Health Optimization Medicine Podcast

1. The Six Nails of Tilopa: A Framework for Mental Freedom | HOMe Podcast #031

   October 21, 202638 minSeason 2 · Episode 31

   In this episode of the Health Optimization Medicine Podcast, Boomer Anderson sits down with Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Scott Sherr for a different kind of conversation focused on mental health …

   Show notes

   In this episode of the Health Optimization Medicine Podcast, Boomer Anderson sits down with Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Scott Sherr for a different kind of conversation focused on mental health, presence, and the Six Nails of Tilopa.

   Dr. Achacoso introduces the Six Nails of Tilopa through the mnemonic RITEC R: don't recall, don't imagine, don't think, don't examine, don't control, and relax into effortless awareness. The discussion explores how these principles can be applied to everyday life, particularly when dealing with grudges, future-oriented anxiety, overthinking, perfectionism, and the desire to control outcomes.

   Join us as we delve into:

   • What Safety Feels Like: How breathing, muscle tension, posture, guarding, and a sense of choice may provide information about how a person is experiencing safety.

   • Six Nails of Tilopa: An introduction to the six principles represented by RITEC R: Don't Recall, Imagine, Think, Examine, Control, and to Relax into effortless awareness.

   • The Sympathetic Hyperdrive: Why the faculty describe modern life as highly stimulating and how chronic sympathetic activation can affect the experience of stress and recovery.

   • HRV and Sympathetic Activation: How Dr. Sherr describes patients who may feel fine while showing persistently low HRV and signs of prolonged sympathetic activation.

   • Past Events and Mental Health: Why learning from the past is different from repeatedly reliving it, and how letting go of grudges can change the way someone experiences the present.

   • Perfectionism and Self-Judgment: How constantly evaluating your own performance can become distracting and exhausting.

   • The Illusion of Control: How the faculty explore the relationship between control, anxiety, decision-making, and the philosophical question of free will.

   • Free Will and the Self: A wide-ranging discussion of whether free will exists and how context, biology, perception, and internal states influence human decisions.

   • The Happiness Game: Dr. Achacoso's practical exercise for noticing how quickly the mind produces another thought.

   • Health Optimization and Presence: Why optimizing health may involve more than quantitative measurements and can also include how fully a person experiences the moment.

   This episode is for you if:

   • You are interested in the biology of safety, stress, and recovery.

   • You want to understand the Cell Danger Response and its different stages.

   • You are interested in how cellular and nervous-system processes may interact.

   • You have experienced a major stressor or illness and are interested in the recovery process that follows.

   • You want to better understand why being intellectually aware of safety may not always correspond with how the body feels.

   • You are interested in the relationship between stress, activation, recovery, and resilience.

   • You want to explore how the body allocates resources between protection, repair, adaptation, and growth.

   • You are interested in Health Optimization Medicine and the HOMeHOPe framework.

   You can also find this episode on…

   YouTube: https://youtu.be/czPLAypqwPI

   Find more from Health Optimization Medicine and Practice (HOMeHOPe):

   Website: https://homehope.org/

   Instagram: https://www.instagram.com/homehopeorg/

   Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

   Find more from Troscriptions:

   Website: https://troscriptions.com/

   Instagram: https://www.instagram.com/troscriptions/

   Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

2. Safety Is A Biological State | HOMe Podcast #030

   October 14, 202643 minSeason 2 · Episode 30

   In this episode of the Health Optimization Medicine Podcast, Dr. Allen Bookatz and Jodi Duval explore safety as a biological state and examine what happens when a threat has ended but the body's response has …

   Show notes

   In this episode of the Health Optimization Medicine Podcast, Dr. Allen Bookatz and Jodi Duval explore safety as a biological state and examine what happens when a threat has ended but the body's response has not yet fully resolved.

   The conversation looks at safety from two interconnected perspectives: the cell and the nervous system. Jodi explains how cells respond to threats through the Cell Danger Response, while Allen explores how the nervous system continuously evaluates the body's internal and external environment and determines how much of the system should remain committed to protection.

   A central theme throughout the episode focuses on the idea that the end of an acute threat is not necessarily the end of the healing response. The discussion explores what happens when the body remains organized around protection, even after the original crisis has passed.

   Join us as we delve into:

   • Safety as a Biological State: Why safety is more than simply removing an immediate threat and why the body may require additional signals before returning to normal function.

   • The Cell Danger Response: How cells respond to infection, toxins, injury, and metabolic stress through stages of containment, rebuilding, and reconnection.

   • Protection, Repair and Reconnection: Why the end of an injury or acute threat is not necessarily the end of the healing process.

   • When the Crisis Is Over but Recovery Isn't: Why someone may continue experiencing changes in energy, cognition, or tolerance after an acute illness or crisis has resolved.

   • The Nervous System and Safety: How the nervous system continuously samples internal and external information and determines how much of the body should remain committed to protection.

   • Safety Does Not Always Mean Calm: Why a safe system can still be highly activated, such as during exercise, and why outward stillness does not necessarily mean that the system has settled.

   • Stress and Recovery: Why stress itself is not necessarily the problem, and how the ability to recover, renew, and complete the response may influence resilience.

   • The Metabolic Cost of Prolonged Protection: How prioritizing defense and repair can defer growth, reserve capacity, and longer-term processes.

   • What Safety Feels Like: How breathing, muscle tension, posture, guarding, and a sense of choice may provide information about how a person is experiencing safety.

   • When the Mind Knows but the Body Doesn't: Why intellectual reassurance and objective evidence may not always correspond with how safety is registered physiologically.

   • The Limits of Measurement: What can currently be measured about cellular and physiological states, and where interpretation remains necessary.

   • Interoception and Body Signals: Why internal sensations can sometimes be amplified or diminished, affecting how the body interprets its own signals.

   • Scientific Uncertainty: Why frameworks such as polyvagal theory should be considered with awareness of ongoing scientific debate and why the broader discussion does not depend on resolving that particular debate.

   • Completing the Response: Why the episode distinguishes between the absence of the original problem and the active completion of the biological response.

   This episode is for you if:

   • You are interested in the biology of safety, stress, and recovery.

   • You want to understand the Cell Danger Response and its different stages.

   • You are interested in how cellular and nervous-system processes may interact.

   • You have experienced a major stressor or illness and are interested in the recovery process that follows.

   • You want to better understand why being intellectually aware of safety may not always correspond with how the body feels.

   • You are interested in the relationship between stress, activation, recovery, and resilience.

   • You want to explore how the body allocates resources between protection, repair, adaptation, and growth.

   • You are interested in Health Optimization Medicine and the HOMeHOPe framework.

   You can also find this episode on…

   YouTube: https://youtu.be/GAxXyJQKv2Y

   Find more from Health Optimization Medicine and Practice (HOMeHOPe):

   Website: https://homehope.org/

   Instagram: https://www.instagram.com/homehopeorg/

   Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

   Find more from Troscriptions:

   Website: https://troscriptions.com/

   Instagram: https://www.instagram.com/troscriptions/

   Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

3. Hidden Toxicities In Your Cells Are Making You Sick | HOMe Podcast Special Episode

   October 7, 202614 minSeason 2 · Episode 30

   In this special episode of the Health Optimization Medicine Podcast, Dr. Jup Kuipers, Dr. Ted Achacoso, Dr. Allen Bookatz, and Dr. Scott Sherr discuss how toxicities can build up over time, affect cellular …

   Show notes

   In this special episode of the Health Optimization Medicine Podcast, Dr. Jup Kuipers, Dr. Ted Achacoso, Dr. Allen Bookatz, and Dr. Scott Sherr discuss how toxicities can build up over time, affect cellular energy production, and eventually show up as problems across different organ systems.

   The team looks at two clinical cases involving mercury and arsenic exposure, and how symptoms were initially treated as separate problems by different specialists. They discuss why chronic, lower-level exposure can be difficult to identify, how heavy metals can interfere with mitochondrial function, and why looking at the cell may reveal a different picture than looking only at the organ that is showing symptoms.

   Join us as we delve into:

   • The Limits of Organ-Based Medicine: Why specialists may correctly identify the affected organ while missing the shared environmental or metabolic cause.

   • Subclinical vs. Acute Toxicity: Why chronic low-level exposure may affect health long before laboratory findings meet the threshold for acute poisoning.

   • Why Blood Testing May Miss the Full Picture: Why circulating levels may not fully represent what has accumulated within cells and tissues.

   • Intracellular Toxicity Testing: How intracellular testing is discussed as a way of assessing mercury, lead, arsenic, and other toxic elements within cellular material.

   • Toxicities and Mitochondrial Function: How heavy metals can interfere with metabolic pathways involved in cellular energy production.

   • Why Symptoms Appear in Different Organs: How the system with the least resilience may become the first place where cellular dysfunction becomes visible.

   • Metabolomics and Early Detection: How metabolomic testing may provide a window into cellular function and help identify metabolic disruption.

   • Disease Management vs. Health Optimization: Why acute and specialist care remain essential, while a health optimization approach focuses on understanding the cellular environment before disease becomes the dominant problem.

   This episode is for you if:

   • You experience symptoms affecting several organ systems without one clear explanation.

   • You want to understand the difference between acute poisoning and chronic, low-level exposure.

   • You are interested in how mercury, arsenic, lead, cadmium, and aluminum may affect cellular energy production.

   • You want to understand why certain toxic exposures can be difficult to identify through conventional testing.

   • You are interested in metabolomics and intracellular testing as tools for looking more deeply at cellular health.

   • You want to understand the difference between managing disease and proactively optimizing health.

   You can also find this episode on…

   YouTube: https://youtu.be/WChkA4twbg4

   Find more from Health Optimization Medicine and Practice (HOMeHOPe):

   Website: https://homehope.org/

   Instagram: https://www.instagram.com/homehopeorg/

   Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

   Find more from Troscriptions:

   Website: https://troscriptions.com/

   Instagram: https://www.instagram.com/troscriptions/

   Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

4. Eye Health & Vision Optimization w/ Dr. Bryce Appelbaum | HOMe Podcast #029

   September 30, 202647 minSeason 2 · Episode 29

   In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Bryce Appelbaum to discuss the connection between vision, screen time, brain function, and nervous system …

   Show notes

   In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Bryce Appelbaum to discuss the connection between vision, screen time, brain function, and nervous system regulation.

   Most people think of vision as eyesight, or how clearly they can see an eye chart. Dr. Appelbaum explains why vision is much broader. It involves how the brain receives information through the eyes, interprets the environment, coordinates movement, and decides how to respond.

   The conversation explores how prolonged screen use can narrow peripheral awareness, increase visual stress, and keep the nervous system in a more activated state. They also discuss the rise of myopia, the difference between eyesight and functional vision, and how vision performance training may support reading, learning, reaction time, spatial awareness, athletic performance, and recovery after concussion or traumatic brain injury.

   Join us as we delve into:

   • Screen Time and the Nervous System: How prolonged engagement with close, two-dimensional screens can contribute to visual stress, tunnel vision, fatigue, and sympathetic activation.

   • Central vs. Peripheral Vision: Why stress narrows visual attention and how soft gaze, panoramic viewing, and access to peripheral vision may help the nervous system move out of fight or flight.

   • Eyesight vs. Vision: Why seeing 20/20 does not necessarily mean the eyes and brain are working together efficiently.

   • The Eye-Brain Connection: How the brain gathers, filters, processes, and interprets visual information before directing movement or action.

   • Brain Fog, Fatigue and Reading Difficulty: How inefficient eye coordination and focusing may contribute to headaches, tired eyes, reduced concentration, poor productivity, and avoidance of visually demanding tasks.

   • The Myopia Epidemic: Why nearsightedness is becoming more common and how genetics, limited outdoor time, near work, poor lighting, and screen use may influence its development.

   • Screen Breaks That Work: Why the 20-20-20 rule should be treated as the maximum interval between visual breaks for people who work on screens.

   • The Limits of Vision Biohacks: Why palming may help relaxation, but broad claims that sunning or simple exercises can eliminate the need for glasses are not supported for everyone.

   This episode is for you if:

   • You spend several hours each day working on a phone, computer, or tablet.

   • You experience headaches, dry eyes, eye strain, blurred vision, brain fog, or fatigue after screen use.

   • You want to understand the difference between eyesight and functional vision.

   • You are concerned about myopia or increasing prescriptions in yourself or your children.

   • You want practical ways to reduce visual stress during the workday.

   • You are interested in vision training for learning, sports, productivity, concussion recovery, or healthy aging.

   • You want to understand how vision may affect nervous system regulation, balance, spatial awareness, and cognitive performance.

   You can also find this episode on…

   YouTube: https://youtu.be/qwtP-0gU5wU

   Find more from Health Optimization Medicine and Practice (HOMeHOPe):

   Website: https://homehope.org/

   Instagram: https://www.instagram.com/homehopeorg/

   HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

   Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

   Find more from Troscriptions:

   Website: https://troscriptions.com/

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   Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

   Find more from Dr. Bryce Appelbaum:

   Website: https://myvisionfirst.com/ScreenFit™: https://screenfit.com/Instagram: https://www.instagram.com/drbryceappelbaum/

   • Get $200 off ScreenFit™ using code SNH at https://screenfit.com/enroll

   • Get 10% off Digital Performance Lenses using code SNH at https://shop.myvisionfirst.com/

5. Unlock Your Brain with Better Glymphatic Clearance | HOMe Podcast #028

   September 23, 202616 minSeason 2 · Episode 28

   In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Jodi Duval explore the glymphatic system and the role sleep plays in clearing metabolic waste from the brain …

   Show notes

   In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Jodi Duval explore the glymphatic system and the role sleep plays in clearing metabolic waste from the brain.

   Getting eight hours of sleep does not necessarily mean getting eight hours of effective brain clearance. The team looks at how the autonomic nervous system, norepinephrine, cerebrospinal fluid and interstitial fluid exchange, aquaporin-4 channels, circadian timing, body temperature, gut barrier integrity, and even anxiety around wearable sleep scores may influence the conditions needed for healthy glymphatic flow.

   The discussion also introduces a practical HOMeHOPe glymphatic optimization protocol focused on creating the chronobiological, bioenergetic, and environmental conditions that support natural overnight brain clearance.

   Join us as we delve into:

   • How the Glymphatic System Works: How cerebrospinal fluid moves through perivascular spaces, exchanges with interstitial fluid, and helps remove metabolic waste including beta-amyloid, tau, and cellular metabolites.

   • Circadian Biology, NAMPT and NAD+: How CLOCK and BMAL1 influence NAMPT and the NAD+ salvage pathway, and why disrupted circadian rhythms can affect cellular maintenance.

   • The Autonomic Nervous System: How elevated sympathetic tone and nighttime norepinephrine can interfere with the conditions required for glymphatic flow.

   • Circadian Biology and Brain Health: Why light timing, cortisol rhythms, and autonomic balance matter for creating the right conditions for overnight clearance.

   • The HOMeHOPe Glymphatic Optimization Protocol: Practical strategies involving morning light, evening light reduction, bedroom temperature, sleeping position, autonomic safety, and gut barrier support.

   • The Role of Sleep Hygiene: Why the environment and signals surrounding sleep may matter just as much as the number of hours spent in bed.

   • The Skeptical Position: The team examines the conventional neurology argument that slow-wave sleep architecture, aging, and aquaporin-4 changes may limit how much glymphatic function can be influenced through lifestyle.

   • Precision vs. Generic Sleep Advice: Why HOMeHOPe emphasizes measurement, metabolomics, circadian markers, and individualized guidance rather than simply telling someone to "get more sleep."

   This episode is for you if:

   • You get enough hours of sleep but still wake up with brain fog or fatigue.

   • You want to understand how the glymphatic system supports brain health during sleep.

   • You are interested in the relationship between sleep hygiene, circadian biology, and brain clearance.

   • You use a wearable to track sleep and want to understand the potential downside of becoming overly focused on sleep scores.

   • You are interested in practical, non-pharmaceutical approaches to supporting healthy brain function and sleep.

   You can also find this episode on…

   YouTube: https://youtu.be/kLFUm2Ik2s4

   Find more from Health Optimization Medicine and Practice (HOMeHOPe):

   Website: https://homehope.org/

   Instagram: https://www.instagram.com/homehopeorg/

   HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

   Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

   Find more from Troscriptions:

   Website: https://troscriptions.com/

   Instagram: https://www.instagram.com/troscriptions/

   Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

6. The Cellular Mechanisms of Stress | HOMe Podcast #027

   September 16, 202614 minSeason 2 · Episode 27

   In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Jodi Duval, and Dr. Allen Bookatz explore what happens inside the cell when the body perceives stress or danger. The discussion …

   Show notes

   In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Jodi Duval, and Dr. Allen Bookatz explore what happens inside the cell when the body perceives stress or danger.

   The discussion focuses on Dr. Robert Naviaux's Cell Danger Response and how mitochondria can alter energy production and signaling in response to perceived threats. The team examines why fatigue, brain fog, inflammation, and exercise intolerance can occur even when standard laboratory testing appears normal, and how the different phases of the cellular response are meant to move from defense through repair and recovery.

   Join us as we delve into:

   • Stress at the Cellular Level: How mitochondria and cells respond when they perceive danger from infection, toxins, injury, environmental exposures, or psychological stress.

   • Why Normal Labs May Not Explain Fatigue: Why standard testing may not capture changes in cellular signaling, mitochondrial output, or a cell's metabolic state.

   • The Three Phases of the Cell Danger Response: How CDR1 involves inflammatory defense, CDR2 involves proliferation and rebuilding, and CDR3 involves differentiation and recovery.

   • Stress, Mitochondria and Energy: Why cells may reduce energy output while continuing to interpret their environment as unsafe.

   • Hormesis and Stress Dosing: Why exercise, temperature exposure, and other acute stressors may be useful when properly dosed, while excessive stress may add to the existing burden.

   • Mitochondrial Nutrient Support: The role discussed for CoQ10, PQQ, magnesium, and NAD+ precursors in supporting the metabolic machinery during the transition through the CDR phases.

   • Parasympathetic Safety Signaling: How extended-exhale breathing, HRV biofeedback, vagal tone work, and other approaches are discussed as ways to reduce chronic sympathetic input.

   • The Limits of the Framework: Why deliberately adding stress to an already overloaded system may be counterproductive when the dose is not appropriate.

   • Disease Management vs. Health Optimization: Why the HOMeHOPe approach looks not only at the trigger but also at the conditions the cell may need to complete its response.

   This episode is for you if:

   • You experience fatigue, brain fog, or exercise intolerance despite relatively normal standard laboratory results.

   • You want to understand the Cell Danger Response and its proposed role in cellular stress.

   • You are interested in mitochondrial function, cellular energy, inflammation, and purinergic signaling.

   • You want to understand why more exercise, stimulation, or stress is not always the right answer.

   • You are interested in hormesis, autonomic regulation, gut health, circadian biology, and metabolomic testing.

   • You want to understand how Health Optimization Medicine approaches cellular stress and recovery.

   You can also find this episode on…

   YouTube: https://youtu.be/0Vx79yABA9k

   Find more from Health Optimization Medicine and Practice (HOMeHOPe):

   Website: https://homehope.org/

   Instagram: https://www.instagram.com/homehopeorg/

   HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

   Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

   Find more from Troscriptions:

   Website: https://troscriptions.com/

   Instagram: https://www.instagram.com/troscriptions/

   Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

7. Read Your Genes! APOE4, Brain Health, and Longevity | HOMe Podcast #026

   September 9, 202611 minSeason 2 · Episode 26

   In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Jup Kuipers, Boomer Anderson, Dr. Allen Bookatz, and Dr. Scott Sherr explore a difficult question: can we influence the biology …

   Show notes

   In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Jup Kuipers, Boomer Anderson, Dr. Allen Bookatz, and Dr. Scott Sherr explore a difficult question: can we influence the biology of an aging brain carrying APOE4 risk?

   APOE4 is not simply a diagnosis, and a genetic result does not tell us what is happening in someone's brain today. The team looks at how APOE4 may affect lipid transport, microglial behavior, vascular integrity, glucose utilization, mitochondrial function, circadian biology, and epigenetic maintenance.

   The discussion also lays out a practical three-phase framework: establish the phenotype, reduce ongoing stressors, restore circadian and bioenergetic alignment, and track whether cognitive, functional, metabolic, vascular, and biological age measures actually improve over time.

   Join us as we delve into:

   • APOE4 Risk vs Diagnosis: What one versus two APOE4 copies may mean, and why genotype is not the same as the current clinical stage.

   • Cellular Energy and Epigenetic Maintenance: Why disrupted energy metabolism can affect the conditions needed for normal transcription and epigenetic maintenance.

   • Circadian Biology, NAMPT and NAD+: How CLOCK and BMAL1 influence NAMPT and the NAD+ salvage pathway, and why disrupted circadian rhythms can affect cellular maintenance.

   • Health Optimization Medicine vs Disease-Centered Prevention: Why the HOMe approach focuses on the cellular environment and the conditions that create and sustain health.

   • The Three-Phase Clinical Framework: How to establish a baseline phenotype, reduce exposomic stressors, restore circadian and bioenergetic alignment, and track outcomes over time.

   • The Skeptical Position: The team considers the argument that APOE4-driven pathology may be too genetically determined for lifestyle and metabolic tuning to meaningfully change the trajectory.

   • What Does a "Reset" Actually Mean?: Why a reset is a claim that needs to be demonstrated through durable improvements in cognition, function, and biomarkers over time.

   This episode is for you if:

   • You have undergone genetic testing and want to better understand what an APOE4 result does and does not tell you.

   • You are interested in the relationship between APOE4, brain aging, metabolism, vascular health, and mitochondrial function.

   • You want to understand how circadian biology, NAD+ salvage, and epigenetic maintenance may intersect with brain health.

   • You are interested in a measurement-based Health Optimization Medicine approach to genetic risk.

   • You want to understand why phenotype, longitudinal tracking, and objective biomarkers matter when evaluating interventions.

   You can also find this episode on…

   YouTube: https://youtu.be/byEspMGRbtI

   Find more from Health Optimization Medicine and Practice (HOMeHOPe):

   Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

   Find more from Troscriptions:

   Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

8. Why You're Frozen in Survival Mode: Understanding CDR | HOMe Podcast #025

   September 2, 202614 minSeason 2 · Episode 25

   In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, and Jodi Duval sit down to discuss what happens when the body's cellular defense systems remain …

   Show notes

   In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, and Jodi Duval sit down to discuss what happens when the body's cellular defense systems remain activated after the original threat has passed.

   Fatigue and brain fog are often treated as problems that require more stimulation, more exercise, or more supplements. But what if low energy is sometimes an adaptive response? The HOMeHOPe faculty explores the Cell Danger Response, how mitochondria and purinergic signaling respond to threats, and why pushing harder can sometimes work against recovery.

   The discussion also introduces a practical three-phase approach to moving from persistent cellular defense toward greater metabolic and bioenergetic flexibility.

   Join us as we delve into:

   • Why Cells Get Stuck in Survival Mode: How infection, toxin exposure, tissue injury, and other stressors can shift cellular priorities toward defense, and what happens when those signals persist after the original crisis.

   • The Cell Danger Response: How mitochondrial function, ATP signaling, inflammation, and purinergic pathways can change during cellular stress.

   • Why More Energy May Not Be the Answer: Why fatigue can sometimes represent an adaptive biological response rather than simply a deficiency that can be corrected with more stimulants or supplements.

   • ATP Has Two Different Messages: How intracellular ATP supports cellular work while extracellular ATP can act as a danger signal through purinergic receptors.

   • The Three Phases of Recovery: How exposomic unburdening, assessment of intracellular and metabolic function, and reinforcement of cellular safety can provide a framework for recovery.

   • Measure, Don't Guess: Why organic acids, acylcarnitines, redox markers, amino acids, micronutrient patterns, and membrane lipids can help identify metabolic constraints and guide targeted interventions.

   • Circadian and Autonomic Regulation: Why morning light, sleep, appropriately graded activity, autonomic regulation, and circadian timing are part of restoring biological capacity.

   • The Limits of the Cell Danger Response Model: Where the evidence is mechanistic or emerging, why the framework should not be used to explain every chronic symptom, and why stronger clinical evidence is still needed.

   This episode is for you if:

   • You work shifts, overnight schedules, or other situations where acute sleep deprivation is sometimes unavoidable.

   • You want to understand how sleep loss affects brain energy metabolism and cognitive performance.

   • You are interested in the relationship between creatine, phosphocreatine, ATP, and brain function.

   • You want to understand the potential and limitations of using creatine during acute cognitive stress.

   • You are interested in cellular bioenergetics and the Health Optimization Medicine approach to precision health.

   You can also find this episode on…

   YouTube: https://youtu.be/0mn-8B6K0bU

   Find more from Health Optimization Medicine and Practice (HOMeHOPe):

   Website: https://homehope.org/

   Instagram: https://www.instagram.com/homehopeorg/

   HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

   Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

   Find more from Troscriptions:

   Website: https://troscriptions.com/

   Instagram: https://www.instagram.com/troscriptions/

   Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

9. The Real Cause of Endotoxemia: Leaky Gut Explained | HOMe #023

   August 26, 202615 minSeason 2 · Episode 23

   In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers explore a misunderstood cause of chronic fatigue and leaky gut: the …

   Show notes

   In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers explore a misunderstood cause of chronic fatigue and leaky gut: the bioenergetic failure of your colonocytes. While many practitioners throw random probiotic strains and anti-inflammatory herbs at gut issues, metabolomic research shows this approach fails to address the root problem.

   The team explains how a starved microbiome forces gut cells to switch energy systems, leaking oxygen into the colon, destroying strict anaerobes, and allowing endotoxins to flood the bloodstream and drain your cellular vitality. From holobiont metabolomics to targeted mucosal protocols, this discussion reframes gut health through the lens of mitochondrial beta oxidation rather than simply managing inflammation.

   Join us as we delve into:

   • The Gut Hypoxia Trap: How starved colonocytes switch to anaerobic glycolysis and leak oxygen into the gut, killing off the strict anaerobes that make butyrate.

   • The Endotoxemia Dilemma: How opportunistic bacteria pry apart tight junctions, allowing lipopolysaccharides (LPS) into the bloodstream and locking your cells into a permanent Cell Danger Response.

   • Why Probiotics Fall Short: Why conventional protocols fail to repair the mucosal shield and how to properly signal Akkermansia muciniphila with complex polyphenols.

   • The 4-Step Clinical Protocol: How to use stool metabolomics, pomegranate ellagitannins, oral tributyrin, and L-glutamine to rebuild the gut barrier from the ground up.

   • Pathogenesis vs Salutogenesis: Why Health Optimization Medicine focuses on restoring root cause physiological health rather than perpetually suppressing symptoms.

   This episode is for you if:

   • You are dealing with chronic fatigue, brain fog, and unyielding food intolerances despite taking probiotics.

   • You want to understand the true biochemical mechanism behind leaky gut and systemic endotoxemia.

   • You are a practitioner looking to replace guesswork with objective metabolomic testing and precision mucosal protocols.

   You can also find this episode on…

   YouTube: https://www.youtube.com/watch?v=_wZH8tJTFWw&feature=youtu.be

   Find more from Health Optimization Medicine and Practice (HOMeHOPe):

   Website: https://homehope.org/

   Instagram: https://www.instagram.com/homehopeorg/

   HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

   Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

   Find more from Troscriptions:

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10. Can Creatine Protect the Brain from Sleep Deprivation? | HOMe Podcast #024

    August 26, 202615 minSeason 2 · Episode 24

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Dr. Jup Kuipers explore how acute sleep deprivation affects brain energy metabolism and …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Dr. Jup Kuipers explore how acute sleep deprivation affects brain energy metabolism and whether creatine monohydrate can help preserve cognitive function when sleep loss is unavoidable.

    Rather than relying on stimulants like caffeine or modafinil to push through fatigue, the team examines whether directly supporting the brain's phosphocreatine and ATP systems can maintain cellular energy and cognitive performance during acute sleep deprivation.

    The discussion looks at recent research on single-dose creatine, brain bioenergetics, blood-brain barrier transport, clinical dosing, and the limits of using creatine as an acute rescue tool.

    Join us as we delve into:

    • Sleep Deprivation as a Bioenergetic Crisis: Why acute sleep loss is more than simply feeling tired, and how depletion of phosphocreatine and ATP can affect executive function and cognitive performance.
    • The Creatine Rescue Effect: What a 2026 randomized crossover study found when healthy participants received a single dose of creatine after prolonged sleep deprivation.
    • Creatine, ATP & the Brain: How creatine acts through the creatine kinase system to help maintain high-energy phosphates during acute metabolic stress.
    • The Blood-Brain Barrier Under Stress: Why sleep deprivation may change the conditions for creatine transport into the brain and create a window for acute supplementation.
    • The Clinical Protocol: What the episode discusses regarding single-dose creatine monohydrate, timing before an acute cognitive stress period, hydration, magnesium, and other cofactors.
    • Creatine Is Not a Substitute for Sleep: Why acute creatine rescue may help preserve cellular function during unavoidable sleep loss, but cannot replace the restorative functions of deep sleep and REM sleep.
    • Health Optimization vs. Disease Prevention: Why HOMeHOPe approaches acute physiological stress by supporting cellular function before the system reaches a state of failure.

    This episode is for you if:

    • You work shifts, overnight schedules, or other situations where acute sleep deprivation is sometimes unavoidable.
    • You want to understand how sleep loss affects brain energy metabolism and cognitive performance.
    • You are interested in the relationship between creatine, phosphocreatine, ATP, and brain function.
    • You want to understand the potential and limitations of using creatine during acute cognitive stress.
    • You are interested in cellular bioenergetics and the Health Optimization Medicine approach to precision health.

    You can also find this episode on… YouTube: https://youtu.be/LvEBMroaLA4

    Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

11. Is Your Cellular Membrane Leaking the Fuel That Keeps You Going? (Why NAD+ Isn't Enough) | HOMe #022

    August 12, 202624 minSeason 2 · Episode 22

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval explore one of the most overlooked causes of declining cellular energy: the …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval explore one of the most overlooked causes of declining cellular energy: the structural breakdown of the mitochondrial membrane.

    While many people invest in premium longevity supplements like NAD+, NMN, and CoQ10 to improve energy production, emerging research suggests these compounds cannot overcome a damaged mitochondrial membrane. The team explains how age-related phosphatidylcholine depletion weakens the mitochondrial lipid bilayer, causing proton leakage, oxidative stress, and reduced ATP production, even when the biochemical machinery appears intact.

    From membrane lipidomics and clinical metabolomics to phosphatidylcholine replacement and methylation support, this discussion reframes mitochondrial health through the lens of structural integrity rather than simply adding more fuel.

    Join us as we delve into:

    • The Leaky Mitochondria Problem: Why declining phosphatidylcholine causes proton leaks that reduce ATP production and accelerate mitochondrial aging.

    • Why NAD+, NMN & CoQ10 Sometimes Fail: How expensive mitochondrial supplements cannot restore energy when the mitochondrial membrane itself has become structurally compromised.

    • Pathogenesis vs. Salutogenesis: Why Health Optimization Medicine focuses on building the biology of health instead of simply preventing disease.

    • Clinical Metabolomics & Membrane Lipidomics: How measuring functional biomarkers provides deeper insight into cellular health than conventional blood tests alone.

    • Phosphatidylcholine Replacement Therapy: Why rebuilding mitochondrial membranes with pharmaceutical-grade phosphatidylcholine, methyl donors, and chronobiology may improve bioenergetics.

    • The Prevention Paradigm Shift: Why optimizing membrane integrity may become a foundational strategy for supporting healthy aging and cellular resilience.

    This episode is for you if:

    • You are taking NAD+, NMN, CoQ10, or other mitochondrial supplements but still struggle with fatigue or poor recovery.

    • You want to understand why mitochondrial membrane health may be more important than simply increasing energy substrates.

    • You are interested in clinical metabolomics, membrane lipidomics, and the future of precision lifestyle medicine.

    • You want to learn how phosphatidylcholine and methylation support contribute to healthy mitochondrial function.

    You can also find this episode on…

    YouTube:

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/

    Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

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12. Dr. Dominic D'Agostino Explains What Ketones Actually Do to Your Body | HOMe Podcast #021

    August 5, 202653 minSeason 2 · Episode 21

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Dominic D'Agostino, the premier researcher in ketogenic metabolic therapies. Moving past the mainstream fads of …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Dominic D'Agostino, the premier researcher in ketogenic metabolic therapies. Moving past the mainstream fads of keto ice cream and internet trends, they break down how exogenous ketones actually impact cellular energy, cardiovascular health, and environmental stress.

    From the liver toxicity associated with certain high-dose ketone esters to the hidden vasodilatory superpowers of L-BHB, this discussion separates the biohacking hype from the physiological reality of ketone supplementation.

    Join us as we delve into:

    • Fad vs. Science: Why serious researchers use the term Ketone Metabolic Therapy instead of Ketogenic Diet, and why peer-reviewed science is growing exponentially despite Google trends.

    • The Metformin VO2 Max Penalty: Exploring recent data showing metformin can blunt VO2 max adaptations to exercise by 50% and acts as a weak mitochondrial toxin.

    • Mitochondrial Hydraulic Efficiency: How ketones physically tighten electron flow in the mitochondria, reducing superoxide (ROS) production and enhancing endogenous antioxidant capacity.

    • The Danger of 1,3-Butanediol: Why relying on high doses of certain ketone esters and diols can trigger dizziness, liver abnormalities, and dependence, and how to formulate them safely.

    • The L-BHB Advantage: Why the lesser-known L-enantiomer of BHB acts as a potent vasodilator, significantly increasing cardiac output and brain blood flow through adenosine signaling.

    • Performance vs. Recovery: Why exogenous ketones might underwhelm a healthy athlete looking for a power boost, but shine in extreme stress environments like hypoxia, hyperoxia, and recovery.

    This episode is for you if:

    • You want to know the difference between a nutritional ketogenic diet and simply taking exogenous ketone supplements.

    • You are concerned about the side effects, liver stress, and acidic load of pushing your blood ketone levels too high.

    • You are interested in the synergistic effects of Hyperbaric Oxygen Therapy (HBOT) combined with ketone therapies for traumatic brain injury and mitigating oxygen toxicity.

    You can also find this episode on…

    YouTube: https://youtu.be/sU-ZNinqqgg

    Find more from Dr. Dominic D'Agostino:

    Website: https://ketonutrition.org/

    Metabolic Health Initiative: https://www.metabolicinitiative.com/

    Instagram: https://www.instagram.com/dominic.dagostino.kt/

    LinkedIn: https://www.linkedin.com/in/dominic-d-agostino-156014b/

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/

    Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

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13. Metformin is Poisoning Your Cells | HOMe Podcast #020

    August 3, 202619 minSeason 2 · Episode 20

    In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, Jodi Duval, and Dr. Jup Kuipers take a deep dive into the shocking new 21-year pre-diabetes …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, Jodi Duval, and Dr. Jup Kuipers take a deep dive into the shocking new 21-year pre-diabetes follow-up study (DPPOS) published in the Journal of the American Medical Association on June 15, 2026. Moving past the mainstream longevity hype surrounding Metformin as an anti-aging cure-all, the faculty breaks down why chemically poisoning your enzymes is a profound mismatch for healthy, active individuals.

    From the bioenergetics of exercise to the clinical application of precision metabolomics, this roundtable shifts the conversation from off-label drug prescriptions to cultivating true cellular safety and mitochondrial hormesis.

    Join us as we delve into:

    • The Metformin Illusion: The long-term results of the DPPOS study proving Metformin completely failed to outperform a placebo for reducing multimorbidity risk, while intensive lifestyle intervention reduced multiple chronic disease risks by over 20%.

    • Mitochondrial Blockade: How Metformin's inhibition of Complex I of the electron transport chain chemically throttles your cells, cutting cardiovascular fitness gains (VO2 max improvements) in half compared to exercise alone.

    • The mTOR Obstacle: Why daily off-label Metformin use actively blunts muscle hypertrophy and strength gains in response to resistance training by blocking key adaptation pathways.

    • The Rating of Perceived Exertion (RPE) Spike: How chemically throttling your mitochondria drives up lactic acid, leaving active biohackers with nagging, unexplained fatigue during workouts.

    • Pathogenesis vs. Salutogenesis: Why functional and preventive medicine remain trapped in disease-centered thinking, and how Health Optimization Medicine shifts the focus to detecting and correcting cellular imbalances.

    • The 3-Phase Metformin Transition Protocol: A step-by-step clinical sequence using early morning circadian anchors, urinary organic acid testing, targeted orthomolecular cofactors, and pulsed phytoceuticals strictly on rest days.

    This episode is for you if:

    • You are currently taking Metformin or berberine off-label for anti-aging but feel like your gym gains and recovery have plateaued.

    • You want to understand the exact biochemical mechanisms of how daily chemical inhibitors block the cellular stress signals required for exercise adaptations.

    • You want to learn how to transition off chronic metabolic blockades and restore biological peak quality of life naturally.

    You can also find this episode on…

    YouTube: https://youtu.be/v1e132gqY_k

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/

    Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

    Website: https://troscriptions.com/

    Instagram: https://www.instagram.com/troscriptions/

    Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

14. The Gut-Brain-Microbiome Axis: Understanding Depression, Serotonin, & Probiotics | HOMe Podcast #019

    July 22, 202632 minSeason 2 · Episode 19

    In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Jup Kuipers, and Jodi Duval take a deep dive into the gut-brain-microbiota axis. Moving …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Jup Kuipers, and Jodi Duval take a deep dive into the gut-brain-microbiota axis. Moving past the simplistic, pathogenic "pill-for-an-ill" approach of conventional psychiatry and the mainstream hype around over-the-counter probiotics, the faculty breaks down why establishing enteric safety must always precede biochemical optimization.

    Join us as we delve into:

    • The Tripartite Axis: How the enteric microbiota, gut barrier, and central nervous system communicate at a molecular and metabolomic level to dictate brain state and mood.

    • Epigenetic Signaling: How gut microbes act as active metabolic factories, fermenting dietary fibers into short-chain fatty acids (SCFAs) like butyrate that cross the blood-brain barrier to upregulate BDNF and support synaptic plasticity.

    • The IDO Serotonin Hijack: How gut-driven inflammation activates indolamine 2,3-dioxygenase (IDO), shunting tryptophan down the kynurenine pathway to produce neurotoxic quinolinic acid instead of serotonin and melatonin.

    • The Microglial Fire: How circulating cytokines cross the blood-brain barrier at the circumventricular organs, placing the brain's microglia into an active defense state that triggers cognitive fatigue and brain fog.

    • The 3-Phase Gut-Brain Protocol: Why seeding probiotics into inflamed soil fails, and how to logically sequence clearing overgrowth, rebuilding mucosal integrity with L-glutamine, and seeding validated strains.

    This episode is for you if:

    • You are running on high-dose over-the-counter probiotics for mood issues but feeling no relief or worsening symptoms.

    • You want to understand the exact cellular and biochemical mechanisms connecting leaky gut to leaky brain and psychiatric distress.

    • You want a practical, clinically sequenced blueprint to restore gut barrier safety before attempting to optimize your neurochemistry.

    You can also find this episode on…

    YouTube: https://youtu.be/AX-Mt1crayc

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/

    Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

    Website: https://troscriptions.com/

    Instagram: https://www.instagram.com/troscriptions/

    Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

15. Why You Can't Out-Supplement a Dysregulated Nervous System | HOMe Podcast #018

    July 15, 202627 minSeason 2 · Episode 18

    In this episode of the Health Optimization Medicine Podcast, Dr. Allen Bookatz, Dr. Ted Achacoso, and Jodi Duval tackle the widespread trend of supplement fatigue. As biohacking becomes a mindset of treating …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Dr. Allen Bookatz, Dr. Ted Achacoso, and Jodi Duval tackle the widespread trend of supplement fatigue.

    As biohacking becomes a mindset of treating symptoms with heavy stimulants and endless pills, the faculty breaks down why forcing adaptation on an exhausted system only drives the body deeper into a chronic state of inflammatory defense.

    From the biophysics of the Cell Danger Response (CDR1) to practical parasympathetic upregulation, this roundtable shifts the focus from treating disease to establishing true autonomic safety.

    Join us as we delve into:

    • The Cell Danger Response (CDR1): How a sympathetic fight-or-flight state physically stiffens cell membranes and halts aerobic respiration.

    • The Vagal Superhighway: How sympathetic dominance halts gut motility, triggers dysbiosis, and blocks neurotransmitter synthesis.

    • The Autonomic Safety Protocol: The critical importance of chronobiology, early morning sunlight, and circadian anchors.

    • Vagal Upregulation & GABA Support: Utilizing transcutaneous auricular vagus stimulation (taVNS), L-theanine, and Kava to quiet the central alarm and exit CDR1.

    • The Myth of Extreme Hormesis: Why intense stressors like ice baths and strict fasts act as active threats, not adaptation triggers, when your cells are already depleted.

    This episode is for you if:

    • You are running on a continuous cycle of intense workouts, strict fasts, and multiple wearables, yet feel more exhausted.

    • You want to understand why your cells cannot use nutrients for energy production when they perceive an active attack.

    • You want to learn how to pulse carefully calibrated hermetic stressors only after restoring baseline energy reserves.

    You can also find this episode on…

    YouTube: https://youtu.be/uE3LhioxwZQ

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/

    Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

    Website: https://troscriptions.com/

    Instagram: https://www.instagram.com/troscriptions/

    Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

16. Cellular Safety and the Dangers of Mechanical Blood Microplastic Detox | HOMe Podcast #017

    July 8, 202621 minSeason 2 · Episode 17

    In this episode of the Health Optimization Medicine Podcast, our faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, Dr. Allen Bookatz, and Jodi Duval, tackle the recent trend of therapeutic plasma …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, our faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, Dr. Allen Bookatz, and Jodi Duval, tackle the recent trend of therapeutic plasma exchange and "blood washing". Moving past the mainstream marketing of plasmapheresis as a longevity cure-all, the team breaks down why mechanical filtering is only a surface-level fix for microplastic toxicity.

    From the autonomic anxiety caused by biological lockdown to the clinical application of precision metabolomics, this roundtable shifts the conversation from invasive procedures to measurable, cellular safety signals.

    Join us as we delve into:

    • The Protein Corona: How circulating microplastics masquerade as pathogens, triggering localized purinergic signaling and the release of extracellular ATP.

    • The Cell Danger Response (CDR1): Why the body halts oxidative phosphorylation and locks down the cell membrane when invaded, and why blood washing can't touch toxins stuck inside tissue matrices.

    • The Problem with Plasmapheresis: The clinical realities and physiological costs of invasive vascular filtering, including the removal of essential immunoglobulins and clotting factors.

    • The True Detox Protocol: Utilizing organic carbon binders (humic and fulvic acids), phase two liver conjugation (glucuronidation/sulfation), and barrier integrity support to properly excrete microplastics.

    • Pulsed Antioxidant Support: When and why to use targeted NAD, alpha-lipoic acid, NAC, and ubiquinol to transition cells out of a defensive lockdown.

    This episode is for you if:

    • You are considering expensive therapies like plasmapheresis to clear environmental toxins.

    • You want to learn how to test your cellular metabolomics for organic acids and brain inflammation.

    • You want to understand how your unique exposome interacts with your cellular safety mechanisms.

    You can also find this episode on…

    YouTube: https://youtu.be/5b4jWqByRAU

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/

    Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

    Website: https://troscriptions.com/

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    Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

17. The HRV Paradox: Why Tracking Your Sleep Makes It Worse | HOMe Podcast #016

    July 1, 202621 minSeason 2 · Episode 16

    In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, and Jodi Duval) tackles one of the most paradoxical trends in modern …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, and Jodi Duval) tackles one of the most paradoxical trends in modern biohacking: sleep tracking. Moving past the mainstream obsession with daily device scores, the team breaks down the biochemical realities of how tracking your HRV might actually be sabotaging your sleep architecture.

    From the autonomic anxiety caused by digital wearables to the clinical application of precision chronobiology, this roundtable shifts the conversation from algorithmic scores to measurable, cellular safety signals.

    Join us as we delve into:

    • The Orthosomnia Epidemic: Why waking up to a red recovery score immediately triggers your prefrontal cortex, activates your HPA axis, and flattens your diurnal cortisol curve.

    • The HRV Paradox: Understanding the actual biological markers of Heart Rate Variability and why an algorithmic score doesn't dictate your physical reality.

    • The Cell Danger Response: How the body is only able to sleep when it feels safe, and why the ultimate "detox" might just be a sleep divorce.

    • Your "Do This on Monday" Protocol: Dr. Ted's clinical sleep anchoring technique, and why prioritizing sleep as the first activity of your day changes your entire circadian rhythm.

    • Precision Cellular Nutrients: The clinical difference between taking generic sedatives and utilizing precision magnesium, glycine, and even strategic carbohydrates (like honey) to optimize GABA and melatonin.

    This episode is for you if:

    • You are experiencing worsening sleep anxiety and chronic insomnia despite meticulously tracking your data every night.

    • You want to learn how to test your cellular metabolomics for brain inflammation instead of relying on a generic smartwatch algorithm.

    • You want to understand how your unique chronobiology dictates your sympathetic and parasympathetic balance.

    You can also find this episode on…

    YouTube: https://youtu.be/n71oG96M1Ek

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/

    Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

    Website: https://troscriptions.com/

    Instagram: https://www.instagram.com/troscriptions/

    Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

18. Decoding the Holobiont: The Ecosystem of Ecosystems | HOMe Podcast Special Episode

    June 24, 202615 minSeason 2 · Episode 16

    In this special in-person roundtable recorded in Washington, D.C., the HOMeHOPe faculty sit down to decode one of the most important perspective shifts in modern health: the Holobiont. Moving away from the …

    Show notes

    In this special in-person roundtable recorded in Washington, D.C., the HOMeHOPe faculty sit down to decode one of the most important perspective shifts in modern health: the Holobiont.

    Moving away from the traditional, siloed medical model of "organology" (treating the heart, gut, and brain as isolated systems managed by different specialists), the faculty discusses why true health optimization requires viewing the human body as a complex, interconnected ecosystem of ecosystems.

    Join us as we delve into:

    • The Holobiont Paradigm: Why you are not just a single organism, but a super-ecosystem made up of human cells and trillions of cooperating microbiota (including in your cornea, ureters, and gut).

    • The Danger of "Organ" Medicine: How specializing solely in individual organs leads to clinical blind spots, and why common prescriptions like statins and PPIs can quietly disrupt cellular energy (CoQ10) and nutrient absorption system-wide.

    • Metabolomics vs. Genetics: Why your DNA only tells you what might happen, while clinical metabolomics tells you exactly what is happening right now.

    • The Cell Danger Response (CDR): How your metabolites act as powerful epigenetic signalers, turning genes on and off to regulate systemic health and recovery.

    • The N-of-1 Future: Why large randomized controlled trials (RCTs) often fail by completely ignoring the gut microbiome, and why personalized, N-of-1 medicine is the only true path forward.

    This episode is for you if:

    • You are tired of being bounced between specialists for interconnected symptoms like mood disturbances, fatigue, and chronic bloating.

    • You want to understand the limitations of DNA testing and why measuring real-time metabolites is the gold standard for biohacking.

    • You are a clinician looking to shift your practice from illness management to foundational cellular optimization.

    You can also find this episode on…

    YouTube: https://youtu.be/ILwab838zVM

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/

    Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference: https://homehope.org/

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

    Website: https://troscriptions.com/

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19. Bypass the Fiber Trend & Optimize Your Gut Health | HOMe Podcast #015

    June 17, 202615 minSeason 2 · Episode 15

    In this episode of the Health Optimization Medicine Podcast, the core faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz) tackles one of the most misunderstood topics in modern …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, the core faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz) tackles one of the most misunderstood topics in modern nutrition: fiber. Moving past the mainstream trend of "fiber-maxing," the team breaks down the actual biochemical realities of how different forms of fiber interact with your unique gut microbiome.

    From the surprising hormonal impacts of over-consuming fiber to the rise of localized conditions, this roundtable shifts the conversation from generic dietary rules to precise, measurable, cellular data.

    Join us as we delve into:

    • The Classification of Fiber: Understanding the biological differences between soluble fiber (which breaks down into calories) and insoluble fiber (which adds bulk to stool).

    • The Fiber Maxing Trap: Why forcing massive amounts of psyllium husk, acacia powder, and green drinks can aggravate conditions like Small Intestinal Bacterial Overgrowth (SIBO) and IBS.

    • The Estrogen Heist: The hidden clinical correlation between high-fiber diets (60g+ per day) and the cessation of menstruation (amenorrhea) in female athletes.

    • Short-Chain Fatty Acids (SCFAs): The crucial roles of propionate, acetate, and butyrate as genetic signalers and the primary fuel source for your large intestine.

    • The Gut as an Immune Organ: Why managing the "gut-associated lymphoid tissue" (GALT) forms the basis of roughly 80% of human immune system function.

    This episode is for you if:

    • You are experiencing worsening gas, bloating, and discomfort despite eating a "clean, high-fiber" vegetarian or whole-food diet.

    • You want to learn how to test your stool for real-time butyrate levels instead of relying on generic probiotic protocols.

    • You want to understand how your unique gut ecosystem mirrors a complex, balancing rainforest.

    You can also find this episode on…

    • YouTube: https://youtu.be/L5StNtmDrdg

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    • Website: https://homehope.org/

    • Instagram: https://www.instagram.com/homehopeorg/

    • HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    • Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

    • Website: https://troscriptions.com/

    • Instagram: https://www.instagram.com/troscriptions/

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20. Why Aging May Be the Root Cause of Chronic Disease | HOMe Podcast #014

    June 10, 202614 minSeason 2 · Episode 14

    In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz reunite in person in Washington, D.C.. Moving away …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz reunite in person in Washington, D.C.. Moving away from traditional classifications of illness, the team breaks down a powerful paradigm shift: chronic disease and aging are not separate processes—chronic disease is aging.

    Drawing from the pioneering frameworks of biogerontologist Aubrey de Grey and the SENS Research Foundation, they discuss how flawed metabolism inherently accumulates structural damage long before a clinical diagnosis ever appears.

    Join us as we delve into:

    •The Metabolism Flaw: How the very process keeping us alive produces reactive oxygen species and damage that eventually leads to tissue breakdown and pathology.

    •Reclassifying Disease: Moving past the old congenital vs. infectious vs. chronic model to target metabolism directly.

    •The $30,000 Stem Cell Mistake: Why dropping thousands on mesenchymal stem cells (MSCs) or exosomes is a waste of money if your body is trapped in a cellular defense posture.

    •The Cell Danger Response (CDR): Understanding Robert Naviaux's work on how ancient defense mechanisms shut down growth and repair under stress.

    •Morbidity Compression: Shifting your biology back to your optimal 21-to-30-year-old baseline to maximize healthspan and ensure you live vibrant before a rapid, peaceful end.

    This episode is for you if:

    •You want to understand why biohacking shortcuts like stem cells require metabolic priming to actually work.

    •You are tired of "normal" lab ranges meant for a sick population and want true, age-optimized biomarkers.

    •You want to stop guessing what vitamins or antioxidants your body needs and start measuring your exact metabolomic fingerprint.

    You can also find this episode on…

    YouTube: https://youtu.be/DygsezbmZxM

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

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21. Health Optimization for Parenting, Pregnancy & Family Life | HOMe Podcast #013

    June 3, 202625 minSeason 2 · Episode 13

    In this episode of the Health Optimization Medicine Podcast, hosts Dr. Scott Sherr and Jodi Duval come together for an intimate, parent-to-parent roundtable. As the only current parents on the HOMeHOPe faculty …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, hosts Dr. Scott Sherr and Jodi Duval come together for an intimate, parent-to-parent roundtable. As the only current parents on the HOMeHOPe faculty, they dive deep into the specific biology of preconception, pregnancy, and pediatric health optimization. Moving beyond typical disease management, they explore how to foster both psychological and cellular safety across the entire family unit.

    Join us as we delve into:

    • The Masterclass Blueprint: Navigating the fastest period of human growth and biological wiring from preconception to age 12.

    • The Energy Demands of Fertility: Why oocytes (eggs) and reproductive organs hold the highest mitochondrial density per cell in the body.

    • Pediatric Shifts: Addressing modern rises in childhood insomnia, allergies, immune dysregulation, and pediatric autoimmunity through an exposomic lens.

    • The Testing Trap: Why traditional adult lab testing templates aren't always required—or appropriate—for resilient, self-correcting children.

    • Family Attunement & Nervous System Regulation: Understanding why adult parent optimization directly dictates child behavior, sleep quality, and home environment stressors.

    This episode is for you if:

    • You are a parent looking to leverage practical bioenergetics, chronobiology, and clean exposomics for your household.

    • You are preparing for pregnancy and want to optimize cellular health during the critical 90-day preconception timeline.

    • Your child is struggling with modern issues like appetite dysregulation, blue-light toxicity, or environmental heavy metal burden.

    • You want a sustainable template for family health that values parent self-care over self-sacrifice.

    You can also find this episode on…

    YouTube: https://youtu.be/WsvoFXcIuZ4

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):

    Website: https://homehope.org/

    Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:

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    Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

22. What Nobody Told You About Your Gut | HOMe Podcast #012

    May 27, 202633 minSeason 2 · Episode 12

    In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty (Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers) dive deep into the unseen world inside your stomach …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty (Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers) dive deep into the unseen world inside your stomach. Moving beyond simple probiotics, they discuss the gut as a "post-natal organ" and explore how the trillions of microbes inside you actually dictate your cravings, your mood, and your immune system.

    𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘀 𝘄𝗲 𝗱𝗲𝗹𝘃𝗲 𝗶𝗻𝘁𝗼:

    •The "tripartite axis" (Gut-Brain-Enteric Microbiota) and how it links directly to treatment-resistant depression and anxiety.

    •Why the vagus nerve is the master switch for your rest-and-digest parasympathetic nervous system.

    •The concept of the "Holobiont": Why your microbial DNA is 100 times larger than your human DNA.

    •How a single weekend of bad eating or a disrupted sleep schedule can completely derail your microbiome in just 72 hours.

    •Why vegetarians sometimes struggle with massive bloating and methane gas production due to bacterial overgrowth.

    𝗧𝗵𝗶𝘀 𝗲𝗽𝗶𝘀𝗼𝗱𝗲 𝗶𝘀 𝗳𝗼𝗿 𝘆𝗼𝘂 𝗶𝗳:

    •You struggle with brain fog, anxiety, or treatment-resistant mood changes.

    •You want to understand the actual mechanics behind "gut feelings" and sudden sugar cravings.

    •You are tired of standard GI advice and want to learn how clinical metabolomics maps your microbiome.

    •You want actionable steps to rebuild your gut ecosystem over the next 3 to 6 months.

    𝗬𝗼𝘂 𝗰𝗮𝗻 𝗮𝗹𝘀𝗼 𝗳𝗶𝗻𝗱 𝘁𝗵𝗶𝘀 𝗲𝗽𝗶𝘀𝗼𝗱𝗲 𝗼𝗻…

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    Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/

    HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

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23. The Problem with Over-Optimization in Modern Health | HOMe Podcast #011

    May 20, 202625 minSeason 2 · Episode 11

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Jup Kuipers come together live in studio in Washington, D.C. to discuss the dangers of over-optimization …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Jup Kuipers come together live in studio in Washington, D.C. to discuss the dangers of over-optimization and the "more is better" mentality. They explore real clinical case studies of patients who inadvertently damaged their health by blindly following supplement trends.

    Join us as we delve into:

    • The dangers of over-supplementing with high-dose Fish Oil and Vitamin B6.

    • How shifting to an "Omega-3 dominant" ratio can actually hinder your immune system's ability to heal injuries.

    • Why you should treat metabolomic testing like the dashboard of a car to prevent the "check engine light" of chronic disease.

    • How clinical metabolomics allows you to stop guessing and start subtracting unnecessary pills from your daily routine.

    This episode is for you if:

    • You are experiencing wellness burnout and taking a massive handful of supplements every day without knowing if they are working.

    • You want to understand the difference between being "fit" (e.g., running a marathon) and being truly cellularly "healthy."

    • You are curious about functional testing and how it differs from the standard disease-focused bloodwork at a primary care clinic.

    • You want a clear strategy to cut through social media influencer noise and build a foundational, personalized health protocol.

    You can also find this episode on… YouTube: https://youtu.be/WSNOBi1e7WY

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

24. Creatine, Cellular Energy, and the Modern Stress Epidemic | HOMe Podcast #010

    May 13, 202626 minSeason 2 · Episode 10

    In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the science and clinical application of creatine. Moving beyond its …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the science and clinical application of creatine. Moving beyond its reputation as just a performance supplement for "gym bros," Boomer Anderson, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Ted Achacoso break down how creatine functions as a critical cellular battery buffer.

    Join us as we delve into:

    • How creatine bypasses the "methylation tax" by saving the body from depleting SAMe reserves to produce energy.

    • Why muscle is a metabolic determinant of resilience and not just a cosmetic feature.

    • The evolutionary mismatch that increases our cellular energy demands due to a highly sympathetic, stressed lifestyle.

    • The role of creatine in brain health is particularly important for supporting working memory, mitigating cognitive fatigue, and protecting against excitotoxicity.

    This episode is for you if:

    • You are curious about how to support your body's cellular energy and mitochondrial function.

    • You follow a vegetarian or plant-based diet and want to understand your specific creatine supplementation needs.

    • You want to understand the difference between maintaining muscle for aesthetic reasons versus metabolic health.

    • You are looking for strategies to mitigate mental fatigue and sleep deprivation.

    You can also find this episode on... YouTube: https://youtu.be/R4x9tu56FXg

    Find more from Health Optimization Medicine and Practice (HOMeHOPe):Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

    Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions:Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/

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25. Understanding Toxicity Through Health Optimization Medicine | HOMe Podcast #009

    May 6, 202615 minSeason 2 · Episode 9

    In this episode of the HOMe Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz explore a foundational principle of Health Optimization Medicine: What's toxic to the cell is toxic …

    Show notes

    In this episode of the HOMe Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz explore a foundational principle of Health Optimization Medicine:

    What's toxic to the cell is toxic to every organ.

    Through real clinical cases — including mercury toxicity, arsenic exposure, and environmental toxin accumulation — the team reveals how modern medicine often misses the root cause of disease by focusing on isolated organ systems instead of cellular function.

    From chronic low-level toxin exposure to acute breakdown events, this episode highlights how toxins disrupt mitochondrial energy production, leading to widespread dysfunction across the body.

    Most importantly, the conversation emphasizes the role of metabolomics in identifying these hidden stressors early — before they manifest as disease.

    Join us as we delve into:

    • Why toxins affect every organ through the cell • A real case of mercury toxicity missed by multiple specialists • How chronic exposure becomes acute illness • Why traditional medicine misses root causes • The role of mitochondria in energy production and health • How metabolomics detects early toxicity and dysfunction

    This episode is for you if:

    • You want to understand the root cause of chronic illness • You're exposed to environmental toxins (food, water, air) • You're interested in preventative and optimization-based medicine • You want to take a proactive approach to long-term health

    You can also find this episode on…Youtube: https://youtu.be/CMhFC5IUKl0

    Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

26. The Trust Crisis in Healthcare (And How to Fix It) | HOMe Podcast #008

    April 29, 202647 minSeason 2 · Episode 8

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with JJ Virgin — nutrition expert, bestselling author, and founder of the Health Business Growth Collective — to explore …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with JJ Virgin — nutrition expert, bestselling author, and founder of the Health Business Growth Collective — to explore how healthcare practitioners can build trust, authority, and impact in today's rapidly evolving landscape.

    With the rise of AI and what JJ calls a "trust recession," the traditional ways of building a practice are no longer enough. Instead, practitioners must learn how to stand out as a trusted authority — combining credibility, authenticity, and real-world proof.

    JJ breaks down her powerful "Trusted Authority Framework," explaining how clinicians can differentiate themselves, connect with patients, and grow their influence without becoming influencers.

    This episode is a must-listen for practitioners looking to grow, scale, and future-proof their practice in the age of AI.

    Join us as we delve into:

    • The "Trust Recession" and why it's reshaping healthcare

    • The difference between being an influencer vs a trusted authority

    • Why vulnerability and storytelling build trust faster than credentials

    • How to develop a contrarian stance that defines your expertise

    • The power of patient stories as proof (and why they outperform credentials)

    • Why most practitioners struggle with imposter syndrome — and how to reframe it

    This episode is for you if:

    • You're a practitioner looking to grow your practice

    • You want to build authority without becoming a social media influencer

    • You're navigating AI, personal branding, and patient trust

    • You want to stand out in a crowded health and wellness space

    You can also find this episode on… YouTube: https://youtu.be/rmyDXStM_Dk

    Find more from JJ Virgin Website: https://jjvirgin.com Health Business Growth Collective: https://hbgc.co Instagram: https://www.instagram.com/jj.virgin/

    Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

27. Mental Health Starts at the Cellular Level | HOMe Podcast #007

    April 22, 202628 minSeason 2 · Episode 7

    In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Dr. Ted Achacoso, Dr. Scott Sherr, and Jodi Duval explore mental health through the lens of health optimization medicine. Rather …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Dr. Ted Achacoso, Dr. Scott Sherr, and Jodi Duval explore mental health through the lens of health optimization medicine.

    Rather than viewing mental health as a set of diagnoses, the conversation reframes it as a function of cellular health — where brain function is driven by mitochondrial performance, inflammation, nutrient status, and environmental inputs.

    From neurotransmitter imbalances to brain inflammation and the gut-brain-microbiome axis, this episode breaks down how modern stressors, lifestyle, and environment impact mental health at the cellular level.

    Most importantly, the team explains why true mental health optimization must begin with optimizing the health of the cell.

    Join us as we delve into:

    • Why mental health should be viewed at the cellular level • The role of mitochondria in brain energy and signaling • Brain inflammation and its impact on mood and cognition • The gut-brain-microbiome axis and neurotransmitter production • Why stress, sleep, and environment drive mental health outcomes

    This episode is for you if:

    • You struggle with brain fog, anxiety, or low mood • You want a deeper, root-cause understanding of mental health • You're a practitioner looking beyond traditional psychiatry • You want to optimize cognitive performance and resilience

    You can also find this episode on…YouTube: https://youtu.be/5xqAzkMUpBs

    Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

28. The Cell Danger Response Explained (Why You're Not Healing) | HOMe Podcast #006

    April 15, 202637 minSeason 2 · Episode 6

    In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, and Jodi Duval as they break down one of the most important frameworks in Health Optimization Medicine — the …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, and Jodi Duval as they break down one of the most important frameworks in Health Optimization Medicine — the Cell Danger Response (CDR).

    Originally developed by Dr. Robert Naviaux, the Cell Danger Response explains how cells respond to threat, adapt for survival, and either resolve or become "stuck" — leading to chronic disease.

    This episode walks through the three stages of the CDR, how mitochondria act as both sensors and signaling hubs, and why many modern conditions — from inflammation to chronic illness — are actually stalled healing processes.

    Most importantly, the team explains how clinicians and individuals can identify where the body is "stuck" and what to do (and NOT do) to support proper resolution.

    Join us as we delve into:

    • What the Cell Danger Response (CDR) is and why it matters
    • The 3 stages: defense, repair, and resolution
    • How mitochondria act as sensors — not just energy producers
    • Why inflammation is a protective response, not the problem
    • How chronic disease reflects a "stalled" healing process

    This episode is for you if:

    • You're dealing with chronic inflammation or unresolved health issues
    • You want to understand the root cause of disease beyond symptoms
    • You're a practitioner looking for a systems-based framework
    • You want to optimize health by working with your biology, not against it

    You can also find this episode on… YouTube: https://youtu.be/NWEq32hlZrE

    Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

29. Microglia, Metabolism & the Future of Brain Health | HOMe Podcast #005

    April 8, 202659 minSeason 2 · Episode 5

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia.

    Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time.

    Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more.

    Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience.

    Join us as we delve into:

    • What microglia are and why they control brain health
    • The difference between M1 (destructive) and M2 (protective) states
    • How metabolism shapes the brain's immune response
    • Why conditions like Alzheimer's are rooted in immune dysfunction
    • The connection between blood sugar, insulin, and brain degeneration

    This episode is for you if:

    • You want to protect your brain and prevent cognitive decline
    • You're interested in the science of Alzheimer's and neurodegeneration
    • You want actionable strategies to improve brain health
    • You're curious about the future of brain optimization and longevity

    You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk

    Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/

    Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

30. The Science of Chronobiology & Health Optimization | HOMe Podcast #004

    April 1, 202624 minSeason 2 · Episode 4

    In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore chronobiology — and how modern life is disrupting the …

    Show notes

    In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore chronobiology — and how modern life is disrupting the body's natural rhythms.

    From jet lag and shift work to late-night scrolling and irregular meals, the conversation dives into what Dr. Ted calls "circadian pollution" — the mismatch between our biology and the environments we've created.

    More importantly, the team breaks down simple, powerful tools to re-entrain your body clock using light, food timing, and movement — all foundational principles in Health Optimization Medicine.

    Join us as we delve into:

    • What chronobiological re-entrainment actually means
    • The difference between the brain clock and organ clocks
    • How light, food, and movement act as biological time signals
    • Why late-night eating creates "metabolic jet lag"
    • How modern life creates circadian disruption

    This episode is for you if:

    • You struggle with sleep, fatigue, or inconsistent energy
    • You travel frequently or work irregular hours
    • You want to optimize your circadian rhythm naturally
    • You're looking for simple, zero-cost ways to improve health

    You can also find this episode on… YouTube: https://youtu.be/WcheAJNzq2k

    Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

    Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

These are the latest 100 of 198 episodes. You’ll find older episodes in the podcast’s feed.