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Core IM | Internal Medicine Podcast
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Core IM | Internal Medicine Podcast

New#223 Amyloidosis Presentation: Gray Matters SegmentNovember 11, 2026 · 27 min
Episodes
231
Released
every two weeks
Latest episode
Nov 11, 2026

About the podcast

Core Internal Medicine via following series: 5 Pearls || Clinically relevant pearls Mind the Gap || Why do we do what we do? Gray Matters || Management Reasoning Hoofbeats || Dissecting clinical reasoning At the Bedside || Explore everyday challenges

Episodes 231

  1. #223 Amyloidosis Presentation: Gray Matters Segment

    27 min

    “Could amyloidosis be the reason behind a patient’s unexplained symptoms?” This episode explores the clinical clues that should prompt clinicians to consider AL amyloidosis and recognize patterns of organ …

  2. #222 AFib Stroke Prevention: WATCHMAN, DOACs, and the CHAMPION-AF Trial | Beyond Journal Club Segment with NEJM Group

    32 min

    If your patient asks you about a left atrial appendage closure device, what should you tell them? In the latest episode of the Beyond Journal Club podcast from CORE IM and NEJM Group, the hosts will help you …

  3. #221 Colon Cancer Screening After Age 75 | 5 Pearls Segment Part 3

    17 min

    “Should you stop screening for colorectal cancer (CRC) at 75?” This episode explores how to individualize screening decisions based on life expectancy, prior colonoscopy findings, and procedural risks. Learn …

  4. #220 Colon Cancer Screening Nuances: 5 Pearls Segment Part 2

    21 min

    “What’s the best way to screen?” This episode breaks down the pros, limitations, and follow-up needs of FIT, Cologuard, CT colonography, and colonoscopy to help you choose the right CRC screening option for …

  5. #219 Updates in Triglycerides

    34 min

    “The triglycerides are high. Now what?” This episode breaks down a practical approach to elevated TGs, from knowing when to check ApoB or non-HDL-C to choosing lifestyle changes, lipid-lowering medications, and …

  6. #218 Early-Onset Colon Cancer: 5 Pearls Segment Part 1

    15 min

    “Too young for colon cancer.” This episode unpacks the red flags of early-onset colorectal cancer (CRC), from blood in the stool and iron deficiency anemia to persistent abdominal pain and changes in bowel …

  7. #217 Treatment for Alcohol Use Disorder: 5 Pearls Segment

    38 min

    “It didn’t work.” This episode breaks down practical treatment options (dosing options for naltrexone, acamprosate, topiramate, gabapentin) and counseling pearls to help you meet patients where they are and …

  8. #216 Clinician Grief: At the Beside Segment

    40 min

    Have you ever lost a patient and found yourself thinking about them long after the shift ended? This episode explores the grief clinicians can carry after a patient dies, including the losses that aren’t always …

    Show notes

    Have you ever lost a patient and found yourself thinking about them long after the shift ended? This episode explores the grief clinicians can carry after a patient dies, including the losses that aren’t always obvious. We also discuss ways to work through that grief, recognize when it becomes complicated, and lean on your team for support.


    🔹Transcript and Shownotes

    04:12 | What is Clinician Grief?

    10:02 | Types of Losses

    10:22 | Loss of a close relationship with a particular patient

    12:56 | Loss due to a professional's identification with the pain of family members

    13:56 | Loss of one's unmet goals and expectations and one's professional self-image and role

    18:47 | Loss related to one's personal system of beliefs and assumptions about life

    21:30 | Past unresolved losses or anticipated future losses

    23:29 | The death of the self

    25:44 | Coping


    Tags: CoreIM, Medical Education, Clinician Wellbeing, Burnout, Secondary Traumatic Stress, Complicated Grief, Coping With Grief, Medical humanities, medical ethics



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  9. #215 Gallbladder & Biliary Testing: 5 Pearls Segment

    35 min

    How to choose between RUQ ultrasound, CT, HIDA, MRCP, EUS, and ERCP based on the clinical picture? When should you move from diagnostic imaging to therapeutic ERCP, and what should you know about …

    Show notes

    How to choose between RUQ ultrasound, CT, HIDA, MRCP, EUS, and ERCP based on the clinical picture? When should you move from diagnostic imaging to therapeutic ERCP, and what should you know about sphincterotomy, stents, and stone removal? Plus, how to interpret bile duct dilation without jumping straight to obstruction?


    🔹Sponsor: Oakstone CME

    Use the code "CORE25" for 25% off: https://www.coreimpodcast.com/MKSAP


    🔹Transcript and Shownotes


    02:11 | Pearl 1: Gallbladder Problems Spectrum

    07:33 | Pearl 2: Choose Imaging Strategically: Start with RUQUS, Escalate as Needed

    14:34 | Pearl 3: Biliary Tree Diagnostics

    19:19 | Pearl 4: Invasives that are Diagnostic and Therapeutic

    27:06 | Pearl 5: Stenting in ERCP


    Tags: CoreIM, Internal Medicine, Medical Education, Gallstones, Cholecystitis, Biliary Disease, ERCP, Biliary Imaging



    Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840

    Our Sponsors:
    * Check out Eko: https://ekohealth.com
    * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com


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  10. #214 Hyponatremia Management: A Core IM Classic

    45 min

    Throwback: Should you really fluid-restrict every patient with SIADH? When can IV fluids make hyponatremia better or worse? Are salt tabs actually doing enough? And what can urine studies tell you before you …

  11. #213 Hypertension First-Line Medications Troubleshooting | Bread & Butter Series

    33 min

    Why can lower-dose combinations be more effective and better tolerated than maximizing one medication? How to troubleshoot common challenges such as amlodipine edema, gout, electrolyte abnormalities, and the …

  12. #212 Top 10 Highlights of the New Lipid Guidelines

    24 min

    Learn from primary care docs what has been practiced and changed from the 2026 ACC/AHA Lipid Guidelines! Learn how the new CPR framework (Calculate, Personalize, Reclassify) and PREVENT risk calculator change …

  13. #211 Breaking Down MASLD vs. MASH and the MAESTRO-NASH & ESSENCE Trials: Beyond Journal Club Segment

    34 min

    MASLD affects nearly one in three adults worldwide, yet many patients remain undiagnosed until advanced fibrosis or cirrhosis develops. So, which patients should clinicians actually be screening? When is a …

  14. #210 HTN in Dialysis: 5 Pearls Segment

    26 min

    What blood pressure should we target in patients on hemodialysis? Why volume control remains the foundation of treatment? How blood pressure targets differ from the general population. Learn practical pearls on …

    Show notes

    What blood pressure should we target in patients on hemodialysis? Why volume control remains the foundation of treatment? How blood pressure targets differ from the general population. Learn practical pearls on medication timing around dialysis, drug dialyzability, antihypertensive selection, and strategies to prevent intradialytic complications while optimizing long-term outcomes.


    🔹Sponsor: Search “Amazon Pharmacy Nationwide Home Delivery" in your EHR to get home delivery (often same-day). Learn more here.


    🔹Transcript and Shownotes:

    02: 19 | Pearl 1: Blood Pressure Targets

    09: 40 | Pearl 2: Timing Medications and Dialyzability

    15: 31 | Pearl 3 - Pharmacologic Management Nuances in Dialysis Patients

    22: 57 | Putting It All Together: The Medication Hierarchy


    Tags: CoreIM, Internal Medicine, Medical Education, Nephrology, ESRD, End-Stage Kidney Disease, Hypertension, Kidney Health, Dry Weight, Volume Overload



    Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840

    Our Sponsors:
    * Check out Eko: https://ekohealth.com
    * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com


    Advertising Inquiries: https://redcircle.com/brands

    Privacy & Opt-Out: https://redcircle.com/privacy
  15. #209 Dialysis and Fluid Management: 5 Pearls Segment

    32 min

    Why is fluid management the most important part of dialysis care? This episode explores the fundamentals of hemodialysis, why ESKD patients have unique physiology, and how volume overload, not just …

  16. #208 AI vs. Human with Post-Op AFib: Bread & Butter Series

    29 min

    Can AI manage post-op atrial fibrillation or does medicine still require human judgment? Using post-op AFib as a case study, we explore where algorithms help, where evidence falls short, and why clinical …

  17. #207 Is There a Doctor on Board? In-Flight Emergencies

    28 min

    We start with a gripping story of seizures and use it as a jumping-off point to unpack practical pearls for in-flight emergencies. Along the way: what’s actually in the emergency medical kit, when planes …

  18. #206 Eosinophilia: 5 Pearls Segment

    43 min

    Can you distinguish benign eosinophilia from a sign of serious disease, and know exactly when to act at the bedside?In this high-yield episode, test your clinical reasoning as we tackle:When eosinophilia …

  19. #205 Nutrition Studies, Coffee and the CRAVE Trial: Beyond Journal Club with the NEJM Group

    32 min

    Is coffee helping or harming our patients’ hearts?In this Beyond Journal Club, we unpack the CRAVE trial and use it as a lens to answer a bigger question:How should clinicians interpret nutrition research …

  20. #204 Diabetic Foot Infections & Osteomyelitis: 5 Pearls Segment

    34 min

    Why can these infections be tricky? How to diagnose osteomyelitis at the bedside? Do we always need IV vs oral antibiotics? And the best for last: Simple, practical wound care strategies for medical students …

  21. #203 POCUS for AKI & Dialysis | Real Cases That Changed Management

    29 min

    A dialysis patient with a chronic cough: is it COPD, or are they still volume overloaded?A patient with AKI and hyperkalemia says they’re still peeing — does that rule out post-obstructive AKI?A patient arrives …

  22. #202 Dementia Part 2: Gray Matters Segment

    47 min

    Most clinicians see dementia medications on the med rec, but many of us aren’t sure how much they actually help. In this episode we break down donepezil, memantine, and the new anti-amyloid drugs, and when to …

  23. #201: Dementia Part 1: Gray Matters Segment

    46 min

    Cognitive decline is tough for all parties. What are the high-yield questions to ask? What should you add to your one-liner? When do you stop using MOCA and try to clearly describe their functional status? Do …

  24. #200: Insulin and QWINT-1 Trial in T2DM: Beyond Journal Club Segment with NEJM Group

    28 min

    From metformin to basal insulin to overlooked older medications, this episode reviews the T2D medication toolkit clinicians use every day. We then dive into new evidence on once-weekly insulin to help you …

  25. #199 Privacy & Confidentiality: At the Bedside Segment

    38 min

    Is patient confidentiality absolute or conditional? When does protecting privacy put others at risk? Can you follow a former patient in the EHR for learning? Should you post a compelling case online even if …

  26. #198 Microskills for Change That are Big Enough to Matter, Small Enough to Win

    29 min

    Baby alligators - those betrayals of purpose , or, death by a thousand paper cuts !Check out our latest episode, where Dr. Eileen Barrett walks us through how to tackle baby alligators with:Regulated …

  27. #197 Hypercoagulability Part 2: 5 Pearls Segment

    38 min

    Gray zones of VTE management! How to approach anticoagulation duration in unprovoked, provoked-irreversible, and provoked-reversible clots?When dose-reduced DOACs make sense for long-term secondary prevention? …

  28. #196 Stories of Courage and Career Development with Horn Award

    19 min

    We hope these stories resonate with anyone who has felt pulled between professional purpose and personal life, and remind you that you’re not alone in wanting both.🔹 Sponsor: Oakstone CMEUse the code "CORE30" …

  29. #195 Antibiotic Duration & BALANCE Trial: Beyond Journal Club with NEJM Group

    22 min

    Antibiotic duration for bacteremia is something most of us learned by habit, not by trial data. In this episode, we walk through the BALANCE trial and use it as a lens to revisit how 1) host, 2) organism, and …

    Show notes

    Antibiotic duration for bacteremia is something most of us learned by habit, not by trial data. In this episode, we walk through the BALANCE trial and use it as a lens to revisit how 1) host, 2) organism, and 3) source should guide treatment. When shorter really is enough, and when it isn’t?

    🔹 Sponsor: Oakstone CME

    Use the code "CORE30" for 30% off: https://www.coreimpodcast.com/MKSAP

    🔹 Transcript and Shownotes

    Timestamp

    (02:58) | Host, Organism, Source: The Core Framework Behind Duration

    (09:02) | How Evidence Shifted Practice

    (11:27) | The BALANCE Trial: Short-Course vs Standard-Course Therapy

    (18:55) | Where does this leave us?


    Tags: CoreIM, Internal Medicine, Infectious disease, Evidence-Based Medicine, Clinical Reasoning, Hospital Medicine, Medical Education



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    Our Sponsors:
    * Check out Eko: https://ekohealth.com
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    Advertising Inquiries: https://redcircle.com/brands

    Privacy & Opt-Out: https://redcircle.com/privacy
  30. #194: Severe Hypertriglyceridemia: 5 Pearls Segment

    38 min

    How quickly can triglycerides rise? At what threshold are patients at risk of pancreatitis or cardiovascular adverse outcomes? What do you have to rule out? How do you counsel on lifestyle changes? Which …

These are the latest 40 of 231 episodes. You’ll find older episodes in the podcast’s feed.

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