Beyond the Endpoint
- Episódios
- 53
- Publicação
- quinzenal
- Último episódio
- 4 nov 2026
Sobre o podcast
The Duke Clinical Research Institute is drawing on gold-standard research and real-world evidence to bring you Beyond the Endpoint, a podcast that is demystifying clinical research and healthcare through conversations with renowned clinicians and scientists.
Episódios 53
Pediatric Dosing: Protecting Children Through Research, Not From It
Danny Benjamin, principal investigator of the Pediatric Trials Network, joins Beyond the Endpoint to explain why kids are not small adults, especially when it comes to dosing. He shares how a neonatal intensive …
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Danny Benjamin, principal investigator of the Pediatric Trials Network, joins Beyond the Endpoint to explain why kids are not small adults, especially when it comes to dosing. He shares how a neonatal intensive care unit conversation grew into a national network, how platform trials changed pediatric research, and what safeguards parents should look for. Learn more and view resources: https://dcri.org/blog/s3-ep-5-pediatric-dosing-protecting-children-through-research-not-itWhat's in a Name? The Journey from PCOS to PMOS
Anuja Dokras, MD, MHCI, PhD, joins Emily O'Brien and new co-host Daniel Edmonston to explain why PCOS is now PMOS, polyendocrine metabolic ovarian syndrome. She traces the global effort behind the new name and …
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Anuja Dokras, MD, MHCI, PhD, joins Emily O'Brien and new co-host Daniel Edmonston to explain why PCOS is now PMOS, polyendocrine metabolic ovarian syndrome. She traces the global effort behind the new name and how it could reduce stigma, improve frontline care, and open doors to new research funding. https://dcri.org/blog/s3-ep-4-whats-name-journey-pcos-pmosBeyond the Headlines: AI, Lp(a), Faster Trials, and the Future of Research Funding
Hosts Manesh Patel and Emily O'Brien look past the headlines on Novartis' Lp(a) drug trial results, AI agents in medicine, the FDA's Operation Trailblazer to speed up clinical trials, Dolly Parton's support for …
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Hosts Manesh Patel and Emily O'Brien look past the headlines on Novartis' Lp(a) drug trial results, AI agents in medicine, the FDA's Operation Trailblazer to speed up clinical trials, Dolly Parton's support for COVID research, and the case for steady NIH funding. https://dcri.org/blog/s3-ep-3-beyond-headlinesThe Critical Filling: 30 Years with Harrington, Peterson & Curtis
Three former DCRI executive directors, Bob Harrington, Eric Peterson, and Lesley Curtis, join Beyond the Endpoint for part two of the institute's 30th anniversary series. They reflect on growth, crisis …
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Three former DCRI executive directors, Bob Harrington, Eric Peterson, and Lesley Curtis, join Beyond the Endpoint for part two of the institute's 30th anniversary series. They reflect on growth, crisis, inconvenient truths, and the culture they believe will carry DCRI through whatever comes next. https://dcri.org/blog/s3-ep-2-critical-filling-30-years-harrington-peterson-curtisThe Foundation & the Future: 30 Years with Califf & Hernandez
To mark DCRI's 30th anniversary, this first episode in a two-part series features founding director Robert Califf and current Executive Director Adrian Hernandez as they look back at the institute's evolution …
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To mark DCRI's 30th anniversary, this first episode in a two-part series features founding director Robert Califf and current Executive Director Adrian Hernandez as they look back at the institute's evolution and ahead to its future. Part two arrives Sept. 23. https://dcri.org/blog/s3-ep-1-foundation-future-30-years-califf-hernandezBeyond the Headlines: PMDD and Antihistamines, Real-Time FDA Study Monitoring Using Al, and More!
In this Beyond the Headlines episode, we examine the FDA's push for real-time clinical trial data, an executive order making psychedelic research a federal priority, advances in CAR T-cell therapy for …
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In this Beyond the Headlines episode, we examine the FDA's push for real-time clinical trial data, an executive order making psychedelic research a federal priority, advances in CAR T-cell therapy for autoimmune conditions, and viral claims about antihistamines as a treatment for premenstrual dysphoric disorder. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-16-beyond-headlinesThe COPD Gap: Diagnosis, Treatment, and Access
COPD is the third leading cause of death worldwide. Yet the disease remains underdiagnosed and underfunded. Host Emily O'Brien and pulmonologist Chris Mosher discuss stigma, funding disparities, barriers to …
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COPD is the third leading cause of death worldwide. Yet the disease remains underdiagnosed and underfunded. Host Emily O'Brien and pulmonologist Chris Mosher discuss stigma, funding disparities, barriers to care, and promising research that's bringing new hope to patients. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-15-copd-gap-diagnosis-treatment-and-accessHard Habits: What Kidney Stones Teach Us About Behavior Change
Why is it so hard to change our behavior, even when we know what we should be doing? Host Emily O'Brien sits down with urologist and DCRI faculty member Dr. Chuck Scales to discuss the science of behavior …
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Why is it so hard to change our behavior, even when we know what we should be doing? Host Emily O'Brien sits down with urologist and DCRI faculty member Dr. Chuck Scales to discuss the science of behavior change and surprising findings from the PUSH trial, the largest kidney stone prevention trial to date. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-14-hard-habits-what-kidney-stones-teach-us-about-behavior-changeClosing the Gap in Cardiac Arrest Survival: Why Bystanders Matter
During a cardiac event, every minute without CPR reduces survival chances by 10%. In this episode, DCRI's Tyler Cope discusses a coordinated effort to train nearly 20,000 people across North Carolina in a …
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During a cardiac event, every minute without CPR reduces survival chances by 10%. In this episode, DCRI's Tyler Cope discusses a coordinated effort to train nearly 20,000 people across North Carolina in a single day and what it takes to get more bystanders to take action in an emergency. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-13-closing-gap-cardiac-arrest-survival-why-bystanders-matterFrom Research to Relief: Raising the Standard in Back Pain Treatment
Nearly 40% of Americans have experienced back pain in the past three months, yet treatment hasn't kept pace with the science. Host Emily O'Brien talks with DCRI researcher Steven George about biopsychosocial …
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Nearly 40% of Americans have experienced back pain in the past three months, yet treatment hasn't kept pace with the science. Host Emily O'Brien talks with DCRI researcher Steven George about biopsychosocial models of care, pragmatic trials, and building a better system for chronic pain management. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-12-research-relief-raising-standard-back-pain-treatmentAll About Allergies: The Evolution of Care & Evidence with Dr. Zach Rubin
Double-board-certified pediatrician and allergist/immunologist Zach Rubin joins Manesh Patel for an evidence-based discussion on allergy science. The conversation dives into the differences between allergies …
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Double-board-certified pediatrician and allergist/immunologist Zach Rubin joins Manesh Patel for an evidence-based discussion on allergy science. The conversation dives into the differences between allergies and sensitivities, recent shifts in food allergy prevention, environmental and metal allergies, and FDA-approved treatments, including Xolair and needle-free EpiPens. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-11-all-about-allergies-evolution-care-evidence-dr-zach-rubinFrom Innovation to Implementation: AI in Action
Guests Michael Pencina and Suresh Balu join the Beyond the Endpoint hosts to explore the impact of AI in healthcare. They discuss the role of AI-powered tools in research, clinical care, and operations, while …
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Guests Michael Pencina and Suresh Balu join the Beyond the Endpoint hosts to explore the impact of AI in healthcare. They discuss the role of AI-powered tools in research, clinical care, and operations, while examining evidence standards, transparency challenges, and the potential evolution of the physician-patient relationship. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-10-innovation-implementation-ai-actionBeyond the Headlines Series: Looking back at 2025 headlines, Dementia & Vaccines, and Cannabis Research
Kick off 2026 with hosts Manesh Patel and Emily O'Brien as they evaluate last year's most discussed health stories and wellness trends, cannabis reclassification, and a shingles vaccine-dementia study. 🔗 Access …
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Kick off 2026 with hosts Manesh Patel and Emily O'Brien as they evaluate last year's most discussed health stories and wellness trends, cannabis reclassification, and a shingles vaccine-dementia study. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-9-beyond-headlinesBehind the Voices: Get to Know Emily & Manesh
Hosts Manesh Patel and Emily O'Brien share their amusing and inspiring personal and professional trajectories, exploring how mentors shaped their paths in clinical research, why asking unconventional questions …
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Hosts Manesh Patel and Emily O'Brien share their amusing and inspiring personal and professional trajectories, exploring how mentors shaped their paths in clinical research, why asking unconventional questions matters, and how success rarely follows a straight line. 🎙️ Listen now for the full conversation: https://dcri.org/blog/s2-ep-8-behind-voices-get-know-emily-maneshFrom Provider to Patient: A Dual Perspective on Colorectal Cancer
Hosts Emily O’Brien and Manesh Patel sit down with Dr. Ajay Kohli and Dr. Julius Wilder for a dual-perspective conversation on colorectal cancer, where they discuss personal experiences, the importance of early …
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Hosts Emily O’Brien and Manesh Patel sit down with Dr. Ajay Kohli and Dr. Julius Wilder for a dual-perspective conversation on colorectal cancer, where they discuss personal experiences, the importance of early detection, screening disparities, and how equitable access to care saves lives. 🔗Access resources related to this episode: https://dcri.org/blog/s2-ep-7-provider-patient-dual-perspective-colorectal-cancerBeyond the Headlines: Recap of the 2025 AHA Scientific Sessions
Recorded at the 2025 American Heart Association Scientific Sessions, hosts Manesh Patel and Emily O'Brien discuss late-breaking cardiovascular research, including gene-editing therapy for cholesterol, AFib …
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Recorded at the 2025 American Heart Association Scientific Sessions, hosts Manesh Patel and Emily O'Brien discuss late-breaking cardiovascular research, including gene-editing therapy for cholesterol, AFib management strategies, and, for coffee lovers, the DECAF trial's findings on caffeine and heart rhythm. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-6-beyond-headlines #AHA25 #beyondtheendpoint #cardiology #podcast #hearthealth #clinicalresearchConnecting the Dots: The Broader Applications of GLP-1s and Where We’re Headed Next
Endocrinologist Jennifer Green discusses how GLP-1 drugs, like Ozempic, evolved from diabetes tools to potential treatments for addiction and heart disease, in this final installment of the obesity series. The …
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Endocrinologist Jennifer Green discusses how GLP-1 drugs, like Ozempic, evolved from diabetes tools to potential treatments for addiction and heart disease, in this final installment of the obesity series. The discussion also touches on critical questions about long-term use, access, and emerging innovations. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-5-connecting-dots-broader-applications-glp-1s-and-where-were-headed-nextObesity, GLP-1s, and the Evidence: What the Data Tells Us
In this second episode of our obesity series, preventive cardiologist Neha Pagidipati sheds light on the discovery, impact, and uses of GLP-1s, like Ozempic and Mounjaro. Learn about the impact these …
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In this second episode of our obesity series, preventive cardiologist Neha Pagidipati sheds light on the discovery, impact, and uses of GLP-1s, like Ozempic and Mounjaro. Learn about the impact these medications are having on diabetes, heart disease, and weight management. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-4-obesity-glp-1s-and-evidence-what-data-tells-usIt's Not Just the Scale: Supporting Sustainable Change in Obesity Treatment
In the first of a three-part series on obesity and GLP-1 medications, our guest Jennifer Norris shares the evolving landscape of obesity treatment. The conversation addresses common misconceptions and examines …
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In the first of a three-part series on obesity and GLP-1 medications, our guest Jennifer Norris shares the evolving landscape of obesity treatment. The conversation addresses common misconceptions and examines how GLP-1 medications, such as Ozempic, have transformed care alongside surgery and lifestyle interventions.Beyond the Headlines: Funding Research, Vaccines, Sleep Health, and AI in Healthcare
The "Beyond the Headlines" series returns with summer healthcare and research news. Hosts Manesh Patel and Emily O'Brien discuss misconceptions about research funding, a Danish study on vaccine safety, the …
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The "Beyond the Headlines" series returns with summer healthcare and research news. Hosts Manesh Patel and Emily O'Brien discuss misconceptions about research funding, a Danish study on vaccine safety, the potential impacts of poor sleep, and how AI tools are transforming medical practice and training. Tags: #medicalnews #healthnews #research #clinicalresearchUnderstanding Autism: Insights from Research and Practice
Ushering in the second season of Beyond the Endpoint, Lauren Franz, MBChB, MPH, interim director of the Duke Center for Autism and Brain Development, joins Manesh Patel and Emily O'Brien for an in-depth …
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Ushering in the second season of Beyond the Endpoint, Lauren Franz, MBChB, MPH, interim director of the Duke Center for Autism and Brain Development, joins Manesh Patel and Emily O'Brien for an in-depth conversation about autism research, care, and community. Franz explains what autism is as a neurodevelopmental spectrum condition and how our understanding of it has evolved significantly over the last decade. The discussion examines the intricate interplay between genetic and environmental factors that may contribute to the development of autism, and explores current intervention approaches. The hosts and guest also discuss the groundbreaking research at Duke University that employs artificial intelligence to analyze medical records for earlier detection of autism. This approach could help shorten the time between when autism can be diagnosed and when it is typically identified. Throughout the episode, Franz stresses the importance of involving the autism community in research and decision-making processes.Playing to Advance Care: A Championship Mindset in Clinical Research
What do championship sports teams and successful research institutions have in common? In the season finale of Beyond the Endpoint, Dr. Adrian Hernandez joins hosts Manesh Patel and Emily O’Brien to break down …
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What do championship sports teams and successful research institutions have in common? In the season finale of Beyond the Endpoint, Dr. Adrian Hernandez joins hosts Manesh Patel and Emily O’Brien to break down what clinical research institutions can learn from their counterparts on the court. From basketball dynasties to resilient mindsets, Dr. Hernandez offers a powerful playbook on building strong research systems, prioritizing patients, and why sharing “negative” results matters. Don’t miss the wrap-up to Season 1! 🔗 Access resources related to this episode https://dcri.org/blog/ep-10-playing-advance-care-championship-mindset-clinical-researchBeyond the Headlines: Protein myths. Anti-aging hype. Autism research. A new diabetes drug?
In this new episode of the Beyond the Endpoint series, “Beyond the Headlines,” hosts Emily O’Brien and Manesh Patel break down what’s you should know about these trending medical topics. From hype to …
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In this new episode of the Beyond the Endpoint series, “Beyond the Headlines,” hosts Emily O’Brien and Manesh Patel break down what’s you should know about these trending medical topics. From hype to headlines—get clinical insight that goes deeper. Access resources related to this episode https://dcri.org/blog/ep-9-beyond-headlines 187880Stepping Up: From Curiosity to Confidence — What to Know Before You Join a Trial
Why do people volunteer for clinical trials — and what should they know before doing so? In this episode of Beyond The Endpoint, we explore common questions, reasons, and myths about clinical trial …
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Why do people volunteer for clinical trials — and what should they know before doing so? In this episode of Beyond The Endpoint, we explore common questions, reasons, and myths about clinical trial participation. Hosts Manesh Patel and Emily O’Brien talk with guest Krista Camuglia, a Research Practice Manager with the Duke Heart Center Clinical Research Unit, who brings unique insights thanks to her work on the frontlines of research coordination. 🎙️ Listen to "Part 1: Why Participate in Clinical Research?" https://dcri.org/blog/ep-7-stepping-why-participate-clinical-researchStepping Up: Why Participate in Clinical Research?
In this episode, cancer survivor Katie Ortman-Doble opens up about her journey through clinical research and why she chose to participate. Hosts Emily O’Brien and Manesh Patel, joined by Jenny Cook, talk about …
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In this episode, cancer survivor Katie Ortman-Doble opens up about her journey through clinical research and why she chose to participate. Hosts Emily O’Brien and Manesh Patel, joined by Jenny Cook, talk about the life-saving potential of clinical trials and the real impact they have on patients and science. Hear Katie’s inspiring story and the reasons behind her decision to join a trial. 🔗 Access resources related to this episode https://dcri.org/blog/ep-7-stepping-why-participate-clinical-researchBridging Science and Policy: A Conversation with Dr. Robert Califf
In this episode of Beyond the Endpoint, former FDA commissioner Dr. Robert Califf joins hosts Manesh Patel and Emily O’Brien to discuss critical challenges shaping the future of patient care. From …
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In this episode of Beyond the Endpoint, former FDA commissioner Dr. Robert Califf joins hosts Manesh Patel and Emily O’Brien to discuss critical challenges shaping the future of patient care. From misinformation to regulatory science to the financialization of healthcare, Dr. Califf has unique insight into the evolving healthcare landscape and the role of data in improving patient outcomes. 🔗 Access resources related to this episode https://dcri.org/blog/ep-6-bridging-science-and-policy-conversation-dr-robert-califfBeyond the Headlines: What’s trending in medical news?
Ozempic curbing alcohol cravings, ADHD linked to shorter life expectancy, and an NBA rising star diagnosed with DVT—what does the science actually say? In this first episode of Beyond the Headlines, a new …
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Ozempic curbing alcohol cravings, ADHD linked to shorter life expectancy, and an NBA rising star diagnosed with DVT—what does the science actually say? In this first episode of Beyond the Headlines, a new Beyond the Endpoint series, hosts Emily O’Brien and Manesh Patel break down the research behind these trending stories. Access resources related to this episode https://dcri.org/blog/ep-5-beyond-headlinesWearables in Clinical Research: Data, Trends, and Challenges
Smartwatches, fitness trackers, and health data—how are wearables reshaping clinical research? In this episode, Dr. Marat Fudim joins us for an insightful discussion on how wearable technology is shaping the …
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Smartwatches, fitness trackers, and health data—how are wearables reshaping clinical research? In this episode, Dr. Marat Fudim joins us for an insightful discussion on how wearable technology is shaping the way we monitor health and conduct research. Topics include: • Are wearables improving patient care or just tracking steps? • How do researchers use wearable data in clinical trials? •What are the biggest challenges in integrating this tech? 🎙️ Listen now and explore the possibilities of wearable health tech! 🔗 Access resources related to this episode https://dcri.org/blog/ep-4-wearables-clinical-research-data-trends-and-challengesThe Intersection of Politics and Medicine: Impacts on Clinical Practice
In this episode of Beyond the Endpoint, Emily O’Brien and Manesh Patel sit down with Leslie Curtis, former senior FDA policy advisor, to explore the FDA’s role in balancing science, public health, and …
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In this episode of Beyond the Endpoint, Emily O’Brien and Manesh Patel sit down with Leslie Curtis, former senior FDA policy advisor, to explore the FDA’s role in balancing science, public health, and regulation, along with how political transitions influence clinical research, healthcare funding, and the approval process for new treatments. 🔗 Access resources related to this episode https://dcri.org/blog/ep-3-intersection-politics-and-medicine-impacts-clinical-practiceBending the Curve on Hypertension
Reducing hypertension risk isn’t just about cutting salt. This week on Beyond The Endpoint, Emily O’Brien, Manesh Patel, and Jenny Cook talk with Dr. Dhruv Kazi about the complex public health battle against …
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Reducing hypertension risk isn’t just about cutting salt. This week on Beyond The Endpoint, Emily O’Brien, Manesh Patel, and Jenny Cook talk with Dr. Dhruv Kazi about the complex public health battle against hypertension. From interventions to strategies for patient and physician adherence, this episode covers scalable solutions to change the future of hypertension. 🔗 Access resources related to this episode https://dcri.org/blog/ep-2-bending-curve-rewriting-future-hypertension
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