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PsychRounds: The Psychiatry Podcast

PsychRounds: The Psychiatry Podcast

NewA Validity-Based Diagnostic Hierarchy with Dr. Mark Ruffalo and Dr. Ronald PiesNovember 4, 2026 · 54 min
Episodes
121
Released
every two weeks
Latest episode
Nov 4, 2026

About the podcast

Welcome to Psych Rounds, the podcast tailored for psychiatry residents and students. Join us, three psychiatric resident physicians, as we delve into quick insights, interviews, and practical tips essential for educational practice. Subscribe for a straightforward yet informal approach to psychiatric knowledge. Contact us: [email protected] Instagram: https://www.instagram.com/psychrounds/

Episodes 121

  1. A Validity-Based Diagnostic Hierarchy with Dr. Mark Ruffalo and Dr. Ronald Pies

    54 min

    Today, we welcome back a former guest, Dr. Mark Ruffalo, and joining him is his colleague and co-author, Dr. Ronald Pies. We will be discussing their recently published article, The Need For A Validity-Based …

    Show notes

    Today, we welcome back a former guest, Dr. Mark Ruffalo, and joining him is his colleague and co-author, Dr. Ronald Pies. We will be discussing their recently published article, The Need For A Validity-Based Hierarchy In DSM-6.


    Article: https://pubmed.ncbi.nlm.nih.gov/42908074/

    Dr. Ruffalo Website: https://www.drruffalo.com/

    Dr. Pies Psychiatric Times Profile: https://www.psychiatrictimes.com/authors/ronald-w-pies-md

  2. A New Long-Acting Injectable: Olanzapine (Zyprexa) Weltruza

    25 min

    Today, we're covering the recent FDA approval of a new Olanzapine long-acting injectable - Weltruza.References: https://pubmed.ncbi.nlm.nih.gov/41632432/https://pubmed.ncbi.nlm.nih.gov/42198294/https://www.tevap …

    Show notes

    Today, we're covering the recent FDA approval of a new Olanzapine long-acting injectable - Weltruza.


    References:

    https://pubmed.ncbi.nlm.nih.gov/41632432/

    https://pubmed.ncbi.nlm.nih.gov/42198294/

    https://www.tevapharm.com/news-and-media/latest-news/new-long-term-safety-data-from-the-completed-phase-3-solaris-trial-support-the-potential-of-olanzapine-la/


  3. Pharmacogenetic Testing in Psychiatry

    22 min

    Welcome back, everyone! We’re back after PRITE, and today we’re discussing pharmacogenetic testing.

  4. GLP-1 Agonists (Ozempic, Wegovy) in Psychiatry

    33 min

    Today, we will discuss GLP-1's and the emerging use of this class of medications in psychiatry.Sources:https://pubmed.ncbi.nlm.nih.gov/42247271/https://pmc.ncbi.nlm.nih.gov/articles/PMC11441540/https://jamanetwo …

    Show notes
  5. Landmark Studies: The STAR*D Trial

    28 min

    We resume our landmark studies series looking at the pivotal study in Major Depressive Disorder (MDD), The STAR*D (Sequenced Treatment Alternatives to Relieve Depression) …

    Show notes

    We resume our landmark studies series looking at the pivotal study in Major Depressive Disorder (MDD), The STAR*D (Sequenced Treatment Alternatives to Relieve Depression) trial.


    References:

    https://pubmed.ncbi.nlm.nih.gov/12778843/

    https://pubmed.ncbi.nlm.nih.gov/19880458/

    https://jamanetwork.com/journals/jamapsychiatry/fullarticle/482026

    https://pubmed.ncbi.nlm.nih.gov/15061154/

    https://pubmed.ncbi.nlm.nih.gov/20370962/

    https://pubmed.ncbi.nlm.nih.gov/37491091/



  6. Dogs in Mental Health with Dr. Nancy Gee: A Biopsychosocial Approach

    55 min

    We have a special guest today to talk about one of our favorite topics... dogs! Most people might intuitively say that they feel like their dogs improve their mental health, but today, we look at the science …

    Show notes

    We have a special guest today to talk about one of our favorite topics... dogs! Most people might intuitively say that they feel like their dogs improve their mental health, but today, we look at the science with the leading expert on the subject.


    Dr. Nancy Gee Profile: https://medschool.vcu.edu/about/portfolio/details/geen2/


    References:

    Dogs Supporting Human Health and Well-Being: A Biopsychosocial Approach:

    https://pubmed.ncbi.nlm.nih.gov/33860004/

    Randomized Controlled Trials: https://pmc.ncbi.nlm.nih.gov/articles/PMC12728353/, https://pmc.ncbi.nlm.nih.gov/articles/PMC11714157/


  7. Centanafadine (Simtriyo): A New Medication for ADHD

    28 min

    Welcome back! Today, we are talking about Simtriyo, which has generated a lot of media attention recently given a newly minted FDA approval for ADHD.References …

    Show notes
  8. Landmark Studies: The CATIE Trial

    22 min

    Today we're starting a new type of series - looking at some of the most seminal studies in psychiatry. We're going to start with the CATIE Trial, which was published in 2005. References …

    Show notes
  9. The Rising Use of Recreational Kratom

    21 min

    Apologies for our little hiatus - a couple of us had cross-country moves in June. But we're back! Today we have an episode on the rising use of recreational Kratom and pertinent tidbits to know from a …

    Show notes

    Apologies for our little hiatus - a couple of us had cross-country moves in June. But we're back! Today we have an episode on the rising use of recreational Kratom and pertinent tidbits to know from a psychiatry standpoint.


    References:


  10. Modafinil (Provigil)

    20 min

    Welcome back! Today, we are looking at Modafinil and it's nuanced use in psychiatry.References:Provigil (modafinil) [prescribing information]. North Wales, PA: Teva Pharmaceuticals USA, Inc. U.S. Food and Drug …

    Show notes

    Welcome back! Today, we are looking at Modafinil and it's nuanced use in psychiatry.


    References:

    1. Provigil (modafinil) [prescribing information]. North Wales, PA: Teva Pharmaceuticals USA, Inc. U.S. Food and Drug Administration. Available at: https://www.accessdata.fda.gov/drugsatfdadocs/label/2015/020717s037s038lbl.pdf

    2. Schwartz JR. Modafinil in the treatment of excessive sleepiness. Drug Des Devel Ther. 2009;2:71–85.

    3. Kaplan S, Goehring EL Jr, Engel T, et al. Cardiovascular outcomes associated with modafinil in patients with obstructive sleep apnea. Pharmacoepidemiol Drug Saf. 2018;27(11):1182–1190. doi:10.1002/pds.4642

    4. Cortese S, Adamo N, Del Giovane C, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2018;5(9):727–738. doi:10.1016/S2215-0366(18)30269-4

    5. Goss AJ, Kaser M, Costafreda SG, Sahakian BJ, Fu CH. Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials. J Clin Psychiatry. 2013;74(11):1101–1107. doi:10.4088/JCP.13r08560

    6. Bahji A, Mesbah-Oskui L. Comparative efficacy and safety of stimulant-type medications for depression: a systematic review and network meta-analysis. J Affect Disord. 2021;292:416–423. doi:10.1016/j.jad.2021.05.119

    7. Nunez NA, Singh B, Jorgensen A, et al. Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: a meta-analysis of randomized controlled trials. Bipolar Disord. 2020;22(2):109–120. doi:10.1111/bdi.12859

  11. Naltrexone

    16 min

    Welcome Back! Today we are discussing the medication Naltrexone and its uses in psychiatry. References: https://www.ncbi.nlm.nih.gov/books/NBK534811/https://pubmed.ncbi.nlm.nih.gov/24825644/https://pubmed.ncbi.n …

    Show notes

    Welcome Back! Today we are discussing the medication Naltrexone and its uses in psychiatry.


    References:


  12. Placebo Effect and Response in Psychiatry

    22 min

    Welcome back! Today, we will be discussing the placebo effect.References:https://pubmed.ncbi.nlm.nih.gov/16503356/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003660/https://www.ncbi.nlm.nih.gov/pmc/articles/PM …

    Show notes
  13. Amantadine (Symmetrel)

    17 min

    Welcome back! Today we are talking all about Amantadine, and it's uses in psychiatry.

  14. VMAT2 Inhibitors: Valbenazine (Ingrezza) and Deutetrabenazine (Austedo)

    17 min

    Welcome back! Today we are featuring the two FDA-approved medications for tardive dyskinesia, the VMAT2 inhibitors Valbenazine (Ingrezza) and Deutetrabenazine (Austedo). References …

    Show notes

    Welcome back! Today we are featuring the two FDA-approved medications for tardive dyskinesia, the VMAT2 inhibitors Valbenazine (Ingrezza) and Deutetrabenazine (Austedo).


    References:

    https://pubmed.ncbi.nlm.nih.gov/41626799/

    https://www.ncbi.nlm.nih.gov/books/NBK548187/

    https://pubmed.ncbi.nlm.nih.gov/41626799/


  15. A DSM Conversation with Dr. Allen Frances

    56 min

    We are back with another special guest episode! Please welcome Dr. Allen Frances, who was intricately involved in the formation of both the DSM III and DSM IV, the latter of which he served as …

    Show notes

    We are back with another special guest episode! Please welcome Dr. Allen Frances, who was intricately involved in the formation of both the DSM III and DSM IV, the latter of which he served as chair.


    https://x.com/AllenFrancesMD

    https://www.amazon.com/stores/author/B001HO76FU

    https://www.psychiatrictimes.com/authors/allen-frances-md


  16. Topiramate (Topamax)

    15 min

    Welcome back! Today we will be doing a brief episode on Topiramate [Topamax], and its clinical uses in psychiatry.References:https://pubmed.ncbi.nlm.nih.gov/21438989/https://pubmed.ncbi.nlm.nih.gov/18774432/http …

    Show notes
  17. What Makes Something a Psychiatric Illness? Featuring Dr. Mark Ruffalo, MSW, DPsa

    55 min

    Welcome back, today we are discussing a deceptively difficult topic: What makes something a psychiatric illness? We are joined by our guest Dr. Mark Ruffalo. He is a psychotherapist in private practice in …

    Show notes

    Welcome back, today we are discussing a deceptively difficult topic: What makes something a psychiatric illness? We are joined by our guest Dr. Mark Ruffalo. He is a psychotherapist in private practice in Tampa, FL, and who also serves as Assistant Professor of Psychiatry at the University of Central Florida College of Medicine as well an Adjunct Assistant Professor of Psychiatry at Tufts University School of Medicine.

    Dr. Ruffalo's Website: https://www.drruffalo.com/

    Dr. Ruffalo's LinkedIn: https://www.linkedin.com/in/mark-l-ruffalo-71929063

    PRISM: https://www.psychiatrictimes.com/view/use-of-the-prism-diagnostic-instrument-in-clinical-practice

    PRISM Writing Contest: https://www.psychiatrictimes.com/view/prism-writing-contest-more-on-this-new-diagnostic-tool-from-mark-ruffalo-msw-dpsa

  18. Lorazepam (Ativan)

    14 min

    Welcome back! Today we are at the highly prescribed and popular benzodiazepine Lorazepam, also known as Ativan. We look at its uses in psychiatry, especially catatonia. But despite anecdotal efficacy, does the …

    Show notes

    Welcome back! Today we are at the highly prescribed and popular benzodiazepine Lorazepam, also known as Ativan. We look at its uses in psychiatry, especially catatonia. But despite anecdotal efficacy, does the evidence hold up?


    References:

  19. The Vitamin Series: Iron Deficiency in Psychiatry

    25 min

    Welcome back! Today we are embarking into the first of hopefully several episodes on the importance of vitamins and minerals in mental health. We will specifically be looking at the role of iron deficiency in …

    Show notes
  20. Nutritional Psychiatry with Dr. Laura Lachance

    49 min

    Welcome back! Today our topic is Nutritional Psychiatry and we've invited a special guest - Dr. Laura Lachance, who has done extensive research in the field. Along with Dr. Drew Ramsey, she has published a …

    Show notes

    Welcome back! Today our topic is Nutritional Psychiatry and we've invited a special guest - Dr. Laura Lachance, who has done extensive research in the field. Along with Dr. Drew Ramsey, she has published a paper looking at an Antidepressant Food Score or AFS and more recently, she was a part of the EASe-GAD trial, a study looking at the impact of omega-3 fatty acids on anxiety.


    Antidepressant Food Scale (AFS): https://pubmed.ncbi.nlm.nih.gov/30254980/

    EASe-GAD Trial: https://pubmed.ncbi.nlm.nih.gov/39316026/

    Gluten and Psychosis: https://pubmed.ncbi.nlm.nih.gov/24368154/

    Nutrition Worksheet for Patients: https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-021-03575-7

    Dr. Lachance's Instagram: https://www.instagram.com/preventivepsychiatry/

  21. Stress, Culture, and Determinism with Dr. Robert Sapolsky

    1 h 3 min

    Welcome back! Today, we are hosting the highly accomplished Dr. Robert Sapolsky, PHD, a professor of professor of biology, neurology, and neurosurgery at Stanford University. He has had extensive research …

    Show notes

    Welcome back! Today, we are hosting the highly accomplished Dr. Robert Sapolsky, PHD, a professor of professor of biology, neurology, and neurosurgery at Stanford University. He has had extensive research particularly in the field of neuroendocrinology and chronic stress, which has acted as one of the foundations of modern psychoneuroendocrinology. He is also a research associate at the Institute of Primate Research in Kenya, with over 30 years of field research in Africa. He is also a renowned author, with major works including but not at all limited to Why Zebras Don’t Get Ulcers, Behave: The Biology of Humans at Our Best and Worst, and most recently, Determined: A Science of Life Without Free Will, which challenges us to reconsider free will, morality, and mental health itself through a scientific lens.

    More about Dr. Sapolsky: https://en.wikipedia.org/wiki/Robert_Sapolsky

    Dr. Sapolsky's Open Stanford Course: https://www.youtube.com/watch?v=-PpDq1WUtAw&list=PL848F2368C90DDC3D

    Dr. Sapolsky's Books: https://www.amazon.com/stores/author/B000APOCFE

    Dr. Sapolsky's Own Podcast:

    Spotify: https://open.spotify.com/show/0wDrkkznSB8S84kKuK9HCo

    Apple: https://podcasts.apple.com/us/podcast/robert-sapolsky-father-offspring-interviews/id1782280922

  22. SSRIs Revisited: The 100th Episode

    33 min

    One hundred episodes later, let’s take it back to one of our very first, the Selective Serotonin Reuptake Inhibitors - with a much-needed update. Thank you to our guests, fans, and listeners.References …

    Show notes

    One hundred episodes later, let’s take it back to one of our very first, the Selective Serotonin Reuptake Inhibitors - with a much-needed update. Thank you to our guests, fans, and listeners.


    References:




  23. Alprazolam (Xanax)

    15 min

    Welcome back! Today we have a very special episode on Alprazolam, brand-name Xanax. This benzodiazepine is one of the most commonly-prescribed and sought out psychotropic medications …

    Show notes

    Welcome back! Today we have a very special episode on Alprazolam, brand-name Xanax. This benzodiazepine is one of the most commonly-prescribed and sought out psychotropic medications.


  24. Climate Change and Mental Health with Dr. Ferdnand Osuagwu

    35 min

    Join us today for an episode on the impact of climate change on mental health. We'll be exploring concepts like eco-anxiety, advocacy, the impact of nuclear war and practical tips. We're joined by guest Dr …

    Show notes

    Join us today for an episode on the impact of climate change on mental health. We'll be exploring concepts like eco-anxiety, advocacy, the impact of nuclear war and practical tips.

    We're joined by guest Dr. Ferdnand Osuagwu, who was the former Chair of the Caucus on Climate Change and Mental Health of the American Psychiatric Association (APA) and founder of the Ferdnand Foundation International, an organization dedicated to underserved and marginalized populations and with a particular emphasis on addressing their needs in the areas of health, education, climate change, social justice and resource mobilization.


    Ferdnand Foundation Website: https://ferdnandfoundation.org/

    Ferdnand Foundation Youtube Channel: https://www.youtube.com/@FerdnandFoundation/featured

  25. Introduction to Benzodiazepines

    22 min

    Today, we are talking about a very popular, yet controversial class of medications - the Benzodiazepines . Let's look at their mechanism of action, clinical indications, pharmacology, risks, withdrawal …

    Show notes
  26. Introduction to Anxiety Disorders

    26 min

    Welcome to an introductory episode on anxiety disorders as requested by a long-time listener. References:https://pmc.ncbi.nlm.nih.gov/articles/PMC5832062/https://pmc.ncbi.nlm.nih.gov/articles/PMC5573565/https:// …

    Show notes
  27. Loxapine (Loxitane) Revisited with Dr. Jonathan Meyer

    24 min

    Join us as we talk about Loxapine, an older medication that’s stood the test of time and found a niche in psychiatric practice. This is a revision of an earlier episode, after Dr. Bradley Miller chatted with …

    Show notes

    Join us as we talk about Loxapine, an older medication that’s stood the test of time and found a niche in psychiatric practice. This is a revision of an earlier episode, after Dr. Bradley Miller chatted with Dr. Jonathan Meyer at the 2025 APA Conference. Dr. Meyer joins us at the beginning to provide an addendum to the original episode.

  28. Pregabalin (Lyrica)

    14 min

    Welcome back! Today, we will be talking about Pregabalin, brand-name Lyrica, a similar medication to Gabapentin, and we will specifically be focusing on its use in psychiatry. What are its benefits and …

    Show notes

    Welcome back! Today, we will be talking about Pregabalin, brand-name Lyrica, a similar medication to Gabapentin, and we will specifically be focusing on its use in psychiatry. What are its benefits and drawbacks compared to Gabapentin?


    Sources:

    - https://pubmed.ncbi.nlm.nih.gov/33563173/

    - https://pubmed.ncbi.nlm.nih.gov/39989902/

    - https://pmc.ncbi.nlm.nih.gov/articles/PMC3699256/

    - https://pubmed.ncbi.nlm.nih.gov/33563173/


  29. Gabapentin (Neurontin)

    20 min

    Welcome back! Today, we will be talking about Gabapentin, brand-name Neurontin, one of the most commonly-prescribed medications in the United States, and we will specifically be focusing on its use in …

    Show notes

    Welcome back! Today, we will be talking about Gabapentin, brand-name Neurontin, one of the most commonly-prescribed medications in the United States, and we will specifically be focusing on its use in psychiatry. It is commonly prescribed for anxiety disorders, alcohol use disorder, and sometimes even bipolar disorder! But what does the evidence say?


    Sources:

  30. Trauma and The Neurosequential Model of Therapeutics with Dr. Bruce Perry

    1 h 1 min

    Welcome back! Today, we have renowned guest Dr. Bruce Perry, one of the world's most influential child psychiatrists, to talk to us about his approach to trauma. We will go over Dr. Perry's Neurosequential …

    Show notes

    Welcome back! Today, we have renowned guest Dr. Bruce Perry, one of the world's most influential child psychiatrists, to talk to us about his approach to trauma. We will go over Dr. Perry's Neurosequential Model of Therapeutics, which integrates neuroscience with child development. Dr. Perry is also a respected author, co-writing books like The Boy Who Was Raised As a Dog, Born for Love: Why Empathy is Essential and Endangered, as well as What Happened to You? Conversations on Trauma, Resilience and Healing.


    Dr. Perry's Website: https://www.bdperry.com/

    Dr. Perry's Books: https://www.amazon.com/Books-Bruce-Perry/s?rh=n%3A283155%2Cp_27%3ABruce%2BPerry

    Dr. Perry's Youtube Channel: https://www.youtube.com/@infonmn326

These are the latest 40 of 121 episodes. You’ll find older episodes in the podcast’s feed.

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