The Science of Everything Podcast
- Épisodes
- 173
- Parution
- mensuelle
- Dernier épisode
- 1 Nov 2026
À propos du podcast
I discuss a variety of topics in both the natural and social sciences, exploring the many fascinating insights that the scientific method yields about the world around us.
Épisodes 173
Episode 165: Gene Technologies
An introduction to the technologies and methods used in the study and manipulation of DNA and genes. We begin with an overview of basic methods for gene isolation and manipulation, including restriction …
Notes de l’épisode
An introduction to the technologies and methods used in the study and manipulation of DNA and genes. We begin with an overview of basic methods for gene isolation and manipulation, including restriction enzymes, gel electrophoresis, cloning vectors, and the polymerase chain reaction. We then examine various techniques of gene sequencing, beginning with Sanger sequencing and then discussing various next generation and third generation sequencing methods. We conclude with a review of genetic engineering, including methods for gene delivery and how CRISPR cas9 has revolutionised the ability to make precise gene edits to specified locations in the genome. Recommended pre-listening is Episodes 34 and 35: DNA Structure and Function Parts 1 and 2.
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Episode 164: Gauge Theory and the Higgs Boson
We conclude our series on the standard model with an introduction to gauge theory. We discuss how the requirement of local gauge invariance generates interaction terms in the Lagrangian, and introduce the U(1) …
Notes de l’épisode
We conclude our series on the standard model with an introduction to gauge theory. We discuss how the requirement of local gauge invariance generates interaction terms in the Lagrangian, and introduce the U(1) x SU(2) x SU(3) group structure of the standard model. We also consider the problem of massive W and Z bosons, and how this was resolved by the introduction of the Higgs field and the mechanism of spontaneous symmetry breaking. Recommended pre-listening is Episode 163: The Standard Model of Particle Physics.
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Episode 163: The Standard Model of Particle Physics
An introduction to the particles and forces that constitute the standard model of particle physics. After some historical background, we introduce each of the three fundamental forces that comprise the standard …
Notes de l’épisode
An introduction to the particles and forces that constitute the standard model of particle physics. After some historical background, we introduce each of the three fundamental forces that comprise the standard model - electromagnetism, the strong nuclear force, and the weak nuclear force. We then compare and contrast the different types of particles these forces interact with, including the difference between fermions and bosons, and between quarks and leptons. We consider the types of interactions experienced by these particles and the three generations of matter. Recommended pre-listening is Episodes 158 & 159: Quantum Electrodynamics Parts 1 and 2.
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Episode 162: Human Evolution
Beginning with primitive Cynodonts in the late Permian, we our evolutionary development through Mesozoic mammaliaforms, the divergence of monotremes from marsupials and placentals, and culiminating in the …
Notes de l’épisode
Beginning with primitive Cynodonts in the late Permian, we our evolutionary development through Mesozoic mammaliaforms, the divergence of monotremes from marsupials and placentals, and culiminating in the emergence of primates in the early Cenozoic. Along the way we discuss the emergence of important traits such as the mammalian ear and various primate adaptations for arboreal life. We then discuss the sequence of hominin species in the lead up to to humans, including Ardipithecus, Australopithecus, Homo erectus, and Neanderthals. We conclude with an analysis of the emergence of distinctive human traits, including bipedalism, encephalisation, and extensive tool use. Recommended pre-listening is Episode 161: Dinosaurs and Other Ancient Reptiles.
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Episode 161: Dinosaurs and Other Ancient Reptiles
A survey of extinct animal species from the Permian through the Cretaceous periods. We discuss important differences between anapsids, synapsids, and diapsids, and then review diverse species from all groups …
Notes de l’épisode
A survey of extinct animal species from the Permian through the Cretaceous periods. We discuss important differences between anapsids, synapsids, and diapsids, and then review diverse species from all groups, including pelycosaurs, therapsids, parareptiles, euryapsids, pterosaurs, pseudosuchia, and dinosaurs. We also consider aspects including bipedal gait, endothermy, gigantism, and the cause of the end Cretaceous mass extinction. Recommended pre-listening is Episode 160: The Evolution of Animals.
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Episode 160: The Evolution of Animals
A journey through the evolutionary history of animals, beginning with the split of the metazoans from protists about 760 million years ago and ending with the rise of the amniotes about 340 million years ago …
Notes de l’épisode
A journey through the evolutionary history of animals, beginning with the split of the metazoans from protists about 760 million years ago and ending with the rise of the amniotes about 340 million years ago. The focus is the development of key morphological traits necessary for more complex animal forms, including the origin of true tissues, bilaterial symmetry, the complete gut, the coelom, internal skeletons, and limbs. We conclude with an analysis of key adaptions that allowed amniotes to life in a wider range of terrestrial habitats. Recommended pre-listening is Episode 155: Embryology and Development and Episode 157: The Geologic Time Scale.
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Episode 159: Quantum Electrodynamics Part 2
Continuing from quantum electrodynamics part 1, here we explore the mathematical machinery used to compute interactions between particles, including propagators, Feynman diagrams, cross sections. We then walk …
Notes de l’épisode
Continuing from quantum electrodynamics part 1, here we explore the mathematical machinery used to compute interactions between particles, including propagators, Feynman diagrams, cross sections. We then walk through a simple example calculation to illustrate how these tools are applied. I conclude with an introduction to the problem of divergent loop integrals and how these can be resolved using renormalisation. Recommended pre-listening is Episode 158: Quantum Electrodynamics Part 1.
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Episode 158: Quantum Electodynamics Part 1
A detailed look into the physics and mathematics of quantum electrodynamics, the theory of how light and matter interact. We discuss the generalisation of the Schrodinger equation to the Klein-Gordon and Dirac …
Notes de l’épisode
A detailed look into the physics and mathematics of quantum electrodynamics, the theory of how light and matter interact. We discuss the generalisation of the Schrodinger equation to the Klein-Gordon and Dirac equations, and howw these describe the propogation of light and fermions respectively. We then consider the process of computing transition probabilities between quantum states, including the S matrix and perturbation theory, and Wick's theorem. Recommended pre-listening is Episode 85: Introduction to Quantum Field Theory.
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Episode 157: The Geologic Time Scale
A survey of the Earth's history through the lens of the geologic timescale. We begin with a discussion of the terminology of geochronologic units and how they are specified using 'golden spikes'. We then review …
Notes de l’épisode
A survey of the Earth's history through the lens of the geologic timescale. We begin with a discussion of the terminology of geochronologic units and how they are specified using 'golden spikes'. We then review the development of Earth's atmosphere, geosphere, and biosphere through the Hadean, Archean, Proterozoic, and Phanerozoic eons. We cover many topics including the supercontinent cycle, the great oxidation event, the evolution of eukaryotes, the Cambrian explosion, and mass extinctions. Recommended pre-listening is Episode 156: Fossils and Dating Methods.
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Episode 156: Fossils and Dating Methods
An introduction to the techniques used to study the history and ages of geological speciments. We begin with an overview of chronostratigraphy, covering principles of relative dating, way up indicators, and …
Notes de l’épisode
An introduction to the techniques used to study the history and ages of geological speciments. We begin with an overview of chronostratigraphy, covering principles of relative dating, way up indicators, and biostratigraphy. We then discuss geochronology, including a review of early attempts to determine the age of the Earth, the principles and assumptions of radiometric dating, and the radioisotopes most commonly used for dating. Finally, we discuss processes and mechanisms of fossilisation, and review some of the most important classes of index fossils. Recommended pre-listening is Episode 74: Minerals and Rocks, and Episode 77: Nuclear Physics.
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Episode 155: Embryology and Development
An introduction to the process of development, beginning with fertilisation and covering the stages of blastocyst formation, implantation into the uterus, gastrulation and its constituent cell movements …
Notes de l’épisode
An introduction to the process of development, beginning with fertilisation and covering the stages of blastocyst formation, implantation into the uterus, gastrulation and its constituent cell movements, neurulation and the role of the notochord, and the beginnings of organogenesis. We also discuss the differences in gastrulation between protostomes and deuterostomes, along with the many specialised structures found in amniotes to protect the growing embryo from drying out. We conclude with overview of some of the genetic mechanisms government the development process, including Hox genes and their role in governing genetic regulatory networks. Recommended prelistening is Episode 25: Tissues, Organs, and Systems.
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Episode 154: Magnetic Resonance Imaging
An overview of Magnetic Resonance Imaging (MRI), beginning from the basic physics of nuclear magnetic resonance, and covering the use of radiowaves to excite nuclear spin states, and the T1 and T2 modes of …
Notes de l’épisode
An overview of Magnetic Resonance Imaging (MRI), beginning from the basic physics of nuclear magnetic resonance, and covering the use of radiowaves to excite nuclear spin states, and the T1 and T2 modes of relaxation. We then explore how these phenomena are used to produce 3d images, including magnetic field gradients, frequency encoding, phase encoding, and Fourier transforms. We conclude with a discussion of functional imaging, including the haemodynamic response, the BOLD signal, echo planar imaging, and the steps of preprocesing. Recommended pre-listening is Episode 14: Principles of Quantum Mechanics, and Episode 61: Magnetism.
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Episode 153: Low Carb Diets
A review of the carbohydrate insulin model of obesity and the related proposal that low carbohydrate diets are superior to traditional low fat diets. I begin with a discussion of the theory behind the …
Notes de l’épisode
A review of the carbohydrate insulin model of obesity and the related proposal that low carbohydrate diets are superior to traditional low fat diets. I begin with a discussion of the theory behind the carbohydrate insulin model, and then assess its plausibility using relevant evidence from rodent studies, dietary studies, ahd controlled feeding experiments. I argue that the scientific evidence does not support the alleged benefits of low carb diets for weight loss in otherwise healthy adults. Recommended pre-listening is Episode 151: Diet and Nutrition, and Episode 152: Obesity, Diabetes, and Hypertension.
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Special Episode: Brain Preservation and Abolishing Death
An interview with Ariel Zeleznikow-Johnston, author of the book 'The Future Loves You: How and Why We Should Abolish Death'. We begin by discussing how best to define death, focusing on the idea of death as the …
Notes de l’épisode
An interview with Ariel Zeleznikow-Johnston, author of the book 'The Future Loves You: How and Why We Should Abolish Death'. We begin by discussing how best to define death, focusing on the idea of death as the permanent disruption of psychological identity, and how such identity is constituted by our personality, desires, and memories. We then consider the science of brain preservation, including the recently-developed technique of Aldehyde-Stabilized Cryopreservation, and how it could be used to indefinitely preserve the brain structure that encodes or personal identity. Ariel argues that such a preserved brain could potentially be used to construct a digital simulation of our brains, essentially allowing us to survive the biological death of our bodies. We conclude by considering some potential challenges of implementign such a technology, and whether it would achieve widespread social acceptance.
Ariel's book:
The Future Loves You: How and Why We Should Abolish Death
Turning Fate into Choice: Patient Self-Determination and Life Extension
More on brain preservation:
A case for developing Aldehyde Stabilized Cryopreservation into a medical procedure
How much protein structure loss is there following glutaraldehyde crosslinking?
Large Mammal BPF Prize Winning Announcement
Mapping the Drosophila brain:
Episode 152: Obesity, Diabetes, and Hypertension
A review of the science between the metabolic syndrome, including discussion of obesity, diabetes, hypertension, and hyperlipidemia. We discuss the pathophysiology of how enlargement of adipocytes disrupts …
Notes de l’épisode
A review of the science between the metabolic syndrome, including discussion of obesity, diabetes, hypertension, and hyperlipidemia. We discuss the pathophysiology of how enlargement of adipocytes disrupts metabolic signalling pathways and leads to buildup of lipid intermediates. We then consider how these effects impair health, examining the causes of insulin resistance, atherosclerosis, and dysregulation of blood pressure. We conclude by looking at how such symptoms lead to pathology and increased mortality in overweight and obese individuals. Recommended prelistening is Episode 151: Diet and Nutrition, and Episode 18: Biochemistry Basics.
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Episode 151: Diet and Nutrition
An introduction to human nutrition, in which we discuss the nutritional importance and role of carbohydrates, fats, proteins, vitamins, and minerals, before considering the effects of malnutrition, how it is …
Notes de l’épisode
An introduction to human nutrition, in which we discuss the nutritional importance and role of carbohydrates, fats, proteins, vitamins, and minerals, before considering the effects of malnutrition, how it is measured, and its prevalence around the world. We conclude with an analysis of basal metabolic rate, reviewing evidence concerning its variability across persons and factors that affect it. Recommended pre-listening is Episode 18: Biochemistry Basics
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Episode 150: How Home Appliances Work
An exploration into the exciting world of home appliances and devices. We begin with a journey through the kitchen, discussing the design and operating principles behind the refrigerator, rice cooker …
Notes de l’épisode
An exploration into the exciting world of home appliances and devices. We begin with a journey through the kitchen, discussing the design and operating principles behind the refrigerator, rice cooker, convection oven, microwave, and dishwasher. We proceed to the laundry to examine how the washing machine, vacuum cleaner, clothes iron, and dryer work. Finally we take a bathroom break and consider how the flush toilet, sinks, and plumbing work.
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Episode 149: The Psychology of Personality
An introduction to the psychological study of personality, beginning with a definition of what is and is not personality and a brief history of the development of the field from Freud and Jung through the …
Notes de l’épisode
An introduction to the psychological study of personality, beginning with a definition of what is and is not personality and a brief history of the development of the field from Freud and Jung through the Myers-Briggs Indicator and the modern trait theories. I then discuss the Big Five personality traits, covering openness, conscientiousness, extraversion, agreeableness, and neuroticism, along with validation and criticisms of this model. I conclude with a brief discussion of values and narrative identity as additional aspects of personality.
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Episode 148: Control of Gene Expression
An introduction to the processes by which cells control which genes are expressed. We begin with an overview of why genetic regulation is necessary and the key stages where such regulation occurs, including key …
Notes de l’épisode
An introduction to the processes by which cells control which genes are expressed. We begin with an overview of why genetic regulation is necessary and the key stages where such regulation occurs, including key concepts such as transcription factors and DNA binding domains. We then discuss prokaryotic gene regulation, focusing on the lac operon in E. coli. We then expand the discussion to cover the various mechanisms of eukaryotic gene regulation, including chromatic remodelling, transcriptional regulation, post-transcriptional regulation, RNA editing, and micro RNAs. Recommended pre-listening is Episodes 34-35: DNA Structure and Function, and Episode 118: Cell Signalling.
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Episode 147: Genetic Mutation and Repair
Here we survey of the causes and consequences of genetic mutation, including a discussion of mechanisms of endogenous and induced mutations, rates of mutation, types of single nucleotide mutations, and the …
Notes de l’épisode
Here we survey of the causes and consequences of genetic mutation, including a discussion of mechanisms of endogenous and induced mutations, rates of mutation, types of single nucleotide mutations, and the phenotypic effects of mutation. We also discuss various mechanisms for detecting and repairing genetic mutations, including base excision repair, DNA mismatch repair, nucleotide excision repair, double strand break repair. We conclude with an examination of large-scale chromosomal changes, including deletions, duplications, inversions, and translocations, unequal crossing over, with a brief look at polypoidy in plants and aneuploidy in humans. Recommended pre-listening is Episodes 34 and 35: DNA Structure and Function, and Episode 44: Cell Division.
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Episode 146: Mendelian Genetics and Inheritance
An introduction to classical Mendelian genetics, in which we discuss Mendel's experiments with peas and the laws of heredity that he discovered, including inheritance of one allele from each parent, the law of …
Notes de l’épisode
An introduction to classical Mendelian genetics, in which we discuss Mendel's experiments with peas and the laws of heredity that he discovered, including inheritance of one allele from each parent, the law of dominance, and the law of independent segregation. We then consider more complex cases of genetic inheritance, including sex-linked traits, incomplete dominance, codominance, and epistasis. The episode concludes with a discussion of quantitative traits determined by many genes, including how genetic variation is described, how sources of variance are identified using genome wide association studies, and the conceptual issues with defining heredity and separating the effects of genes from those of environment.
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The Science of Everything Podcast - YouTubeEpisode 145: Relativity and Black Holes
Continuing our series on General Relativity, we discuss the derivation of the Schwarzschild metric as a vacuum solution to Einstein's Field Equations, and analyse the physical meaning of this solution …
Notes de l’épisode
Continuing our series on General Relativity, we discuss the derivation of the Schwarzschild metric as a vacuum solution to Einstein's Field Equations, and analyse the physical meaning of this solution, including the properties of the singularity, event horizon, and effects of time dilation and length compression. We then consider how solutions like the Schwarzschild metric yield testable predictions such as gravitational lensing and graviational redshift, which serve as important evidence in support of General Relativity. We conclude with a discussion about some of the more exotic aspects of black holes, including Hawking radiation, the no hair theorem, and the black hole information loss paradox. Recommended pre-listening is Episode 136: Introduction to General Relativity.
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Episode 144: Anthropogenic Climate Change
Our climate change series concludes with a discussion of the various lines of evidence indicating that recent warming is the result of human-produced greenhouse gases, including greater warming at night …
Notes de l’épisode
Our climate change series concludes with a discussion of the various lines of evidence indicating that recent warming is the result of human-produced greenhouse gases, including greater warming at night, cooling of the stratosphere, and relative depletion of C14 in the atmosphere. We then consider the various expected impacts of climate change, including increased extreme weather events, acidification of the oceans, changes to crop yields, and affects on various ecosystems. We end with an analysis of the relative costs and benefits of mitigation, and discuss likjely climate projections for the remainder of the 21st century. Recommended pre-listening is Episode 143: Climate Modelling.
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https://www.patreon.com/jamesfodor
https://www.paypal.me/ScienceofEverything
Check out out youtube channel!
The Science of Everything Podcast - YouTubeEpisode 143: Climate Modelling
An overview of climate models, beginning with a summary of the major types of models, and then a more detailed disussion of hte primitive equations and parameterised feedbacks that characterise the widely used …
Notes de l’épisode
An overview of climate models, beginning with a summary of the major types of models, and then a more detailed disussion of hte primitive equations and parameterised feedbacks that characterise the widely used Atmospheric General Circulation Models. We also discuss techniques for model validation and some evidence regarding the accuracy of various climate models. Recommended pre-listening is Episode 142: The Greenhouse Effect.
If you enjoyed the podcast please consider supporting the show by making a PayPal donation or becoming a Patreon supporter.
https://www.patreon.com/jamesfodor
https://www.paypal.me/ScienceofEverything
Check out out youtube channel!
The Science of Everything Podcast - YouTubeEpisode 142: The Greenhouse Effect
A detailed discussion of the greenhouse effect and its impact on Earth's climate. We begin with a discussion of Earth’s energy budget, the various greenhouse gases and their interactions with longwave …
Notes de l’épisode
A detailed discussion of the greenhouse effect and its impact on Earth's climate. We begin with a discussion of Earth’s energy budget, the various greenhouse gases and their interactions with longwave radiation, and a summary of major sources of greenhouse gas emisions. We then examine the mechanisms of the greenhouse effect in more detail using the idealised greenhouse model and radiative transfer models. We conclude with an analysis of the sensitivity of Earth's climate to changes in greenhouse gas concentrations, and how this interacts with the atmospheric lapse rate. Recommended prelistening is Episode 141: Natural Climate Change.
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Episode 141: Natural Climate Change
An overview of the natural mechanisms by which climate changes over time. Beginning with an introduction to the concepts of radiative forcing and climate sensitivity, we then discuss solar forcing, orbital …
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An overview of the natural mechanisms by which climate changes over time. Beginning with an introduction to the concepts of radiative forcing and climate sensitivity, we then discuss solar forcing, orbital changes, volcanic eruptions, and silicate weathering, covering how each process operates and the effects it has on Earth's climate over varying periods of time. Recommended pre-listening is Episode 140: A History of Earth's Climate.
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Episode 140: A History of Earth's Climate
A journey through the history of Earth's changing climate, in which we explore how Earth's climate has fluctuated over the past billion years. After reviewing the various temperature proxies used to estimate …
Notes de l’épisode
A journey through the history of Earth's changing climate, in which we explore how Earth's climate has fluctuated over the past billion years. After reviewing the various temperature proxies used to estimate past climactic conditions, we discuss the varying hothouse and icehouse periods of Earth's history, the onset of the Quarternay Ice Age, the current interglacial period, the anomoly of the Younger Dryas, the Medieval Warm Period and Little Ice Ages, and the rapid rise in temperatures during the twentieth century. Recommended pre-listening is Episode 90: Climate Systems.
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Special Episode: Dinosaurs in Popular Culture
In this special collaboration with I Know Dino podcast, we discuss the history and impact of dinosaurs in popular culture and media. We cover the history of the scientific study of dinosaurs and how their …
Notes de l’épisode
In this special collaboration with I Know Dino podcast, we discuss the history and impact of dinosaurs in popular culture and media. We cover the history of the scientific study of dinosaurs and how their presentation in media has changed over time with new discoveries, and what aspects of their behaviour and appearance tend to be presented accuracy or inaccurately. We also discuss lesser-known aspects of understanding dinosaurs, such as how changes in the atmosphere and ecosystem would affect dinosaurs of they were to be alive today.
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Episode 139: Cybersecurity and Cryptocurrencies
An introduction to cryptography, internet security, and cryptocurrency, beginning with an overview of RSA cryptography and covering the use of public and private keys and their incorporation into the Transport …
Notes de l’épisode
An introduction to cryptography, internet security, and cryptocurrency, beginning with an overview of RSA cryptography and covering the use of public and private keys and their incorporation into the Transport Layer Security protocol used for secure internet communications. We then examine the key features of cryptocurrencies, including the blockchain, proof of work consensus mechanism, the use of hash functions, and the role of crypto mining. We conclude with a discussion of some of the advantages and disadvantages of cryptocurrencies, including their anonymity, volatility, use in crime, and environmental impacts.
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Episode 138: Biochemistry and Metabolism
A discussion of the metabolic pathways involved in breaking down proteins, carbohydrates, and lipids into simple components, extracting their energy, and building back up into more complex components needed for …
Notes de l’épisode
A discussion of the metabolic pathways involved in breaking down proteins, carbohydrates, and lipids into simple components, extracting their energy, and building back up into more complex components needed for bodily function. We cover glycolysis, the citric acid cycle, lipolysis, beta oxidation, amino acid deamination, gluconeogenesis, fatty acid synthesis, and amino acid synthesis. Our overall focus is on the central role of acetyl-CoA and how the different metabolic pathways interact and intersect. Recommended pre-listening is Episode 18: Biochemistry Basics and Episode 75: Cellular Respiration.
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