American Journal of Psychiatry Audio
- Episódios
- 226
- Publicação
- mensal
- Último episódio
- 1 nov 2026
Sobre o podcast
Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month's issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research. This podcast is subject to the Terms of Use at ww.psychiatry.org. The views and opinions expressed in this podcast are those of the individual speakers only and do not necessarily represent the views of the American Psychiatric Association, its officers, trustees, or members. The content of this podcast is provided for general informational purposes only and is not intended as, and shall not be understood or construed as, medical or any other type of professional advice nor does it represent any statement of the standard of care. We strongly recommend that any listener follow the advice of physicians directly involved in their care and contact their local emergency response number for any medical emergency. The information within this podcast is provided as-is and is not guaranteed to be correct, complete, or accurate.
Episódios 226
November 2026: Prevalence and Correlates of Past-Year Psilocybin Use in the United States
Dr. Kevin Yang (UCSD School of Medicine) joins the podcast to discuss a priority data letter published in the November issue that looks at the past-year prevalence of psilocybin use in the general population in …
Notas do episódio
Dr. Kevin Yang (UCSD School of Medicine) joins the podcast to discuss a priority data letter published in the November issue that looks at the past-year prevalence of psilocybin use in the general population in the United States. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss how the rest of the issue fits together.
- 00:32 Yang interview
- 01:30 Correlation with past-year major depressive episodes
- 02:43 Considering psilocybin as a recreational drug
- 04:35 Shifting landscape for psilocybin research
- 06:53 Psilocybin usage by demographics
- 08:19 Immediate clinical implications
- 10:07 Limitations
- 10:57 Future research
- 11:48 Kalin interview
- 12:04 Yang et al.
- 16:12 Watson et al.
- 19:47 Takamiya et al.
- 23:50 Edmond et al.
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October 2026: The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment-Resistant Depression: Critical Findings, Lessons Learned, and Future Directions
Dr. Charles Conway (Washington University School of Medicine, St. Louis) joins the podcast to discuss the RECOVER trial, a RCT that looked at vagus nerve stimulation and its effects on profoundly treatment …
Notas do episódio
Dr. Charles Conway (Washington University School of Medicine, St. Louis) joins the podcast to discuss the RECOVER trial, a RCT that looked at vagus nerve stimulation and its effects on profoundly treatment resistant depression. Following that, AJP Editor-in-Chief Dr. Ned Kalin is joined by the October issue guest editor, Dr. William McDonald (Emory University, Atlanta) to discuss the rest of the October issue, which focuses on neuromodulation and precision therapeutics.
- 00:42 Conway interview
- 02:34 Quality of life
- 05:13 Ethical considerations of a sham arm in this population
- 07:00 Timing and VNS treatment
- 08:03 Clinical implications
- 09:02 Limitations
- 10:12 Further research
- 11:30 McDonald and Kalin interview
- 13:50 Song et al.
- 14:08 Li et al.
- 15:44 Donnery et al.
- 16:38 Valiengo et al.
- 17:28 Rush
- 20:03 Mahmoudi
- 22:37 Conway et al.
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September 2026: Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial
Dr. Heon-Jeong Lee (Korea University, Seoul) joins AJP Audio to discuss an app-based intervention designed to help individuals with mood disorders regulate their circadian rhythms to prevent recurrence of mood …
Notas do episódio
Dr. Heon-Jeong Lee (Korea University, Seoul) joins AJP Audio to discuss an app-based intervention designed to help individuals with mood disorders regulate their circadian rhythms to prevent recurrence of mood episodes. Afterwards, Dr. Ned Kalin will join us again to discuss the rest of the September issue of the Journal, which takes a close look at clinical treatment.
- 00:44 Findings
- 01:42 How the app works
- 03:05 Differences between the app and traditional lifestyle advice
- 04:14 Ethics surrounding shame treatment arms
- 05:43 Broader applicability of the intervention
- 06:50 Limitations
- 08:19 Immediate clinical implications
- 09:33 Further research
- 10:08 Kalin interview
- 10:27 Yeom et al.
- 16:02 Schacht et al.
- 20:31 Khosravani et al.
- 24:52 Peterson et al.
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August 2026: Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure
Dr. Deepak Cyril D'Souza (Yale University School of Medicine) joins the podcast to discuss a study looking at two cohorts of patients hospitalized with first instances of psychosis, one with cannabis exposure …
Notas do episódio
Dr. Deepak Cyril D'Souza (Yale University School of Medicine) joins the podcast to discuss a study looking at two cohorts of patients hospitalized with first instances of psychosis, one with cannabis exposure and one without. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the August issue of the Journal, which takes a look at issues surrounding schizophrenia spectrum disorder, from the clinical to basic science.
- 00:40 D'Souza interview
- 02:38 Subtyping and schizophrenia spectrum disorder
- 04:19 Relapse and long-term implications for cannabis induced psychosis
- 05:43 Improvements in cognition
- 08:03 Differences between the groups
- 09:26 Greater access and greater potency of cannabis products
- 11:29 Further research
- 13:45 Kalin interview
- 13:59 D'Souza et al.
- 21:34 Forsyth et al.
- 27:36 Enwright et al.
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July 2026: Social Determinants of Health in Psychiatric Disorders: Exciting Opportunities for Biopsychosocial Research and Clinical Care
Dr. Dilip Jeste (Social Determinants of Health Network, La Jolla, CA) joins the podcast to discuss how social determinants of health interact with treatment for psychiatric disorders. Afterwards, AJP …
Notas do episódio
Dr. Dilip Jeste (Social Determinants of Health Network, La Jolla, CA) joins the podcast to discuss how social determinants of health interact with treatment for psychiatric disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin once again puts the rest of the July issue into context.
- 00:31 Impacts of social determinants of health on psychiatric disorders, research, and clinical care
- 04:43 Health related social needs versus social determinants of health
- 08:47 Loneliness as a risk factor
- 12:36 A clinician's role in societal factors
- 14:47 Mechanistic understandings social determinants and the exposome
- 18:17 Further research
- 22:25 Kalin interview
- 22:30 Jeste and Gyan
- 23:33 Blundell et al.
- 28:03 Yang et al.
- 32:20 Van der Meer et al.
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June 2026: Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
Dr. Jason Tucciarone and Dr. Alan Schatzberg (Stanford University, Stanford, CA) join AJP Audio to discuss the use of low-dose buprenorphine as an adjunctive therapy to extend the anti-suicidal effects of …
Notas do episódio
Dr. Jason Tucciarone and Dr. Alan Schatzberg (Stanford University, Stanford, CA) join AJP Audio to discuss the use of low-dose buprenorphine as an adjunctive therapy to extend the anti-suicidal effects of ketamine treatment in patients with major depressive disorder and suicidal ideation. AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the June issue of the Journal, which takes a close look at issues surrounding suicide and severe depression.
- 01:20 Tucciarone and Schatzberg interview
- 03:36 Disparity between effects on suicidal ideation and antidepressant ratings
- 05:36 Ethics of placebo and ketamine in patients with suicidal ideation
- 08:28 Immediate clinical implications
- 11:40 Limitations
- 14:10 Further research
- 16:19 Kalin interview
- 16:24 Tucciarone et al.
- 20:39 Rovers et al.
- 24:30 Jelen et al.
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Special Episode: The Future of DSM
In this special episode of AJP Audio, AJP Editor-in-Chief Dr. Ned Kalin is joined by Dr. María Oquendo (Perelman School of Medicine at the University of Pennsylvania, Philadelphia), chair of APA's Future DSM …
Notas do episódio
In this special episode of AJP Audio, AJP Editor-in-Chief Dr. Ned Kalin is joined by Dr. María Oquendo (Perelman School of Medicine at the University of Pennsylvania, Philadelphia), chair of APA's Future DSM Strategic Committee to discuss a series of commentaries published in the May issue of the Journal discussing the strategic vision for the future of DSM.
- 00:39 Oquendo interview
- 03:07 Size of the response
- 04:18 Feedback
- 06:04 Incorporating the feedback
- 07:57 Emphasizing science with a title change for DSM
- 10:18 A living document
- 12:35 Changes from previous versions of DSM
- 16:08 Changes in documentation and coding
- 18:51 Lived experience
- 20:02 Working with AJP
Links to the commentaries:
- Initial Strategy for the Future of DSMMaría A. Oquendo, M.D., Ph.D., et al.
- The Future of DSM: A Report From the Structure and Dimensions SubcommitteeDost Öngür, M.D., Ph.D., et al.
- The Future of DSM: Are Functioning and Quality of Life Essential Elements of a Complete Psychiatric Diagnosis?Karen Drexler, M.D., et al.
- The Future of DSM: Role of Candidate Biomarkers and Biological FactorsBruce Cuthbert, Ph.D., et al.
- The Future of DSM: A Strategic Vision for Incorporating Socioeconomic, Cultural, and Environmental Determinants and IntersectionalityMilton L. Wainberg, M.D., et al.
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May 2026: Psychiatric Comorbidities in Substance Use Disorders: Sex-Based Differences in a National Real-World Clinical Sample
Dr. Eduardo Butelman (Icahn School of Medicine at Mount Sinai, New York) joins AJP Audio to discuss the varying incidence of psychiatric comorbidities across patients diagnosed with substance use disorders …
Notas do episódio
Dr. Eduardo Butelman (Icahn School of Medicine at Mount Sinai, New York) joins AJP Audio to discuss the varying incidence of psychiatric comorbidities across patients diagnosed with substance use disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the May issue, which includes a discussion on the future of the DSM.
- 00:53 Butelman interview
- 02:23 Mechanisms of difference between males and females
- 04:04 Patterns of response between males and females in substance use disorders
- 05:54 Implications for research into sex-based differences
- 07:33 Racial and ethnic variations in findings
- 09:30 Limitations
- 10:46 Immediate clinical implications?
- 12:09 Further research
- 13:18 Kalin interview
- 13:38 Butelman et al.
- 17:11 Hinojosa et al.
- 22:49 van Rooij et al.
- 26:06 The future of DSM
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April 2026: Mobile Health for Alcohol Use Assessment: Longitudinal Effects of Breathalyzer Self-Monitoring in Everyday Contexts
Yang Lu, M.S., and Catharine E. Fairbairn, Ph.D. (University of Illinois, Urbana-Champaign) join AJP Audio to discuss the longitudinal effects of the use of personal alcohol breathalyzers in a natural setting …
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Yang Lu, M.S., and Catharine E. Fairbairn, Ph.D. (University of Illinois, Urbana-Champaign) join AJP Audio to discuss the longitudinal effects of the use of personal alcohol breathalyzers in a natural setting on alcohol usage. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the April issue, which focuses on subjects related to substance use disorders.
- 00:57 What did you discover about the long term effects of using a personal blood alcohol monitor?
- 03:12 Do health monitoring devices actually change behaviors?
- 04:10 What did your cohort look like?
- 08:49 Disparate impact of monitoring on heavy drinkers and light drinkers
- 11:36 Clinical implications
- 14:34 Limitations
- 15:46 Avenues for further research
- 18:39 Kalin interview
- 18:46 Lu et al.
- 24:00 Wittekind et al.
- 29:50 Nicholson et al.
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March 2026: Primary Prevention of PTSD Symptoms in Combat-Deploying Soldiers Using Attention Bias Modification: A Randomized Controlled Trial
Chelsea Dyan Gober Dykan, M.A. (Tel Aviv University, Israel), joins AJP Audio to discuss a study looking at two versions of attention bias modification with an eye towards a prophylactic impact on developing …
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Chelsea Dyan Gober Dykan, M.A. (Tel Aviv University, Israel), joins AJP Audio to discuss a study looking at two versions of attention bias modification with an eye towards a prophylactic impact on developing PTSD in a cohort of combat-bound soldiers. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the March issue into context.
- 00:57 Attention bias modifications
- 03:54 Response-time and gaze-contingent paradigms
- 05:05 Differences in efficacy between the two arms
- 08:06 Ethical considerations in investigating combat-bound soldiers
- 10:44 Controlling for combat experiences in studying PTSD
- 12:24 Duration of the effect
- 13:44 Limitations
- 15:03 Immediate clinical implications
- 16:22 Further research
- 17:05 Kalin interview
- 17:22 Dykan et al.
- 21:03 Kaul et al.
- 26:19 Kantrowitz et al.
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February 2026: Doxycycline Use in Adolescent Psychiatric Patients and Risk of Schizophrenia: An Emulated Target Trial
Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk …
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Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.
- 00:53 Doxycycline and the risk of developing schizophrenia
- 04:03 Emulated target trials versus randomized control trials
- 06:43 Methods of action
- 09:24 Dosage and exposure levels for doxycycline
- 10:15 Immediate clinical applications
- 10:56 Limitations of the study
- 11:33 Future research
- 12:43 Kalin interview
- 13:00 Lång et al.
- 19:43 Zhao et al.
- 25:20 Metrik et al.
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Special Episode: 2025 Articles of Import and Impact
This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025. 00:39 Ned H. Kalin …
Notas do episódio
This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025.
- 00:39 Ned H. Kalin, M.D., discusses "Transcriptomic Analysis of the Human Habenula in Schizophrenia" by Ege A. Yalcinbas, Ph.D., et al.
- 06:23 Elisabeth Binder, M.D., Ph.D., discusses "Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study" by Zhiqiang Sha, Ph.D., et al.
- 11:17 Kathleen T. Brady, M.D., Ph.D., discusses "High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies" by Stephanie Lake, Ph.D., et al.
- 15:35 David A. Lewis, M.D., discusses "20 Years of Aberrant Salience in Psychosis: What Have We Learned?" by Philip R. Corlett, Ph.D., and Kurt M. Fraser, Ph.D.
- 17:27 William M. McDonald, M.D., discusses "Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research" by Roger S. McIntyre, M.D., F.R.C.P.C., et al.
- 24:04 Daniel S. Pine, M.D., discusses "Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial" by Carlos M. Grilo, Ph.D., et al.
- 26:06 Carolyn Rodriguez, M.D., Ph.D., discusses "Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders" by Emily R. Stern, Ph.D., et al.
- 30:26 Sean T. Lynch, M.D., discusses "From Medical Practice to Mass Incarceration: A Historical Analysis of Racial and Ethnic Targeting in U.S. Drug Policy" by Rathisha Pathmathasan, D.O., et al.
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January 2026: Reduced Threat-Related Neural Efficiency: A Possible Biomarker for Pediatric Anxiety Disorders
Dr. Julia Linke (University of Mainz, Germany) joins AJP Audio to discuss the use of neural efficiency, a measure of brain activity, as a potential biomarker in the treatment of children with anxiety disorder …
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Dr. Julia Linke (University of Mainz, Germany) joins AJP Audio to discuss the use of neural efficiency, a measure of brain activity, as a potential biomarker in the treatment of children with anxiety disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.
- 00:31 Linke interview
- 02:15 State or a trait?
- 04:15 Neural efficiency and CBT
- 05:22 Potential as a biomarker
- 07:08 Patient-rated and parent-rated measures of anxiety
- 08:16 Immediate clinical implications
- 09:50 Limitations
- 10:43 Future directions of research
- 11:44 Kalin interview
- 11:50 Linke et al.
- 15:16 Mallard et al.
- 18:11 Naples et al.
- 21:44 Mac Giollabhui et al.
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December 2025: Adjunctive Lumateperone in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial
Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson & Johnson Company, Bedminster, NJ) joins AJP Audio to discuss a phase 3 randomized controlled trial looking at the use of the antipsychotic medication …
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Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson & Johnson Company, Bedminster, NJ) joins AJP Audio to discuss a phase 3 randomized controlled trial looking at the use of the antipsychotic medication lumateperone as adjunctive to antidepressant therapy in the treatment of patients with major depressive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue of the Journal.
- 00:48 Durgam interview
- 03:09 Mechanism of action
- 04:44 Patient-reported outcomes
- 06:31 Immediate clinical implications
- 07:32 Limitations
- 08:08 Further research
- 09:25 Kalin interview
- 09:38 Durgam et al.
- 13:09 Lin et al.
- 17:22 Brodsky et al.
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November 2025: Contingency Management for Stimulant Use Disorder and Association With Mortality: A Cohort Study
Dr. Lara Coughlin (University of Michigan, Ann Arbor) joins AJP Audio to discuss a study looking the impact of contingency management on all cause mortality in patients with stimulant use disorder. Afterwards …
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Dr. Lara Coughlin (University of Michigan, Ann Arbor) joins AJP Audio to discuss a study looking the impact of contingency management on all cause mortality in patients with stimulant use disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue of the Journal.
- 01:09 Coughlin interview
- 02:05 Stimulant use disorder and contingency management
- 04:37 Mortality
- 05:12 Contingency management and "moral hazard"
- 08:30 Clinical uptake of contingency management
- 09:28 Broader applicability to psychiatric conditions
- 10:31 Limitations
- 11:39 Further research
- 12:32 Kalin interview
- 12:49 Coughlin et al.
- 16:41 Yalcinbas et al.
- 22:22 Na et al.
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October 2025: Differential Effects of Ovarian Steroids in Women With and Without Premenstrual Dysphoric Disorder: A Replication and Extension of Findings
Dr. Shau-Ming Wei (National Institute of Mental Health, Bethesda, MD) joins AJP Audio to discuss a replication study looking at impact of hormone addback to a hormone suppression regimen for the treatment of …
Notas do episódio
Dr. Shau-Ming Wei (National Institute of Mental Health, Bethesda, MD) joins AJP Audio to discuss a replication study looking at impact of hormone addback to a hormone suppression regimen for the treatment of premenstrual dysphoric disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the October issue of the Journal.
- 00:34 Wei interview
- 02:59 PMDD
- 04:22 Up and downsides of hormone suppression
- 05:52 Hormone addback
- 07:15 Limitations of the current study
- 08:38 Further research
- 10:42 Kalin interview
- 10:58 Wei et al.
- 15:25 Sanacora et al.
- 20:07 Whittle et al.
- 23:06 Cooper et al.
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September 2025: Neighborhood Social Vulnerability and Racial Disparities in Schizophrenia Spectrum Disorder Prevalence
Dr. Deidre Anglin (City College, CUNY, New York) joins AJP Audio to discuss the disparate impact of schizophrenia spectrum disorder diagnosis on racial and ethnic minorities in the United States based on …
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Dr. Deidre Anglin (City College, CUNY, New York) joins AJP Audio to discuss the disparate impact of schizophrenia spectrum disorder diagnosis on racial and ethnic minorities in the United States based on localized neighborhood data. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the September issue of the Journal.
- 00:31 Anglin interview
- 04:40 Zip code sizes
- 05:18 The long legacy of redlining
- 07:17 Socially vulnerable neighborhoods
- 09:43 Structural racism, clinicians, and working with individuals
- 13:45 Limitations
- 15:56 Further research
- 18:08 Kalin interview
- 18:13 Anglin et al.
- 25:19 Vano et al.
- 29:40 Moussa-Tooks et al.
- 33:34 Zhang et al.
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August 2025: Telehealth Prescribing of Stimulants for ADHD and Associated Risk for Later Stimulant and Substance Use Disorders
Dr. Vinod Rao (Massachusetts General Hospital, Boston) join AJP Audio to discuss predicting the relative risk of patients with an ADHD diagnosis developing a later stimulant or substance use disorder based on …
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Dr. Vinod Rao (Massachusetts General Hospital, Boston) join AJP Audio to discuss predicting the relative risk of patients with an ADHD diagnosis developing a later stimulant or substance use disorder based on the method of prescription, in person or via telehealth. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the August issue of the Journal.
- 00:07 Rao interview
- 01:53 Stimulant use disorder versus substance use disorder
- 02:59 Cohort size and incidence of SUDs
- 04:28 Length of clinician engagement in non-profit versus for profit hospital systems
- 05:18 Patient cohort
- 06:20 Potential difference in mechanism between prescribing practices
- 07:35 Continued use of telehealth
- 08:43 Limitations
- 10:03 Further research
- 11:17 Kalin interview
- 11:24 Rao et al.
- 15:41 Mahjani et al.
- 19:59 Zhang et al.
- 25:11 Sha et al.
- 29:33 Gao and Olfson
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July 2025: National Trends in Suicidal Thoughts and Suicide Attempts Among High School Students in the United States
Dr. Tanner Bommersbach (University of Wisconsin School of Medicine and Public Health) and Dr. Greg Rhee (University of Connecticut and Yale University School of Medicine) join AJP Audio to discuss estimating …
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Dr. Tanner Bommersbach (University of Wisconsin School of Medicine and Public Health) and Dr. Greg Rhee (University of Connecticut and Yale University School of Medicine) join AJP Audio to discuss estimating national trends in suicidal ideation and attempts in high school students with and without accompanying high-risk behaviors. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the July issue of the Journal.
- 00:07 Bommersbach and Rhee interview
- 00:36 Trends in suicide among high school students in the US
- 02:49 Variation in rates based on gender, racial identity, and sexuality
- 03:50 Did the rates increase during the COVID-19 pandemic?
- 04:14 Lessons to be learned from COVID?
- 05:23 Behavior risk factors
- 06:33 Clinical implications
- 08:19 Inflections in risk factors due to the pandemic?
- 08:52 Limitations
- 09:32 Future research
- 10:16 Kalin interview
- 10:31 Bommersbach et al.
- 14:20 Müller et al.
- 18:54 Ahn et al.
- 21:47 McCabe et al.
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June 2025: Stratifying Risk for Postpartum Depression at Time of Hospital Discharge
Dr. Roy Perlis (Mass General Bringham, Boston) joins AJP Audio to discuss a machine learning model to examine electronic health records in individuals who had recently given birth designed to detect those who …
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Dr. Roy Perlis (Mass General Bringham, Boston) joins AJP Audio to discuss a machine learning model to examine electronic health records in individuals who had recently given birth designed to detect those who might develop postpartum depression. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the June issue into context.
- 00:31 Perlis interview
- 02:56 Lack of validation in screening methods
- 04:03 Stumbling blocks on the road to validation
- 05:10 Synergy between screening scores and machine learning models
- 06:36 Issues with clinician adoption?
- 08:44 Administrative burden for running these models
- 10:38 Current clinical application
- 12:37 Screening without those with a history of depression
- 13:48 Limitations
- 15:30 Future research
- 17:26 Kalin interview
- 17:41 Clapp et al.
- 21:41 Kępińska et al.
- 25:19 Savitz et al.
- 25:25 Miller
- 28:38 Wall et al.
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May 2025: Randomized Controlled Trial of "Bounce Back Now," a Mobile App to Reduce Post-Disaster Symptoms of Posttraumatic Stress, Depressed Mood, and Sleep Disturbance
Dr. Kenneth Ruggiero (Medical University of South Carolina, Charleston) joins AJP Audio to discuss the the effectiveness of an app-based intervention at reducing the symptoms of sleeplessness and posttraumatic …
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Dr. Kenneth Ruggiero (Medical University of South Carolina, Charleston) joins AJP Audio to discuss the the effectiveness of an app-based intervention at reducing the symptoms of sleeplessness and posttraumatic stress in a broad cohort in the wake of a natural disaster. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the May issue into context.
- 00:38 Ruggiero interview
- 03:13 Bounce Back Now app
- 05:03 Natural disasters and other sources of trauma
- 07:31 Low cost and broad-based intervention
- 08:49 Limitations
- 10:19 Changes in how the intervention was designed
- 11:17 Uptake and interactions with the app
- 13:15 Future directions
- 14:36 Kalin interview
- 14:50 Ruggiero et al.
- 19:26 Norman et al.
- 23:29 Conrod et al.
- 27:53 Olfson et al.
- 31:44 Olfson et al.
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April 2025: Anticholinergic Burden and Cognitive Function in Psychosis: A Systematic Review and Meta-Analysis
Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest …
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Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.
- 00:32 Mancini interview
- 02:26 Anticholinergic burden method of action
- 02:58 Balancing the impact of side effects in schizophrenia treatment
- 04:52 Limitations
- 05:34 The need for further studies
- 05:59 Clinical implications
- 06:32 Further research
- 07:01 Trials needed
- 07:54 Kalin interview
- 08:03 Mancini et al.
- 11:23 Tiihonen et al.
- 13:43 Zhou et al.
- 16:28 Omlor et al.
- 18:51 Orhan et al.
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March 2025: The Impact of Xanomeline and Trospium Chloride on Cognitive Impairment in Acute Schizophrenia: Replication in Pooled Data From Two Phase 3 Trials
Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients. Afterwards, AJP …
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Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.
- 00:45 Horan interview
- 03:15 Novel mechanism of action in the treatment of schizophrenia
- 05:39 Side effect profiles
- 07:20 Clinical impacts
- 08:31 The need for further investigation
- 09:58 Limitations
- 11:05 Further research
- 13:08 Kalin interview
- 13:21 Horan et al.
- 17:34 Levenstein et al.
- 19:00 Fountoulakis et al.
- 20:57 Couture et al.
- 23:18 Stern et al.
- 27:35 McGirr et al.
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February 2025: Real-Time Assessment of Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and Depressive Disorders
Dr. Andrea King (University of Chicago Medicine) joins AJP Audio to discuss a novel, real time assessment of the reward, stimulation, and negative affect of alcohol use in people with alcohol use disorder with …
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Dr. Andrea King (University of Chicago Medicine) joins AJP Audio to discuss a novel, real time assessment of the reward, stimulation, and negative affect of alcohol use in people with alcohol use disorder with and without depressive disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the February issue, which focuses closely on issues surrounding addiction.
- 00:35 King interview
- 00:45 Allostatic model of addiction
- 02:12 Gathering data and the groups studied
- 07:37 The ethics of studying alcohol use in patients with AUD
- 10:38 Findings
- 13:29 The impacts of alcohol's pleasurable effects on people with AUD and those without
- 14:32 Limitations of natural environment research versus laboratory research
- 18:18 Clinical implications
- 20:09 Further research
- 22:56 Kalin interview
- 23:03 King et al.
- 26:21 Brand et al.
- 28:12 Conway et al.
- 32:17 Kypriotakis et al.
- 35:42 Kuhn et al.
- 39:37 Grilo et al.
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January 2025: Special Issue on Psychedelics
Dr. Charles Nemeroff (University of Texas at Austin) joins AJP Editor-in-Chief Dr. Ned Kalin to discuss the January issue of the American Journal of Psychiatry. Dr. Nemeroff is a guest editor of the special …
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Dr. Charles Nemeroff (University of Texas at Austin) joins AJP Editor-in-Chief Dr. Ned Kalin to discuss the January issue of the American Journal of Psychiatry. Dr. Nemeroff is a guest editor of the special issue, which takes a close look at the potential, pitfalls, and clinicial implications of psychedelics in mental health treatment.
- 00:38 Nemeroff interview
- 02:27 McIntyre et al.
- 04:06 Ramaekers et al.
- 05:44 Ghaznavi et al.
- 08:01 Fonzo et al.
- 09:17 Wolfgang et al.
- 10:45 Psychedelics and psychotherapies
- 12:31 Aaronson et al.
- 14:17 Pagni et al.
- 15:31 Kirlić et al.
- 17:06 Olson
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December 2024: Discrimination Exposure, Neural Reactivity to Stress, and Psychological Distress
Devon Grey and David Knight (University of Alabama, Birmingham) join AJP Audio to discuss how exposure to discrimination impacts neural reactivity to stress and psychological distress in adolescents …
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Devon Grey and David Knight (University of Alabama, Birmingham) join AJP Audio to discuss how exposure to discrimination impacts neural reactivity to stress and psychological distress in adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins us to discuss the rest of the December issue of AJP.
- 00:36 Grey and Knight interview
- 02:41 Demographics of the cohort
- 03:46 Neurobiological mechanisms of discrimination impacts
- 06:14 Racial discrimination and mental health impacts
- 09:34 Discrimination as a chronic stressor and prolonged activation of the stress response system
- 10:45 Limitations
- 13:52 Further research
- 14:38 Kalin interview
- 14:52 Grey et al.
- 17:35 Sippel et al.
- 18:06 Fox and Shackman
- 19:42 Kliemann et al.
- 22:16 Kamboj et al.
- 27:07 Pathak et al.
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November 2024: Disparities in Treatment for Alcohol Use Disorder Among All of Us Participants
Dr. Phuc Le (Cleveland Clinic, Case Western Reserve University, Cleveland) joins AJP Audio to discuss racial, ethnic, and sociodemographic disparities in treatment in alcohol use disorder among participants of …
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Dr. Phuc Le (Cleveland Clinic, Case Western Reserve University, Cleveland) joins AJP Audio to discuss racial, ethnic, and sociodemographic disparities in treatment in alcohol use disorder among participants of the All of Us cohort. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the November issue, which takes a close look at issues surrounding substance use disorders.
- 00:41 Le interview
- 01:52 Disparities in treatment of AUDs in the US
- 03:43 What is the VA system doing right?
- 05:25 All of Us
- 06:39 Immediate clinical implications
- 08:15 Limitations
- 09:38 Further research
- 10:55 Kalin interview
- 11:07 Le et al.
- 13:44 Imperio et al.
- 14:43 McClure et al.
- 17:23 Perlman et al.
- 20:57 Savage et al.
- 24:17 Compton et al.
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October 2024: Real-World Effectiveness of Menopausal Hormone Therapy in Preventing Relapse in Women With Schizophrenia or Schizoaffective Disorder
Dr. Bodyl Brand (Oxford University, UK) joins AJP Audio to discuss the effectiveness of menopausal hormone therapy in preventing psychosis relapse in women with schizophrenia and schizoaffective disorder …
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Dr. Bodyl Brand (Oxford University, UK) joins AJP Audio to discuss the effectiveness of menopausal hormone therapy in preventing psychosis relapse in women with schizophrenia and schizoaffective disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the rest of the October issue of the American Journal of Psychiatry, which focuses on other issues touching psychosis and schizophrenia spectrum disorders.
- 01:05 Brand interview
- 03:08 MHT and potential side effects in schizophrenia treatment
- 06:16 Estrogen and psychosis prophylaxis
- 07:44 MHT effectiveness
- 10:15 Clinical implications
- 11:27 Strengths and limitations
- 13:47 The need for further study
- 15:54 Further research
- 17:24 Kalin interview
- 17:47 Brand et al.
- 20:17 Partanen et al.
- 23:54 Moran et al.
- 26:48 Gallucci et al.
- 30:38 Arion et al.
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September 2024: Peer Social Genetic Effects and the Etiology of Substance Use Disorders, Major Depression, and Anxiety Disorder in a Swedish National Sample
Dr. Jessica Salvatore (Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey) joins AJP Audio to discuss peer social genetic effects and their impact on alcohol and substance use, anxiety, and …
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Dr. Jessica Salvatore (Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey) joins AJP Audio to discuss peer social genetic effects and their impact on alcohol and substance use, anxiety, and major depressive disorders in adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the rest of the September issue of the American Journal of Psychiatry.
- 00:52 Salvatore interview
- 02:49 Can the genetic makeup of other people impact your risk for psychiatric conditions?
- 04:12 Impact on genetic predisposition
- 05:12 Why look at these effects through a genetic lens?
- 07:17 Limitations
- 10:05 Clinical implications
- 12:40 Further research
- 13:32 Kalin interview
- 13:47 Salvatore et al.
- 15:54 Dalhuisen et al.
- 19:23 Hess et al.
- 24:14 Larsen et al.
- 26:43 Schwippel et al.
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August 2024: Sexual Identity Continuity and Change in a U.S. National Probability Sample of Sexual Minority Adults: Associations With Mental Health and Problematic Substance Use
Dr. Evan Krueger (Tulane University School of Social Work) joins AJP Audio to discuss the impact of sexual identity change and continuity on the mental health and substance use of adults who identify as a …
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Dr. Evan Krueger (Tulane University School of Social Work) joins AJP Audio to discuss the impact of sexual identity change and continuity on the mental health and substance use of adults who identify as a sexual minority. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the August issue of AJP.
- 00:52 Krueger interview
- 02:49 The Generations Study
- 04:21 How the sample differed
- 05:42 Differences between male and female, monosexual and plurisexual
- 07:53 Clinical implications for this population
- 09:39 Limitations
- 11:11 Life course and societal changes as potential factors?
- 13:05 Further research
- 14:31 Kalin interview
- 14:37 Krueger et al.
- 17:21 Amstadter et al.
- 20:45 Hilbert et al.
- 23:13 Bommersbach et al.
- 25:49 Zhou et al.
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