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Clinical Chemistry Podcast

Clinical Chemistry Podcast

NewGenetic Investigation of X-Linked Defects with Optimized Targeted Long-Read SequencingNovember 9, 2026 · 11 min
Episodes
1,122
Released
weekly
Latest episode
Nov 9, 2026

About the podcast

This free monthly podcast is offered by Clinical Chemistry. Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today's clinical laboratory.

Episodes 1,122

  1. Genetic Investigation of X-Linked Defects with Optimized Targeted Long-Read Sequencing

    11 min

    Jia Zheng, Keying Li, Jin Han, Chi Chun Chan, Huilin Wang, Jasmine Yan Tung Law, Lin Chen, Fan Jiang, Rui Zhang, Hailei Liang, Xiaofang Chen, Mengmeng Shi, Matthew Hoi Kin Chau, Ye Cao, Yvonne K Kwok, Yuanfang …

    Show notes

    Jia Zheng, Keying Li, Jin Han, Chi Chun Chan, Huilin Wang, Jasmine Yan Tung Law, Lin Chen, Fan Jiang, Rui Zhang, Hailei Liang, Xiaofang Chen, Mengmeng Shi, Matthew Hoi Kin Chau, Ye Cao, Yvonne K Kwok, Yuanfang Zhu, Tak Yeung Leung, Kwong Wai Choy, Zirui Dong. Genetic Investigation of X-Linked Defects with Optimized Targeted Long-Read Sequencing. Clinical Chemistry, Volume 72, Issue 11, November 2026, Pages 1145–1160. https://doi.org/10.1093/clinchem/hvag088

  2. Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient Care

    13 min

    Joely A Straseski, Hubert W Vesper, Thomas A Long, Gary L Horowitz. Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient …

    Show notes

    Joely A Straseski, Hubert W Vesper, Thomas A Long, Gary L Horowitz. Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient Care. Clinical Chemistry, Volume 72, Issue 10, October 2026, Pages 1046–1055. https://doi.org/10.1093/clinchem/hvag068

  3. TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations

    12 min

    Jillian Kodger, Joe M El-Khoury. TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations. Clinical Chemistry, Volume 72, Issue 9, September 2026, Pages 1003–1004 …

    Show notes

    Jillian Kodger, Joe M El-Khoury. TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations. Clinical Chemistry, Volume 72, Issue 9, September 2026, Pages 1003–1004. https://doi.org/10.1093/clinchem/hvag075

  4. Audio Summary November2026

    5 min

  5. Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes

    11 min

    Tianyu Cao, Michael Fang, Amelia S Wallace, Natalie Daya Malek, Arielle Valint, Dan Wang, Justin B Echouffo-Tcheugui, Scott L Zeger, Elizabeth Selvin. Patterns of One-Year Change in HbA1c and Continuous Glucose …

    Show notes

    Tianyu Cao, Michael Fang, Amelia S Wallace, Natalie Daya Malek, Arielle Valint, Dan Wang, Justin B Echouffo-Tcheugui, Scott L Zeger, Elizabeth Selvin. Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes. Clinical Chemistry, Volume 72, Issue 10, October 2026, Pages 1039–1045. https://doi.org/10.1093/clinchem/hvag067

  6. Mining and Refining Elusive Microproteins from Noncanonical Open Reading Frames

    18 min

    Yifei K Yang. Mining and Refining Elusive Microproteins from Noncanonical Open Reading Frames. Clinical Chemistry, Volume 72, Issue 10, October 2026, Pages 1101–1103. https://doi.org/10.1093/clinchem/hvag107

  7. Point of Concern for Troponin Testing with High-Sensitivity Assays in the Near Patient Setting

    12 min

    Peter A Kavsak. Point of Concern for Troponin Testing with High-Sensitivity Assays in the Near Patient Setting, Clinical Chemistry, 2026; 72(10): hvag034. https://doi.org/10.1093/clinchem/hvag034

  8. October 2026 Audio Summary

    5 min

  9. Alpha-Synuclein-Specific RT-QuIC As a Tool for the Differential Diagnosis of Neurodegenerative Diseases Using Peripheral Tissues

    9 min

    Melissa Ix, Richard Dodel, J Alexander Ross. Alpha-Synuclein-Specific RT-QuIC As a Tool for the Differential Diagnosis of Neurodegenerative Diseases Using Peripheral Tissues. Clinical Chemistry, Volume 72 …

    Show notes

    Melissa Ix, Richard Dodel, J Alexander Ross. Alpha-Synuclein-Specific RT-QuIC As a Tool for the Differential Diagnosis of Neurodegenerative Diseases Using Peripheral Tissues. Clinical Chemistry, Volume 72, Issue 8, August 2026, Pages 830–844. https://doi.org/10.1093/clinchem/hvag037

  10. Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy

    15 min

    Matthew Lee, Jeffrey A SoRelle, Arun Everest-Dass, David E Gerber, Mitchell S von Itzstein. Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision …

    Show notes

    Matthew Lee, Jeffrey A SoRelle, Arun Everest-Dass, David E Gerber, Mitchell S von Itzstein. Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy. Clin Chem 2026; 72(9): 926–47. https://doi.org/10.1093/clinchem/hvag062

  11. Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma

    13 min

    Shengjie Li, Jiazhen Cao, Jun Ren, Kun Chen, Jianing Wu, Yingzhu Li, Yunxiao Song, Chengxun Li, Wenjun Cao, Ming Guan. Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma. Clin …

    Show notes

    Shengjie Li, Jiazhen Cao, Jun Ren, Kun Chen, Jianing Wu, Yingzhu Li, Yunxiao Song, Chengxun Li, Wenjun Cao, Ming Guan. Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma. Clin Chem 2026; 72(8): 880–92.

    https://doi.org/10.1093/clinchem/hvag036

  12. Audio Summary September 2026

    5 min

  13. Performance, Safety, and Patient Experience of an Autonomous Robotic Phlebotomy Device: A Multicenter Trial

    10 min

    Luuk F P Giesen, Jeroen A Roest, Frederique M A Koopman, Martine M L Deckers, Helena Chon, Christian M Hackeng, Jurgen A Riedl, Michiel de Bruin, Brooke M Katzman, Warry van Gelder, Janne Cadamuro, Mads Nybo …

    Show notes

    Luuk F P Giesen, Jeroen A Roest, Frederique M A Koopman, Martine M L Deckers, Helena Chon, Christian M Hackeng, Jurgen A Riedl, Michiel de Bruin, Brooke M Katzman, Warry van Gelder, Janne Cadamuro, Mads Nybo, Michael A Fouraux, Thijs C van Holten, Robert de Jonge. Performance, Safety, and Patient Experience of an Autonomous Robotic Phlebotomy Device: A Multicenter Trial. Clinical Chemistry, Volume 72, Issue 8, August 2026, Pages 845–856. https://doi.org/10.1093/clinchem/hvag029

  14. Exploring Sex-Specific High-Sensitivity Cardiac Troponin Thresholds for Rule-Out of Non-ST-Elevation Myocardial Infarction

    11 min

    Ingar Ziad Restan, Yong Yong Tew, Ole-Thomas Steiro, Ziwen Li, Hilde L Tjora, Jørund Langørgen, Torbjørn Omland, Paul Collinson, Rune Bjørneklett, Kjell Vikenes, Trude Steinsvik, Øyvind Skadberg, Øistein R …

    Show notes

    Ingar Ziad Restan, Yong Yong Tew, Ole-Thomas Steiro, Ziwen Li, Hilde L Tjora, Jørund Langørgen, Torbjørn Omland, Paul Collinson, Rune Bjørneklett, Kjell Vikenes, Trude Steinsvik, Øyvind Skadberg, Øistein R Mjelva, Alf Inge Larsen, Vernon V S Bonarjee, Nicholas L Mills, Kristin M Aakre. Exploring Sex-Specific High-Sensitivity Cardiac Troponin Thresholds for Rule-Out of Non-ST-Elevation Myocardial Infarction. Clinical Chemistry, Volume 72, Issue 8, August 2026, Pages 868–879. https://doi.org/10.1093/clinchem/hvag030

  15. Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility

    14 min

    Juexiao Sherry Wang, C J Battey, Kyle Trettin, Ravi Patel, Anu Srinivasan, Janani Saikumar, Divya Kushnoor, Ben F Habermeyer, Sangita Ganesh, Nafei Xu, Nathaniel Friedrich, Summer Pierson, Helen Wan, Heather …

    Show notes

    Juexiao Sherry Wang, C J Battey, Kyle Trettin, Ravi Patel, Anu Srinivasan, Janani Saikumar, Divya Kushnoor, Ben F Habermeyer, Sangita Ganesh, Nafei Xu, Nathaniel Friedrich, Summer Pierson, Helen Wan, Heather LaBreche, Genevieve M Gould, Dale Muzzey. Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 679–691. https://doi.org/10.1093/clinchem/hvag005

  16. Audio Summary August 2026

    5 min

  17. From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians

    9 min

    Ryan Pearce, Leslie J Donato, Vlad C Vasile, Allan S Jaffe, Jeffrey W Meeusen. From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians. Clinical Chemistry, Volume 72, Issue 7, July 2026, Pages …

    Show notes

    Ryan Pearce, Leslie J Donato, Vlad C Vasile, Allan S Jaffe, Jeffrey W Meeusen. From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians. Clinical Chemistry, Volume 72, Issue 7, July 2026, Pages 814–816. https://doi.org/10.1093/clinchem/hvag044

  18. Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis

    11 min

    Anna C H Hoge, Thomas E Grys, Erin H Graf. Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis. Clinical Chemistry, Volume 72, Issue 5, May …

    Show notes

    Anna C H Hoge, Thomas E Grys, Erin H Graf. Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 575–582. https://doi.org/10.1093/clinchem/hvaf187

  19. Audio Summary July 2026

    5 min

  20. DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping

    12 min

    Ann M Moyer, Emma Lundquist, Emily K Thoreson, Michelle L Kluge, Katrina E Kotzer, Elyse M Love, Heather L Glessner, Sarah K Arneson, Loralie J Langman, Linnea M Baudhuin, John Logan Black. DPYD Sequencing …

    Show notes

    Ann M Moyer, Emma Lundquist, Emily K Thoreson, Michelle L Kluge, Katrina E Kotzer, Elyse M Love, Heather L Glessner, Sarah K Arneson, Loralie J Langman, Linnea M Baudhuin, John Logan Black. DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 662–669. https://doi.org/10.1093/clinchem/hvag007.

  21. Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions

    19 min

    Lisa A Lansdon, Binu Porath, Mari Mori, David T Miller, Diane Dunham Drexler, Catherine Wattenberg, Morgan Richardson, Robert D Steiner, Peter J Freeman. Universal Presence of Gene/Variant Nomenclature Errors …

    Show notes

    Lisa A Lansdon, Binu Porath, Mari Mori, David T Miller, Diane Dunham Drexler, Catherine Wattenberg, Morgan Richardson, Robert D Steiner, Peter J Freeman. Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 652–661. https://doi.org/10.1093/clinchem/hvag010

  22. Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine

    10 min

    Patrick M Bossuyt, Tze Ping Loh, Katy Bell, Sally Lord, Andrea R Horvath. Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine. Clinical Chemistry, Volume 72, Issue 5, May 2026 …

    Show notes

    Patrick M Bossuyt, Tze Ping Loh, Katy Bell, Sally Lord, Andrea R Horvath. Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 546–553.

    https://doi.org/10.1093/clinchem/hvag014

  23. Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring

    14 min

    Grace Drew, Colleen S Kraft, Nirja Mehta. Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring. Clinical Chemistry …

    Show notes

    Grace Drew, Colleen S Kraft, Nirja Mehta. Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 554–563.

    https://doi.org/10.1093/clinchem/hvaf156

  24. Audio Summary June 2026

    5 min

  25. Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?

    14 min

    Andrea L Benedet, Burak Arslan, Kubra Tan, Hanna Huber, Ilaria Pola, Guglielmo Di Molfetta, Hlin Kvartsberg, Anna Orduña Dolado, Shorena Janelidze, Kaj Blennow, Henrik Zetterberg, Oskar Hansson, Pedro …

    Show notes

    Andrea L Benedet, Burak Arslan, Kubra Tan, Hanna Huber, Ilaria Pola, Guglielmo Di Molfetta, Hlin Kvartsberg, Anna Orduña Dolado, Shorena Janelidze, Kaj Blennow, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Nicholas J Ashton. Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility? Clinical Chemistry, Volume 72, Issue 2, February 2026, Pages 303–315, https://doi.org/10.1093/clinchem/hvaf162

  26. Methods to Improve Confidence in the Accuracy of Molecular Testing for Multidrug-Resistant Tuberculosis

    10 min

    Denise M O'Sullivan, Gerwyn M Jones, Manca Zolnir-Dovc, Richard Phillips, Rejoice Arthur, Bariki Mtafya, Daniel Adon Mapamba, Daniela Maria Cirillo, Ewa Augustynowicz-Kopeć, Mei Mei Ho, Belinda Dagg, Sven O …

    Show notes

    Denise M O'Sullivan, Gerwyn M Jones, Manca Zolnir-Dovc, Richard Phillips, Rejoice Arthur, Bariki Mtafya, Daniel Adon Mapamba, Daniela Maria Cirillo, Ewa Augustynowicz-Kopeć, Mei Mei Ho, Belinda Dagg, Sven O Friedrich, Francesca Colavita, Antonella Vulcano, Prince Asare, Dorothy Yeboah-Manu, Timothy D McHugh, Jim F Huggett. Methods to Improve Confidence in the Accuracy of Molecular Testing for Multidrug-Resistant Tuberculosis. Clinical Chemistry, Volume 72, Issue 3, March 2026, Pages 390–397. https://doi.org/10.1093/clinchem/hvaf178

  27. Audio Summary May 2026

    5 min

  28. Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets

    12 min

    Thomas J S Durant, Seung Joo Lee, Sarah N Dudgeon, Elizabeth Knight, Brent Nelson, H Patrick Young, Lucila Ohno-Machado, Wade L Schulz. Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark …

    Show notes

    Thomas J S Durant, Seung Joo Lee, Sarah N Dudgeon, Elizabeth Knight, Brent Nelson, H Patrick Young, Lucila Ohno-Machado, Wade L Schulz. Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 451–460. https://doi.org/10.1093/clinchem/hvaf192

  29. Scientific Fraud at Scale: Challenges for Trust in Published Data

    10 min

    Preejith P Vachali, Adam J McShane. Scientific Fraud at Scale: Challenges for Trust in Published Data. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 518–519. https://doi.org/10.1093/clinchem/hvag002

  30. Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing

    12 min

    Yusheng Zhu, Jarrett Sell. Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 439–450. https://doi.org/10.1093/clinchem/hvaf155

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