000ozt
- Nurse Practitioner-Led CIED Monitoring During MRI 10.1016/j.hroo.2026.04.031 External Link
- MRI in Nonconditional Pacemakers and ICDs https://academic.oup.com/europace/article/22/2/288/5717383
- Heart Rhythm Society Consensus Document 10.1016/j.hrthm.2017.04.025 External Link
III PFA-SHAM trial
- PFA-SHAM Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484
- SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283
IV Orthopedic Injuries in Cardiology
What Will It Take to Make Fluoroscopy Labs Safer?
https://www.medscape.com/viewarticle/what-will-it-take-make-fluoroscopy-labs-safer-2026a1000ox6
- Expert Consensus Statement on Enhanced Radiation Protection https://www.jacc.org/doi/10.1016/j.jcin.2026.06.011
- 'Shed the Lead' and the Injuries. Should Cath Labs Go Lead-Free? https://www.medscape.com/viewarticle/shed-lead-and-injuries-should-cath-labs-go-lead-free-2024a1000hnb
- Health Hazards of Working in the Interventional Laboratory https://doi.org/10.1016/j.jacc.2014.11.056
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Jul 17 2026 This Week in Cardiology Podcast
DAPT back in the news, a practice-changing trial in VTE therapy, new knowledge in sudden cardiac death, heart failure definitions updated, and a dumb decision by NICE in the UK are the topics discussed by John …
Shownotes
DAPT back in the news, a practice-changing trial in VTE therapy, new knowledge in sudden cardiac death, heart failure definitions updated, and a dumb decision by NICE in the UK are the topics discussed by John Mandrola, MD, in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Antiplatelet Therapy After Stenting
- DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588
- HOST-EXAM Trial at 2 years https://pubmed.ncbi.nlm.nih.gov/34010616/
- HOST-EXAM Trial at 10 years 10.1016/S0140-6736(26)00422-8 External Link
- Nick Kurzen on X https://x.com/ncurzen/status/2077676739463922151
II Aspirin Proves Its Mettle After Hip and Knee Replacement
- EPCAT III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2603649
- CRISTAL Trial https://jamanetwork.com/journals/jama/fullarticle/2795528
III New (and old) Knowledge in Sudden Cardiac Death
- Sudden Cardiac Death and its Relation to Cardiac Disease at Autopsy https://doi.org/10.1016/j.jacc.2026.01.029
- Sudden Cardiac Death Due to MI With Obstructive and Nonobstructive Coronary Arteries https://doi.org/10.1016/j.jacc.2026.01.030
- Frequency of Sudden Cardiac Death and Profiles of Risk https://www.ajconline.org/article/S0002-9149(97)00477-3/fulltext
IV Heart Failure Diagnosis
- AHA/ACC/ESC/WHF Expert Consensus Document http://jacc.org/doi/10.1016/j.jacc.2026.05.036
V NICE Makes a Dumb Decision
- NICE Recommends New Nonsteroidal MRA for Heart Failure
https://www.medscape.com/viewarticle/nice-recommends-new-nonsteroidal-mra-heart-failure-2026a1000nzv
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Jul 10 2026 This Week in Cardiology
Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets after cardiac arrest are the topics John …
Shownotes
Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets after cardiac arrest are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Oct 10, 2025 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1002990
- ICE vs TEE in Atrial Fibrillation Ablation https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370
II FFR Without the Wire – Angiography-Derived FFR to Guide PCI
- ALL-RISE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600949
- FAST III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601841
- FAVOR III Trial 10.1016/S0140-6736(24)02175-5 External Link
- FAME 2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1205361
- Venk Murthy on X https://x.com/venkmurthy/status/2074849421452329456?s=20
III More Bad News for Ticagrelor
Jul 11, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1002704
- Prasugel, Ticagrelor, or Clopidogrel After PCI https://jamanetwork.com/journals/jamacardiology/fullarticle/2849614
IV The Polypill in Heart Failure
- POLY-HF trial https://www.nature.com/articles/s41591-026-04504-5
V Oxygen Targets After Cardiac Arrest
- LOGICAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513814
- ICU-ROX Trial https://link.springer.com/article/10.1007/s00134-020-06196-y
- Secondary Analysis of the PILOT Trial https://journal.chestnet.org/article/S0012-3692(25)00553-7/fulltext
- Oxygen Targets in Comatose Survivors of Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa2208686
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Jun 26 2026 This Week in Cardiology
Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the topics John Mandrola, MD, discusses in …
Shownotes
Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
- PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137
II Statins and Frailty
Statin Initiation Tied to Lower Frailty Risk in Older Adults https://www.medscape.com/viewarticle/statin-initiation-tied-lower-frailty-risk-older-adults-2026a1000lec
- Statins and Survival Free of Incident Frailty https://doi.org/10.1093/eurheartj/ehag451
III LA Posterior Wall Isolation Fails Again
- CORNERSTONE Trial https://doi.org/10.1093/eurheartj/ehag486
- CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186
IV Does the Display of Test Results Improve Clinical Decisions?
- Interval Likelihood Ratios for Clinical Decsion-Making https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500249
- Making Sense of Health Statistics https://journals.sagepub.com/doi/full/10.1111/j.1539-6053.2008.00033.x
V AI and the ECG and Saving Doctors
- Case Report — AI-Enhanced Diagnostics https://www.nature.com/articles/s41591-026-04454-y
- The New York Times article https://www.nytimes.com/2026/06/22/health/artificial-intelligence-heart-damage.html
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Jun 19 2026 This Week in Cardiology
Listener feedback, more long-term data on the TAVR/SAVR question, population prevalence of valvular heart disease in the US, and a CMS proposal to expand TAVR coverage are the topics John Mandrola, MD …
Shownotes
Listener feedback, more long-term data on the TAVR/SAVR question, population prevalence of valvular heart disease in the US, and a CMS proposal to expand TAVR coverage are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
- ICD Trends and Outcomes: 15-Year Analysis https://doi.org/10.1093/europace/euag110
- MADIT-RIT https://www.nejm.org/doi/full/10.1056/NEJMoa1211107
II More Long Term Data on TAVR vs SAVR
- PARTNER 2 Trial https://www.jacc.org/doi/10.1016/j.jacc.2026.03.169
- 10-Year Outcomes of SAPIEN 3 TAVR or SAVR in Intermediate-Risk Patients https://doi.org/10.1016/j.jacc.2026.03.170
- TAVR at a Decade: Editorial https://doi.org/10.1016/j.jacc.2026.04.042
- EVOLUT Trial https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5063
- Updated 5-year Outcomes of TAVR vs SAVR in AS https://heart.bmj.com/content/early/2026/02/11/heartjnl-2025-327092
- NOTION Trial https://doi.org/10.1093/eurheartj/ehae043
- PARTNER 3 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2509766
- NOTION 2 Trial https://academic.oup.com/eurheartj/article/45/37/3804/7673297
- TAVR vs SAVR Editorial : https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehag407/8708044
III The PREVUE-VALVE Study
- PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137
IV CMS has Proposed New Coverage for TAVR
- CMS Proposal Document https://www.cms.gov/medicare-coverage-database/view/ncacal-decision-memo.aspx?proposed=Y&ncaId=321
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Jun 12 2026 This Week in Cardiology
Listener feedback, transcatheter tricuspid valve replacement, a new metabolic disease called CKM, the ARISE-FLUIDS Trial, the BIHCA trial, and temporal trends in ICD therapies are the topics John Mandrola, MD …
Shownotes
Listener feedback, transcatheter tricuspid valve replacement, a new metabolic disease called CKM, the ARISE-FLUIDS Trial, the BIHCA trial, and temporal trends in ICD therapies are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
- LOSE-AF Trial https://jamanetwork.com/journals/jama/fullarticle/2849335
- ARREST-AF Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2840225
- POP-AF Trial https://doi.org/10.1093/eurheartj/ehaf689
- PRAGUE-25 Trial https://www.jacc.org/doi/10.1016/j.jacc.2025.04.042
II Transcatheter Tricuspid Valve Replacement
- TRISCEND Cost Study https://doi.org/10.1016/j.shj.2026.101049
- TRISCEND II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2401918
III More Disease Creation – the CKM Syndrome
ACC/AHA Release First-Ever Guideline for CKM Syndrome https://www.medscape.com/viewarticle/acc-aha-release-first-ever-guideline-ckm-syndrome-2026a1000jbs
- CKM Guideline in Circulation https://www.ahajournals.org/doi/10.1161/CIR.0000000000001447
IV Two Trials That Teach Important EBM Lessons
- ARISE-FLUIDS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2516225
- Dr Josh Farkas Post on X https://x.com/PulmCrit/status/2065064796270022845?s=20
V Bicarbonate for Inpatient Cardiac Arrest –The BIHCA trial
- BIHCA Trial https://jamanetwork.com/journals/jama/fullarticle/2850405
VI The Decline of VT in Heart Failure
- Trends and Outcomes in ICD Recipients: 15-Year Analysis https://doi.org/10.1093/europace/euag110
- Declining Risk of Sudden Death in HF https://www.nejm.org/doi/full/10.1056/NEJMoa1609758
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Jun 05 2026 This Week in Cardiology
Chemical cardioversion in the ED, HF monitoring, weight loss in AF, and surgical LAA excision are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare …
Shownotes
Chemical cardioversion in the ED, HF monitoring, weight loss in AF, and surgical LAA excision are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Chemical Cardioversion of AF in the ED: The FLECA-ED Trial
- FLECA-ED Rationale paper https://pmc.ncbi.nlm.nih.gov/articles/PMC10299428/
- FLECA-ED ESC Slides https://esc365.escardio.org/presentation/321209
- Review on Flecainide Use Despite CAST https://doi.org/10.1016/j.hrthm.2025.08.034
- RACE 7 ACWAS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1900353
II Heart Failure Monitoring – The ALLEVIATE-HF Trial
- ALLEVIATE-HF Trial https://doi.org/10.1016/j.jacc.2026.03.075
- CHAMPION Trial https://doi.org/10.1016/S0140-6736(11)60101-3
- GUIDE HF Trial https://doi.org/10.1016/S0140-6736(21)01754-2
- ALLEVIATE-HF Editorial: Alerts Are Not Treatment https://doi.org/10.1016/j.jacc.2026.04.014
- Steve Stiles Medscape report on CHAMPION https://www.medscape.com/viewarticle/755189
III A Negative Weight Loss Study in AF
- LOSE-AF Trial https://jamanetwork.com/journals/jama/fullarticle/2849335
IV Surgical LAA Excision
- OPINION Trial https://doi.org/10.1093/eurheartj/ehaf674
- LAAOS 3 trial https://www.nejm.org/doi/full/10.1056/NEJMoa2101897
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May 29 2026 This Week in Cardiology
A life-long treatment for high LDL, a VESALIUS subanalysis, tirzepatide beats semaglutide again, arrhythmia burden in cardiac amyloidosis, and a lipid guideline rebuttal are the topics John Mandrola, MD …
Shownotes
A life-long treatment for high LDL, a VESALIUS subanalysis, tirzepatide beats semaglutide again, arrhythmia burden in cardiac amyloidosis, and a lipid guideline rebuttal are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Permanent Lipid Lowering therapy
- Verve 102 Therapy for FH https://www.nejm.org/doi/full/10.1056/NEJMoa2601283
II Vesalius Substudy on PCSK9i Use in Patients With Previous PCI
- VESALIUS Subgroup Analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080616
- VESALIUS Study - NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
III Tirzepatide looking to be best again
- SURPASS-EARLY Trial https://www.acpjournals.org/doi/10.7326/ANNALS-25-05602
- SURMOUNT-5 Trial https://www.nejm.org/doi/abs/10.1056/NEJMoa2416394
IV Arrhythmias in Cardiac Amyloidosis
Loop Recorders Reveal Arrhythmias in Cardiac Amyloidosis https://www.medscape.com/viewarticle/loop-recorders-reveal-arrhythmias-cardiac-amyloidosis-2026a1000gq9
- EXCALIBUR Study https://www.jacc.org/doi/10.1016/j.jacc.2026.04.030
V Lipid Guidelines
· In Defense of the 2026 Dyslipidemia Guideline https://www.medscape.com/viewarticle/defense-2026-dyslipidemia-guideline-2026a1000hd0
- Lipid Guidelines: Four Major Concerns https://www.medscape.com/viewarticle/lipid-guidelines-four-major-concerns-2026a1000fim
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May 22 2026 This Week in Cardiology
Three more digoxin trials, yet another GLP-1 drug on the horizon, vagal nerve stimulation, trial inside baseball, and more on lipid guidelines are the topics John Mandrola, MD, discusses in this week's podcast …
Shownotes
Three more digoxin trials, yet another GLP-1 drug on the horizon, vagal nerve stimulation, trial inside baseball, and more on lipid guidelines are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I More About Low-dose Digoxin in HF — The DECISION Trial(s)
- DECISION Trial https://www.nature.com/articles/s41591-026-04406-6
- Digitalis Glycosides in HF — JAMA Meta-Analysis https://jamanetwork.com/journals/jama/fullarticle/2848972
- DIGIT-HF Trial https://www.nejm.org/doi/10.1056/NEJMoa2415471
- RADIANCE Trial (1993) https://www.nejm.org/doi/full/10.1056/NEJM199307013290101
- DECISION Withdrawal Study https://doi.org/10.1093/eurheartj/ehag385
- Digoxin Discontinuation vs Continuation in Chronic HF https://doi.org/10.1016/j.amjcard.2007.02.099
II Yet another GLP-1 Drug Announced this Week
Lillly News Release on Retatrutide https://investor.lilly.com/news-releases/news-release-details/lillys-triple-agonist-retatrutide-delivered-powerful-weight-loss
III A Big Story in HF Science – Vagal Nerve Stimulation in HFrEF
- ANTHEM HFrEF trial https://doi.org/10.1016/j.jacc.2026.03.040
- Editorials
An Unfinished ANTHEM https://doi.org/10.1016/j.jacc.2026.04.033
When Trials Stop Prematurely https://doi.org/10.1016/j.jacc.2026.03.039
IV Lipid Guideline News
Lipid Guidelines: Four Major Concerns
https://www.medscape.com/viewarticle/lipid-guidelines-four-major-concerns-2026a1000fim
- Editorial: Time to Move Beyond the Statin Nocebo Effect https://www.jacc.org/doi/10.1016/j.jacc.2026.04.002
- Correspondence: SAMSON N-of-1 Trial of Statin, Placebo, or No Treatment https://www.nejm.org/doi/full/10.1056/NEJMc2031173
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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May 15, 2026 This Week in Cardiology
Another positive digoxin trial, another classic coronary physiology study from Imperial College London (ORBITA-FIRE), news in hypertrophic cardiomyopathy, and TAVR done in the wrong patients are the topics John …
Shownotes
Another positive digoxin trial, another classic coronary physiology study from Imperial College London (ORBITA-FIRE), news in hypertrophic cardiomyopathy, and TAVR done in the wrong patients are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Digoxin in Rheumatic Heart Disease
- Dig-RHD Trial https://jamanetwork.com/journals/jama/fullarticle/2848973
- Safety and Efficacy of Digoxin: Meta-Analysis https://www.bmj.com/content/351/bmj.h4451.long
- DIGIT-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415471
- DIG Trial https://www.nejm.org/doi/full/10.1056/NEJM199702203360801
- RADIANCE Trial https://www.nejm.org/doi/full/10.1056/NEJM199307013290101
II The Physiologic Threshold for Angina
- ORBITA-FIRE Trial https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.125.078738
III Prediction in Hypertrophic Cardiomyopathy
- Predictors of Long-Term Outcomes in HCM https://jamanetwork.com/journals/jama/fullarticle/2848800#250998713
IV TAVR Trends in Young Patients
- Temporal Trends in AVR for Aortic Stenosis in Patients
- Wall Street Journal article https://www.wsj.com/health/healthcare/heart-valve-tavr-surgery-aorta-1e0eda70
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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May 08 2026 This Week in Cardiology
Listener feedback from the DanGer Shock investigators, complete vs staged revascularization, polygenic risk scores, and quality improvement failure in an RCT are the topics John Mandrola, MD, discusses in this …
Shownotes
Listener feedback from the DanGer Shock investigators, complete vs staged revascularization, polygenic risk scores, and quality improvement failure in an RCT are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
- DanGer Shock Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2312572
- CHIP-BCIS 3 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2515704
II Immediate Complete vs Staged Revascularization in STEMI
- Meta-analysis: Timing of Complete Revasc in Patients with STEMI and Multivessel Disease https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.126.016601
- COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775 FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
- iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918
III Polygenic Risk Scores for Prediction
- Polygenic Risk Report in US-Based Hospitals for 8 CV Conditions https://www.jacc.org/doi/10.1016/j.jacc.2026.03.035
IV Practice Improvement Policies Undergo the Proper Test – Randomization
- Quality Improvement on Hospitalizations and Health Outcomes for People with CHD https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.125.012904
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May 01 2026 This Week in Cardiology
Time to quadruple therapy, the disappointing AVANT GUARD trial, PFA risks, the TREAT-PVC trial, and NSTEMI care in the frail elderly are the topics John Mandrola, MD, discusses in this week's podcast. This …
Shownotes
Time to quadruple therapy, the disappointing AVANT GUARD trial, PFA risks, the TREAT-PVC trial, and NSTEMI care in the frail elderly are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Time to Quadruple Therapy in HFrEF
- Time to Quadruple Therapy After Diagnosis of HFrEF https://jamanetwork.com/journals/jamacardiology/fullarticle/2846899
II AVANT GUARD
PFA Bests Meds as First-Line Treatment for Persistent AF in Randomized Trial https://www.medscape.com/viewarticle/pulsed-field-ablation-bests-meds-first-line-treatment-2026a1000dsm
Pulsed Field Ablation of AF Disappoints in Setup for Success: AVANT GUARD https://www.medscape.com/viewarticle/pulsed-field-ablation-af-disappoints-setup-success-avant-2026a1000ddt
- AVANT GUARD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600929
- Persistent AF: Meta-analysis of Invasive Strategies 10.1016/j.ijcard.2018.11.127 External Link
III Speaking of Scary News on PFA – The TIFFANY Study
- Abstract - The TIFFANY Study https://www.heartrhythmjournal.com/article/S1547-5271(26)01747-9/fulltext
- Delayed Myocardial Ischemia and Malignant Arrhythmias After PFA https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.077983
- Alberto Alfie Comment https://x.com/ALFIEEP1/status/2050029151315189774?s=20
IV TREAT PVC Trial
- TREAT-PVC Trial https://doi.org/10.1016/j.jacep.2026.01.011
- TREAT-AF Study 2020 https://doi.org/10.1016/j.jacep.2019.11.008
V NSTEMI In Frail Older Patients
- SENIOR-RITA Trial https://www.nejm.org/doi/10.1056/NEJMoa2407791
- Subanalysis of Senior RITA Trial https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2847995
- Timing of Invasive Strategy in Patients With Non-ST-Elevation Acute Coronary Syndrome -- Meta-analysis https://doi.org/10.1016/S0140-6736(17)31490-3
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Apr 24 2026 This Week in Cardiology
PCSK9 inhibitors in high-risk diabetes without ASCVD, the CAAN-AF trial, conduction system pacing vs biventricular pacing, PFA and stroke, and therapeutic fashion infects expert consensus are the topics John …
Shownotes
PCSK9 inhibitors in high-risk diabetes without ASCVD, the CAAN-AF trial, conduction system pacing vs biventricular pacing, PFA and stroke, and therapeutic fashion infects expert consensus are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I VESALIUS-CV
- VESALIUS-CV Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
- JAMA Substudy https://jamanetwork.com/journals/jama/fullarticle/2847162
II How Best to Maximize CRT Benefit in Patients with AF
- CAAN-AF Trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag206/8654625?searchresult=1
- Role of AV Node Ablation: Meta-analysis of Observational Studies https://www.jacc.org/doi/10.1016/j.jacc.2011.10.891
III Stroke Rates in PFA vs Thermal Ablation
- Comparative Safety of RF versus PFA for AF in a High-Volume US Medical Center https://esc365.escardio.org/Ehra-congress/sessions/18281
IV Five New CSP Studies Presented and Published
- HeartSync-LBBP Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2845803
- PhysioSync-HF Trial
https://jamanetwork.com/journals/jamacardiology/fullarticle/2845802
- LEFT-BUNDLE-CRT Trial https://doi.org/10.1093/eurheartj/ehag225
- Long-Term Follow-up of His-Alternative I Trial https://www.jacc.org/doi/10.1016/j.jacep.2026.02.016
- LECART Trial https://esc365.escardio.org/Ehra-congress/sessions/17140
V New EP Training Document Published
- Advanced Training Statement on Clinical Cardiac Electrophysiology https://www.jacc.org/doi/10.1016/j.jacc.2026.01.074
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Apr 17 2026 This Week in Cardiology
SPIRIT-HF, another spironolactone trial in HFpEF; the ESSENCE imaging study of the drug olezarsen; the SirPAD trial in peripheral artery disease; and ultrasound-guided femoral venous access are the topics John …
Shownotes
SPIRIT-HF, another spironolactone trial in HFpEF; the ESSENCE imaging study of the drug olezarsen; the SirPAD trial in peripheral artery disease; and ultrasound-guided femoral venous access are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I ACC: SPIRIT-HF Trial
- FINEARTS-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
- TOPCAT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1313731
- TOPCAT Americas Trial https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255
II A New Class of Lipid Lowering Drug Has a Dubious Debut At ACC
- ESSENCE-TIMI 73b Imaging Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080012
- ESSENCE-TIMI 73b Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2507227
- IMPROVE IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1410489
III Drug-Coated Balloons Looked Quite Good in PAD interventions
Sirolimus-Coated Balloon Reduces Amputation Risk in Peripheral Artery Disease
https://www.medscape.com/viewarticle/sirolimus-coated-balloon-reduces-amputation-risk-peripheral-2026a1000a83
- SirPAD trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600360
IV Another Vascular Story from the European Heart Rhythm Association
- ULYSSES Trial https://doi.org/10.1093/eurheartj/ehag291
- ULTRA-FAST Trial https://doi.org/10.1093/europace/eux175
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Apr 10 2026 This Week in Cardiology
Three imaging-guided PCI trials (two with surprising results), LDL targets, an oral PCSK9 inhibitor, and another beta-blocker withdrawal trial are the topics John Mandrola, MD, discusses in this week's podcast …
Shownotes
Three imaging-guided PCI trials (two with surprising results), LDL targets, an oral PCSK9 inhibitor, and another beta-blocker withdrawal trial are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I IVUS-Guided PCI
- OPTIMAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600440
- IVUS-CHIP Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601521
- ILUMIEN IV Trial https://www.nejm.org/doi/10.1056/NEJMoa2305861
- DKCRUSH VIII Trial https://doi.org/10.1016/j.jacc.2026.01.081
II Ez-PAVE Trial — Low vs Very Low LDL-targets
Does Ez-PAVE Support 'Lower Is Better' for LDL-C? https://www.medscape.com/viewarticle/does-ez-pave-support-lower-better-ldl-c-2026a1000akx
- Ez-PAVE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600283
- 2026 ACC/AHA Lipid Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423
III CORALreef AddOn
- CORALreef AddOn Trial https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.03.036
- This Week in Caardiology 2-6-26 https://www.medscape.com/viewarticle/1003240
- CORALreef Lipids Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
IV Another Post-MI Beta-blocker Withdrawal Study: SMART-DECISION
- SMART-DECISION Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601005
- ABYSS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Apr 03 2026 This Week in Cardiology
John Mandrola offers an ACC recap of 5 big trials—Hi-PEITHO, PROTAVI, ORBITA-CTO, CHIPS-BCIS3 and CHAMPION AF This podcast is intended for healthcare professionals only. To read a partial transcript or to …
Shownotes
John Mandrola offers an ACC recap of 5 big trials—Hi-PEITHO, PROTAVI, ORBITA-CTO, CHIPS-BCIS3 and CHAMPION AF
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Catheter Based Fibrinolysis of Pulmonary Embolism –Hi PEITHO
- Fibrinolysis Treatment Validated in Large Trial for Acute Intermediate-Risk PE https://www.medscape.com/viewarticle/fibrinolysis-treatment-validated-large-trial-acute-2026a10009im
- Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism (HI PEITHO) https://www.nejm.org/doi/full/10.1056/NEJMoa2516567
- National Early Warning Score (NEWS) https://www.england.nhs.uk/ourwork/clinical-policy/sepsis/nationalearlywarningscore/
II PRO-TAVI trial
- Deferral of percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation (PRO-TAVI) 10.1016/S0140-6736(26)00308-9 External Link
- PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation (Notion 3) https://www.nejm.org/doi/full/10.1056/NEJMoa2401513
III ORBITA CTO Sham vs PCI for Angina Relief
- Tightly Blinded Trial Confirms PCI Reduces Angina in Obstructive Occlusion https://www.medscape.com/viewarticle/tightly-blinded-trial-confirms-pci-reduces-angina-2026a10009ob
- A Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina - ORBITA-CTO https://www.jacc.org/doi/10.1016/j.jacc.2026.03.027
- ORBITA 1 10.1016/S0140-6736(17)32714-9 External Link
- ORBITA 2 https://www.nejm.org/doi/full/10.1056/NEJMoa2310610
- DECISION CTO https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.031313
- EuroCTO https://doi.org/10.1093/eurheartj/ehy220
IV CHIPS BCIS3 Impella Supported High-Risk PCI
- Adoption Before Evidence: CHIP-BCIS3 Humbles Impella https://www.medscape.com/viewarticle/adoption-before-evidence-chip-bcis3-humbles-impella-2026a10009jh
- Left Ventricular Unloading in High-Risk PCI (CHIP BCIS3) https://www.nejm.org/doi/full/10.1056/NEJMoa2515704
- Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock (DanGer Shock) https://www.nejm.org/doi/full/10.1056/NEJMoa2312572
V CHAMPION AF – Watchman vs DOAC in Patients With AF
- CHAMPION-AF Trial Finds LAAC an Alternative for NOAC in Lower-Risk Patients https://www.medscape.com/viewarticle/champion-af-trial-finds-laac-alternative-noac-lower-risk-2026a10009ij
- Six Reasons Why CHAMPION-AF Should Not Change Practice https://www.medscape.com/viewarticle/six-reasons-why-champion-af-should-not-change-practice-2026a10009i7
- Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation (CHAMPION AF) https://www.nejm.org/doi/full/10.1056/NEJMoa2517213
- Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation (CLOSURE AF) https://www.nejm.org/doi/full/10.1056/NEJMoa2513310
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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