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From Our Neurons to Yours
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From Our Neurons to Yours

by Wu Tsai Neurosciences Institute at Stanford University, Nicholas Weiler

NewBrain development in the clinic and the classroom | Karen Parker & Jason Yeatman (with the Future of Everything podcast)November 6, 2026 · 32 min
Episodes
91
Released
every two weeks
Latest episode
Nov 6, 2026
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About the podcast

This award-winning show from Stanford’s Wu Tsai Neurosciences Institute is a field manual for anyone who wants to understand their own brain and the new science reshaping how we learn, age, heal, and make sense of ourselves.

Each episode, host Nicholas Weiler sits down with leading scientists to unpack big ideas from the frontiers of the field—brain-computer interfaces and AI language models; new therapies for depression, dementia, and stroke; the mysteries of perception and memory; even the debate over free will. You’ll hear how basic research becomes clinical insight and how emerging tech might expand what it means to be human. If you’ve got a brain, take a listen.

Episodes 91

  1. Brain development in the clinic and the classroom | Karen Parker & Jason Yeatman (with the Future of Everything podcast)

    32 minSeason 9 · Episode 21

    On today’s show, something special: a conversation we recorded live at our 13th Annual Symposium on “Building the Brain”. The event featured experts at the frontiers of brain development research asking …

    Show notes

    On today’s show, something special: a conversation we recorded live at our 13th Annual Symposium on “Building the Brain”.

    The event featured experts at the frontiers of brain development research asking questions like how much of our brain wiring is driven by genetics versus experience and whether we could use AI to understand the way infants naturally learn about the world around them. You can see some of these talks on our YouTube channel.

    Each year at the Symposium we also host a fireside chat where leading Stanford researchers help us take a step back and look at the state of the field as a whole.

    This year, we collaborated with The Future of Everything podcast and its host, bioengineer Russ Altman, to bring that conversation to you.

    Russ spoke onstage with Karen Parker, who studies how our brains – and those of other primates – develop socially. She’s been studying how hormones like oxytocin and vasopressin are linked to differences in social cognition and the implications for children with autism, and she’s been working to translate these basic science findings to clinical trials.

    Also on stage was Jason Yeatman, who studies how children learn to read and the challenges faced by kids with dyslexia. He’s developed online reading assessment tools and brought them to 1.2 million students at nearly 3,000 schools.

    While their individual work is different in approach, the conversation sheds light on the opportunities and obstacles researchers face in turning scientific discovery into real-world impact, whether in the clinic or the classroom.

    Learn more:

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  2. Predicting the brain: the Stanford Digital Brain Project | Dan Yamins & Russ Poldrack

    55 min

    This week, Wu Tsai Neuro launched the Stanford Digital Brain Project, an ambitious effort to build predictive models of the human brain.So today on the show, we’re bringing you two conversations to get you up …

    Show notes

    This week, Wu Tsai Neuro launched the Stanford Digital Brain Project, an ambitious effort to build predictive models of the human brain.

    So today on the show, we’re bringing you two conversations to get you up to speed on what this new initiative is and why it matters.

    First we’re going to revisit a conversation from last year with Wu Tsai Neuro Faculty Scholar Dan Yamins about the vision for building digital models of the brain. We talked about how such models would let neuroscientists test hypotheses about brain function or develop personalized interventions for brain diseases in a virtual environment far faster than can be done in the lab.

    Then, in the second half of the episode, we'll bring you a conversation with cognitive neuroscientist Russ Poldrack, one of the leaders of the new initiative, about what it's actually going to take to build this thing. We talk about the experiments now getting underway to capture the brain data that'll be needed to train these models, and why collecting this kind of data is already a remarkable scientific undertaking on its own, well before anyone actually builds a model out of it.

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  3. What an immune invasion teaches us about Alzheimer’s disease | Julia Belk

    46 min

    Today we’re going to be talking about a recent study that is rewriting neuroscience textbooks, potentially changing our understanding of Alzheimer’s disease, our brain’s immune system, and the potential for …

    Show notes

    Today we’re going to be talking about a recent study that is rewriting neuroscience textbooks, potentially changing our understanding of Alzheimer’s disease, our brain’s immune system, and the potential for immunotherapy for the brain.

    Today’s guest is Julia Belk, lead author of a new study that discovered that as we age, immune cells from the blood somehow cross the supposedly impenetrable blood–brain barrier, and replace the brain’s native immune cells, the microglia. The findings help us understand growing links between the aging immune system and Alzheimer’s disease and why certain blood mutations – ones traditionally linked to cancer – might actually protect against neurodegeneration.

    Julia is an HHMI Hannah Gray postdoctoral fellow in the lab of Sidd Jaiswal at Stanford Medicine. Their research was supported by the Knight Initiative for Brain Resilience at Wu Tsai Neuro.

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  4. What's on our brains: Behind the scenes of From Our Neurons to Yours

    30 minSeason 9 · Episode 18

    Today on the show we're doing something a little different.Quite different, actually. Nine seasons in, listeners might wonder: Why do we make this show? How do we prepare for it? What do we hope you get …

    Show notes

    Today on the show we're doing something a little different.

    Quite different, actually. Nine seasons in, listeners might wonder: Why do we make this show? How do we prepare for it? What do we hope you get out of it? What even is the Wu Tsai Neurosciences Institute?

    The idea has been brewing for a while, and this time we're doing it: From Our Neurons To Yours is taking you behind the scenes of From Our Neurons To Yours. Producer Michael Osborne joins host Nicholas Weiler to talk about where the show came from, how we get ready to bring you to the frontiers of neuroscience, and yes, what Wu Tsai Neuro is all about.



    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  5. How do our brains stay healthy as we age? | Tom Clandinin

    43 minSeason 9 · Episode 17

    Today on the show, we explore the complex biology underlying a seemingly straightforward question: How do our brains stay healthy – or not – as we age?There seems to be a constant flow of new secrets to healthy …

    Show notes

    Today on the show, we explore the complex biology underlying a seemingly straightforward question: How do our brains stay healthy – or not – as we age?

    There seems to be a constant flow of new secrets to healthy brain aging – inflammation, estrogen levels, how the brain clears out its waste. We've talked about many of these explanations on the show, and it can be easy to think that whatever the latest one is, that's the one. At least until the next one comes along.

    In reality, each of those things is probably part of a larger complex system that guides brain aging. But if that's the case, how do the parts fit together, and how do scientists figure out interventions that could slow or prevent neurodegeneration?

    That's a tricky challenge to be sure, but it's that challenge we're going to dive into with today's guest, neurobiologist Tom Clandinin.

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  6. Sugar on the brain | Carolyn Bertozzi

    52 minSeason 9 · Episode 16

    Today on the show, we bring you a conversation with Carolyn Bertozzi, the Baker Family Director of Sarafan ChEM-H and the Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences. Bertozzi …

    Show notes

    Today on the show, we bring you a conversation with Carolyn Bertozzi, the Baker Family Director of Sarafan ChEM-H and the Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences.

    Bertozzi is a Nobel Laureate, a MacArthur Fellow, and an all around cool person – although it didn't come up in the conversation, she used to play in a band with Rage Against the Machine's Tom Morello.

    Although Bertozzi wouldn’t call herself a neuroscientist — she’s a chemist at heart – her work is having a big impact on neuroscience. Today, she focuses on the sugar molecules that stud the outer surfaces of our cells. It turns out that these molecules are incredibly important for how cells communicate with each other. But understanding these molecules is so complex and challenging that Bertozzi had to invent a new branch of chemistry in order to study them. In this episode, we'll hear how this research is opening doors not only within neuroscience but across biology and drug development as well.

    Learn more

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  7. After Ozempic: the revolution in peptide science | Jonathan Long

    50 minSeason 9 · Episode 15

    Health influencers and scientists have both gone crazy for peptides. The peptide health craze stems from a lot of online hype — centered on gray-market compounds that haven't been rigorously tested in …

    Show notes

    Health influencers and scientists have both gone crazy for peptides.

    The peptide health craze stems from a lot of online hype — centered on gray-market compounds that haven't been rigorously tested in humans and aren't regulated for safety or purity. But among scientists, there is a genuine "revolution" underway — spurred by technological developments revealing an order of magnitude more peptides in our bodies than we ever realized, and by the unexpected and unparalleled success of GLP-1 drugs like Ozempic.

    To learn more about what’s driving this excitement – and how much of the peptide hype is really worth your attention – we spoke with Stanford biochemist Jonathan Long, an associate professor of pathology at Stanford Medicine, an affiliate of the Wu Tsai Neurosciences Institute, and an Institute Scholar of Stanford Sarafan ChEM-H.

    Editor's Note: After we went to press, Colorado biotech Enveda announced promising but early Phase 1 safety results for ENV-308, an oral drug engineered to mimic Lac-Phe — the "exercise in a pill" molecule Long's lab first characterized in 2022. The trial didn't test actual weight-loss or fitness effects, so the real thing isn't here yet — but Long, a scientific advisor to Enveda, calls it "an extremely exciting potential scientific breakthrough." Read more

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  8. Transcranial magnetic stimulation and the future of psychiatry | Corey Keller

    46 minSeason 9 · Episode 14

    Transcranial magnetic stimulation (TMS) is one of the most promising new technologies in psychiatry. Essentially, it allows us to reach inside the brain, stimulate it, and alter the brain circuits that go awry …

    Show notes

    Transcranial magnetic stimulation (TMS) is one of the most promising new technologies in psychiatry. Essentially, it allows us to reach inside the brain, stimulate it, and alter the brain circuits that go awry in disorders like depression.

    As the late Nolan Williams once explained, we've known for a long time that mental health disorders are caused by changes in electrical circuits in our brains, until TMS came along, we didn't had a good way of nudging those circuits back toward healthier function.

    But for all its promise, there is still much we don't understand about what exactly TMS is doing. We know it sends electromagnetic waves into the brain and changes the flow of electricity within. What we don't know is how it changes brain circuits and networks or why that helps treat depression, obsessive-compulsive disorder, or any of the other conditions where it's being used.

    Today's guest, Corey Keller, is dedicated to addressing that gap. He's been developing methods for recording inside the brain to help us understand how treatments like TMS change our brain circuits and address psychiatric disease.

    Learn more

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  9. How brain imaging is transforming mental health (finally) | Leanne Williams

    53 minSeason 9 · Episode 13

    Back in the 1950s, doctors didn't know a whole lot about the heart. If someone came in with chest pain, clinicians would ask a few questions, then take a stab at treating what might be heartburn or a heart …

    Show notes

    Back in the 1950s, doctors didn't know a whole lot about the heart. If someone came in with chest pain, clinicians would ask a few questions, then take a stab at treating what might be heartburn or a heart attack.

    That's where mental health care is today, according to today's guest, Leanne Williams.

    For example: you come into a psychiatrist’s office. The psychiatrist determines that you’ve experienced five or more depressive symptoms for at least two consecutive weeks and you get a diagnosis of major depressive disorder. Maybe you get prescribed some combination of therapy and medication. For some it works. For others it doesn’t. On average, finding an effective treatment for depression takes patients about 7 years – one of the reasons we’re in a mental health crisis.

    Williams says that the key issue is that psychiatry does not base its diagnoses or treatment plans on any direct test of the organ of interest: the brain. According to Leanne’s research, people with depression actually fall into clearly different categories, caused by changes in specific brain networks that can be seen using brain imaging. She’s shown that using this data can lead to much more targeted and effective therapies.

    Williams leads the Precision Mental Health Center at Stanford and is helming a new international task force that aims to create a road map for transforming mental health diagnosis and treatment based on biological data and brain imaging. We invited Leanne on the show to tell us about a sea change she sees happening in psychiatry.

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  10. Is chronic fatigue a gut-brain reflex? (Big Ideas in Neuroscience) | Julia Kaltschmidt

    36 minSeason 9 · Episode 12

    Why does being sick make you so exhausted – and why does that exhaustion sometimes outlast the illness itself? Today, neuroscientist Julia Kaltschmidt returns to the podcast to talk about the body's hidden …

    Show notes

    Why does being sick make you so exhausted – and why does that exhaustion sometimes outlast the illness itself? Today, neuroscientist Julia Kaltschmidt returns to the podcast to talk about the body's hidden "sickness reflex," the gut-brain circuitry behind it, and what those things might reveal about chronic fatigue.

    Kaltschmidt, a Wu Tsai Neurosciences Institute faculty scholar and professor of neurosurgery at Stanford Medicine, is an expert on the enteric nervous system — the gut's own semi-independent network of 200 to 600 million neurons. She's leading a new Big Ideas in Neuroscience project mapping out exactly how the body tells the brain it's sick, alongside Luis de Lecea, an expert in the brain circuitry of sleep, and Christoph Thaiss, who studies communication between the gut, the immune system, and the brain.

    The team believes that understanding the "reflex" of sickness fatigue could eventually lead to something patients with chronic fatigue and long COVID don't currently have: a real biomarker, and a path to treatment, for a condition that's too often been dismissed as "all in your head."

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  11. Is neurodegeneration a waste-management problem? | Monther Abu-Remaileh

    42 minSeason 9 · Episode 11

    For decades, the field focused on the plaques and tangles of misfolded proteins that show up in the brains of patients with Alzheimer’s, Parkinson’s and other disorders. The natural assumption was that if you …

    Show notes

    For decades, the field focused on the plaques and tangles of misfolded proteins that show up in the brains of patients with Alzheimer’s, Parkinson’s and other disorders. The natural assumption was that if you could design a drug to clear out that gunk, you could save the brain. But so far, that bet hasn't paid off.

    Now, researchers are taking a big step back and asking whether the plaques aren't a culprit, but rather a clue pointing to something more fundamental going wrong in our brain cells as we age? Put another way, why do our brains get jammed up with these junk proteins in the first place?

    Today’s guest, chemical engineer and geneticist Monther Abu-Remaileh, is one of the researchers working hard to answer that question. His research goes deep on a tiny cellular structure called the lysosome, little sacs filled with acid and enzymes that break down worn-out proteins and cellular debris. The lysosome is like a sustainable recycling center for a major city, managing waste streams, recycling raw materials, and coordinating with the rest of the cell to keep things running – and when it breaks down, the whole cell starts to fail.

    Among other accomplishments, Abu-Remaileh, a member of the Knight Initiative for Brain Resilience Steering Committee, has developed clever techniques for probing the lysosome that have put him at the frontier of a transformation in how we think about the lysosome, a transformation that could point the way to slow all manner of neurodegeneration – or even prevent it from happening in the first place.

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  12. A new precision neuroscience of language (Big Ideas in Neuroscience) | Cory Shain

    46 minSeason 9 · Episode 10

    Right now, as you're reading this sentence, something remarkable is happening in your brain. Light waves from your screen hit your eyes, transform into electrical signals, and take on meaning. You …

    Show notes

    Right now, as you're reading this sentence, something remarkable is happening in your brain. Light waves from your screen hit your eyes, transform into electrical signals, and take on meaning. You understand what you're reading. This is language — our human superpower.

    But despite 150 years of intensive research, we still do not have a complete picture of how the brain actually accomplishes all of this. We don't even have a good answer to a seemingly simple question: Where in the brain does language happen? It turns out, the answer may be different in different people.

    Today we'll hear from neuro-linguist Cory Shain, one of the leaders of a new Big Ideas in Neuroscience project here at Wu Tsai Neuro that is combining multiple brain recording techniques to build individualized maps of the language network—and use these insights to improve brain implants for people who've lost the ability to speak or write due to brain injury or illness.

    Learn more

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  13. How childhood (and Pokémon) shape how we see the world | Kalanit Grill-Spector

    46 minSeason 9 · Episode 9

    Today's episode is all about how childhood literally shapes the brain.Our most important experiences – from learning to read, to the growing complexity of our social lives at school, and even the video …

    Show notes

    Today's episode is all about how childhood literally shapes the brain.

    Our most important experiences – from learning to read, to the growing complexity of our social lives at school, and even the video games we play – leave physical traces in how our brains get organized that shape how we see the world as adults.

    But how does the brain actually know what parts of our lives are actually important enough to reorganize around? How do particular experiences get under the hood to leave their mark on the developing brain?

    Today's guest, Stanford psychology professor Kalanit Grill-Spector, has spent her career trying to answer these questions. She's has been imaging children's brains – from infants to teenagers – to watch this reorganization unfold. Her work focuses on how our visual experience as children shapes our brains and how we see the world – what she and her team have found is not always what they expected.

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  14. The FDA's psychedelic sea-change: what accelerated clinical trials for psilocybin, methylone, and ibogaine mean for mental health and neuroscience research | Boris Heifets

    46 minSeason 9 · Episode 8

    Last month we saw a big shift in the federal government’s approach to psychedelic medicine.Specifically, following an executive order by President Trump, the FDA announced it is fast-tracking its review of …

    Show notes

    Last month we saw a big shift in the federal government’s approach to psychedelic medicine.

    Specifically, following an executive order by President Trump, the FDA announced it is fast-tracking its review of several clinical trials of psychedelic drugs for patients with mental health disorders. The executive order also directed more funds towards psychedelic research and a review of psychedelics’ status as highly restricted Schedule 1 substances.

    To help us understand what all this means for the future of psychedelic medicine and the neuroscience of psychedelics, we’re joined by Boris Heifets, an anesthesiologist at Stanford Medicine who runs a lab studying how psychedelics affect the nervous system and their impact on patients with psychiatric conditions.

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  15. Will work for dopamine: why hard work motivates us | Neir Eshel

    43 minSeason 9 · Episode 7

    Today’s episode is about the neuroscience of hard work—or maybe more specifically, the value we place on hard work.There’s something different about hiking to the top of a mountain versus taking a helicopter …

    Show notes

    Today’s episode is about the neuroscience of hard work—or maybe more specifically, the value we place on hard work.

    There’s something different about hiking to the top of a mountain versus taking a helicopter. The view from the top is exactly the same, but if you’ve done the hard slog to get there, the payoff is going to be much more rewarding.

    The question is, how does the brain know the difference? To answer this, we need to take a deep dive into the brain’s reward system, and one of our favorite neurotransmitters, dopamine. And it turns out, the way dopamine operates is more complicated than we thought.

    Our guest today, Stanford Medicine psychiatrist Neir Eshel, tells us about new research that’s starting to reveal exactly how the brain pushes us to work hard for the things that matter to us.

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  16. Could Parkinson's start in the gut? | Kathleen Poston

    41 minSeason 9 · Episode 6

    Traditionally, we think of Parkinson's as a movement disorder—defined by slowed movement, stiff muscles, and involuntary shaking. But it turns out there are other symptoms that appear years or even decades …

    Show notes

    Traditionally, we think of Parkinson's as a movement disorder—defined by slowed movement, stiff muscles, and involuntary shaking. But it turns out there are other symptoms that appear years or even decades before movement problems bring patients to the clinic: sleep disturbances, chronic constipation, and loss of smell.

    For today's guest, these early symptoms represent an incredible opportunity to understand where Parkinson's begins and to identify patients much earlier in the disease.

    Kathleen Poston is a neurologist and division chief for movement disorders at Stanford Medicine. She's also a member of the steering committee for the Knight Initiative for Brain Resilience at Wu Tsai Neuro, and advises the Michael J. Fox Foundation and pharmaceutical companies on Parkinson's research.

    We discuss why non-motor symptoms might hold the key to early diagnosis, how new biomarkers are redefining the disease, and whether Parkinson's might actually start in the gut.

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    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  17. How see-through brains could transform neuroscience (Big Ideas in Neuroscience) | Guosong Hong

    36 minSeason 9 · Episode 5

    What if we could make the brain see-through? It sounds like science fiction, but it could revolutionize how we study the brain. Today on the show, we're talking with Guosong Hong, a faculty scholar here at …

    Show notes

    What if we could make the brain see-through?

    It sounds like science fiction, but it could revolutionize how we study the brain.

    Today on the show, we're talking with Guosong Hong, a faculty scholar here at the Wu Tsai Neurosciences Institute who has a unique reputation for developing creative techniques that literally shed light on the brain—from using fluorescent nanomaterials and focused ultrasound to create a virtual flashlight inside the skull, to discovering a common food dye that temporarily makes skin, muscle, and even parts of the brain transparent.

    Now, Guosong and colleagues are taking this work to the next level through a Wu Tsai Neuro Big Ideas grant, genetically engineering mice to have see-through brains from birth.

    Learn More

    Note: Episode transcript will be uploaded within 24-48 hours of publication

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  18. Could boosting gut–brain communication prevent memory loss? A tale of microbes, memory, and our internal senses | Christophe Thaiss

    43 minSeason 9 · Episode 4

    Our memories and senses are deeply connected—like how a favorite song can recreate a whole glorious teenage summer. It turns out this relationship might extend beyond our five external senses to include our …

    Show notes

    Our memories and senses are deeply connected—like how a favorite song can recreate a whole glorious teenage summer. It turns out this relationship might extend beyond our five external senses to include our internal senses: the signals telling us what's happening inside our bodies, sometimes beyond the veil of conscious perception.

    New research by Wu Tsai Neurosciences Institute affiliate Christoph Thaiss suggests that losing these internal signals as we age — in part due to changes in our gut microbiome — could one reason why our memories decline as we get older.

    Today we're talking with Thaiss about his new study in Nature that traces a surprising path from gut microbes to memory formation in the mouse brain.

    Learn More

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  19. Why do some of us age faster than others? | Claire Bedbrook and Ravi Nath

    38 minSeason 9 · Episode 3

    Today on the show, why do some of us age faster than others? Why do some of us grow old and die before our time while others seem to simply endure? And most of us have probably wondered at one point or another …

    Show notes

    Today on the show, why do some of us age faster than others? Why do some of us grow old and die before our time while others seem to simply endure? And most of us have probably wondered at one point or another, which track am I on?

    Turns out it might be possible to predict the whole trajectory of an animal's life at a surprisingly young age, just by looking closely at subtle patterns of behavior. That's the conclusion of a new study from researchers at the Knight Initiative for Brain Resilience here at Wu Tsai Neuro, out March 12, 2026 in the journal Science.

    The study focused on the African turquoise killifish, a little fish that lives fast and dies young. This species has one of the shortest lifespans of any vertebrate, which makes it ideal for studying the entire arc of a life in the laboratory setting.

    The important point here is that even short-lived killifish are dealt different lots by the fates. Even when you control for genetics and the environment, some killifish only live a month or two, while others can live as long as a year. So the big question is, what drives this difference in longevity?

    To learn more, we're joined today by the study's two lead researchers, Wu Tsai Neurosciences Institute Postdoctoral Scholars, Claire Bedbrook and Ravi Nath, who performed the research in the labs of Anne Brunet and Karl Deisseroth here at Stanford.

    Learn More


    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  20. A new neuroscience of pregnancy (Big Ideas in Neuroscience) | Nirao Shah & Katrin Svensson

    38 minSeason 9 · Episode 2

    We know shockingly little about what goes on in a mother’s brain during pregnancy.For example, we know only a handful of the hormones involved—out of hundreds scientists think may exist—and very little about …

    Show notes

    We know shockingly little about what goes on in a mother’s brain during pregnancy.

    For example, we know only a handful of the hormones involved—out of hundreds scientists think may exist—and very little about how they might impact the brain. This gap in our understanding is one of the reasons we don’t have great treatments for pregnancy-related maladies, whether it’s extreme nausea, or anxiety and depression.

    Closing this gap is the mission of the new Stanford Neuro-Pregnancy Initiative, part of the Wu Tsai Neurosciences Institute's Big Ideas in Neuroscience Program.

    Today on the show, we speak with initiative leaders Nirao Shah, a neuroscientist who studies sex differences in animal behavior, and Katrin Svensson is an expert in how our tissues use hormones to communicate in health and disease. Together with Longzhi Tan, an expert in gene regulation and 3d genome structure, the team aims to chart the cellular and molecular transformation that occurs in a mother's brain during pregnancy, in hopes of better understanding this fundamental event in a person's life and improving health outcomes for both mothers and infants.

    Learn more:

    References:

    • Hoekzema, E., et al. (2017) Pregnancy leads to long-lasting changes in human brain structure. Nat Neurosci 20, 287–296. This is the landmark neuroimaging study discussed in the episode that provided evidence of long-lasting, pregnancy-induced changes in the structure of the human brain.
    • Fejzo, M., et al. (2024) GDF15 linked to maternal risk of nausea and vomiting during pregnancy. Nature 625, 760–767. This recent paper provides strong evidence that the hormone GDF15 acts on the brainstem to cause nausea and vomiting in pregnancy.
    • Knoedler J, et al. A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell. 185, e1–e18 (2022). This is the work from Dr. Shah’s lab mentioned in the episode, identifying a specific circuit in the hypothalamus that changes its connectivity across the estrous cycle to control female mating behavior.
    • Ladyman S.R., et al. (2021) A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin eLife 10:e62260 This is the research mentioned from Dr. Grattan’s lab showing that the hormone prolactin acts on the hypothalamus to reduce locomotor activity and anxiety-like behavior in pregnant mice.

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  21. Why do our minds wander? What the brain's default mode tells us about our humanity | Vinod Menon

    48 minSeason 9 · Episode 1

    Here’s a question for you that may at first seem trivial, but is actually profound: Why do our minds drift? If you have ever dabbled in mindfulness or meditation, you know this mind wandering has an almost …

    Show notes

    Here’s a question for you that may at first seem trivial, but is actually profound: Why do our minds drift?

    If you have ever dabbled in mindfulness or meditation, you know this mind wandering has an almost gravitational pull. In fact, researchers now think we spend as much as 50 percent of our waking time in this state, which cognitive scientists have dubbed the brain’s “default mode.”

    Today’s guest is Vinod Menon. He’s a giant in the field of cognitive science who played a central role in defining the brain “default mode network” back in 2003.

    In our conversation, he argues our tendency to daydream may be at the core of our self-identities, our creativity – and also many of our most troubling psychiatric disorders, from Alzheimer’s to ADHD.

    Vinod Menon is Rachel L. and Walter F. Nichols, MD., Professor of Psychiatry & Behavioral Science at Stanford Medicine, and an affiliate of the Wu Tsai Neurosciences Institute.

    Learn More

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  22. Is Alzheimer's an energy crisis in the brain? Inflammation, metabolism and a new path in the search for cures | Kati Andreasson

    43 minSeason 8 · Episode 10

    For decades, Alzheimer's research has focused on clearing amyloid plaques from the brain. But new drugs that successfully remove plaques have proven clinically "underwhelming", leaving the field searching …

    Show notes

    For decades, Alzheimer's research has focused on clearing amyloid plaques from the brain. But new drugs that successfully remove plaques have proven clinically "underwhelming", leaving the field searching for alternative approaches.

    Stanford neurologist Katrin Andreasson has spent twenty years pursuing a different path—investigating how aging triggers an energy crisis in the brain's immune and support cells. Her work reveals that inflammation and metabolic dysfunction in microglia and astrocytes may be the real drivers of Alzheimer's pathology.

    Most remarkably, her recent research—supported by the Knight Initiative for Brain Resilience here at the Wu Tsai Neurosciences Institute—shows that targeting inflammation in the peripheral immune system—outside the brain entirely—can restore memory in mouse models of the disease.

    While human trials are still needed, Andreasson's findings offer fresh hope and demonstrate the critical importance of supporting curiosity-driven science, even when it challenges prevailing dogma.

    Learn More:

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  23. "The Emergent Mind: How Intelligence Arises in People and Machines" | Jay McClelland

    40 minSeason 8 · Episode 9

    The AI revolution of the past few years is built on brain-inspired neural network models originally developed to study our own minds. The question is, what should we make of the fact that our own rich mental …

    Show notes

    The AI revolution of the past few years is built on brain-inspired neural network models originally developed to study our own minds. The question is, what should we make of the fact that our own rich mental lives are built on the same foundations as the seemingly soulless chat-bots we now interact with on a daily basis?

    Our guest this week is Stanford cognitive scientist Jay McClelland, who has been a leading figure in this field since the 1980s, when he developed some of the first of these artificial neural network models. Now McClelland has a new book, co-authored with SF State University computational neuroscientist Gaurav Suri, called "The Emergent Mind: How Intelligence Arises in People and Machines."

    We spoke with McClelland about the entangled history of neuroscience and AI, and whether the theory of the emergent mind described in the book can help us better understand ourselves and our relationship with the technology we've created.

    Learn More

    New book sheds light on human and machine intelligence | Stanford Report

    How Intelligence – Both Human and Artificial – Happens | KQED Forum

    From Brain to Machine: The Unexpected Journey of Neural Networks | Stanford HAI

    Wu Tsai Neuro's Center for Mind, Brain, Computation and Technology

    McClelland, J. L. & Rumelhart, D. E. (1981). An interactive activation model of context effects in letter perception: Part 1. An account of basic findings. Psychological Review, 88, 375-407. [PDF]

    Rumelhart, D. E., McClelland, J. L., & the PDP research group. (1986). Parallel distributed processing: Explorations in the microstructure of cognition. Volumes I & II. Cambridge, MA: MIT Press.

    McClelland, J. L. & Rogers, T. T. (2003). The parallel distributed processing approach to semantic cognition. Nature Reviews Neuroscience, 4, 310-322. [PDF]

    McClelland, J. L., Hill, F., Rudolph, M., Baldridge, J., & Schuetze, H. (2020). Placing language in and integrated understanding system: Next steps toward human-level performance in neural language models. Proceedings of the National Academy of Sciences, 117(42), 25966-25974. [PDF]

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  24. Could brain implants read our thoughts? | Erin Kunz

    37 minSeason 8 · Episode 8

    Imagine what it’s like to lose your ability to speak. You know what you want to say, but the connection between your brain and the muscles that form words is no longer functioning. For people with conditions …

    Show notes

    Imagine what it’s like to lose your ability to speak. You know what you want to say, but the connection between your brain and the muscles that form words is no longer functioning. For people with conditions like ALS, or who experience a severe stroke, this is a devastating reality.

    Today's guest is Erin Kunz, a postdoctoral researcher in the Neural Prosthetics Translational Laboratory at Stanford, who is part of a global community of scientists working towards the vision of a brain–computer interface — or BCI — to bypass those broken circuits and restore the ability to speak to people with paralysis.

    We discuss how these BCIs work and the inspiring progress the tech has made in recent years, as well as the troubling question of whether a technology designed to decode what people intend to say from their brain activity could one day read out thoughts they never intended to communicate?

    Learn More


    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  25. NeuroForecasting: how brain activity can predict stock prices or viral videos | Brian Knutson

    40 minSeason 8 · Episode 7

    Neuroscientists have spent the past few decades tracing the network of brain systems—some deep and emotional, and others more analytical and deliberate— that work together as we make tough choices like where to …

    Show notes

    Neuroscientists have spent the past few decades tracing the network of brain systems—some deep and emotional, and others more analytical and deliberate— that work together as we make tough choices like where to invest our money as well as more everyday decisions like which videos to watch online—or, for that matter, which podcast to listen to.

    You can imagine that the ability to listen in on the brain systems that guide our choices might start to let scientists predict our decisions. But today's guest has taken this a step further, showing that measuring brain activity in just a few individuals can actually forecast widespread social behaviors, like which stock prices are likely to go up or down on the market, or which videos are likely to go viral.

    Join us as we talk with Brian Knutson, a professor of psychology in Stanford's School of Humanities and Sciences, about the frontiers of neuroeconomics, bridging psychology, economics, and neuroscience.

    Learn More

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  26. "Why Brains Need Friends: The Neuroscience of Social Connection" | Ben Rein

    39 minSeason 8 · Episode 6

    We are more isolated from one another than ever before — by our technology, by our political divides, and most of all, by our choices. This week on the show, we talk with neuroscientist Ben Rein about why this …

    Show notes

    We are more isolated from one another than ever before — by our technology, by our political divides, and most of all, by our choices.

    This week on the show, we talk with neuroscientist Ben Rein about why this social isolation is terrible for our health — implicated in not only rising rates of mental illness, but also heart disease, dementia and more.

    We discuss Ben's new book, "Why Brains Need Friends: The Neuroscience of Social Connection", published earlier this week, and try to work out a plan for an improved social diet to restore our brains — and our society — to good health.

    Learn More:

    ---

    We are honored to have won a silver Signal Award for best science and education podcast of 2025, as well as an audience choice award — thanks so much to everyone who voted for the show!

    ---

    We want to hear from your neurons! Email us at at [email protected]

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  27. From doodles to Descartes: sketching and the human cognitive toolkit | Judith Fan

    40 minSeason 8 · Episode 5

    Before the written word — and possibly even before speech — humans have communicated through drawing. From crude scratches in the dirt or on cave walls to the arcane symbology of the laboratory whiteboard, our …

    Show notes

    Before the written word — and possibly even before speech — humans have communicated through drawing. From crude scratches in the dirt or on cave walls to the arcane symbology of the laboratory whiteboard, our instinct for conveying our thoughts visually is pretty extraordinary.

    We see or understand something in the world, we build an idea in our mind of what we think we see, and then using our hand and the utensil we re-create it to communicate the share our perception with others. Along the way, we add in our own understanding and experience to craft that communication in ways that might not correspond with a specific object in the world at all.

    How we do this — and how we can learn to be better visual communicators — is at the heart of our conversation with Judy Fan, who runs the Cognitive Tools Lab in Stanford University's Department of Psychology.

    We've been nominated for a 2025 Signal Award for Best Science & Education Podcast! Vote for us in the "Listener's Choice" category by October 9.

    Learn More:

    • Cognitive Tools Lab, Stanford Department of Psychology
    • Fan, J., et al. (2023) "Drawing as a versatile cognitive tool." Nature Reviews Psychology. (pdf)
    • Hawkins, R., Sano, M., Goodman, N., and Fan, J. (2023). Visual resemblance and interaction history jointly constrain pictorial meaning. Nature Communications. [pdf]
    • Fan, J., et al. (2020). Relating visual production and recognition of objects in human visual cortex. Journal of Neuroscience. [pdf]
    • Fan, J., Yamins, D., and Turk-Browne, N. (2018). Common object representations for visual production and recognition. Cognitive Science. [pdf]
    • More recent papers

    We want to hear from your neurons! Email us at at [email protected]

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  28. What is psychosis? Navigating an altered reality | Jacob Ballon & Shannon Pagdon

    46 minSeason 8 · Episode 4

    Imagine if you couldn't distinguish between dreams and reality. If you couldn't tell whether what you were seeing or hearing was really there in front of you. What if you discovered you couldn't …

    Show notes

    Imagine if you couldn't distinguish between dreams and reality. If you couldn't tell whether what you were seeing or hearing was really there in front of you. What if you discovered you couldn't trust your own perceptions?

    Psychosis is something three out of every a hundred people will experience at some point in their lifetimes. But what exactly is it, and is it something people can learn to live with?

    Today we're fortunate to have on the show Dr. Jacob Ballon, the founding co-director of Stanford Medicine's Inspire Clinic, and Shannon Pagdon, a doctoral student, peer counselor, and advocate for those living with psychosis.

    Learn More:

    We want to hear from your neurons! Email us at at [email protected]

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

  29. "I Heard There Was a Secret Chord: Music as Medicine" | Daniel Levitin

    46 minSeason 8 · Episode 3

    Most of us can agree: music is awesome. Regardless of which songs speak to you, music probably plays an important role in your life. The question is, what makes music so powerful? Why does a particular …

    Show notes

    Most of us can agree: music is awesome. Regardless of which songs speak to you, music probably plays an important role in your life. The question is, what makes music so powerful? Why does a particular combination of sounds and rhythms grab us and affect us in the way that it does? And is it true that music can help heal patients with Alzheimer's, Parkinson's, PTSD, chronic pain, and more?

    To help us understand what we're learning about the neuroscience of music and how it can heal and enrich our lives, we're speaking with Daniel Levitin. He's a musician and a producer as well as a neuroscientist and bestselling author. His newest book is "I Heard There was a Secret Chord: Music As Medicine."

    Learn More:

    We want to hear from your neurons! Email us at at [email protected]

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

    Chapters (16)

  30. How we learn to read (and why some struggle): what neuroscience teaches us about a transformative human technology | Bruce McCandliss

    39 minSeason 8 · Episode 2

    In this episode, we explore the fascinating neuroscience behind how children learn to read with Bruce McCandliss, director of the Stanford Educational Neuroscience Initiative.Key topics include:• How our brains …

    Show notes

    In this episode, we explore the fascinating neuroscience behind how children learn to read with Bruce McCandliss, director of the Stanford Educational Neuroscience Initiative.

    Key topics include:
    • How our brains "recycle" visual and language circuits to create reading expertise
    • The crucial threshold when reading shifts from effortful to automatic
    • Why some children struggle more than others to develop reading fluency
    • How teachers can tailor instruction to help struggling readers
    • The profound ways literacy reshapes our brains and cognition

    Join us for a mind-expanding look at one of humanity's most transformative technologies - written language - and how mastering it quite literally changes our brains.

    Learn More

    Recent Academic Articles & News Coverage

    We want to hear from your neurons! Email us at at [email protected]

    Send us a text!

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    We want to hear from your neurons! Email us at at [email protected]

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

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