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Amy Proal on rethinking chronic disease

October 22, 2025 · 53 min

Show notes

What if chronic diseases, from Alzheimer’s to autoimmune conditions, share a hidden cause: lingering infections deep within our tissues?


Microbiologist Amy Proal, co-founder of the PolyBio Research Foundation, joins host Allison Duettmann to discuss how persistent pathogens could drive inflammation, aging, and many chronic illnesses, and why our current “autoimmunity” model might be missing the root cause.


They explore PolyBio’s groundbreaking work collecting rarely studied tissue samples, the link between viruses and Alzheimer’s, the rise of long COVID, and simple tools, like clean indoor air, that could prevent future pandemics. Amy also outlines an optimistic vision: strengthening, not suppressing, the immune system to build a healthier, more resilient civilization.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.


Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts


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