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This Week in Neuroscience

This Week in Neuroscience

NewTWiN 76: Light Switches Go To StockholmOctober 29, 2026 · 1 h 19 min
Episodes
75
Released
monthly
Latest episode
Oct 29, 2026

About the podcast

A podcast about the nervous system.

Episodes 75

  1. TWiN 76: Light Switches Go To Stockholm

    1 h 19 minEpisode 76

    TWiN explains the science behind the 2026 Nobel Prizes in Physiology or Medicine for discoveries on light-gated ion channels and optogenetics. Hosts: Vincent Racaniello and Tim Cheung Subscribe (free): Apple …

    Show notes

    TWiN explains the science behind the 2026 Nobel Prizes in Physiology or Medicine for discoveries on light-gated ion channels and optogenetics.

    Hosts: Vincent Racaniello and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  2. TWiN 75: Arc, tau, and Alzheimer's

    1 h 9 minEpisode 75

    Jason Shepherd joins TWiN to discuss the work in his laboratory showing that Arc protein plays a role in intercellular transmission of tau protein, which becomes hyperphosphorylated and misfolded, a major …

    Show notes

    Jason Shepherd joins TWiN to discuss the work in his laboratory showing that Arc protein plays a role in intercellular transmission of tau protein, which becomes hyperphosphorylated and misfolded, a major histopathological hallmark of Alzheimer's disease.

    Hosts: Vincent Racaniello and Tim Cheung

    Guest: Melissa Cooper

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  3. TWiN 74: Plastic astrocyte networks with Melissa Cooper

    1 h 6 minEpisode 74

    Melissa Cooper joins TWiN to discuss her discovery that astrocytes connect specific brain regions through plastic networks. Hosts: Vincent Racaniello and Tim Cheung Guest: Melissa Cooper Subscribe (free): Apple …

    Show notes

    Melissa Cooper joins TWiN to discuss her discovery that astrocytes connect specific brain regions through plastic networks.

    Hosts: Vincent Racaniello and Tim Cheung

    Guest: Melissa Cooper

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  4. TWiN 73: The price of a bigger brain

    1 h 27 minEpisode 73

    TWiN unpacks a striking paradox, that the very cell divisions that built the human brain's most advanced layers also put them at greatest risk, and how a dedicated DNA repair pathway saves them. Hosts: Vincent …

    Show notes

    TWiN unpacks a striking paradox, that the very cell divisions that built the human brain's most advanced layers also put them at greatest risk, and how a dedicated DNA repair pathway saves them.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  5. TWiN 72: What cesarean babies miss

    1 h 9 minEpisode 66

    TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin. .Hosts: Vincent …

    Show notes

    TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin.

    .Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  6. TWiN 71: Psychedelics rewire the brain from within

    1 h 31 minEpisode 70

    TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds …

    Show notes

    TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  7. TWiN 70: Unraveling the axon wrap

    1 h 19 minEpisode 70

    TWiN explains the role of a ubiquitin ligase component in regulating the sheathing of multiple axons by Schwann cells. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple …

    Show notes

    TWiN explains the role of a ubiquitin ligase component in regulating the sheathing of multiple axons by Schwann cells.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  8. TWiN 69: Fibromyalgia and the microbiome

    1 h 11 minEpisode 69

    TWiN explains a study which showed that transplanting gut microbiota from women with fibromyalgia into mice induces pain, as well as phenotypes commonly observed in patients, such as immune activation …

    Show notes

    TWiN explains a study which showed that transplanting gut microbiota from women with fibromyalgia into mice induces pain, as well as phenotypes commonly observed in patients, such as immune activation, metabolomic changes, and reduced skin innervation.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  9. TWiN 68: Firewall for the brain

    1 h 14 minEpisode 68

    TWiN explores the use of speech brain-computer interfaces to restore communication to people with paralysis, and reveals strategies for protecting private inner speech. Hosts: Vincent Racaniello, Vivianne …

    Show notes

    TWiN explores the use of speech brain-computer interfaces to restore communication to people with paralysis, and reveals strategies for protecting private inner speech.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  10. TWiN 67: Interpreting situation-specific facial signals

    1 h 31 minEpisode 67

    TWiN explores how theta phase shifts mediate contextual perception of facial expressions during everyday social interactions. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple …

    Show notes

    TWiN explores how theta phase shifts mediate contextual perception of facial expressions during everyday social interactions.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  11. TWiN 66: Neuroscience of overeating

    1 h 24 minEpisode 66

    TWiN reviews the underlying neurobiological mechanisms of overeating and obesity, the role of the hypothalamus and reward systems in controlling food intake and energy balance, and how dysregulation in these …

    Show notes

    TWiN reviews the underlying neurobiological mechanisms of overeating and obesity, the role of the hypothalamus and reward systems in controlling food intake and energy balance, and how dysregulation in these systems leads to overeating.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  12. TWiN 65: Air pollutants promote dementia

    1 h 37 minEpisode 65

    TWiN explains epidemiological data showing that exposure to air pollution was associated with an increased risk of developing Lewy body dementia, and nasal administration of air pollution in mice led to brain …

    Show notes

    TWiN explains epidemiological data showing that exposure to air pollution was associated with an increased risk of developing Lewy body dementia, and nasal administration of air pollution in mice led to brain atrophy and impaired cognition and motor function.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  13. TWiN 64: How the brain decides what we see

    1 h 14 minEpisode 64

    TWiN explains how visual neurons show functional flexibility by selectively responding to subsets of inputs representing attended objects while ignoring those conveying information about irrelevant objects …

    Show notes

    TWiN explains how visual neurons show functional flexibility by selectively responding to subsets of inputs representing attended objects while ignoring those conveying information about irrelevant objects.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  14. TWiN 63: Microbiome-targeted neurotherapy

    1 h 32 minEpisode 63

    TWiN discusses research showing that Lactobacillus acidophilus promotes cognitive function recovery after cerebral ischemia, by regulating microglial peroxisomal function. Hosts: Vincent Racaniello, Vivianne …

    Show notes

    TWiN discusses research showing that Lactobacillus acidophilus promotes cognitive function recovery after cerebral ischemia, by regulating microglial peroxisomal function.

    Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  15. TWiN 62: Memories of bad food

    1 h 22 minEpisode 62

    TWiN explains research which identifies the regions of the brain that register a long-lasting aversion to potentially poisonous food even with meal to illness delays of several days. Hosts: Vincent Racaniello …

    Show notes

    TWiN explains research which identifies the regions of the brain that register a long-lasting aversion to potentially poisonous food even with meal to illness delays of several days.

    Hosts: Vincent Racaniello, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  16. TWiN 61: Blood to the brain

    1 h 40 minEpisode 61

    TWiN reveals that proteins travel from the blood to the brain where they are taken up by microglia, revealing a new mode of communication between the brain and the periphery. Hosts: Vincent Racaniello, Tim …

    Show notes

    TWiN reveals that proteins travel from the blood to the brain where they are taken up by microglia, revealing a new mode of communication between the brain and the periphery.

    Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  17. TWiN 60: You get the gist of it?

    1 h 5 minEpisode 60

    TWiN discusses experiments which show that high-fidelity memories that lose their precision with time depends on reorganization of hippocampal circuitry. Hosts: Vincent Racaniello, Jason Shepherd, and Tim …

    Show notes

    TWiN discusses experiments which show that high-fidelity memories that lose their precision with time depends on reorganization of hippocampal circuitry.

    Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  18. TWiN 59: AI co-scientist

    1 h 15 minEpisode 59

    Tim explains AI co-scientist, a tool released by Google, which it hopes to help scientists generate hypotheses and research proposals, and to accelerate the speed of scientific and biomedical discoveries …

    Show notes

    Tim explains AI co-scientist, a tool released by Google, which it hopes to help scientists generate hypotheses and research proposals, and to accelerate the speed of scientific and biomedical discoveries.

    Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  19. TWiN 58: Tongue-dragging rescue behavior

    1 h 14 minEpisode 58

    TWiN explains a study showing that when a mouse is confronted with an unconscious conspecific, it engages in behavior including tongue-dragging to resuscitate the animal via a tongue-brain connection. Hosts …

    Show notes

    TWiN explains a study showing that when a mouse is confronted with an unconscious conspecific, it engages in behavior including tongue-dragging to resuscitate the animal via a tongue-brain connection.

    Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  20. TWiN 57: Repetitive injury, herpes, and Alzheimer's

    40 minEpisode 57

    TWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer's disease. Hosts: Vincent Racaniello and Tim Cheung …

    Show notes

    TWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer's disease.

    Hosts: Vincent Racaniello and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  21. TWiN 56: Astrocytes help neurons remember

    1 h 1 minEpisode 56

    TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during …

    Show notes

    TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during circuit plasticity and memory recall.

    Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  22. TWiN 55: A brain circuit for day/night balance

    1 h 9 minEpisode 55

    TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change. Hosts: Vincent Racaniello, Jason …

    Show notes

    TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change.

    Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  23. TWiN 54: How pregnancy transforms the brain

    1 h 5 minEpisode 54

    TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting. Hosts: Vincent Racaniello, Jason Shepherd, and Vivianne Morrison Subscribe (free) …

    Show notes

    TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting.

    Hosts: Vincent Racaniello, Jason Shepherd, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  24. TWiN 53: Slowing time by cooling the brain

    1 h 10 minEpisode 53

    Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down …

    Show notes

    Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions.

    Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

    Guest: Joseph J. Paton and Felipe Rodrigues

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  25. TWiN 52: Probiotic improves social behavior in children with ASD

    1 h 6 minEpisode 52

    Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD …

    Show notes

    Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD.

    Hosts: Jason Shepherd, Timothy Cheung, and Vivianne Morrison

    Guest: Mauro Costa-Mattioli

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  26. TWiN 51: Sensory processing dysfunction in autism spectrum disorders

    1 h 11 minEpisode 51

    TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can …

    Show notes

    TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models.

    Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  27. TWiN 50: Neurological sequelae after COVID-19

    1 h 4 minEpisode 50

    TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain …

    Show notes

    TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19.

    Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  28. TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all?

    1 h 31 minEpisode 49

    TWiN welcomes mice to the elite club of 'self-aware' animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. Hosts: Vincent Racaniello, Timothy …

    Show notes

    TWiN welcomes mice to the elite club of 'self-aware' animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition.

    Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  29. TWiN 48: Traumatic brain injury and retroviruses

    51 minEpisode 48

    TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe …

    Show notes

    TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury.

    Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

  30. TWiN 47: Walking after spinal cord injury

    55 minEpisode 47

    TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. Hosts: Vincent Racaniello, Jason …

    Show notes

    TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface.

    Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to [email protected]

These are the latest 40 of 75 episodes. You’ll find older episodes in the podcast’s feed.

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