The Human Upgrade: Biohacking for Longevity & Performance

1. Immortal Jellyfish, Fructose & Cancer, Cleaner Air for Blood Sugar, Carbon Dioxide for Alzheimer's, and More : 1573

   13 novembre 202611 minÉpisode 1573À suivre

   Scientists Test Carbon Dioxide Exposure To Help Clear Alzheimer's-Related Proteins From The BrainResearchers at the University of New Mexico are investigating whether intermittent exposure to carbon …

   Notes de l’épisode

   Scientists Test Carbon Dioxide Exposure To Help Clear Alzheimer's-Related Proteins From The Brain

   Researchers at the University of New Mexico are investigating whether intermittent exposure to carbon dioxide-enriched air can stimulate the brain's glymphatic waste-clearance system and increase the movement of proteins associated with Alzheimer's disease into the bloodstream. In a preliminary human experiment involving 12 participants, alternating between ordinary air and air containing 5% CO2 for approximately 30 minutes produced rhythmic changes in cerebral blood vessels, followed by temporary increases in blood levels of amyloid-beta. Participants with signs of cognitive decline also showed a tau-related response. The findings, reported in July 2026, build on a 2025 study published in npj Parkinson's Disease demonstrating that intermittent carbon dioxide exposure stimulated cerebrospinal fluid movement and increased circulating levels of several neurodegeneration-related proteins. Although these results suggest a potential method for influencing brain waste transport, they do not establish that Alzheimer's plaques were removed or cognitive function improved. Host Dave Asprey explores carbon dioxide signaling, vasomotion, cerebral blood flow, glymphatic clearance, and the relationship between deep sleep and brain detoxification, examining whether controlled vascular stimulation could eventually support new approaches to protecting long-term brain health.

   Sources:

   New Scientist: Inhaling High-Dose CO2 Clears Alzheimer's Proteins From The Brain

   2025 Peer-Reviewed Study: The Influence Of Intermittent Hypercapnia On Cerebrospinal Fluid Flow And Clearance

   ~~~

   
   

   Bedroom Air Purifiers Reduce Blood Sugar Fluctuations By Nearly 8% In Human Trial

   Researchers at NYU Langone Health found that improving bedroom air quality produced measurable improvements in glucose regulation among adults with prediabetes. In a randomized, double-blind clinical trial involving 150 participants, four weeks of HEPA air filtration reduced indoor fine particulate pollution (PM2.5) by 36%, lowered glucose variability by 7.7%, and reduced post-breakfast glucose excursions by 16.6% compared with sham filtration. Presented at the American Heart Association's Scientific Sessions in November 2026, the findings suggest that airborne pollutants may influence metabolic health and blood sugar stability, even in environments with relatively modest pollution levels. Although researchers have not established whether these improvements translate into reduced diabetes risk or long-term cardiovascular benefits, the trial provides evidence that modifying environmental exposures can affect glucose regulation without introducing a new dietary intervention or medication. Host Dave Asprey explores the relationship between indoor air pollution, inflammation, insulin signaling, continuous glucose monitoring, and metabolic flexibility, explaining why bedroom air filtration may represent an overlooked opportunity for improving metabolic health and reducing environmental stress.

   Sources:

   NYU Langone Health: Cleaner Bedroom Air May Help Manage Blood Sugar In Prediabetes

   ~~~

   
   

   Scientists Discover How The Immortal Jellyfish Can Reverse Its Own Development

   Scientists studying Turritopsis dohrnii, commonly known as the immortal jellyfish, are uncovering the molecular mechanisms behind its extraordinary ability to reverse from an adult jellyfish into an earlier developmental stage and eventually produce new adults. An October 2026 BBC feature highlights research into the species' unusual cellular plasticity, including the ability of specialized adult tissues to undergo reprogramming and contribute to new developmental structures. A 2022 genomic study published in Proceedings of the National Academy of Sciencesidentified differences involving DNA replication and repair, telomere maintenance, oxidative stress regulation, stem-cell populations, and genes associated with cellular reprogramming. Unlike animals that simply regenerate damaged body parts, this jellyfish can reorganize its adult body and restart its developmental cycle, offering researchers an unusual biological model for investigating rejuvenation. Although the findings do not demonstrate that human aging can be reversed using the same mechanisms, they raise important questions about the future of regenerative medicine. Host Dave Asprey explores cellular reprogramming, epigenetic regulation, DNA repair, telomere biology, tissue regeneration, and biological age reversal, examining whether mechanisms found in nature could eventually help restore damaged tissues, rejuvenate aging organs, and improve the body's capacity for cellular repair.

   Sources:

   BBC: The Immortal Jellyfish Can Beat Ageing. It Could Inspire Treatments For Diseases Of Old Age

   PNAS: Comparative Genomics Of Mortal And Immortal Cnidarians Unveils Novel Keys Behind Rejuvenation

   ~~~

   
   

   Researchers Discover Fructose Can Help Ovarian Cancer Cells Spread Through A Surprising Metabolic Mechanism

   Researchers at The Wistar Institute discovered that chemotherapy-surviving ovarian cancer cells can release fructose that helps neighboring cancer cells detach and spread through a previously unrecognized metabolic mechanism. Published in Nature Aging in July 2026, the research found that senescent cells, sometimes called zombie cells, released fructose as part of their senescence-associated secretory phenotype (SASP), altering mitochondrial complex I activity and signaling involving NAD+, sirtuins, and SREBP. These changes reduced cholesterol in cancer-cell membranes, weakened cellular adhesion, and increased metastatic dissemination in experimental models. Researchers also observed more extensive metastatic disease in mice receiving a high-fructose diet compared with glucose-fed controls, although the findings do not establish that dietary fructose causes cancer metastasis in humans. The research highlights how senescent cells can influence surrounding tissues through metabolic signaling rather than simply promoting inflammation or uncontrolled cell growth. Host Dave Asprey examines fructose metabolism, cellular senescence, mitochondrial function, cancer-cell signaling, and the tumor microenvironment, exploring why the metabolic activity of chemotherapy-surviving cells could become an important target for future cancer treatments and longevity research.

   Sources:

   Nature Aging: Original Research On Fructose, Cellular Senescence, And Ovarian Cancer Dissemination

   ~~~

   
   

   Brain Imaging Study Finds Higher Intelligence Linked To Less Dense Neural Wiring

   Neuroscientists examining brain scans and cognitive performance in 757 adults discovered that higher reasoning scores were associated with lower estimates of cortical neurite density and branching complexity, despite a positive relationship between reasoning performance and overall cortical volume. Published in Nature Communications in 2018, the study analyzed two independent groups using advanced diffusion MRI to investigate how microscopic brain architecture relates to intelligence. The findings suggest that neural efficiency may depend partly on more selective organization of neural circuitry, potentially reducing redundant signaling and supporting effective information processing. Researchers also discussed synaptic pruning, the brain's natural process of eliminating unnecessary connections, as a possible contributor to more efficient neural networks. However, the study measured indirect imaging markers rather than counting individual synapses, and it did not establish that reducing brain connections improves intelligence. Host Dave Asprey explores neural efficiency, neuroplasticity, synaptic pruning, brain energy consumption, cognitive performance, and information processing, explaining why the organization of neural networks may matter as much as their overall size or complexity.

   Sources:

   Nature Communications: Diffusion Markers Of Dendritic Density And Arborization In Gray Matter Predict Differences In Intelligence

   
   

   This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners interested in Alzheimer's prevention, brain detoxification, metabolic health, cellular rejuvenation, cancer metabolism, and cognitive optimization. Host Dave Asprey examines research on intermittent carbon dioxide exposure and glymphatic clearance, HEPA air filtration and blood sugar regulation, the immortal jellyfish's unusual cellular reprogramming abilities, fructose-driven ovarian cancer dissemination, and the relationship between neural architecture and intelligence. The discussion explores how environmental exposures, cellular signaling, mitochondrial metabolism, DNA repair, and brain organization influence human biology, translating emerging scientific discoveries into practical considerations for improving cognitive performance, supporting metabolic health, and understanding the future of regenerative medicine and longevity.

   
   

   New episodes every Tuesday, Thursday, Friday, and Sunday.

   
   

   Keywords: carbon dioxide Alzheimer's, CO2 brain clearance, glymphatic system Alzheimer's, amyloid beta clearance, tau protein clearance, intermittent hypercapnia, cerebrospinal fluid flow, vasomotion, brain detoxification, Alzheimer's prevention, HEPA air purifier blood sugar, bedroom air quality glucose, PM2.5 metabolic health, air pollution insulin resistance, prediabetes glucose variability, continuous glucose monitoring, immortal jellyfish, Turritopsis dohrnii, jellyfish reverse aging, cellular reprogramming, biological age reversal, epigenetic rejuvenation, DNA repair longevity, telomere maintenance, regenerative medicine, fructose ovarian cancer, fructose cancer metastasis, senescent cells cancer, cellular senescence, zombie cells, cancer metabolism, mitochondrial complex I, NAD+ sirtuins, neural efficiency intelligence, dendritic density, synaptic pruning, neuroplasticity, brain connections intelligence, cognitive optimization, Dave Asprey, The Human Upgrade, biohacking news 2026

   
   

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   Timestamps

   00:00

2. The Hidden Health Warnings in Your Poop (And Why You Should Look) | Chloe Melas : 1572

   12 novembre 20261 h 8 minÉpisode 1572À suivre

   Get Chloe's book The Girl’s Guide To Guts at thegirlsguidetoguts.com Gut microbiome, stool testing, colon cancer warning signs, ulcerative colitis, chronic constipation, fiber, inflammation, digestive health …

   Notes de l’épisode

   Get Chloe's book The Girl’s Guide To Guts at thegirlsguidetoguts.com 

   
   

   Gut microbiome, stool testing, colon cancer warning signs, ulcerative colitis, chronic constipation, fiber, inflammation, digestive health, and the connection between gut bacteria and biological aging. 

   
   

   Host Dave Asprey sits down with Chloe Melas, NBC journalist and author of The Girl's Guide to Guts, to explore what your poop reveals about your health, the gut microbiome, chronic inflammation, colon cancer warning signs, digestive disorders, and the connection between gut bacteria and longevity. After living with ulcerative colitis for 15 years, Chloe shares her experience navigating chronic constipation, abnormal bowel movements, repeated antibiotic treatments, and a healthcare system that often overlooked the role of nutrition, lifestyle, and gut health. 

   
   

   Chloe explains why your stool can serve as a daily health report card, revealing potential warning signs that deserve attention. She describes spending more than a decade without normal bowel movements, regularly checking for blood in her stool, and struggling with symptoms that many people mistakenly associate only with diarrhea. Dave and Chloe examine the differences between irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), Crohn's disease, and ulcerative colitis, along with the importance of recognizing changes in bowel habits. They also discuss the rise of colorectal cancer in younger adults, including Chloe's account of a woman whose rectal bleeding was initially attributed to hemorrhoids before she received a stage three colon cancer diagnosis. 

   
   

   The conversation explores how fiber, gut bacteria, and the microbiome influence digestive health and biological aging. Chloe describes how incorporating psyllium husk and other fibers into her routine coincided with a dramatic improvement in her symptoms and five years of remission. Dave explains how different types of dietary fiber interact with gut bacteria, why microbial diversity matters, and how stool testing can reveal information about the microorganisms living in your digestive tract. They discuss soluble fiber, prebiotics, resistant starch, polyphenols, methane-associated digestive issues, and the challenges of identifying which foods and supplements work best for an individual's gut. 

   
   

   Finally, Dave and Chloe examine the future of personalized gut health, microbiome testing, and unconventional digestive therapies. They explore fecal microbiota transplantation, experimental parasite-based treatments, the potential influence of environmental exposures, and the relationship between gut health, inflammation, and the brain. Chloe reflects on the importance of advocating for yourself, asking better questions, and recognizing that persistent digestive symptoms should not simply be accepted as normal. Together, they make the case for paying closer attention to bowel habits, understanding your microbiome, and taking a more proactive approach to long-term digestive health. 

   
   

   You'll Learn: 

   • What your poop, bowel movement patterns, and stool appearance can reveal about digestive health and potential warning signs 
   • Why blood in your stool, persistent constipation, and changes in bowel habits deserve medical attention, including their possible connection to colorectal cancer 
   • How ulcerative colitis, Crohn's disease, IBS, and IBD differ, and why digestive disorders don't always cause diarrhea 
   • How gut microbiome diversity relates to inflammation, metabolism, and biological aging, and what stool testing can and cannot reveal 
   • Why different types of fiber, including psyllium husk, resistant starch, and soluble prebiotic fibers, can affect digestion differently 
   • How antibiotics, diet, stress, and other lifestyle factors may influence gut bacteria and digestive symptoms 
   • What fecal microbiota transplantation and experimental microbiome therapies could mean for the future of digestive health 
   • Why tracking bowel movements, recognizing abnormal symptoms, and advocating for better medical care can help you take control of your gut health 

   
   

   Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

   
   

   New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

   
   

   Keywords: Chloe Melas, Dave Asprey, The Girl's Guide to Guts, poop, stool health, bowel movements, gut health, gut microbiome, microbiome diversity, stool testing, gut bacteria, biological aging, longevity, colon cancer, colorectal cancer, colon cancer symptoms, blood in stool, rectal bleeding, ulcerative colitis, inflammatory bowel disease, IBD, irritable bowel syndrome, IBS, Crohn's disease, chronic constipation, digestive disorders, digestive inflammation, gut brain axis, vagus nerve, fiber, dietary fiber, psyllium husk, soluble fiber, prebiotics, resistant starch, polyphenols, methane, antibiotics, gut dysbiosis, H. pylori, fecal microbiota transplant, FMT, parasite therapy, helminth therapy, personalized medicine, biohacking, digestive health, disease prevention 

   
   

   Resources: 

   • Get Chloe's book The Girl’s Guide To Guts at thegirlsguidetoguts.com 

   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

   • Danger Coffee: https://dangercoffee.com/discount/davetube 

   • My Daily Supplements: SuppGrade Labs (15% Off) 

   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

   
   

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   Timestamps:  

   00:00 - Trailer 

   01:05 - Living With Hidden Illness 

   06:38 - Antibiotics and Her Diagnosis 

   13:26 - Fiber Changed Everything 

   24:17 - Breaking the Bowel Taboo 

   31:15 - Hypermobility and Inflammation 

   37:35 - Sunlight and Red Light 

   43:38 - Raising Health-Conscious Kids 

   48:59 - Discussing Colon Cancer Risk 

   54:00 - Mold and Gut Health 

   01:01:11 - Exploring Fecal 

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3. Why Your Brain Craves Things That Make You Miserable | Luke Storey : 1571

   10 novembre 20261 h 7 minÉpisode 1571À suivre

   Get your copy of Luke’s new book: A Horse Named Lonesome https://ahorsenamedlonesome.com The Neuroscience of Addiction, Breaking Bad Habits, Childhood Trauma, Psychedelic Healing, Loneliness & Emotional …

   Notes de l’épisode

   Get your copy of Luke’s new book: A Horse Named Lonesome https://ahorsenamedlonesome.com 

   
   

   The Neuroscience of Addiction, Breaking Bad Habits, Childhood Trauma, Psychedelic Healing, Loneliness & Emotional Recovery 

   
   

   Host Dave Asprey sits down with Luke Storey, host of The Life Stylist Podcast and author of A Horse Named Lonesome, to explore the science of addiction, loneliness, childhood trauma, emotional healing, psychedelics, brain chemistry, and the surprising relationship between human connection and happiness. Drawing on nearly three decades of recovery from drug addiction, Luke explains why overcoming substance abuse doesn't necessarily resolve the emotional patterns behind it, how unresolved trauma can shape relationships and behavior, and why having fewer, deeper friendships may lead to greater fulfillment. 

   
   

   Luke shares his journey from childhood trauma and early substance use to long-term sobriety, revealing why he continued struggling with codependency, unhealthy relationships, and self-destructive patterns even after 20 years without addictive drugs. He discusses his controversial decision to explore ayahuasca and other psychedelics after two decades of sobriety, the emotional breakthroughs he experienced, and the importance of distinguishing personal healing experiences from approaches that may be appropriate for others. Dave and Luke examine the relationship between addiction, trauma, altered states of consciousness, meditation, and the brain's ability to change entrenched behavioral patterns. 

   
   

   The conversation turns to nicotine, dopamine, cravings, and the biology of addiction. Luke describes his experience with heavy nicotine use, dependence, and the cognitive and emotional challenges of stopping abruptly. Dave explores how nicotine delivery methods influence habitual behavior, the distinction between dependence and addiction, and the potential roles of mitochondrial function, cellular energy, ketones, and GLP-1 signaling in cravings and self-control. They also discuss modafinil, nootropics, NAD therapies, and how changing your physical and mental state can influence behavior, focus, and emotional regulation. 

   
   

   Dave and Luke also examine the hidden costs of obsessive self-improvement and health optimization. Luke reflects on periods when pursuing physical health and personal development became disconnected from the deeper purpose of living a meaningful life. They discuss the difference between healthy ambition and compulsive self-improvement, why physical performance alone cannot guarantee emotional well-being, and how relationships, purpose, and spiritual practices contribute to a more fulfilling life. 

   
   

   Finally, Luke introduces his new book, A Horse Named Lonesome, and explores why people can feel profoundly lonely even when surrounded by others. He shares how childhood isolation shaped his understanding of connection, why solitude and loneliness are fundamentally different experiences, and how reducing superficial relationships helped him develop a smaller circle of meaningful friendships. Dave and Luke discuss how trauma, negative thought patterns, and emotional disconnection can interfere with intimacy, and why cultivating genuine relationships may be one of the most important investments in long-term happiness and well-being. 

   
   

   You'll Learn: 

   • Why overcoming addiction doesn't always resolve the childhood trauma, emotional patterns, and relationship difficulties that contributed to it 
   • How Luke approached psychedelics after 20 years of sobriety, and what his experiences taught him about trauma and emotional healing 
   • How nicotine dependence, dopamine signaling, and habitual behaviors influence cravings, focus, and self-control 
   • Why mitochondrial health, cellular energy, ketones, and GLP-1 signaling are being explored in connection with addictive behaviors 
   • How meditation, breathwork, psychedelics, and other altered states may influence emotional regulation and entrenched patterns of thinking 
   • Why obsessive biohacking and self-improvement can interfere with happiness, relationships, and a meaningful life 
   • How childhood loneliness and unresolved trauma can affect adult relationships, intimacy, and emotional connection 
   • Why having fewer close friends may be more fulfilling than maintaining a large network of superficial relationships 
   • How to distinguish healthy solitude from harmful isolation and build deeper, more authentic human connections 

   
   

   Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

   
   

   New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

   
   

   Keywords: Luke Storey, Dave Asprey, A Horse Named Lonesome, The Life Stylist Podcast, loneliness, friendship, fewer friends, happiness, human connection, addiction recovery, sobriety, childhood trauma, emotional healing, psychedelics, ayahuasca, ibogaine, nicotine, dopamine, cravings, addiction neuroscience, brain chemistry, mitochondria, ketones, GLP-1, modafinil, NAD, meditation, breathwork, altered states, codependency, self-improvement, biohacking, emotional health, mental health, relationships, solitude, personal growth, longevity 

   
   

   Resources: 

   • Get your copy of Luke’s new book: A Horse Named Lonesome https://ahorsenamedlonesome.com 

   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

   • Danger Coffee: https://dangercoffee.com/discount/davetube 

   • My Daily Supplements: SuppGrade Labs (15% Off) 

   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

   
   

   Thank you to our sponsors!      

   - OneSkin| For a limited time try the new OS-01 FACE RICH CREAM with 15% off at oneskin.co/DAVE. 

   - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. 

   - Puori | Use my code DAVE at P-U-O-R-I dot com slash D-A-V-E for 32% off Puori Fish Oil when you start a subscription. That’s puori.com slash DAVE, and use code DAVE at checkout. 

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   Timestamps:  

   00:00 - Trailer 

   00:55 - Luke’s Road to Recovery 

   06:33 - Psychedelics and Sobriety 

   13:52 - Ayahuasca and Childhood Trauma 

   20:30 - Bad Trips  

   25:59 - Surrender  

   31:16 - Nicotine, Dependence, and Withdrawal 

   40:43 - Nootropics 

   47:24 - Biohacking Meets Spirituality 

   57:11 - A Horse Named Lonesome 

   01:04:37 - Being Lonely 

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4. 15 Minutes Every Morning Kills Insulin Belly Fast : 1570

   8 novembre 202617 minÉpisode 1570À suivre

   There's a 15 minute habit you can do every morning that kills insulin belly. That's the fat packed around your organs. It drains into your liver, forces your body to make more insulin, and insulin locks your …

   Notes de l’épisode

   There's a 15 minute habit you can do every morning that kills insulin belly. That's the fat packed around your organs. It drains into your liver, forces your body to make more insulin, and insulin locks your fat cells shut so nothing can get out.

   
   

   I know because 20 years ago I was 31, weighed 300 pounds, and my doctor told me my blood looked like sludge and I was headed for a heart attack. So I did exactly what he said. I trained six days a week, 90 minutes a day, for 18 months. My waist stayed at 46 inches.

   
   

   Today that waist is gone. So is my arthritis, my brain fog, and my pre-diabetes. And it didn't start with a diet or a workout. It started with light.

   
   

   In this video I'll show you two ways to test whether you have insulin belly (one takes 10 seconds and costs nothing), why a standard blood sugar test misses it for years, and the three levers that reversed mine.

   
   

   You'll Learn:

   • What “insulin belly” is and why visceral fat poses different risks than fat under your skin
   • Why you can be “thin outside, fat inside”—and which measurements reveal more than BMI
   • What research on red light suggests about blood sugar and mitochondrial function
   • Why Dave prioritizes morning sunlight and a dark bedroom at night
   • Dave’s three timing rules for meals and movement to support insulin sensitivity
   • How cold exposure, brown fat, and gut bacteria may influence metabolic health
   • What Dave learned going from a 46-inch waist to a 32-inch waist

   
   

   
   

   Timestamps:

   00:00 - What Is Insulin Belly?

   03:03 - Two Tests Beyond BMI

   04:35 - Red Light, Blood Sugar & Mitochondria

   06:10 - Dave’s 15-Minute Morning Routine

   10:12 - Lever One: Morning Light & Dark Nights

   11:20 - Lever Two: Meal & Exercise Timing

   13:25 - Lever Three: Cold Exposure & Gut Health

   15:19 - Blue Light: Why Timing Matters

   
   

   Thank you to our sponsors!

   -KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off

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   -Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighs or top sirloins in every box for a year with free shipping always.

   -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

   
   

   Connect with Dave Asprey!

   
   

   Website: https://daveasprey.com

   TikTok: https://www.tiktok.com/@daveaspreyofficial

   Instagram: https://www.instagram.com/dave.asprey/

   Facebook: https://www.facebook.com/Daveaspreyofficial/

   X: https://x.com/daveasprey

   YouTube: https://www.youtube.com/c/daveaspreybpr

   
   

   The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

   
   

   Try TrueDark glasses: https://truedark.com

   Try Danger Coffee: https://dangercoffee.com/discount/davetube

   Try Suppgrade Labs: https://shopsuppgradelabs.com/

   Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

   Join my Substack: https://substack.daveasprey.com

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   40 Years of Zen: https://40yearsofzen.com

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5. Brain-Cleaning Beds, Forever Chemicals, Peptide Freedom, Coffee for Your Heart, and More : 1568

   6 novembre 202610 minÉpisode 1568À suivre

   Scientists Test Vibrating Mattress To Help Clear Alzheimer's-Related Proteins From The Brain Researchers at the University of Oulu in Finland tested a vibrating mattress combined with nitroglycerin, a …

   Notes de l’épisode

   Scientists Test Vibrating Mattress To Help Clear Alzheimer's-Related Proteins From The Brain 

   Researchers at the University of Oulu in Finland tested a vibrating mattress combined with nitroglycerin, a blood-vessel-relaxing drug, in 29 healthy adults and found that blood levels of amyloid-beta 42 increased approximately 35% following the combined treatment. Published in Nature Communications, the study also identified MRI changes suggesting altered cerebrospinal fluid dynamics, potentially involving the glymphatic system and mechanosensitive Piezo1 ion channels. While the results suggest increased movement of brain-associated proteins into circulation, they do not establish that Alzheimer's plaques were removed or that cognition improved. Host Dave Asprey explores the potential of mechanical stimulation, nitric oxide signaling, and brain waste clearance as emerging approaches to neurodegenerative disease prevention, and why sleep and vascular health remain essential to protecting long-term cognitive performance. 

   Sources: 

   https://doi.org/10.1038/s41467-026-78894-y 

   ~~~

   
   

   Yale Researchers Discover Taurine Controls A Key Inflammatory Switch Linked To Aging 

   Yale researchers identified a previously unrecognized role for taurine in regulating the NLRP3 inflammasome, an immune signaling complex associated with chronic inflammation and biological aging. Published in Cell, the research found that activated macrophages released up to 80% of their intracellular taurine, while restoring taurine suppressed inflammatory signaling. Surprisingly, circulating taurine levels were higher in older adults than younger adults, challenging the assumption that taurine universally declines with age and highlighting the importance of intracellular nutrient regulation. Host Dave Asprey examines the connection between taurine, inflammaging, immune function, and longevity, explaining why cellular nutrient availability may matter more than blood concentrations and what this emerging mechanism means for supplementation and inflammation management. 

   Sources: 

   https://doi.org/10.1016/j.cell.2026.09.061 

   ~~~

   
   

   Blood And Plasma Donation Shown To Reduce Forever Chemicals In Human Trial 

   A randomized clinical trial involving 285 Australian firefighters found that regular blood and plasma donation significantly reduced circulating concentrations of certain PFAS, the persistent environmental pollutants commonly known as forever chemicals. Published in JAMA Network Open, the study found that plasma donation every six weeks reduced average PFOS concentrations by 2.9 ng/mL over 12 months, compared with a 1.1 ng/mL reduction from whole-blood donation every 12 weeks and virtually no change in the control group. Because PFAS bind to proteins in blood, removing plasma offers a direct method of reducing circulating chemical concentrations, although the trial did not establish long-term health benefits. Host Dave Asprey explains why this physical removal strategy deserves attention alongside conventional detoxification approaches, and how reducing exposure through drinking water, food packaging, and environmental sources remains a critical first step. 

   Sources: 

   https://doi.org/10.1001/jamanetworkopen.2022.6257 

   ~~~

   
   

   HHS Eases Restrictions On Six Popular Biohacking Peptides Including BPC-157 And MOTS-c 

   On October 28, 2026, the Department of Health and Human Services announced a draft enforcement-discretion policy covering six compounded peptides: BPC-157, Epitalon, KPV, MOTS-c, Semax, and TB-500. Under the interim approach, HHS says it does not intend to take enforcement action against qualifying compounders when specific manufacturing, sourcing, formulation, labeling, and adverse-event reporting conditions are satisfied, while the FDA's formal regulatory evaluation continues. The announcement represents a significant shift for compounds being investigated or promoted for tissue repair, inflammation, mitochondrial function, cognitive performance, and longevity, although none received FDA approval through this action. Host Dave Asprey discusses what the policy could mean for peptide access, pharmaceutical regulation, product purity, and medical oversight, and why better manufacturing standards must accompany expanded access to experimental therapies. 

   Sources: 

   https://www.federalregister.gov/d/2026-22192 

   https://www.hhs.gov/sites/default/files/hhs-503a-peptide-enforcement-discretion-policy-appendix-b.pdf 

   https://www.foley.com/insights/publications/2026/10/peptides-hhs-announces-limited-enforcement-discretion-for-compounding-of-six-peptides/ 

   ~~~

   
   

   Drinking Coffee Linked To 39% Lower Recurrence Hazard Of Atrial Fibrillation In Clinical Trial 

   A randomized clinical trial published in JAMA found that patients assigned to drink at least one cup of caffeinated coffee daily experienced fewer recurring episodes of atrial fibrillation or atrial flutter following electrical cardioversion than patients assigned to avoid caffeinated beverages. The six-month DECAF trial followed 200 adults and found arrhythmia recurrence in 47% of coffee drinkers compared with 64% of participants assigned to abstinence, corresponding to a 39% lower recurrence hazard in the time-to-event analysis. The findings challenge routine recommendations to avoid coffee among patients with existing atrial fibrillation, although the trial did not establish whether caffeine, coffee polyphenols, or associated behaviors produced the benefit. Host Dave Asprey explores caffeine's effects on cardiovascular function, adenosine signaling, and inflammation, explaining why individualized responses matter more than blanket dietary restrictions. 

   Sources: 

   https://doi.org/10.1001/jama.2025.21056 

   
   

   This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners interested in Alzheimer's prevention, brain detoxification, immune aging, environmental toxins, peptide therapies, and cardiovascular optimization. Host Dave Asprey examines emerging research on glymphatic clearance, taurine and the NLRP3 inflammasome, PFAS removal through plasma donation, changing federal peptide regulations, and coffee's surprising relationship with atrial fibrillation, translating complex science into practical considerations for protecting cognitive function, reducing inflammation, and improving long-term health. 

   
   

   New episodes every Tuesday, Thursday, Friday, and Sunday. 

   
   

   Keywords: vibrating mattress brain detox, glymphatic system Alzheimer's, amyloid beta clearance, nitric oxide brain health, Piezo1 mechanosensitive channels, taurine inflammaging, NLRP3 inflammasome, taurine immune cells, Yale taurine study, chronic inflammation aging, PFAS forever chemicals, plasma donation PFAS removal, blood donation detox, PFOS reduction, BPC-157 peptide regulations, HHS peptide policy 2026, MOTS-c, Epitalon, KPV peptide, Semax, TB-500, FDA peptide compounding, coffee atrial fibrillation, DECAF clinical trial, caffeine heart health, cardiovascular longevity, Dave Asprey, The Human Upgrade, biohacking news 2026 

   
   

   Thank you to our sponsors!  

   - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighs or top sirloins in every box for a year with free shipping always 

   - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE 

   - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 

   - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. 

   
   

   Resources:   

   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

   • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

   • Danger Coffee: https://dangercoffee.com/discount/dave15   

   • My Daily Supplements: SuppGrade Labs (15% Off)   

   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   

   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

   • Upgrade Labs: https://upgradelabs.com   

   
   

   Timestamps: 

   00:00 - Intro 

   00:18 - Vibrating Mattress & Brain Clearance 

   01:54 - Taurine & Inflammation 

   03:17 - PFAS & Plasma Donation 

   05:26 - HHS Peptide Policy 

   07:32 - Coffee & Atrial Fibrillation 

   09:10 - Outro 

   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6. How to Get Really Good at Anything: The 3 Ingredients of Mastery | Roman Tsunder : 1569

   5 novembre 202659 minÉpisode 1569À suivre

   Get Roman Tsunder's book and learn more at https://pttow.com/ How to Master Any Skill, the Science of Peak Performance, Obsession, Deep Focus, Finding Your Purpose, Overcoming Failure, and Achieving Success …

   Notes de l’épisode

   Get Roman Tsunder's book and learn more at https://pttow.com/ 

   
   

   How to Master Any Skill, the Science of Peak Performance, Obsession, Deep Focus, Finding Your Purpose, Overcoming Failure, and Achieving Success Without Burnou 

   
   

   Host Dave Asprey sits down with Roman Tsunder, entrepreneur, founder of PTTOW!, and author of Plan to Take On the World, to explore the three ingredients of mastery, peak performance, obsession, deep focus, flow states, overcoming fear, and achieving success without sacrificing your health. Drawing on decades of experience bringing together influential entrepreneurs, creative leaders, and world-class performers, Roman reveals what separates people who become exceptional at their craft from those who struggle to reach their potential. 

   
   

   Roman introduces his OHF framework: Obsession, Hours, and Focus, explaining why these three ingredients consistently appear among people who achieve extraordinary results. Through examples including legendary surfer Kelly Slater, music producer Steve Aoki, and other high performers, he examines the difference between healthy obsession and compulsive ambition, why sustained practice matters, and what he calls "blackout focus." Dave challenges whether relentless dedication is always necessary and explores how some exceptionally successful people achieve mastery through curiosity, enjoyment, and flow rather than constant struggle. 

   
   

   The discussion turns to finding your purpose and developing a genuine passion for what you do. Roman explains why purpose may be easier to recognize through feelings of energy, excitement, and expansion than through intellectual analysis alone. He introduces practical approaches for identifying meaningful work, including revisiting childhood interests, recognizing recurring patterns of curiosity, and exploring what he calls a "shadow career." Dave and Roman discuss how reducing energy-draining responsibilities and spending more time on activities that naturally engage your attention can support both performance and fulfillment. 

   
   

   Finally, they examine failure, rejection, resilience, and the psychology of achievement. Roman recounts receiving 73 rejection letters from 72 Wall Street firms before pursuing a different entrepreneurial path. He explains how rejection can create unexpected opportunities and why the ability to recover from setbacks is essential to long-term success. Dave explores the connection between childhood adversity and ambition, the role of vulnerability in leadership, and how to distinguish productive challenges from destructive patterns of overwork. 

   
   

   You'll Learn: 

   • How Roman's Obsession, Hours, and Focus framework explains the habits behind exceptional performance and mastery 
   • Why healthy obsession differs from compulsive grinding, and how to pursue ambitious goals without sacrificing your health 
   • How deep focus, sustained practice, and flow states contribute to developing expertise in almost any field 
   • Why chronic stress and fight-or-flight activation can undermine performance, recovery, and long-term well-being 
   • How breathwork, meditation, and nervous system regulation may help manage fear and improve performance under pressure 
   • How to identify your purpose through personal interests, energizing activities, childhood experiences, and unexplored career ambitions 
   • Why failure, rejection, vulnerability, and resilience play important roles in personal growth, leadership, and long-term achievement 

   
   

   Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

   
   

   New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

   
   

   Keywords: Roman Tsunder, Dave Asprey, PTTOW, Plan to Take On the World, mastery, skill mastery, peak performance, obsession, healthy obsession, deep focus, blackout focus, deliberate practice, high achievement, success habits, flow state, finding purpose, personal growth, motivation, discipline, burnout, chronic stress, fight or flight, nervous system regulation, breathwork, meditation, Transcendental Meditation, Joe Dispenza, fear, resilience, overcoming failure, rejection, childhood trauma, leadership, entrepreneurship, productivity, mental performance, biohacking, longevity 

   
   

   Resources: 

   • Get Roman Tsunder's book and learn more at https://pttow.com/ 

   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

   • Danger Coffee: https://dangercoffee.com/discount/davetube 

   • My Daily Supplements: SuppGrade Labs (15% Off) 

   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

   
   

   Thank you to our sponsors!      

   - Beyond Biohacking 2027 | Register with code DAVE for a discount https://beyondconference.com  

   - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE  

   - Caldera+Lab | If you're looking for one simple product that actually makes a difference, that's The Great, visit CalderaLab.com/DAVE and use code DAVE for 20% off your first order.  

   - Fatty15 | Go to fatty15.com/DAVE to get an additional 15% off their 90-day Starter Kit. 

   
   

   Timestamps:  

   00:00 - Trailer 

   01:02 - Intro 

   03:00 - The OHF Framework 

   10:07 - Talent, Genetics & Luck 

   15:30 - Grinding vs. Flow 

   20:00 - Fear as Fuel 

   24:57 - Breathwork & Healing 

   30:00 - Health & Corporate Awakening 

   36:00 - Lies Successful People Tell 

   43:00 - Finding Your Purpose 

   52:40 - Failure & Rejection 

   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7. The Truth About Vitamins, Supplements & Prescription Drugs | Phil Cowley : 1567

   3 novembre 20261 h 8 minÉpisode 1567À suivre

   Triquetra Discount: Use code Dave20 at Triquetrahealth.com/dave Multivitamin Mistakes, MTHFR Genetics, B Vitamins, Creatine & Prescription Drug Risks Host Dave Asprey sits down with Phil Cowley, a pharmacist …

   Notes de l’épisode

   Triquetra Discount: Use code Dave20 at Triquetrahealth.com/dave 

   
   

   Multivitamin Mistakes, MTHFR Genetics, B Vitamins, Creatine & Prescription Drug Risks 

   
   

   Host Dave Asprey sits down with Phil Cowley, a pharmacist, founder of Cache Valley Pharmacy, and creator of Phil's My Pharmacist, to explore multivitamins, prescription medications, supplement effectiveness, MTHFR genetics, methylated B vitamins, creatine, and the hidden problems within modern healthcare. 

   
   

   After opening his pharmacy in Logan, Utah, in 2001, Phil spent two decades serving patients and dispensing millions of prescriptions. By 2021, declining insurance reimbursements threatened his business despite increasing prescription volume. He turned to social media to share practical, affordable health advice, eventually building an audience of more than six million followers. Now, he explains what his experience behind the pharmacy counter taught him about medication side effects, nutritional deficiencies, supplement quality, and why conventional healthcare often overlooks individual biology. 

   
   

   The conversation examines common multivitamin mistakes, including the use of synthetic folic acid and pyridoxine (vitamin B6). Phil explains why certain nutrient forms may be less suitable for some individuals, how excessive B6 intake can cause peripheral neuropathy, and why buying more supplements doesn't necessarily improve health. They explore MTHFR genetic variants, methylation, and folate metabolism, including potential implications for cognitive function, inflammation, blood pressure, fertility, and neurological development. 

   
   

   Phil also reveals why creatine is his favorite supplement, discussing its potential benefits for brain health and muscle performance. He and Dave examine creatine dosing, hydration, electrolytes, absorption, and why creatine supplementation can influence kidney-related blood test results. 

   
   

   The discussion turns to Big Pharma, prescription drug pricing, and pharmacy benefit managers (PBMs). Phil shares how insurance reimbursement practices threatened his independent pharmacy despite increasing prescription volume. They also explore compounding pharmacies, customized hormone formulations, injectable vitamins, GLP-1 medications, and the challenges of providing personalized treatment within the conventional healthcare system. 

   
   

   Finally, Dave and Phil examine personalized medicine, genetic testing, medication interactions, and nutritional deficiencies, including the relationship between statins and CoQ10. They discuss why individual biology should guide supplement choices and how addressing underlying metabolic processes may offer a more comprehensive approach to long-term health. 

   
   

   This episode is essential listening for anyone interested in multivitamins, methylated B vitamins, MTHFR genetics, creatine, prescription drugs, supplement effectiveness, personalized nutrition, metabolic health, and longevity. 

   
   

   You'll Learn: 

   • Why common multivitamins contain different forms of B vitamins, and how folic acid, folinic acid, L-methylfolate, and P5P differ 
   • How MTHFR genetic variants influence folate metabolism and why individual responses to supplements can vary 
   • What Phil recommends considering when using creatine for brain health, muscle performance, hydration, and kidney-related blood testing 
   • How pharmacy benefit managers, insurance reimbursement, and drug pricing affect independent pharmacies and patient care 
   • Why compounding pharmacies create customized medications, including hormone formulations, injectable vitamins, and certain GLP-1 treatments 
   • How personalized supplementation, nutrient testing, medication interactions, and genetics may help inform more individualized healthcare decisions 

   
   

   Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

   
   

   New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  

   
   

   Keywords: Phil Cowley, Phil's My Pharmacist, Dave Asprey, multivitamins, supplement mistakes, synthetic vitamins, methylated B vitamins, folic acid, methylfolate, MTHFR, methylation, vitamin B6, P5P, vitamin B12, folate metabolism, creatine, creatine dosage, brain health, kidney function, prescription drugs, drug interactions, pharmacy benefit managers, PBMs, Big Pharma, compounding pharmacy, GLP-1 medications, statins, CoQ10, personalized supplements, pharmacogenetics, longevity 

   
   

   Resources: 

   • Triquetra | Use code Dave20 at Triquetrahealth.com/dave for a discount 

   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

   • Danger Coffee: https://dangercoffee.com/discount/davetube 

   • My Daily Supplements: SuppGrade Labs (15% Off) 

   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

   
   

   Thank you to our sponsors!      

   - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh 

   - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. 

   - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. 

   - Calroy | Learn more about Selentra HP and get your exclusive discount at calroy.com/dave 

   
   

   Timestamps:  

   00:00 - Trailer 

   00:40 - Intro 

   01:45 - Drugs Stolen From Nature 

   06:05 - Listening to Patients 

   09:33 - Pharmacy Business & PBMs 

   14:10 - Compounding Pharmacy Explained 

   20:42 - Why Creatine Is Amazing 

   28:23 - MTHFR & Methylation 

   46:44 - Lab Tracking & Longevity 

   50:58 - Science Bullies & Urine Therapy 

   59:19 - Future of Pharmacy 

   01:03:01 - TriQuetra Health & Closing  

   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8. I Tried EVERY Controversial Focus Drug : 1566

   1 novembre 202638 minÉpisode 1566À suivre

   I've tried every controversial focus drug I could get my hands on. Modafinil, LSD, psilocybin, mescaline, DMT, ketamine, MDMA, amphetamine, ephedrine, the racetams, and a shelf of Russian compounds most people …

   Notes de l’épisode

   I've tried every controversial focus drug I could get my hands on. Modafinil, LSD, psilocybin, mescaline, DMT, ketamine, MDMA, amphetamine, ephedrine, the racetams, and a shelf of Russian compounds most people have never heard of. I've spent 20 years and millions of dollars testing this on my own brain, and here's what I found: some of them work, most don't do what you've been told, and none of them are free.

   
   

   But the one I'd crown above all of them is legal, costs almost nothing, and you can buy it this afternoon. You've just been lied to about it for 60 years by the people who made a fortune doing it. In this video I'll show you what each compound actually does inside your brain, what it takes from you on the other side, and the four rules I follow so the best one doesn't turn into the worst one.

   
   

   You'll Learn:

   • Why modafinil is considered the closest thing to a "Limitless pill" and how it affects sleep
   • How LSD, psilocybin, MDMA, and ketamine affect the brain differently from focus drugs
   • Why Adderall and amphetamines can make you hyper-focused on the wrong things
   • How racetams became the original nootropics for cognitive enhancement
   • What Russian scientists developed for cosmonauts and soldiers, including bromantane, Semax, and Selank
   • Why pharmaceutical nicotine ranks among the most controversial focus enhancers
   • How nicotine affects acetylcholine, attention, memory, and potentially brain aging
   • Why nicotine and smoking have very different health risks
   • How delivery speed influences addiction risk, from cigarettes to patches and lozenges
   • Dave's four rules for reducing nicotine risks and who should avoid it
   • What Dave learned from spending $2.5 million experimenting with cognitive enhancement

   
   

   Timestamps:

   00:00 - Trailer

   01:07 - Modafinil: The Limitless Pill

   03:45 - Psychedelics vs. Focus Drugs

   05:31 - Microdosing & The Placebo Effect

   07:43 - Cocaine & Drug Tolerance

   08:33 - Amphetamines & Adderall

   17:09 - Racetams: The Original Nootropics

   21:12 - Russian Smart Drugs

   29:17 - Nicotine for Focus & Cognition

   33:53 - Nicotine Risks & Safety Rules

   
   

   Thank you to our sponsors!

   -Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.

   -ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.

   -Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit Simplify.us/NestEgg to learn more.

   -Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

   
   

   Connect with Dave Asprey!

   
   

   Website: https://daveasprey.com

   TikTok: https://www.tiktok.com/@daveaspreyofficial

   Instagram: https://www.instagram.com/dave.asprey/

   Facebook: https://www.facebook.com/Daveaspreyofficial/

   X: https://x.com/daveasprey

   YouTube: https://www.youtube.com/c/daveaspreybpr

   
   

   The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

   
   

   Try TrueDark glasses: https://truedark.com

   Try Danger Coffee: https://dangercoffee.com/discount/davetube

   Try Suppgrade Labs: https://shopsuppgradelabs.com/

   Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

   Join my Substack: https://substack.daveasprey.com

   Upgrade Labs: https://upgradelabs.com

   40 Years of Zen: https://40yearsofzen.com

   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9. Placebo Pills, Cannabis, Wall Squats for Blood Pressure, Birdwatching, and the Porn brain : 1564

   30 octobre 202611 minÉpisode 1564À suivre

   Placebos Improved IBS Symptoms Even When Patients Knew the Pills Were InactiveIn a randomized trial of 80 adults with irritable bowel syndrome, participants who knowingly took placebo pills reported greater …

   Notes de l’épisode

   Placebos Improved IBS Symptoms Even When Patients Knew the Pills Were Inactive

   In a randomized trial of 80 adults with irritable bowel syndrome, participants who knowingly took placebo pills reported greater symptom improvement than those receiving no treatment. After three weeks, 59% of the placebo group reported adequate relief compared with 35% of controls. A larger follow-up study also found that openly prescribed placebos improved reported IBS symptoms more than a no-pill control. Host Dave Asprey explores how conditioning, expectations, and the ritual of taking a treatment may influence symptoms without deception. He explains why these findings do not mean symptoms are imaginary or that positive thinking can cure disease, but raise questions about how the brain, treatment context, and learned physiological responses shape the experience of illness.

   Sources:

   • PLOS ONE: Placebos Without Deception—A Randomized Controlled Trial in Irritable Bowel Syndrome
   • Pain: Open-Label Placebo vs. Double-Blind Placebo for Irritable Bowel Syndrome
   • Harvard Health: A Placebo Can Work Even When You Know It’s a Placebo

   
   

   Once-Weekly Wall Squats Preserved Some Blood-Pressure Benefits After More Frequent Training

   A randomized trial involving 100 adults found that isometric wall-squat training reduced blood pressure, with some benefits maintained after participants cut back to one or two sessions per week. The important detail is that participants first completed four weeks of training three times weekly. Those who subsequently reduced to one weekly session finished the eight-week study with systolic blood pressure approximately 6.6 mmHg below baseline, while those continuing three weekly sessions experienced the largest improvement. Host Dave Asprey explores how sustained muscle contractions may influence vascular resistance and autonomic regulation, and why the minimum dose needed to maintain a benefit can differ from the dose needed to build it. He explains why this study does not show that beginners get the same results from one weekly session or that wall squats replace medication.

   Sources:

   • BMJ Open Sport & Exercise Medicine: Isometric Exercise Training and Blood Pressure Control
   • Full Study: Exploring the Dose-Response to Training Frequency

   
   

   Expert Birdwatchers Showed Brain Differences Linked to Attention and Perception

   A study comparing 29 expert birdwatchers with 29 beginners found differences in brain structure and activity associated with bird-identification expertise. Experts showed lower mean diffusivity in regions involved in attention and perception, an MRI finding researchers interpreted as more compact tissue organization. Some differences were also present in older experts, raising questions about how sustained learning may relate to cognitive aging. Host Dave Asprey examines why birdwatching involves more than spending time outdoors: identifying unfamiliar species requires attention, visual discrimination, memory, and continued learning. He explains why these findings are interesting without proving that birdwatching prevents dementia or slows cognitive decline, since researchers cannot determine whether the hobby caused the differences or whether preexisting characteristics helped people become experts.

   Sources:

   • The Journal of Neuroscience: The Tuned Cortex—Expertise-Related Structural and Functional Remodeling Across the Adult Lifespan
   • Society for Neuroscience: Skills From Being a Birder May Change—and Benefit—Your Brain
   • BBC Future: Birdwatching Rewires the Brain and Slows Cognitive Decline

   
   

   Early THC Exposure Changed Serotonin Signaling in Mice Through an mTOR-Related Pathway

   A mouse study found that chronic THC exposure beginning early in life altered signaling through serotonin 5-HT2A receptors and increased sensitivity to a subsequently administered serotonergic drug. THC alone did not significantly disrupt the study’s baseline sensorimotor-gating measure, but previously exposed mice showed a greater disruption after the additional drug challenge. Giving rapamycin during THC exposure prevented several signaling changes and the heightened behavioral response, implicating the Akt/mTOR pathway. Host Dave Asprey explores how cannabinoid exposure may influence other neurotransmitter systems and why the timing of exposure matters when interpreting the experiment. He emphasizes that this was a mechanistic animal study, not proof that all cannabis use causes psychosis or that rapamycin can prevent cannabis-related psychiatric effects in humans.

   Sources:

   • PubMed: Chronic Cannabis Promotes Pro-Hallucinogenic Signaling of 5-HT2A Receptors Through the Akt/mTOR Pathway
   • Neuropsychopharmacology: Full Study

   
   

   Pornography Consumption Was Linked to Brain Differences, but Cause and Effect Remain Unclear

   A brain-imaging study of 64 healthy men found that greater reported pornography consumption was associated with lower gray-matter volume in part of the right caudate, lower activation in the left putamen during a sexual-image task, and lower functional connectivity between the right caudate and a prefrontal region involved in cognitive control. Host Dave Asprey examines what these findings may suggest about reward processing, repeated exposure, and habituation while distinguishing those possibilities from claims the study did not establish. Researchers did not directly measure dopamine depletion, demonstrate brain damage, or show that pornography caused the observed differences. Because participants were assessed at one point in time, preexisting brain characteristics could also help explain differences in consumption. The study raises questions about behavior and brain biology without resolving which came first.

   Sources:

   • JAMA Psychiatry: Brain Structure and Functional Connectivity Associated With Pornography Consumption—The Brain on Porn
   • National Center on Sexual Exploitation: Research Spotlight—The Brain on Porn

   
   

   This episode is designed for biohackers, longevity enthusiasts, people interested in cognitive performance and cardiovascular health, and anyone trying to separate provocative brain research from proven cause and effect. Host Dave Asprey examines why placebos may improve symptoms without deception, how reduced-frequency wall-squat training can preserve some blood-pressure benefits, what expert birdwatchers reveal about learning and the aging brain, how early THC exposure altered serotonin signaling in mice, and what pornography brain-imaging research can actually establish. The larger lesson is evidence: distinguish symptom relief from disease treatment, maintenance from improvement, brain differences from brain damage, and a compelling animal mechanism from a proven human intervention.

   
   

   Keywords: open label placebo, placebo without deception, placebo effect, placebo IBS study, irritable bowel syndrome, mind body connection, conditioning and symptoms, wall squats blood pressure, wall sit exercise, isometric exercise training, minimum effective exercise dose, systolic blood pressure, vascular resistance, autonomic regulation, birdwatching brain health, birding cognitive aging, cognitive longevity, neuroplasticity, attention and memory, skill learning brain, THC brain research, cannabis serotonin signaling, cannabis psychosis research, 5-HT2A receptors, Akt mTOR pathway, rapamycin research, pornography brain study, pornography reward circuitry, caudate nucleus, brain imaging research, correlation versus causation, Dave Asprey, The Human Upgrade, biohacking research roundup

   
   

   Thank you to our sponsors!  

   • Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit Simplify.us/NestEgg to learn more.
   • Neuronic | Go to www.neuronic.online Code DAVE for $100 off
   • Puori | Use my code DAVE at P-U-O-R-I dot com slash D-A-V-E for 32% off Puori Fish Oil when you start a subscription. That’s puori.com slash DAVE, and use code DAVE at checkout.
   • iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

   
   

   
   

   Resources:   

   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

   • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

   • Danger Coffee: https://dangercoffee.com/discount/dave15   

   • My Daily Supplements: SuppGrade Labs (15% Off)   

   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   

   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

   • Upgrade Labs: https://upgradelabs.com  

   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10. The No-Brainer Solution To Stop Overeating : 1565

    29 octobre 202652 minÉpisode 1565À suivre

    Use Dave10 at calocurb.com to get a discount How Hops Extract Suppresses Hunger, Reduces Cravings, Supports Weight Loss, and Makes Intermittent Fasting EasierHost Dave Asprey sits down with Sarah Kennedy, CEO …

    Notes de l’épisode

    Use Dave10 at calocurb.com to get a discount 

    
    

    How Hops Extract Suppresses Hunger, Reduces Cravings, Supports Weight Loss, and Makes Intermittent Fasting Easier

    
    

    Host Dave Asprey sits down with Sarah Kennedy, CEO of Calocurb, to explore the surprising science of hunger suppression, natural GLP-1 activation, intermittent fasting, weight loss, visceral fat reduction, and a patented hops extract that may help people eat less without relying on willpower. 

    
    

    The conversation centers on Amarasate, a natural compound derived from New Zealand hops, the same plant used to make beer. Originally investigated through a multimillion-dollar research program, this bitter plant extract activates specialized receptors in the digestive tract that stimulate the body's natural appetite-regulating hormones. Sarah explains how this discovery led to Calocurb, a supplement designed to reduce hunger, control cravings, and make fasting and calorie restriction easier. 

    
    

    Dave and Sarah break down the biology of GLP-1, CCK, PYY, ghrelin, and leptin, exploring how these hormones influence hunger, fullness, food cravings, and metabolic health. Unlike injectable GLP-1 medications such as Ozempic and Wegovy, Amarasate works through bitter taste receptors in the gut to stimulate the body's own satiety signaling. They examine why the timing and location of these signals matter, how quickly the extract begins working, and what distinguishes this approach from conventional appetite suppressants. 

    
    

    Sarah shares findings from four human clinical trials, including research reporting an average 18% reduction in calorie intake following consumption of the hops extract. They discuss how activating gut receptors can influence eating behavior, why some people struggle with persistent hunger despite consuming enough calories, and how manipulating the body's natural fullness signals could change approaches to weight management. 

    
    

    The discussion also examines a six-month randomized, placebo-controlled study involving approximately 150 participants, which reported an average 5.5% reduction in body weight, with estimated fat loss and no detected average muscle loss. Sarah describes findings suggesting approximately 3.5 times greater visceral fat reduction compared with placebo, raising questions about whether targeted appetite regulation could support healthier body composition. Dave and Sarah explore why preserving lean muscle while reducing abdominal fat is especially important for metabolic health, healthy aging, and longevity. 

    
    

    They also explore how hops extract may make intermittent fasting and extended fasting easier by reducing hunger and food cravings. Dave discusses the practical challenges of fasting, while Sarah explains how bitter receptor activation can help people manage appetite without constantly fighting the urge to eat. They examine the potential applications for time-restricted eating, longer fasting windows, calorie control, and sustainable weight management. 

    
    

    Finally, Dave and Sarah challenge conventional assumptions about willpower, hunger, and obesity, exploring why overeating is not simply a failure of discipline. They discuss the relationship between gut-brain signaling, metabolic hormones, food intake, and the emerging science of naturally regulating appetite, including how plant-derived compounds could complement nutrition, exercise, and other metabolic health strategies. 

    
    

    This episode is essential listening for anyone interested in natural appetite suppression, hops extract, intermittent fasting, GLP-1, hunger hormones, weight loss, visceral fat, muscle preservation, metabolic health, gut-brain signaling, and science-backed strategies for controlling cravings and eating less. 

    
    

    You'll Learn: 

    • How a patented compound extracted from hops activates bitter receptors in the gut to stimulate GLP-1, CCK, and PYY, the hormones involved in hunger and fullness 
    • Why clinical research found that hops extract reduced calorie intake by approximately 18%, and what that means for appetite control and overeating 
    • How a six-month clinical trial reported 5.5% body-weight loss, reduced visceral fat, and no detected average muscle loss 
    • Why hunger, cravings, and overeating involve complex hormonal signaling rather than simply a lack of willpower 
    • How natural appetite regulation may make intermittent fasting, extended fasting, and calorie restriction easier to maintain 
    • How hops-derived compounds differ from injectable GLP-1 medications, and what the research suggests about their potential role in weight management 

    
    

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Keywords: Sarah Kennedy, Sarah Kennedy Calocurb, Dave Asprey, The Human Upgrade, Calocurb, Amarasate, hops extract, hops weight loss, hops appetite suppressant, natural appetite suppressant, natural hunger suppressant, stop overeating, reduce hunger, control cravings, food cravings, hunger control, weight loss, fat loss, visceral fat reduction, belly fat, muscle preservation, lean muscle mass, GLP-1, natural GLP-1, GLP-1 activation, GLP-1 alternatives, Ozempic, Wegovy, CCK, cholecystokinin, PYY, peptide YY, ghrelin, leptin, hunger hormones, satiety hormones, bitter taste receptors, gut-brain axis, gut-brain signaling, intermittent fasting, fasting without hunger, extended fasting, time-restricted eating, fasting made simple, calorie restriction, calorie intake reduction, metabolic health, obesity, weight management, body composition, fat loss without muscle loss, biohacking, longevity, natural weight loss supplements 

    
    

    Resources: 

    • Calocurb | Use Dave10 at calocurb.com to get a discount 

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off) 

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

     

    
    

    Thank you to our sponsors!      

    - Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit Simplify.us/NestEgg to learn more. 

    - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. 

    - Mars Men | For a limited time, our listeners get 50% off FOR LIFE, Free Shipping, AND 3 Free Gifts at Mars Men at Mengotomars.com. 

    - Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

    
    

    
    

    Timestamps:  

    00:00 - Trailer 

    01:32 - Intro 

    03:06 - Discovering Hops Extract 

    07:58 - Finding the Right Hop 

    10:15 - Clinical Trial Results 

    15:34 - No Rebound Weight Gain 

    19:47 - Personal Story & Fasting 

    23:05 - Women's Fasting Study 

    29:32 - Willpower & Hunger 

    38:42 - Combining With GLP-1s 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11. The Easiest Treatment That Made Me 15 Years Younger : 1563

    27 octobre 202643 minÉpisode 1563À suivre

    Explore House of Evolution: https://daveasprey.com/house-of-evolution/ Host Dave Asprey sits down with Dr. Tim Cook, a physician and longevity medicine expert who previously served as personal physician to two …

    Notes de l’épisode

    Explore House of Evolution: https://daveasprey.com/house-of-evolution/ 

    
    

    Host Dave Asprey sits down with Dr. Tim Cook, a physician and longevity medicine expert who previously served as personal physician to two Governors General of Canada, to explore experimental gene therapy, biological age reversal, stem cell re-education, immune rejuvenation, muscle growth, and the emerging science of extending human lifespan. 

    
    

    Recorded in the Amazon rainforest in Ecuador, the conversation explores three advanced longevity treatments Dave and Tim are working with through House of Evolution, their venture focused on expanding access to experimental therapies. They discuss how these technologies work, the early results they're observing, and why some treatments are currently available outside the United States. 

    
    

    Dave reveals that after undergoing a two-day stem cell re-education treatment, blood testing approximately two months later indicated his immune system was 15.2 years younger. Tim explains how the procedure uses signaling molecules from umbilical cord blood stem cells to influence a patient's own immune cells before returning them to the body. They explore the potential implications for chronic inflammation, autoimmune conditions, and age-related immune dysfunction. 

    
    

    The discussion turns to follistatin gene therapy, an experimental treatment designed to increase a protein involved in muscle growth and maintenance. Dave and Tim share preliminary results, including a reported average nine-year reduction in biological-age measurements, increased lean muscle mass, and reductions in body fat. They examine why preserving muscle and reducing visceral fat may be critical for longevity, particularly as anabolic resistance and sarcopenia become more common with age. 

    
    

    They also explore klotho gene therapy, which targets a longevity-associated protein involved in kidney function, cognitive health, and aging. Tim describes early observations of substantially increased klotho levels following treatment, while Dave explains why this protein has become a major focus of his longevity research. The conversation also examines plasmid-based gene delivery, how it differs from directly editing human DNA, and the unanswered questions surrounding long-term safety and effectiveness. 

    
    

    Dave and Tim challenge conventional thinking about healthspan, lifespan, and longevity escape velocity, discussing whether emerging treatments could eventually help people maintain youthful physical and cognitive function for decades longer. They examine how advanced biomarker testing and predictive models are being used to track biological aging and estimate changes in life expectancy. 

    
    

    Finally, they look ahead to stem cell banking, genetic reprogramming, and regenerative medicine, including the possibility of rejuvenating a person's own cells and growing replacement tissues. They also address the high costs, limited availability, and regulatory challenges surrounding these technologies, emphasizing that many of the results discussed remain preliminary rather than clinically established evidence of age reversal. 

    
    

    This episode is essential listening for anyone interested in biological age reversal, gene therapy, follistatin, klotho, stem cell re-education, immune rejuvenation, autoimmune disease, muscle growth, visceral fat, regenerative medicine, longevity escape velocity, and the future of anti-aging medicine. 

    
    

    You'll Learn: 

    • How Dave's two-day stem cell re-education treatment was followed by a reported 15.2-year reduction in his measured immune age, and how the procedure works 
    • Why follistatin gene therapy is being investigated for muscle growth, sarcopenia, body composition, and biological aging 
    • How experimental plasmid-based gene therapies increase protein production without intentionally editing the human genome 
    • What early klotho gene therapy results suggest about protein levels, cognitive performance, kidney health, and longevity 
    • Why immune system aging, chronic inflammation, and visceral fat may contribute to age-related disease and physical decline 
    • How stem cell banking, cellular reprogramming, and regenerative medicine could shape the future of longevity treatments 

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Keywords: Dr. Tim Cook, Tim Cook longevity doctor, Dave Asprey, The Human Upgrade, House of Evolution, anti-aging treatments, reverse aging, biological age reversal, biological age testing, immune age, immune system rejuvenation, stem cell re-education, stem cell therapy, umbilical cord blood stem cells, immune cell reprogramming, autoimmune disease, chronic inflammation, inflammaging, gene therapy, follistatin gene therapy, follistatin, klotho gene therapy, klotho protein, minicircle gene therapy, plasmid DNA, MiniCircle, muscle growth, muscle loss, sarcopenia, anabolic resistance, lean muscle mass, body fat reduction, visceral fat, regenerative medicine, stem cell banking, genetic reprogramming, longevity medicine, longevity escape velocity, lifespan extension, healthspan, biological aging, experimental longevity treatments, biohacking, human longevity 

    
    

    Resources: 

    • The House of Evolution is A members-only longevity community combining gene expression therapy, stem cell therapy, and small-group experiences in destinations around the world. Apply here https://daveasprey.com/house-of-evolution/ 

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off) 

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  

    
    

    Thank you to our sponsors!      

    - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh 

    - Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit Simplify.us/NestEgg to learn more. 

    - OneSkin | For a limited time try the new OS-01 FACE RICH CREAM with 15% off at oneskin.co/DAVE. 

    - MOD | Visit https://mod.com/ for a consultation and get 10% off your first order plus free shipping with promo code DAVE. 

    
    

    Timestamps:  

    00:00 — Trailer 

    00:59 — Follistatin Gene Therapy 

    05:25 — How Plasmids Work 

    09:30 — Longevity Escape Velocity 

    16:30 — Follistatin Results & Data 

    21:30 — Klotho: The Cognitive Protein 

    24:30 — House of Evolution 

    30:30 — Stem Cell Re-Education 

    39:00 — Stem Cell Banking 

    41:30 — The Future of Longevity 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12. How To Reverse Your Age For $5 Day (Budget Biohacking) : 1562

    25 octobre 202624 minÉpisode 1562À suivre

    I have spent $2.5 million on this body, and Bryan Johnson spends about $5,400 a day on his. But does it need to be that expensive to biohack? So I gave myself a challenge: build a complete anti-aging protocol …

    Notes de l’épisode

    I have spent $2.5 million on this body, and Bryan Johnson spends about $5,400 a day on his. But does it need to be that expensive to biohack? So I gave myself a challenge: build a complete anti-aging protocol for $5/day, where every single thing on it has to be validated in humans, not mice. I could not spend the five dollars. In this video I'll show you the entire list and the two most powerful things I found… which cost nothing at all.

    
    

    You'll Learn:

    • How to build a science-backed longevity routine for less than $5 a day
    • Why omega-3s, GlyNAC, and magnesium may help slow aging and support cellular repair
    • How creatine, vitamin D, and L-theanine support brain health, muscle function, and focus
    • Why blackout curtains, red light, and blue-light-blocking glasses can improve sleep and circadian health
    • How walking, morning sunlight, fiber, and quality sleep can improve longevity without expensive supplements
    • What Dave learned from spending $2.5 million on biohacking and why preventing damage is cheaper than repairing it

    
    

    Timestamps:

    00:00 — The $5/Day Challenge

    02:50 — Omega-3s: Aging Clock

    04:24 — GlyNAC: Master Antioxidant

    06:06 — Magnesium for Sleep

    07:50 — Creatine: Brain and Muscle

    09:39 — Vitamin D and Theanine

    12:09 — Light: Curtains and Bulbs

    15:52 — Free: Walking, Sun, Fiber

    19:00 — The Full Cost Summary

    20:09 — Why I Spent Millions

    
    

    Thank you to our sponsors!

    -Echo | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.

    -MyVitalC | Visit www.myvitalc.com/davesfav to unlock Dave’s discount

    -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.

    -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestorelaser.com/DAVE

    
    

    Connect with Dave Asprey!

    
    

    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

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    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

    
    

    Try TrueDark glasses: https://truedark.com

    Try Danger Coffee: https://dangercoffee.com/discount/davetube

    Try Suppgrade Labs: https://shopsuppgradelabs.com/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Join my Substack: https://substack.daveasprey.com

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

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13. Avoid THESE "Healthy" Superfoods : 1561

    23 octobre 20261 h 16 minÉpisode 1561À suivre

    We just had to bring this one back for you. Today, we’re digging once again into specifics about food that you haven’t heard on the show before. This one may very well influence you to rethink your “healthy” …

    Notes de l’épisode

    We just had to bring this one back for you. Today, we’re digging once again into specifics about food that you haven’t heard on the show before. This one may very well influence you to rethink your “healthy” diet and change how you feel about food completely. To get there, I’m excited to welcome back Teri Cochrane, an integrative practitioner and pioneer in personalized healthcare. 

    Teri is the founder of the Global Sustainable Health Institute® and developer of The Cochrane Method®, a future-facing algorithm for decoding the human body. Teri is also one of the world’s leading experts on dietary amyloids, which is a topic I love talking about.

    In today’s episode, we get into what amyloids are and how they turn on viruses, cause cancer, and shorten our lives. We also explore the dangers of oxalates and histamines, plus hacks to reduce and release them. Teri and I both have our own recipes for releasing oxalates that you can try at home (they’re surprisingly simple). 

    We talk about how dirty poultry is killing us—and how superfoods like kale and almonds aren’t any better. We break down the benefits of regenerative farming, and share ways to make your dollar stretch if you can’t afford grass-fed meat. Plus, Teri tells us what she personally eats. 

    
    

    Timestamps:

    00:00 — Intro

    02:01 — The Big 4 Metabolic Impairments

    08:21 — The Dangers of Oxalates

    12:02 — The Fifth Disruptor: Histamine

    16:22 — Becoming Your Own Body Interpreter

    28:41 — How Do We Get Off Oxalates?

    35:41 — Dave’s Recipe for Releasing Oxalates

    44:40 — Hacks for Histamines

    50:32 — Amyloid 101: What You Should Know

    56:56 — Should You Beware of B6?

    59:54 — What’s the Best Kind of Protein?

    
    

    Thank you to our sponsors!

    -Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.

    -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.

    -Neuronic | Go to www.neuronic.online Code DAVE for $100 off

    -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE irestorelaser.com/DAVE

    
    

    Resources

    Website: tericochrane.com

    Instagram: @tericochranebeyondnutrition

    YouTube: @TeriCochrane

    The Global Sustainable Health Institute: globalsustainablehealthinstitute.com

    Read: The Wildatarian Diet by Teri Cochrane 

    What You Eat is Turning Your Genes On and Off – Teri Cochrane – #646

    
    

    Connect with Dave Asprey!

    
    

    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr

    
    

    Danger Coffee: https://dangercoffee.com/discount/dave15?

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Join my Substack: https://substack.daveasprey.com

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14. How to Trigger Flow States From The 5 Brain Chemicals You Need : 1559

    22 octobre 202656 minÉpisode 1559À suivre

    The Neuroscience of Flow, Peak Performance, Psychedelics, Trauma, Intuition & Consciousness with Steven KotlerHost Dave Asprey sits down with Steven Kotler, New York Times bestselling author and leading …

    Notes de l’épisode

    The Neuroscience of Flow, Peak Performance, Psychedelics, Trauma, Intuition & Consciousness with Steven Kotler

    
    

    Host Dave Asprey sits down with Steven Kotler, New York Times bestselling author and leading researcher in the neuroscience of flow, to explore how altered states of consciousness influence peak performance, mental health, creativity, intuition, and our perception of reality.

    
    

    Steven Kotler is a bestselling author of 17 books, including The Art of Impossible and We Are as Gods, and the founder of the Flow Research Collective. For decades, he has studied the neurobiology of peak performance, working with elite athletes, military personnel, and high-performing professionals to understand how people can reliably access flow states.

    
    

    Dave and Steven begin by exploring the neuroscience of flow and why it may be one of the most powerful altered states available without drugs. Steven explains how dopamine, norepinephrine, serotonin, anandamide, and endorphins contribute to the flow experience, why his research suggests caffeine can increase flow susceptibility, and how chasing the neurochemical high of peak performance can become dangerous.

    
    

    They discuss the darker side of flow training, including its potential risks for people prone to mania, the importance of recovery, and why attempting to remain in a flow state indefinitely can undermine performance. Steven shares how his training programs approach sleep, attention, and behavioral changes to help people access flow more consistently.

    
    

    The conversation then moves into psychedelics, ketamine-assisted therapy, and the neuroscience of trauma. Steven introduces emerging research suggesting that unresolved emotional patterns may involve the brain's predictive processing systems. Dave shares a personal experience involving Joe Rogan and how revisiting an early childhood memory changed his emotional response to public criticism.

    
    

    Dave and Steven also explore how the brain constructs reality, including the neuroscience of perception, sensory processing, and the flexible boundary between ourselves and our environment. They discuss how flow alters our sense of self, why the brain predicts what we experience before we consciously perceive it, and how these mechanisms may help explain certain spiritual and out-of-body experiences.

    
    

    Finally, Steven reveals new research investigating the neurological connections between flow, intuition, synchronicity, and purpose. He discusses emerging theories of consciousness, the role of information processing in subjective experience, and how artificial intelligence may change the future of human performance.

    
    

    You'll Learn:

    • How flow states influence dopamine, norepinephrine, serotonin, anandamide, and endorphins, and why Steven's research suggests caffeine may help make the brain more susceptible to flow.
    • Why chasing the neurochemical high of flow can become dangerous, how flow training may affect people prone to mania, and why sleep and recovery are essential for sustained peak performance.
    • How ketamine-assisted therapy may help uncover forgotten emotional experiences and why Steven believes the brain's predictive processing systems play an important role in trauma.
    • How the brain constructs our perception of reality, why sensory information reaches consciousness at different speeds, and what happens to our sense of self during altered states.
    • Why flow may enhance intuition and how emerging neuroscience research is investigating connections between synchronicity, purpose, and the brain's information-processing systems.
    • How Steven is using neuroscience, artificial intelligence, and years of flow training data to develop more accessible methods for improving focus, learning, and performance.

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    
    

    Keywords: Steven Kotler, Dave Asprey, flow state, neuroscience of flow, peak performance, Flow Research Collective, dopamine, caffeine and flow, altered states, consciousness, psychedelics, ketamine therapy, trauma, predictive processing, neuroplasticity, intuition, synchronicity, brain science, mental performance, cognitive enhancement, flow triggers, serotonin, anandamide, meditation, human optimization, artificial intelligence, We Are as Gods, The Art of Impossible

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Resources: 

    • Explore Steven Kotler's books, research, and flow training programs at https://www.flowresearchcollective.com/

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off) 

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

    
    

    Thank you to our sponsors!    

    • ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  
    • Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save
    • OneSkin | For a limited time try the new OS-01 FACE RICH CREAM with 15% off at oneskin.co/DAVE
    • Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.

    
    

    Timestamps:  

    00:00 — Trailer

    01:12 — Intro

    05:08 — Psychedelics and Peak Performance

    11:10 — Trance, Voices, and Shamanism

    18:00 — Dangers of Flow Training

    24:00 — Ketamine and Innate Intelligence

    30:00 — The Prediction Problem

    35:25 — Embodied Cognition

    46:30 — Consciousness and Synchronicity

    50:20 — New Books and Research

    53:00 — Flow for the Many

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15. The 6-Minute Morning Routine That Can Change Your Life : 1558

    20 octobre 202649 minÉpisode 1558À suivre

    The Miracle Morning, Visualization, Affirmations, Meditation, Morning Routines, Productivity & the Psychology of Success with Hal ElrodHost Dave Asprey sits down with Hal Elrod, bestselling author of The …

    Notes de l’épisode

    The Miracle Morning, Visualization, Affirmations, Meditation, Morning Routines, Productivity & the Psychology of Success with Hal Elrod

    
    

    Host Dave Asprey sits down with Hal Elrod, bestselling author of The Miracle Morning and personal development expert, to explore morning routines, visualization, affirmations, meditation, productivity, circadian rhythms, habit formation, and the psychology of success.

    
    

    Hal Elrod is the creator of The Miracle Morning, a bestselling book and personal development method that has helped millions improve their daily habits. After surviving a devastating car accident at age 20 and later battling life-threatening cancer, Hal developed a philosophy centered on resilience, personal responsibility, and consistent daily practices.

    
    

    Dave and Hal challenge the idea that success requires waking up at 5 AM. They discuss chronotypes, circadian biology, and why morning routines should work with your natural sleep patterns. Hal introduces his six-part SAVERS framework, explaining how meditation, affirmations, visualization, exercise, reading, and journaling can transform your morning in as little as six minutes.

    
    

    They explore how smartphones disrupt attention, why visualization works best when paired with mental rehearsal, and how these techniques can help overcome procrastination. Hal shares how he used visualization to train for a 52-mile ultramarathon, while Dave discusses advanced meditation, neurofeedback, and the role of emotional states in mental performance.

    
    

    The conversation also challenges traditional positive affirmations. Hal explains why unrealistic statements often fail and shares a three-step method for setting commitments, identifying motivations, and taking action. Dave connects these practices to consciousness, altered states, and the relationship between intention and human performance.

    
    

    Finally, Hal reflects on surviving cancer and a near-fatal car accident, sharing how his daily practices helped him build resilience. Dave and Hal discuss the balance between disciplined action, belief, and the mental states that influence our ability to achieve meaningful goals.

    
    

    This episode is essential listening for anyone interested in morning routines, visualization, affirmations, meditation, productivity, habit formation, circadian rhythms, overcoming procrastination, mental performance, emotional resilience, consciousness, and the science of personal development.

    
    

    You'll Learn:

    • Why waking up at 5 AM isn't necessary for success and how to build a morning routine around your natural circadian rhythm and chronotype
    • How Hal Elrod's six SAVERS practices can improve daily focus, discipline, and emotional well-being in as little as six minutes
    • Why checking your smartphone first thing in the morning can undermine attention, productivity, and your ability to respond intentionally throughout the day
    • How to use visualization and detailed mental rehearsal to overcome procrastination, strengthen motivation, and follow through on difficult goals
    • Why traditional positive affirmations often fail and how to create actionable affirmations based on specific commitments, meaningful reasons, and daily behaviors
    • How meditation, emotional states, and intentional daily habits helped Hal navigate life-threatening health challenges and develop greater resilience

    
    

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Keywords:

    Hal Elrod, Dave Asprey, The Miracle Morning, Miracle Morning routine, SAVERS method, six minute morning routine, morning habits, 5 AM wake up, circadian rhythm, sleep chronotypes, visualization techniques, mental rehearsal, positive affirmations, actionable affirmations, meditation, morning meditation, overcoming procrastination, habit formation, productivity habits, goal setting, self discipline, emotional resilience, neurofeedback, altered states, consciousness, biohacking

    
    

    Resources: 

    • Explore Hal Elrod's Miracle Morning method, books, documentary, and app at https://miraclemorning.com/

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off) 

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

    
    

    Thank you to our sponsors!      

    -Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

    -Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save.

    -BodyHealth |Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase.

    -Quantum Upgrade | Go to QuantumUpgrade.io/DAVE. to claim your 15-day free trial

    
    

    Timestamps:  

    00:00 — Trailer

    01:30 — Intro & Miracle Morning

    05:03 — The SAVERS Acronym

    10:38 — Social Media & Smartphones

    16:30 — Combining SAVERS & Visualization

    22:08 — The Ultramarathon Story

    28:24 — Affirmations & State

    34:10 — Manifestation & Consciousness

    37:26 — Near-Death & Miracles

    42:30 — Perception & Brain Power

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16. 400mg Before Bed Improves Deep Sleep by 1700% : 1557

    18 octobre 202613 minÉpisode 1557À suivre

    Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/I slept 8 hours a night and got 5 minutes of deep sleep …

    Notes de l’épisode

    Try TrueDark glasses: https://truedark.com

    Try Danger Coffee: https://dangercoffee.com/discount/davetube

    Try Suppgrade Labs: https://shopsuppgradelabs.com/

    
    

    I slept 8 hours a night and got 5 minutes of deep sleep, and no doctor could help me. Then I found a molecule that hits the same receptor as Valium but WITHOUT sedating you. 400 mg before bed, stacked with four things that cost nothing, took me from 5 minutes to 90. Here's all five, plus WHY it’s mission critical you get this precious deep sleep (hint: it has to do with your memory as you age).

    
    

    Thank you to our sponsors!

    -ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.

    -Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

    -Fatty15 | Go to fatty15.com/DAVE to get an additional 15% off their 90-day Starter Kit

    -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

    
    

    Connect with Dave Asprey!

    
    

    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr

    
    

    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

    
    

    Danger Coffee: https://dangercoffee.com/discount/dave15?

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Join my Substack: https://substack.daveasprey.com

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17. John Gray: Why Men Stop Wanting Their Wives : 1556

    16 octobre 20261 h 45 minÉpisode 1556À suivre

    The king is back! You probably recognize his name as the author of the famous book, Men Are From Mars, Women Are From Venus. But what's especially exciting is how John has evolved his insights to address the …

    Notes de l’épisode

    The king is back! You probably recognize his name as the author of the famous book, Men Are From Mars, Women Are From Venus. 

    But what's especially exciting is how John has evolved his insights to address the changing dynamics between men and women in the modern world, as he highlighted in his 2020 book, Beyond Mars and Venus: Relationship Skills for Today's Complex World.

    Now, why is this episode a must-listen? Well, John isn't just a relationship expert; he's also a seasoned biohacker who understands the profound impact of our environment – including relationships – on our hormones, happiness, and dopamine levels. In essence, he's been biohacking before it even had a name. With decades of wisdom, he offers invaluable insights into navigating the complexities of male-female relationships in today's world.

    Delve into the fundamental differences between men and women, the importance of appreciation in relationships, what truly motivates men, and practical tips on boosting testosterone and managing emotions. We also explore how men and women process feelings differently, the art of setting boundaries, and the language of love as the language of hormones.

    Get ready for a masterclass in understanding the dynamics of modern relationships and how to create lasting happiness.

    
    

    Timestamps:

    00:00 — Intro

    04:57 — Hormones Drive Relationships

    08:29 — Emotional Manipulation & Control

    20:42 — Detachment & The Cave

    31:37 — Listening Without Losing It

    39:49 — When Negativity Never Passes

    46:54 — Fasting & Testosterone Science

    01:04:23 — Languages of Love & Hormones

    01:14:54 — Surviving Public Attacks

    01:31:41 — Porn, Polarity & Reassurance

    01:44:00 — Wrap-Up

    
    

    Thank You To Our Sponsors!

    • Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
    • The One Device | Use code DAVE for $10 off at theonedevice.com/dave
    • Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
    • iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

    
    

    Resources: 

    • Learn More About John’s Work At: https://www.marsvenus.com/

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off) 

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

    
    

    Timestamps:

    00:00 — Intro

    04:57 — Hormones Drive Relationships

    08:29 — Emotional Manipulation & Control

    20:42 — Detachment & The Cave

    31:37 — Listening Without Losing It

    39:49 — When Negativity Never Passes

    46:54 — Fasting & Testosterone Science

    01:04:23 — Languages of Love & Hormones

    01:14:54 — Surviving Public Attacks

    01:31:41 — Porn, Polarity & Reassurance

    01:44:00 — Wrap-Up

    
    

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18. Sleep Expert: 80% of Sleep Problems Come From THIS : 1555

    15 octobre 202640 minÉpisode 1555À suivre

    Sleep Anxiety, Insomnia, Circadian Rhythms, Chronotypes, Sleep Trackers & How to Sleep Better with Dr. Michael Breus Host Dave Asprey sits down with Dr. Michael Breus, clinical psychologist, sleep specialist …

    Notes de l’épisode

    Sleep Anxiety, Insomnia, Circadian Rhythms, Chronotypes, Sleep Trackers & How to Sleep Better with Dr. Michael Breus 

    
    

    Host Dave Asprey sits down with Dr. Michael Breus, clinical psychologist, sleep specialist, and internationally recognized sleep expert known as The Sleep Doctor, to explore insomnia, sleep anxiety, circadian rhythms, chronotypes, nighttime awakenings, temperature regulation, sleep medications, wearable sleep trackers, and the science of improving sleep quality. 

    
    

    The conversation challenges conventional thinking about sleep, including whether everyone needs eight hours, why trying harder to fall asleep can make insomnia worse, and how the body's internal clock influences energy, productivity, and recovery. 

    
    

    Dr. Breus explains why he believes fear and anxiety contribute to a substantial proportion of sleep problems. He describes how worrying about falling asleep, waking up at 3 a.m., or feeling exhausted the next day can create a cycle of stress that makes restful sleep increasingly difficult. Dave and Michael explore how cognitive behavioral therapy, emotional regulation, and changing your relationship with sleep may help break that cycle without relying exclusively on medication. 

    
    

    They also examine the science of chronotypes, the biological differences that influence when people naturally feel alert or sleepy. Michael explains why aligning sleep, work, meals, and exercise with your individual circadian rhythm may improve sleep efficiency and daytime performance. Dave shares how changing his exposure to artificial light and adjusting his daily routines helped him shift from being a night owl to maintaining an earlier bedtime. 

    
    

    The discussion then turns to the three physiological conditions Michael considers essential for falling asleep: lowering core body temperature, reducing heart rate, and decreasing anxiety. He explains why simply turning down the thermostat may not be enough to cool your body under the covers, how temperature-controlled mattresses can support thermoregulation, and why something as simple as warming your feet may help your body release heat. 

    
    

    Dave and Michael also discuss blue light, nighttime lighting, and the environmental signals that regulate circadian timing. They examine why light exposure, meal timing, exercise, temperature, and social interaction can influence the body's internal clock, along with the limitations of conventional blue-light-blocking glasses. 

    
    

    The conversation explores why sleeping pills may fail to address the underlying causes of chronic insomnia, how nighttime awakenings can trigger negative thinking, and why the fear of being tired may sometimes become more disruptive than the tiredness itself. Dave shares his experience deliberately restricting sleep while building his businesses, and Michael explains the difference between temporarily functioning with less sleep and maintaining healthy sleep habits over the long term. 

    
    

    They also challenge the growing obsession with sleep scores, deep sleep measurements, and wearable tracking devices. Michael explains why consumer sleep trackers cannot provide the same measurements as a clinical sleep study, why individual sleep-stage estimates should be interpreted cautiously, and why how you feel in the morning remains an important indicator of sleep quality. 

    
    

    Finally, Dave and Michael examine emerging research on creatine supplementation and sleep deprivation, including whether creatine can temporarily support cognitive performance after insufficient sleep. They discuss the potential benefits, limitations, and risks of using supplements to compensate for lost sleep, emphasizing why improving sleep quality should remain the priority. 

    
    

    This episode is essential listening for anyone interested in insomnia, sleep anxiety, waking up at 3 a.m., circadian rhythms, chronotypes, sleep optimization, blue light, temperature regulation, sleep medications, cognitive behavioral therapy, wearable sleep trackers, deep sleep, creatine, cognitive performance, longevity, and the science of getting better sleep. 

    
    

    You'll Learn: 

    • Why Dr. Michael Breus believes fear and anxiety contribute to many sleep problems, and how worrying about sleep can make insomnia worse 
    • How your chronotype influences your ideal bedtime, wake-up time, energy levels, and the amount of sleep you may need 
    • Why lowering body temperature, heart rate, and anxiety can help you fall asleep faster and improve sleep quality 
    • How nighttime light exposure, meal timing, exercise, and bedroom temperature influence circadian rhythms and sleep 
    • Why waking up at 3 a.m. can trigger negative thinking, and how changing your response to nighttime awakenings may help 
    • What sleep trackers get wrong about deep sleep, how to interpret your sleep data, and whether creatine can help when you're sleep-deprived 

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Keywords: Michael Breus, Dr. Michael Breus, The Sleep Doctor, Dave Asprey, The Human Upgrade, sleep expert, insomnia, sleep anxiety, sleep disorders, sleep problems, sleep quality, sleep optimization, how to fall asleep, waking up at 3am, circadian rhythm, chronotypes, sleep cycles, sleep deprivation, deep sleep, REM sleep, blue light, blue light blocking glasses, bedroom temperature, thermoregulation, sleep trackers, Oura Ring, sleep scores, cognitive behavioral therapy, sleeping pills, creatine, cognitive performance, biohacking, longevity  

    
    

    Resources: 

    • Learn More About Michael’s Work At: http://chronoquiz.com/ 

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off) 

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

    
    

    Thank you to our sponsors!      

    - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off 

    - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. 

    - fatty15 | Go to fatty15.com/DAVE to get an additional 15% off their 90-day Starter Kit. 

    - MOD | Visit https://mod.com/ for a consultation and get 10% off your first order plus free shipping with promo code DAVE. 

    
    

    Timestamps:  

    00:00 — Trailer 

    01:27 — Intro 

    02:46 — Chronotypes & Sleep Compression 

    05:00 — Blue Light Glasses Debate 

    07:50 — Night Owls & Morning Meetings 

    12:15 — Circadian Time Cues 

    14:21 — Temperature & Thermoregulation 

    19:58 — EMFs & Sleep Sensitivity 

    25:01 — Sleep Research & Fear 

    30:28 — Sleep Deprivation Experiment 

    36:15 — Trackers & Creatine 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19. The Science Behind Joint and Cartilidge Repair : 1554

    13 octobre 202649 minÉpisode 1554À suivre

    Explore Calroy's vascular health and joint support supplements, including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave Cartilage Regeneration, Joint Pain, Nitric Oxide, Blood Flow, Muscle …

    Notes de l’épisode

    Explore Calroy's vascular health and joint support supplements, including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave 

    
    

    Cartilage Regeneration, Joint Pain, Nitric Oxide, Blood Flow, Muscle Strength & Longevity with Kiran Krishnan 

    
    

    Host Dave Asprey sits down with Kiran Krishnan, research microbiologist, systems biology researcher, and co-founder of Microbiome Labs, to explore cartilage regeneration, joint pain, osteoarthritis, nitric oxide, vascular health, inflammation, muscle growth, gut health, bone density, and the biological mechanisms that influence how the body ages. 

    
    

    Kiran Krishnan is a research microbiologist, health and wellness expert, and entrepreneur who specializes in the human microbiome, gut health, inflammation, and systems biology. Over the past 20 years, he has founded several successful health and supplement companies, including co-founding and leading Microbiome Labs, a leading microbiome therapeutics brand among healthcare professionals. He is also a co-founder and partner in three other health companies. Kiran has conducted and published scientific research, contributed chapters to scientific textbooks, holds global patents, and is a sought-after speaker on human health and the microbiome. 

    
    

    His latest work explores the relationship between blood vessel health, chronic inflammation, and the body's ability to repair damaged cartilage. Through research involving compounds designed to support vascular function, nitric oxide production, and joint health, Kiran is investigating whether age-related tissue degeneration can be slowed or potentially reversed. 

    
    

    Dave opens the conversation by sharing his lifelong struggle with joint pain, including an arthritis diagnosis at age 14 and three knee surgeries. Kiran explains why cartilage degeneration may begin long before symptoms appear and how declining blood flow, damaged microvessels, and chronic inflammation can interfere with the body's natural cartilage repair mechanisms. 

    
    

    They explore the role of the endothelial glycocalyx, the protective lining inside blood vessels, and why nitric oxide production becomes increasingly important with age. Kiran explains how impaired circulation can affect everything from joint lubrication and cartilage health to cognitive performance, digestion, muscle recovery, and sexual function. 

    
    

    Kiran also discusses research involving Cartigenix, a joint support supplement developed using compounds from Boswellia and celery seed. He describes clinical trials involving patients with osteoarthritis, including reported improvements in joint pain, inflammation, and cartilage regeneration, even among older adults with advanced joint degeneration. Dave and Kiran examine how Cartigenix, Arterosil, and Vascanox target different aspects of joint and vascular health, while distinguishing the Cartigenix trial results from the proposed benefits of combining all three products. 

    
    

    The conversation then shifts to practical strategies for improving circulation and metabolic health. Dave and Kiran discuss why walking after meals may help regulate blood sugar, how the cephalic response prepares the digestive system for food, and why excessive endurance exercise may create trade-offs for recovery and long-term health. 

    
    

    They also challenge conventional thinking about muscle growth and longevity. Kiran explains why functional strength may matter more than muscle size, how nitric oxide and microcirculation influence the delivery of amino acids to muscle tissue, and why maintaining healthy blood vessels could be an overlooked factor in preserving strength as you age. 

    
    

    Finally, Kiran previews emerging research on bone regeneration, gut health, and a new postbiotic-based formulation being developed for bone health, particularly during perimenopause and menopause. He shares early findings involving bone repair and osteocyte production, while Dave explains why maintaining strong bones, healthy joints, and efficient circulation should be foundational priorities for anyone interested in longevity. 

    
    

    This episode is essential listening for anyone interested in cartilage regeneration, osteoarthritis, chronic joint pain, nitric oxide, blood circulation, vascular health, inflammation, muscle growth, strength training, gut health, bone density, menopause, cellular repair, supplements, biohacking, and the science of maintaining physical performance as you age. 

    
    

    You’ll Learn: 

    • Why cartilage breaks down with age and how impaired blood flow and chronic inflammation interfere with joint repair 
    • What Kiran's clinical research suggests about cartilage regeneration and joint recovery in people with osteoarthritis 
    • How nitric oxide and the endothelial glycocalyx influence circulation, cardiovascular health, cognitive function, and longevity 
    • Why functional strength may be more important than muscle size for healthy aging, and how blood flow affects muscle growth and recovery 
    • How walking after meals, supporting digestion, and improving vascular function may benefit blood sugar regulation and gut health 
    • What emerging research suggests about bone regeneration, postbiotics, and maintaining bone density during menopause and aging 

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Keywords: Kiran Krishnan, Dave Asprey, The Human Upgrade, cartilage regeneration, cartilage repair, joint pain, osteoarthritis, arthritis, knee pain, joint health, bone on bone arthritis, Cartigenix, Calroy, Arterosil, Vascanox, nitric oxide, blood flow, vascular health, endothelial glycocalyx, chronic inflammation, Boswellia, muscle growth, muscle strength, strength training, muscle recovery, gut health, microbiome, bone density, bone regeneration, longevity, anti aging, biohacking  

    
    

    Resources: 

    • Grab A Discount On Calroy's Vascular Health And Joint Support Supplements, Including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave 

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off) 

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

    
    

    Thank you to our sponsors!      

    - ALP | Go to alppouch.com, code DAVE for 10% off. 

    - Visit www.myvitalc.com/davesfav to unlock Dave’s discount 

    - Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide. 

    - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY. 

    
    

    Timestamps:  

    00:00 — Trailer 

    01:05 — Intro 

    04:44 — The Glycocalyx Explained 

    10:30 — Why Joints Degrade 

    15:16 — Rebuilding Cartilage 

    21:17 — Nitric Oxide & Gut Health 

    26:28 — Hacking the Cephalic Response 

    31:23 — Strength vs. Size for Longevity 

    37:47 — Muscle Building Supply System 

    42:51 — New Bone Regeneration Product 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20. Your Brain Has a Focus Switch (Here's How to Turn It On) : 1553

    11 octobre 202619 minÉpisode 1553À suivre

    Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/This video reveals that the brain has a documented …

    Notes de l’épisode

    Try TrueDark glasses: https://truedark.com

    Try Danger Coffee: https://dangercoffee.com/discount/davetube

    Try Suppgrade Labs: https://shopsuppgradelabs.com/

    
    

    This video reveals that the brain has a documented neurological focus state driven by prefrontal cortex activation and norepinephrine signaling that most people access accidentally but can learn to trigger reliably. Dave explains the biological mechanism and the specific supplement and behavioral stack that activates this state within 20 minutes.

    
    

    You'll Learn:

    • Why your brain has a neurochemical "focus switch" and how to flip it on in about 20 minutes, with no extra willpower or motivation
    • How norepinephrine and dopamine work together to lock you into deep focus, and what happens when only one of them is present
    • Why chronic stress, poor sleep, and sitting all day drain the exact chemicals your focus depends on
    • How L-tyrosine gives your brain the raw materials to make focus chemicals, and the dose and timing that work
    • Why the 1:2 ratio of caffeine to L-theanine beats coffee alone for working memory, accuracy, and calm, sustained concentration
    • Which options like modafinil and Rhodiola rosea support norepinephrine and dopamine, and how they compare
    • How morning light and five minutes of movement set your focus chemistry for the entire day
    • Why focus is never about effort, and how the right chemistry makes deep work feel effortless

    
    

    Thank You To Our Sponsors:

    -Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

    -ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.

    -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.

    -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

    
    

    Timestamps: 

    00:00 — The Focus Switch

    01:44 — Habit One: Chronic Stress

    03:38 — Habit Two: Bad Sleep

    04:58 — Habit Three: Sitting

    06:21 — Norepinephrine and Dopamine

    09:40 — L-Tyrosine

    10:41 — Caffeine and L-Theanine

    12:30 — Modafinil and Rhodiola

    14:42 — The 20-Minute Protocol

    17:34 — The Right Fuel

    
    

    Connect with Dave Asprey!

    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr

    
    

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21. Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552

    9 octobre 202611 minÉpisode 1552À suivre

    Infections Were Linked to About 1 in 8 Cancer Cases Worldwide A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers …

    Notes de l’épisode

    Infections Were Linked to About 1 in 8 Cancer Cases Worldwide 

    
    

    A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H. pylori and HPV were the largest contributors, followed by hepatitis B, Epstein-Barr virus, and hepatitis C. Host Dave Asprey explores how persistent infections can contribute to cancer through chronic inflammation, DNA damage, altered immune surveillance, and other biological pathways. He explains why this does not mean cancer is contagious or that infection inevitably leads to cancer, but argues that identifying, preventing, and treating infections such as H. pylori, hepatitis B, and hepatitis C can be an overlooked part of a long-term prevention strategy. 

    
    

    Sources: 

    -IARC: Global Burden of Cancer Attributable to Infections in 2024 

    -PubMed: Global Burden of Cancer Attributable to Infections in 2024 

    ~~~~ 

    
    

    What We Really Know About Persistent Finasteride Side Effects 

    Finasteride reduces the conversion of testosterone into DHT by inhibiting 5-alpha reductase, but that enzyme also participates in pathways involved in neuroactive steroids. Some former users report persistent sexual, cognitive, mood, and physical symptoms after stopping the drug, a collection of symptoms commonly called post-finasteride syndrome. Small studies have reported differences in neurosteroids, gene expression, androgen signaling, and peripheral nerve function among symptomatic former users, but these studies cannot establish that finasteride caused those changes or determine how common persistent symptoms are. Host Dave Asprey examines the evidence between the two extremes, neither dismissing persistent symptoms nor assuming that finasteride permanently damages everyone who takes it. European regulators have also recognized suicidal ideation as a possible adverse effect of oral finasteride, although its frequency remains unknown. 

    Sources: 

    -EMA: Finasteride and Dutasteride Safety Review 

    -PubMed: Neuroactive Steroids After Finasteride Discontinuation 

    PubMed: Neuroactive Steroids and Features in Post-Finasteride Patients 

    PubMed: Differential Gene Expression in Post-Finasteride Syndrome 

    ~~~ 

    
    

    One Cup of Blueberries a Day Improved Measures of Vascular Function 

    In a six-month randomized controlled trial involving 115 adults with metabolic syndrome, consuming the equivalent of one cup of blueberries per day improved endothelial function and a measure of arterial stiffness, while a half-cup dose did not produce the same effects. Host Dave Asprey explains why describing blueberries simply as “antioxidants” misses much of their biology. Anthocyanins and other polyphenols can interact with gut microbes and influence vascular, inflammatory, and nitric oxide-related signaling. He also examines a small smoothie experiment showing that the polyphenol oxidase found in bananas sharply reduced the circulating metabolites of certain flavan-3-ols, while emphasizing that the experiment did not prove bananas erase the benefits of blueberries. 

    Sources: 

    -American Journal of Clinical Nutrition: Blueberries and Cardiometabolic Function 

    -Food & Function: Polyphenol Oxidase and Flavan-3-ol Bioavailability 

    ~~~ 

    
    

    Vitamin D Matters to Male Reproductive Biology, But It Is Not a Fertility Treatment 

    Vitamin D receptors are present throughout the male reproductive system, and vitamin D signaling may influence processes involved in sperm motility and fertilization. Observational research has linked low vitamin D with poorer sperm motility, but clinical outcomes are less straightforward. In a randomized trial of 330 vitamin D-insufficient infertile men, supplementation raised vitamin D levels but did not improve overall semen parameters. Researchers observed potentially interesting signals involving spontaneous pregnancy and live birth among a subgroup of men with low sperm counts, but those findings require confirmation. Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense while arguing that male fertility needs to be evaluated as a larger system involving metabolic health, sleep, heat exposure, medications, hormones, micronutrients, toxins, oxidative stress, and semen testing. 

    Sources: 

    -PubMed: Vitamin D Supplementation, Semen Quality and Live Birth Rate 

    ~~~ 

    
    

    CoQ10 Shows Why a Great Mechanism Does Not Guarantee a Great Treatment 

    CoQ10 plays a central role in mitochondrial energy production and electron transport, making it an appealing candidate for diseases involving mitochondrial dysfunction, oxidative stress, and neuronal energy failure. Early biological reasoning and smaller studies looked promising, but larger clinical trials have repeatedly failed to show the expected neurological benefits. A randomized trial of 600 people with early Parkinson’s disease found no evidence that high-dose CoQ10 slowed disease progression, while a large Huntington’s disease trial was stopped early for futility. A Phase II ALS trial also found insufficient evidence to justify moving to a larger Phase III study. Host Dave Asprey uses CoQ10 as a broader lesson in biohacking: a supplement can have a legitimate biological function while still failing to improve the clinical outcome you care about. 

    Sources: 

    -PubMed: High-Dose CoQ10 in Early Parkinson Disease 

    -Neurology: CoQ10 in Huntington Disease 

    -PubMed: Phase II CoQ10 Trial in ALS 

    ~~~ 

    
    

    This episode is designed for biohackers, longevity enthusiasts, men thinking about hair loss or fertility, and anyone trying to distinguish a compelling biological mechanism from a proven intervention. Host Dave Asprey examines how chronic infections contribute to cancer risk, what the evidence really says about persistent finasteride symptoms, why blueberries may influence vascular health through polyphenol signaling, where vitamin D fits into male fertility, and why CoQ10 is a powerful example of promising biology failing to translate into clinical outcomes. The larger lesson is simple: understand the mechanism, look for meaningful human outcomes, measure your own biology, and avoid confusing a plausible explanation with proof that an intervention works. 

    
    

    Keywords: infection cancer risk, cancer causing infections, H pylori cancer, HPV cancer, Epstein Barr virus cancer, chronic infection cancer, finasteride side effects, post finasteride syndrome, finasteride neurosteroids, allopregnanolone finasteride, DHT hair loss, blueberries cardiovascular health, blueberries endothelial function, blueberry polyphenols, anthocyanins gut microbiome, banana smoothie polyphenols, polyphenol oxidase, vitamin D male fertility, vitamin D sperm quality, male infertility, CoQ10 mitochondria, CoQ10 Parkinson’s disease, CoQ10 neurodegeneration, mitochondrial health, biohacking research roundup 

    
    

    Thank you to our sponsors!  

    - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh 

    - The One Device | Use code DAVE for $10 off at theonedevice.com/dave 

    - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. 

    - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE 

    
    

    Resources:   

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

    • Danger Coffee: https://dangercoffee.com/discount/dave15   

    • My Daily Supplements: SuppGrade Labs (15% Off)   

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

    • Dave Asprey’s BEYOND Conference: https://beyondconference.com   

    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

    • Upgrade Labs: https://upgradelabs.com   

     

    Timestamps: 

    00:00 — Intro 

    00:45 — Infections From 2024 

    02:15 — Finasteride Concerns 

    04:38 — Blueberries and Bananas 

    06:40 — Vitamin D and Fertility 

    08:18 — CoQ10 Trial Failures 

    09:47 — Takeaway 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22. How to Unlock Psychic Abilities to Know When You’ll Die : 1551

    8 octobre 20261 h 4 minÉpisode 1551À suivre

    Get a free digital and audiobook copy of Angelic Attendants at https://askjulieryan.com/request-ebook/ Psychic Abilities, Medical Intuition, Energy Healing, Remote Viewing & What Happens When We Die with Julie …

    Notes de l’épisode

    Get a free digital and audiobook copy of Angelic Attendants at https://askjulieryan.com/request-ebook/ 

    
    

    Psychic Abilities, Medical Intuition, Energy Healing, Remote Viewing & What Happens When We Die with Julie Ryan 

    
    

    Host Dave Asprey sits down with Julie Ryan, psychic, medical intuitive, inventor, author, entrepreneur, and host of the Ask Julie Ryan podcast, to explore intuition, consciousness, energetic healing, remote viewing, communication with spirits, past lives, dreams, and what Julie says happens as people approach death. 

    
    

    Julie Ryan is a psychic and medical intuitive who says she can sense medical conditions, facilitate energetic healings, communicate with spirits, scan animals, access past lives, and tell how close someone may be to death. She is also an inventor, author, radio host, podcaster, and serial entrepreneur who has founded nine companies across five industries. Her surgical device inventions are sold globally, and unlike many people working in the intuitive space, Julie says her psychic and medical intuitive abilities were learned. 

    
    

    Her book Angelic Attendants: What Really Happens As We Transition From This Life Into The Next explores what she describes as the process of dying, including the presence of angels, deceased family members, friends, pets, and other experiences that may occur near the end of life. 

    
    

    Julie explains how she went from building companies and inventing surgical devices to learning psychic and medical intuitive skills she now teaches to others. She describes how she believes people can remotely sense information about the body, distinguish intuition from ordinary thoughts, and develop abilities that often get ignored or shut down as people grow older. 

    
    

    Dave and Julie explore what it means to “scan” someone from a distance, how Julie says she perceives injuries and illness inside the body, and why she sees intuition as another form of information processing rather than something reserved for a small group of gifted people. Julie also explains why visual, auditory, and kinesthetic learners may experience intuitive information differently. 

    
    

    They also discuss energetic healing, emotional trauma, brainwave patterns, spiritual experiences during surgery, communication with deceased loved ones, and the role dreams may play in receiving intuitive information. Dave shares his own experiences with intuition, altered brain states, grief, and the peaceful death of his mother. 

    
    

    This episode is essential listening for anyone interested in psychic abilities, intuition, consciousness, energy healing, remote viewing, medical intuition, dreams, the afterlife, grief, near-death awareness, spirituality, neuroscience, and the possibility that human perception may extend beyond what most people are trained to notice. 

    
    

    You’ll Learn: 

    • How Julie says psychic and medical intuitive abilities can be learned and trained 
    • How she remotely “scans” the body and interprets information about illness, injury, and healing 
    • How to tell the difference between intuition and ordinary thoughts or emotions 
    • What Julie says happens spiritually during surgery, dreams, and communication with deceased loved ones 
    • How her 12 phases of transition may indicate when someone is approaching death 
    • Why Dave believes intuition and science can overlap, especially in observation, discovery, and consciousness research 

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Keywords: Julie Ryan, psychic abilities, psychic powers, medical intuitive, medical intuition, intuition, intuitive abilities, energy healing, energetic healing, remote viewing, consciousness, spirituality, afterlife, what happens when you die, death and dying, near death, spirit communication, communicating with spirits, deceased loved ones, past lives, psychic training, intuitive training, spiritual healing, dreams, vivid dreams, grief, angels, guardian angels, consciousness research, neuroscience, brainwaves, psychic brain, spiritual experiences, emotional healing, energy medicine, mind body connection, holistic healing, biohacking, human potential, Dave Asprey, The Human Upgrade  

    
    

    Resources: 

    • Get A Free Digital And Audiobook Copy Of Angelic Attendants At https://askjulieryan.com/request-ebook/ 

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off) 

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

    
    

    Thank you to our sponsors!      

    - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh 

    - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. 

    - Caldera + Lab | If you're looking for one simple product that actually makes a difference, that's The Great, visit CalderaLab.com/DAVE and use code DAVE for 20% off your first order. 

    - Calroy | Learn more about Selentra HP and get your exclusive discount at calroy.com/dave 

    
    

    Timestamps:  

    00:00 — Trailer 

    01:00 — Psychic Powers 

    03:52 — Scanning Through Spirit 

    07:02 — First Intuitive Knowing 

    14:10 — Fairies and Elementals 

    17:29 — No Evil Spirits 

    23:11 — Medical Intuition  

    32:00 — The Energy Field Membrane 

    37:43 — Spirits in the Operating Room 

    46:17 — Dreams, Mold, and Lyme 

    54:04 — What Happens as We Die 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23. How to Live Healthier Without Obsessing Over Health : 1550

    6 octobre 202652 minÉpisode 1550À suivre

    Grab 20% off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E. Clean Living, Stress Reduction, Sleep, Skincare & Simple Wellness Habits with Miranda Kerr Host Dave Asprey sits down with …

    Notes de l’épisode

    Grab 20% off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E. 

    
    

    Clean Living, Stress Reduction, Sleep, Skincare & Simple Wellness Habits with Miranda Kerr 

    
    

    Host Dave Asprey sits down with Miranda Kerr, founder of KORA Organics, entrepreneur, model, and longtime wellness advocate, to explore clean living, stress, sleep, skincare, meditation, parenting, and why her approach to health has become simpler over time. 

    
    

    Miranda shares how her mother’s cancer diagnosis when she was 16 changed the way her family looked at everyday ingredients and helped spark her lifelong interest in organic living, holistic health, and reducing unnecessary exposures. That experience later became a driving force behind KORA Organics and her focus on certified organic skincare. 

    
    

    They explore the habits Miranda now prioritizes after years of experimenting with wellness, including morning sunlight, quality food, meditation, sleep, breathwork, strong relationships, and time with family. She also explains how she manages stress while raising four children and running an international company. 

    
    

    Dave and Miranda discuss raising healthy kids without making health feel restrictive, navigating different health values within a family, and why acceptance matters when you cannot control another person’s choices. 

    
    

    The episode also covers clean beauty, plant-based retinol alternatives, non-nano zinc sunscreen, essential oils, rose quartz, intention, and the philosophy behind KORA Organics. Miranda also explains why constantly chasing new wellness tools eventually pushed her back toward a smaller set of foundational habits that consistently make her feel better. 

    
    

    This episode is essential listening for anyone interested in clean living, stress reduction, meditation, sleep, healthy parenting, skincare, organic beauty, biohacking, and building a wellness routine that supports your life rather than taking it over.  

    
    

    You’ll Learn: 

    • Why Miranda’s mother’s health scare changed the way she thought about food, skincare, and everyday ingredients 
    • Why her wellness routine has become simpler instead of more complicated over time 
    • The foundational habits Miranda prioritizes for energy, stress, sleep, and overall health 
    • How meditation, breathwork, morning sunlight, and evening light management fit into her daily routine 
    • How she teaches her children about healthy food without creating fear or restriction 
    • Why acceptance matters when your partner does not share the same health priorities 
    • How Miranda approaches clean beauty, organic skincare, retinol alternatives, and non-nano mineral sunscreen 
    • Why KORA Organics incorporates rose quartz, positive words, essential oils, and intention into its products 
    • How constantly experimenting with wellness tools can become counterproductive 
    • Why sunlight, sleep, food, relationships, and stress management remain the foundation even after years of exploring wellness 

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Keywords: Miranda Kerr, KORA Organics, clean living, clean beauty, wellness, healthy living, holistic health, skincare, organic skincare, certified organic skincare, healthy skin, anti-aging skincare, skin health, non-nano zinc sunscreen, mineral sunscreen, retinol alternative, bakuchi oil, meditation, TM meditation, breathwork, stress reduction, stress management, sleep, circadian rhythm, morning sunlight, blue light, grounding, healthy parenting, raising healthy kids, nutrition, toxins, environmental toxins, ingredient safety, essential oils, rose quartz, mindset, intention, biohacking, healthy aging, wellness routine, simple wellness, holistic wellness 

    
    

    Resources: 

    • Grab 20% Off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E 

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off) 

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) 

     

    Thank you to our sponsors!      

    - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off 

    - Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

    - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26. 

    - LMNT | Right now, grab any LMNT drink mix and they'll throw in a free sample pack. Go to drinklmnt.com/dave to get yours. 

    
    

    Timestamps:  

    00:00 — Trailer 

    00:51 — Miranda’s Health Awakening 

    06:21 — Mind, Body & Crystals 

    13:12 — Roots of Positive Thinking 

    17:04 — The McDonald's Birthday Hack 

    22:36 — Acceptance in Relationships 

    28:34 — Intention Behind the Products 

    32:28 — Proving Organic Skincare Works 

    36:56 — Stress & Morning Rituals 

    42:09 — Back to Basics 

    48:17 — Health Without Public Pressure 

    51:06 — Closing Thoughts 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24. It's Boring, But It Slashed ALL My Visceral Fat In My 50s : 1549

    4 octobre 202619 minÉpisode 1549À suivre

    Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/I'm in the best shape of my life, and it has nothing to …

    Notes de l’épisode

    Try TrueDark glasses: https://truedark.com

    Try Danger Coffee: https://dangercoffee.com/discount/davetube

    Try Suppgrade Labs: https://shopsuppgradelabs.com/

    
    

    I'm in the best shape of my life, and it has nothing to do with working harder. In this video, I break down the 5 unconventional hacks that helped me lose over 100 pounds, kill brain fog, and feel two decades younger, starting with something as simple as what I put in my morning coffee. If you're tired of doing everything 'right' and still feeling old, this one's for you.

    
    

    You'll Learn:

    • How putting grass-fed butter and MCT oil in your coffee can unlock steady energy and effortless fat loss
    • Why eating more saturated fat, not less, supports your brain, hormones, and metabolism
    • How the "calories in, calories out" myth keeps you stuck and why food quality matters far more than quantity
    • Which "healthy" foods like spinach, oats, and beans are packed with anti-nutrients that cause inflammation and block nutrient absorption
    • How intermittent fasting flips your body from sugar-burning to fat-burning mode and triggers cellular repair
    • Why dialing in your nutrition beats grinding in the gym and how over-exercising can actually stall fat loss and speed up aging

    
    

    Timestamps:

    00:00 — The 300-Pound Millionaire

    01:26 — Discovery in Tibet

    03:05 — Eat More Saturated Fat

    04:38 — The Low-Fat Scam

    07:01 — Quality Over Quantity

    09:20 — Hidden Plant Toxins

    12:04 — Watch the Fructose

    13:08 — Skip Breakfast

    16:38 — Diet Beats the Gym

    
    

    
    

    Thank you to our sponsors!

    - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

    -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.

    -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

    
    

    Connect with Dave Asprey!

    
    

    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr

    
    

    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

    
    

    Danger Coffee: https://dangercoffee.com/discount/dave15?

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Join my Substack: https://substack.daveasprey.com

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25. Vagus Nerve Memory, Cat Cancer Genes, Inherited Intelligence, Mulberry Microbes, and Vitamin D : 1548

    2 octobre 202611 minÉpisode 1548À suivre

    Vagus Nerve Stimulation Improves Cognitive Scores in a Small Trial In a 24-week trial involving people with mild cognitive impairment, participants assigned to electrical stimulation at vagus-innervated parts …

    Notes de l’épisode

    Vagus Nerve Stimulation Improves Cognitive Scores in a Small Trial 

    In a 24-week trial involving people with mild cognitive impairment, participants assigned to electrical stimulation at vagus-innervated parts of the ear improved by an average of 3.2 points on a general cognitive test, compared with 0.3 points in a sham-stimulation group. Host Dave Asprey explores the proposed connection between the vagus nerve and the locus coeruleus, a brainstem region involved in attention and learning. He explains why an improved test score is intriguing but does not show that vagus nerve stimulation prevents Alzheimer’s disease—or that a consumer device will reproduce the study’s results.pubmed.ncbi.nlm.nih+1 

    Sources: 

    https://pubmed.ncbi.nlm.nih.gov/36150665/ 

    https://pmc.ncbi.nlm.nih.gov/articles/PMC13214873/ 

    https://theconversation.com/vagus-nerve-stimulation-shows-promise-as-a-way-to-counter-alzheimers-disease-and-age-related-memory-loss-269465 

    ~~~

    
    

    Nearly 500 Cat Tumors Reveal Cancer Genes Shared With Humans 

    Researchers analyzed 493 matched tumor and normal-tissue samples across 13 types of cancer in domestic cats. They found alterations in genes familiar to human cancer researchers, including TP53, and tested whether a mutation called FBXW7 might predict drug sensitivity in lab-grown models of feline mammary tumors. Host Dave Asprey examines why naturally occurring cancers in pets could help scientists investigate treatments across species, while making clear that a promising response in six laboratory tumor models is not a proven treatment for cats or people.pmc.ncbi.nlm.nih 

    Sources: 

    https://pmc.ncbi.nlm.nih.gov/articles/PMC7618901/ 

    https://pubmed.ncbi.nlm.nih.gov/41712721/ 

    https://www.sciencedaily.com/releases/2026/09/260924231826.htm 

    ~~~

    
    

    Twin-Family Study Challenges a Simple Explanation for Inherited Intelligence 

    Why do parents and children often score similarly on tests of cognitive ability? Researchers using Germany’s TwinLife data found that genetic transmission explained more of that resemblance than the particular shared-home-environment pathway their model tested. Host Dave Asprey unpacks the distinction between why relatives resemble one another and whether a child’s environment matters. The study does not show that parenting, education, or other experiences have no effect on cognition.pub.uni-bielefeld+1 

    Sources: 

    https://pub.uni-bielefeld.de/record/2993432 

    https://www.psypost.org/genetics-not-shared-environments-drives-parent-child-similarities-in-cognitive-ability/ 

    ~~~

    
    

    Mulberry Compounds May Change Gut Bacteria and Metabolism 

    A review of mulberry research highlights how leaves, fruit, and differently processed extracts contain distinct mixtures of compounds that gut microbes may use. In mouse experiments, a fraction combining mulberry polyphenols and polysaccharides produced more favorable microbiome and metabolic changes than either fraction alone; transferring microbes from treated mice passed along some of those effects. Host Dave Asprey explores the idea that a plant extract’s preparation may matter as much as its name—and why the findings do not yet establish a microbiome benefit from mulberry products in humans.pmc.ncbi.nlm.nih+1 

    Sources: 

    https://pmc.ncbi.nlm.nih.gov/articles/PMC13406227/ 

    https://www.sciencedaily.com/releases/2026/09/260928100551.htm 

    ~~~

    
    

    Magnesium Changes Vitamin D Metabolism—But Not Always in the Same Direction 

    Magnesium helps regulate the pathways that process vitamin D, but “more magnesium means more vitamin D” is too simple. In a 12-week randomized trial involving 180 adults, magnesium supplementation changed a measured vitamin D metabolite differently depending on participants’ starting vitamin D levels: the modeled difference was positive at 30 ng/mL and negative at 50 ng/mL. Host Dave Asprey explains why this matters to people tracking supplement stacks and bloodwork, while distinguishing a change in a lab marker from a demonstrated health benefit.pubmed.ncbi.nlm.nih+1 

    Sources: 

    https://pmc.ncbi.nlm.nih.gov/articles/PMC6693398/ 

    https://pubmed.ncbi.nlm.nih.gov/29480918/ 

    https://www.sciencedaily.com/releases/2018/02/180226122548.htm 

    
    

    
    

    This episode is designed for biohackers, longevity enthusiasts, pet owners, parents, and anyone trying to separate a compelling biological mechanism from a proven health intervention. Host Dave Asprey examines brain stimulation and memory, what cat cancers could teach human researchers, how genes and environment contribute to cognitive similarity, whether mulberry’s microbiome effects translate beyond mice, and why nutrient interactions are rarely as simple as a supplement headline suggests. Several studies discussed here predate this week’s coverage; this is a research roundup, not a list of five newly published trials.pmc.ncbi.nlm.nih+4 

    
    

    New episodes every Tuesday, Thursday, Friday, and Sunday. 

    
    

    Keywords: vagus nerve stimulation memory, auricular vagus nerve stimulation, mild cognitive impairment, Alzheimer’s research, locus coeruleus, cat cancer genetics, feline oncogenome, FBXW7 feline mammary cancer, comparative oncology, parent child cognitive ability, TwinLife cognitive ability study, intelligence genetics, shared environment cognition, mulberry gut microbiome, mulberry polyphenols polysaccharides, microbiota transfer mice, magnesium vitamin D metabolism, magnesium supplementation vitamin D, biohacking research roundup 

    
    

    Thank you to our sponsors!  

    - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh 

    - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. 

    - The One Device | Use code DAVE for $10 off at theonedevice.com/dave 

    - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE 

    
    

    Resources:   

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

    • Danger Coffee: https://dangercoffee.com/discount/dave15   

    • My Daily Supplements: SuppGrade Labs (15% Off)   

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

    • Dave Asprey’s BEYOND Conference: https://beyondconference.com   

    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

    • Upgrade Labs: https://upgradelabs.com   

    
    

    Timestamps: 

    00:00 — Intro 

    00:18 — Vagus Nerve 

    01:51 — Cat Cancer 

    03:53 — Genetics & Parenting 

    05:46 — Mulberries 

    07:43 — Magnesium & Vitamin D 

    09:25 — Takeaway 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26. Dave’s Anti-Aging Skincare Routine: Exosomes, Methylene Blue & NAD+ : 1547

    1 octobre 202647 minÉpisode 1547À suivre

    Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode. Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with …

    Notes de l’épisode

    Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode. 

    
    

    Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young Goose 

    
    

    Host Dave Asprey sits down with Amitay Eshel and Anastasia Khodzhaeva, co-founders of Young Goose, to explore the emerging science of skin longevity, cellular aging, mitochondrial function, exosomes, NAD+, red light therapy, and what it may take to keep skin functioning younger for longer. 

    
    

    Anastasia is a biologist, biohacker, and co-CEO of Young Goose who began her career in biomedical research focused on liver fibrosis and breast cancer before moving into wellness, product development, and longevity-focused skincare. Amitay is co-founder and CEO of Young Goose and host of the Biohacking Beauty podcast, with more than a decade of experience across health, wellness, beauty, and business development. Together, they focus on applying longevity science and performance optimization to skin health. 

    
    

    Amitay and Anastasia explain why wrinkles may be only one visible sign of a much deeper biological process involving declining cellular energy, weakened barrier function, oxidative stress, senescence, and changes in how skin cells repair themselves. They break down how newer approaches to skincare are moving beyond surface-level hydration toward targeting the cellular mechanisms associated with aging. 

    
    

    The conversation goes deep into testing, including a metabolomics-based approach designed to assess skin metabolic age from a small blood sample and analyze 17 different metabolites. They also discuss emerging proteomics testing that can examine thousands of proteins involved in processes such as collagen production, oxidative stress, mitochondrial function, and cellular repair. 

    
    

    Dave, Amitay, and Anastasia explore some of the most unusual compounds now being used in skin longevity, including methylene blue, NAD+ precursors, spermidine, ergothioneine, superoxide dismutase, copper peptides, ectoin, and gotu kola. They explain how these compounds may interact with mitochondrial energy production, oxidative stress, mitophagy, collagen signaling, and the broader hallmarks of aging. 

    
    

    They also break down red light therapy and why combining light with certain topical compounds may influence the response. The discussion covers methylene blue and electron transport, copper peptides and mitochondrial biogenesis, light-activated DNA repair enzymes, photodamage, reactive oxygen species, and why dose and timing may matter when using red or near-infrared light. 

    
    

    The episode also dives into platelet-derived “Vampire Exosomes,” how exosomes carry cellular instructions through microRNAs, why formulation and stability matter, and how these signaling particles may influence skin repair, inflammation, collagen production, and senescence. Dave and the Young Goose team also discuss growth factors, klotho, senomorphic strategies, cellular longevity, and why extending the functional life of healthy cells may become an important frontier in longevity science. 

    
    

    They also explore practical skincare routines, including how to layer products, what Dave uses while traveling, how airplanes and dry environments affect skin, why aggressive acids may not always fit a long-term skin longevity strategy, and how AI-based skin analysis could make skincare increasingly personalized. 

    
    

    This is essential listening for anyone interested in skin longevity, anti-aging skincare, exosomes, methylene blue, NAD+, red light therapy, mitochondrial health, senescent cells, collagen, peptides, cellular repair, metabolomics, proteomics, biohacking, and the future of personalized skincare. 

    
    

    You’ll Learn: 

    • Why wrinkles may be a downstream sign of deeper cellular aging 
    • How skin metabolic age can be assessed using metabolomics and multiple biological markers 
    • What methylene blue may do inside mitochondria and why it pairs with red light 
    • How NAD+ precursors, spermidine, copper peptides, SOD, and ergothioneine may support skin biology 
    • Why platelet-derived “Vampire Exosomes” are being studied for cellular signaling, repair, and senescence 
    • How red light therapy interacts with mitochondrial function, oxidative stress, and DNA repair 
    • Why some traditional acids and surface-level skincare strategies may not address long-term skin function 
    • How proteomics and AI could change the way skincare is measured and personalized 
    • What Dave and the Young Goose team use to support skin during travel and other high-stress environments 

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Keywords: Amitay Eshel, Anastasia Khodzhaeva, Young Goose, Biohacking Beauty, skincare, anti-aging skincare, skin longevity, skin aging, younger skin, exosomes, vampire exosomes, platelet-derived exosomes, methylene blue, NAD+, NAD precursors, red light therapy, mitochondria, mitochondrial health, mitochondrial dysfunction, cellular aging, cellular repair, senescent cells, senescence, senomorphics, collagen, copper peptides, GHK-Cu, spermidine, ergothioneine, superoxide dismutase, SOD, ectoin, gotu kola, mitophagy, metabolomics, proteomics, skin metabolic age, klotho, oxidative stress, peptides, skin barrier, DNA repair, photodamage, biohacking, longevity 

    
    

    Resources:    

    • Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode. 

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off)     

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     

    
    

    Thank you to our sponsors!      

    - Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. 

    - Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

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    - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. 

    
    

    Timestamps:  

    00:00 — Trailer 

    01:09 — Skin Testing & Metabolomics 

    04:48 — Longevity Skincare Paradigm 

    07:50 — Airplane Skincare Routine 

    11:15 — Tardigrade Juice & Antioxidants 

    16:00 — Mitochondrial Dysfunction 

    21:00 — Skincare Ingredients: Old vs New 

    27:20 — Vampire Exosomes 

    32:30 — Red Light Therapy Stacking 

    38:00 — Proteomics & Klotho 

    41:00 — Exosome Safety, Growth Factors & MicroRNAs 

    44:00 — Senescent Cells & Senomorphics 

    47:00 — Skin Longevity Takeaways

    50:00 — Outro 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27. The Silent Fatty Liver Epidemic: Why Thin, Sober People Are Still at Risk : 1546

    29 septembre 202657 minÉpisode 1546À suivre

    Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode. Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and …

    Notes de l’épisode

    Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode.

    
    

    Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain function, weight management, and longevity. 

    
    

    Siggi explains why fatty liver can develop without obvious symptoms and why someone can appear lean and healthy while still have significant liver fat. Drawing on thousands of liver scans, he shares what his team has observed in people whose blood markers appeared normal despite signs of fatty liver on imaging, and explains how tools such as FibroScan can reveal liver fat, stiffness, and fibrosis. 

    
    

    Dave and Siggi go deep into triglycerides, cholesterol, insulin resistance, brain fog, weight gain, bile production, thyroid hormone activation, testosterone, estrogen metabolism, and liver regeneration. They also explore how alcohol, environmental chemicals, plastics, processed foods, artificial sweeteners, medications, and other exposures may place additional stress on the liver. 

    
    

    The conversation also tackles rapid weight loss and GLP-1 medications, including Siggi’s concerns about compounds released from fat tissue during aggressive weight loss and why protecting muscle, eating enough protein, and supporting liver function may matter during the process. 

    
    

    Dave and Siggi also discuss alcohol, estrogen, hormone replacement therapy, glutathione, choline, bile flow, supplement quality, and why liver health may influence systems throughout the body. The episode takes an unexpected turn into microchimerism and organ transplantation, including donor cells, DNA, cellular memory, and reported changes in behavior or personality after transplantation. 

    
    

    This is essential listening for anyone interested in fatty liver, metabolic health, GLP-1s, weight loss, hormone health, estrogen, testosterone, thyroid function, alcohol, brain fog, insulin resistance, liver scans, longevity, choline, glutathione, bile flow, and biohacking. 

    
    

    You’ll Learn: 

    
    

    • Why fatty liver can develop even in people who are thin or rarely drink alcohol 
    • Why normal bloodwork may not always reveal what is happening inside the liver 
    • How liver health connects to metabolism, brain fog, weight gain, hormones, and thyroid function 
    • What rapid weight loss and GLP-1 use may mean for liver function 
    • How alcohol, estrogen, HRT, bile, choline, and glutathione interact with liver health 
    • Why liver scans, nutrition, and supplement quality may matter for long-term health 

    
    

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

    
    

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

    
    

    Keywords: Siggi Clavien, de-liver-ance, The Liver Clinic, liver health, fatty liver, fatty liver disease, MASLD, liver detox, liver function, liver scan, FibroScan, liver fibrosis, triglycerides, cholesterol, metabolic health, GLP-1, weight loss, toxins, alcohol, estrogen, HRT, testosterone, thyroid health, brain fog, insulin resistance, bile, choline, glutathione, artificial sweeteners, supplements, longevity, liver regeneration, microchimerism, biohacking 

    
    

    Resources:    

    • Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode. 

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off)     

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     

    
    

    Thank you to our sponsors!      

    - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off 

    - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE. 

    - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. 

    - Mars Men | For a limited time, our listeners get 50% off for life plus Free Shipping AND 3 Free Gifts when you checkout at MenGoToMars.com. 

    
    

    Timestamps:  

    00:00 — Trailer 

    01:00 — Liver Basics & Signs 

    05:30 — Liver Scan Technology 

    08:15 — Chemicals & Liver Disease 

    11:30 — Deliverance Formula Story 

    17:15 — Estrogen, Alcohol & HRT 

    22:30 — GLP-1s & Liver Toxicity 

    28:00 — Bile & Gut Health 

    33:10 — Chimerism & Transplants 

    41:30 — Hormesis & Painkillers 

    50:00 — Sweeteners, Hormones & Thyroid 

    55:00 — Outro - Discount 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28. Every Way to Melt Visceral Fat FAST In 14 Minutes : 1545

    27 septembre 202614 minÉpisode 1545À suivre

    Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Try Longevity Gummies …

    Notes de l’épisode

    Try TrueDark glasses: https://truedark.com

    Try Danger Coffee: https://dangercoffee.com/discount/davetube

    Try Suppgrade Labs: https://shopsuppgradelabs.com/

    Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey

    
    

    This video explains the most effective ways to lose visceral fat, escalating from least to most effective, like a caloric deficit & diet quality (high protein, cut alcohol), Aerobic exercise (cardio), resistance training, sleep optimization, and stress reduction.

    
    

    If diet and exercise aren't melting stubborn belly fat, fix your sleep first with 300mg of Magnesium 101 before bed, available at https://shopsuppgradelabs.com/discount/DAVETUBE?redirect=/products/magnesium-101 with code DAVETUBE for 15% off.

    
    

    You'll Learn:

    • Why protein burns 20–30% of its own calories just to digest — and how that "thermic effect" makes it the most powerful diet lever for cutting visceral fat
    • Why short, intense workouts (as little as 10–20 minutes a week) beat long cardio sessions for triggering fat-burning hormones
    • How cold exposure activates brown fat to burn visceral fat as fuel, and why consistency matters more than intensity
    • Why resistance training is one of the most effective tools for long-term fat loss, not just muscle-building
    • How poor sleep tanks growth hormone by up to 70% a night and drives up cortisol, both of which directly promote visceral fat storage
    • Why chronic stress is the single biggest driver of visceral fat, and how it creates a self-reinforcing loop that resists diet and exercise alone

    
    

    
    

    Thank you to our sponsors!

    • Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
    • Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
    • iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

    
    

    Timestamps:

    00:00 — Introduction & Calorie Myth

    01:27 — Power of Protein

    02:37 — Cut Sugar & Carbs

    03:48 — HIIT for Fat Loss

    05:44 — Cold Exposure

    06:32 — Resistance Training

    08:22 — Sleep & Growth Hormone

    10:30 — Stress & Cortisol

    13:39 — Breaking the Fat Loop

    
    

    Connect with Dave Asprey!

    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr

    
    

    The Human Upgrade Podcast: https://www.instagram.com/

    TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

    
    

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

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29. Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food Additives, Taurine, and more : 1544

    25 septembre 202615 minÉpisode 1544À suivre

    Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside …

    Notes de l’épisode

    Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion 

    Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause and addiction. The company has not announced a hair-loss drug, clinical trial, acquisition, or partnership, but Chief Scientific Officer Martin Holst Lange pointed to the category during the company's 2026 Capital Markets Day. Host Dave Asprey breaks down why hair loss makes strategic sense for a company already deeply involved in endocrine biology, how emerging treatments are moving beyond traditional options like minoxidil and finasteride, and why sudden shedding during rapid GLP-1 weight loss may be telogen effluvium rather than traditional pattern baldness. 

    Sources: 

    https://www.bloomberg.com/news/articles/2026-09-22/ozempic-maker-novo-looks-to-target-hair-loss-in-consumer-push 

    https://www.novonordisk.com/investors/capital-markets-day-2026.html 

    https://www.irishexaminer.com/business/companies/arid-41914219.html 

    ~~~

    
    

    Nearly One in Six Pediatric GLP-1 Users Diagnosed With a Nutritional Deficiency 

    A study of 2,031 children and adolescents ages 10 to 17 who were prescribed GLP-1 receptor agonists found that 16.88% received a new diagnosis related to a nutritional deficiency within one year. Vitamin D deficiency was the most common, appearing in about 12.4% of the group, while smaller numbers were diagnosed with nutritional anemia or iron deficiency anemia. Host Dave Asprey explains why the study does not prove GLP-1 drugs caused these deficiencies, but highlights a bigger concern: only about 5% of the children had documented nutrition counseling within the first 30 days, even though appetite suppression during adolescence can reduce intake of protein, iron, calcium, vitamin D, B vitamins, and other nutrients needed for growth. 

    Sources: 

    https://doi.org/10.1177/21532176261486979 

    https://www.sciencedaily.com/releases/2026/09/260923035926.htm 

    https://pharmaceutical-journal.com/article/news/children-taking-glp-1s-can-be-at-risk-of-nutritional-deficiencies-study-finds 

    ~~~

    
    

    Stronger Stomach-Brain Synchrony Associated With Poorer Mental Health 

    Researchers studying the electrical rhythm of the stomach alongside brain activity found an unexpected relationship: stronger synchronization between gastric signals and certain brain networks was associated with worse mental health measures, including higher anxiety, depression, stress, and fatigue. The strongest associations appeared in networks involved in attention and cognitive control. Host Dave Asprey explains why the findings do not prove stomach-brain synchronization causes mental health problems, but expand the gut-brain conversation beyond the microbiome to include electrical activity, neural signaling, hormones, immune pathways, and metabolites. 

    Sources: 

    https://www.nature.com/articles/s44220-025-00468-6 

    https://health.au.dk/en/display/artikel/the-stomachs-brain-is-more-in-sync-with-the-mind-during-mental-distress 

    https://medicalxpress.com/news/2025-08-stomach-brain-sync-mind-mental.html 

    ~~~

    
    

    Food Preservatives and Additive Mixtures Associated With Cardiovascular Risk 

    A large French NutriNet-Santé study involving more than 112,000 adults found that higher exposure to total preservatives was associated with a higher incidence of hypertension, while several individual additives were also linked to elevated risk. A newer September 2026 analysis from the same cohort examined combinations of additives people commonly consume together and found several mixtures associated with higher rates of hypertension, cardiovascular disease, or coronary heart disease. Host Dave Asprey explains why these observational findings cannot prove that preservatives cause cardiovascular disease, but raises a larger question about whether evaluating food additives one compound at a time accurately reflects the mixtures people consume in real packaged foods. 

    Sources: 

    https://academic.oup.com/eurheartj/article/doi/10.1093/eurheartj/ehag308/8679203 

    https://link.springer.com/article/10.1186/s12916-026-05132-z 

    https://www.escardio.org/news/press/press-releases/common-food-preservatives-linked-to-high-blood-pressure-and-heart-disease/ 

    ~~~

    
    

    Taurine Pretreatment Reduces Depression-Like Changes in Chronically Stressed Rats 

    A 2017 study in male rats found that taurine pretreatment reduced several behavioral and biochemical effects of chronic unpredictable stress. Taurine-treated animals maintained more normal reward-seeking behavior and performed better on some learning and memory measures, while researchers also observed changes in corticosterone, glutamate, serotonin, dopamine, noradrenaline, BDNF, and FGF2. Host Dave Asprey explains why this does not show that taurine treats depression in humans, especially because the taurine was injected and given before the chronic stress began, but uses the study to explore a broader principle: much of stress resilience may be built before the stress ever arrives. 

    Sources: 

    https://www.nature.com/articles/s41598-017-05051-3 

    https://pmc.ncbi.nlm.nih.gov/articles/PMC5504064/ 

    
    

    
    

    This episode is designed for biohackers, longevity enthusiasts, parents, and high-performance listeners who want emerging health research translated into practical decisions without getting trapped by headline science. Host Dave Asprey explores what rapid weight loss can mean for hair and nutrient status, why the gut-brain axis extends far beyond the microbiome, what food-additive research can and cannot tell us about cardiovascular risk, and why stress resilience may depend as much on what you do before a challenge as what you do after it. 

    
    

    New episodes every Tuesday, Thursday, Friday, and Sunday. 

    
    

    Keywords: Novo Nordisk hair loss, Ozempic hair loss, Wegovy hair shedding, GLP-1 telogen effluvium, minoxidil hair loss, finasteride hair loss, pediatric GLP-1 nutritional deficiencies, GLP-1 vitamin D deficiency, GLP-1 children nutrition, liraglutide adolescents, semaglutide teenagers, stomach brain connection, gastric brain coupling, gut brain axis mental health, electrogastrography anxiety, gut brain depression, food preservatives cardiovascular disease, food additives hypertension, NutriNet-Santé preservatives, ultra-processed foods heart disease, additive mixtures cardiovascular risk, taurine stress resilience, taurine depression study, taurine BDNF, chronic stress taurine, biohacking news 2026 

    
    

    Thank you to our sponsors!  

    - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh 

    - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 

    - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE 

    
    

    Resources:   

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

    • Danger Coffee: https://dangercoffee.com/discount/dave15   

    • My Daily Supplements: SuppGrade Labs (15% Off)   

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

    • Dave Asprey’s BEYOND Conference: https://beyondconference.com   

    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

    • Upgrade Labs: https://upgradelabs.com   

    
    

    Timestamps: 

    00:00 — Intro 

    00:18 — Novo Nordisk & Hair Loss 

    02:52 — GLP-1s & Kids' Nutrition 

    05:08 — Stomach-Brain Sync 

    07:49 — Preservatives & Heart Risk 

    10:53 — Taurine & Stress Resilience 

    13:28 — Outro 

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30. The Best Singular Hack To Change EVERYTHING About Your Life : 1543

    24 septembre 20261 h 14 minÉpisode 1543À suivre

    Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on …

    Notes de l’épisode

    Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.

    Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study: 

    • Social connections are really good for you. Loneliness kills.
    • It’s the quality of your close relationships that matters.
    • Good close relationships don’t just protect your body, they protect your brain.

    
    

    Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:

    • how relationships improve your physical, mental and emotional health. (More than you know!)
    • how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)
    • what social fitness is and how to practice it. (Yes, it’s a flex.)
    • ways to enliven and energize your relationships. (Energy totally matters.)
    • why casual and work relationships matter more than you think. (A surprisingly big contribution.)

    
    

    You'll Learn:

    • Why loneliness physically harms your body — affecting your brain, immune function, sleep, and pain sensitivity
    • The likely mechanism behind why relationships improve health: how a good listener helps regulate your stress response
    • What "social fitness" is and why relationships wither from neglect, even without conflict
    • The four attachment styles and why knowing yours matters before committing to a relationship
    • Why intergenerational friendships may be one of the most underused tools for personal growth and happiness

    
    

    Resources:    

    • Visit https://metabolismfixbook.com/ to learn more about JJ Virgin’s new book, The Metabolism Fix, and access the bonus resources she created to go with it. 

    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    

    • Danger Coffee: https://dangercoffee.com/discount/davetube 

    • My Daily Supplements: SuppGrade Labs (15% Off)     

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

    
    

    Timestamps:

    00:00 — Introduction & the Study

    04:43 — What Makes a Good Life

    08:47 — How Relationships Heal

    13:44 — Happiness: Nature vs Nurture

    17:59 — Measuring Happiness

    23:56 — Life Stages & Happiness

    35:34 — Social Fitness

    44:30 — Energizing Relationships

    56:14 — Attachment & Childhood

    1:05:04 — Casual Friends & Legacy

    
    

    Thank you to our sponsors!      

    - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh 

    - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. 

    - BodyHealth | Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase. 

    - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26.  

    
    

    
    

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Voici les 40 derniers épisodes sur 614. Les épisodes plus anciens se trouvent dans le flux du podcast.